| Co-Investigator(Kenkyū-buntansha) |
大石 直也 京都大学, 医学研究科, 特定准教授 (40526878)
植木 美乃 名古屋市立大学, 医薬学総合研究院(医学), 教授 (40467478)
藤原 広臨 京都大学, 医学研究科, 講師 (10599608)
杉原 玄一 京都大学, 医学研究科, 助教 (70402261)
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| Budget Amount *help |
¥125,450,000 (Direct Cost: ¥96,500,000、Indirect Cost: ¥28,950,000)
Fiscal Year 2020: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2019: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2018: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2017: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2016: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
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| Outline of Final Research Achievements |
The monoaminergic nervous system has been considered important in the control of the volition in the bench settings so far. This project focused on the living human brain using PET, which was able to clarify the molecular aspects that controls will-power through imaging data of dopamine release under the will-power-related actions and impairments of the monoaminergic (serotonin and dopamine) and GAAB systems and developments of neuroinflammation in brain disorders lacking in will-power. Based on brain connectome analysis using task-based and resting-state fMRI, we clarified the relationship between various lifestyles related to willpower and willpower-related networks in healthy subjects, and abnormal brain networks and biomarker candidates in various neuropsychiatric disorders that reduce willpower.
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