| Budget Amount *help |
¥102,310,000 (Direct Cost: ¥78,700,000、Indirect Cost: ¥23,610,000)
Fiscal Year 2020: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2019: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2018: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2017: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2016: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
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| Outline of Final Research Achievements |
The increase in the number of young people with social withdrawal (hikikomori), who avoid going out and interacting with others for more than 6 months, and modern-type depression, which shows a different response to medication than traditional depression, has become a social problem. In this study, we developed assessment methods including diagnostic criteria for patients with these mental conditions. We have succeeded in preliminary identification of inflammation- and glial-related molecular basis as the biological basis of these disorders. We also developed a mouse model of hikikomori and identified several pathological bases by analyzing the neuron-glia interactions in the brain. Based on the findings of this study, we would like to develop new treatment methods for patients with hikikomori and modern-type depression.
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