| Budget Amount *help |
¥174,070,000 (Direct Cost: ¥133,900,000、Indirect Cost: ¥40,170,000)
Fiscal Year 2020: ¥37,310,000 (Direct Cost: ¥28,700,000、Indirect Cost: ¥8,610,000)
Fiscal Year 2019: ¥37,310,000 (Direct Cost: ¥28,700,000、Indirect Cost: ¥8,610,000)
Fiscal Year 2018: ¥37,310,000 (Direct Cost: ¥28,700,000、Indirect Cost: ¥8,610,000)
Fiscal Year 2017: ¥37,310,000 (Direct Cost: ¥28,700,000、Indirect Cost: ¥8,610,000)
Fiscal Year 2016: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
|
|---|
| Outline of Final Research Achievements |
We have elucidated the role of the input-output system of orexin neurons in arousal, and how the arousal control system is involved in the function of the reward system, and how behavior can be altered through the reinforcement of emotional memory. We found that orexin regulates fear levels as well as arousal levels through NA neurons in the nucleus accumbens. Retrograde tracing of orexin and histamine neurons revealed a part of the arousal control system including the hypothalamus, brainstem and limbic system. We also clarified the role of GABAergic neurons in the striatum internus in inducing arousal. Furthermore, we showed that excitation of QRFP-positive neurons localized in the anterior ventral periventricular nucleus can induce a prolonged hypometabolic state.
|
