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Symbiotic Relationship between Influenza Virus and Waterfowl in Nature

Planned Research

Project AreaNeo-virology: the raison d'etre of viruses
Project/Area Number 16H06434
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University (2020, 2022)
The University of Tokyo (2016-2019)

Principal Investigator

Watanabe Tokiko  大阪大学, 微生物病研究所, 教授 (60557479)

Co-Investigator(Kenkyū-buntansha) 河岡 義裕  東京大学, 医科学研究所, 教授 (70135838)
Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥59,280,000 (Direct Cost: ¥45,600,000、Indirect Cost: ¥13,680,000)
Fiscal Year 2020: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2019: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2018: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2017: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2016: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Keywordsインフルエンザウイルス / 共生 / バイローム解析 / ウイルスー宿主の共生関係 / ウイルス―宿主の共生関係
Outline of Final Research Achievements

We infected mallard ducks, the natural host of influenza viruses, with avian influenza viruses and found that they were asymptomatic, but innate immune responses were induced in their intestinal tracts in the early phase of infection and acquired immune responses in the late phase of infection.
We also established new animal infection models and analyzed the pathogenicity of avian influenza viruses and SARS-CoV-2. We collected samples from domestic and foreign wild animals and metagenomically analyzed them to identify novel crane adenoviruses and bat coronaviruses.

Academic Significance and Societal Importance of the Research Achievements

インフルエンザウイルスと自然宿主である水禽との共生が、宿主の腸内環境や生命活動に及ぼす影響やその機能メカニズムを調べることは、生物や生態系におけるウイルスの役割の理解につながる。
国内外の野生動物のウイルス叢や細菌叢を網羅的に解析することは、ウイルスが宿主の微生物叢に及ぼす影響を調べる上で非常に重要である。また新規ウイルスの発見にもつながり、ウイルスの多様性を解明するという本領域の目的達成につながる。

Report

(6 results)
  • 2022 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (209 results)

All 2023 2022 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (13 results) Journal Article (94 results) (of which Int'l Joint Research: 54 results,  Peer Reviewed: 72 results,  Open Access: 36 results,  Acknowledgement Compliant: 6 results) Presentation (99 results) (of which Int'l Joint Research: 53 results,  Invited: 55 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] ウイスコンシン大学(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] シエラレオネ大学(シエラレオネ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] サンパウロ州立パウリスタ大学(ブラジル)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Wisconsin-Madison(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Sierra Leone(シエラレオネ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] UNSEP/Universidade Estadual do Maranhao/LACEN(ブラジル)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ガブリエル・レネ・モレノ自治大学(ボリビア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] シエラレオネ大学(シエラレオネ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ウイスコンシン大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] シエラレオネ大学(シエラレオネ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Wisconsin-Madison(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Animal Health Research Institute(エジプト)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Chinese Academy of Agricultural Sciences(中国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Genomic diversity of SARS-CoV-2 can be accelerated by mutations in the nsp14 gene2023

    • Author(s)
      Takada Kosuke、Ueda Mahoko Takahashi、Shichinohe Shintaro、Kida Yurie、Ono Chikako、Matsuura Yoshiharu、Watanabe Tokiko、Nakagawa So
    • Journal Title

      iScience

      Volume: 26 Issue: 3 Pages: 106210-106210

    • DOI

      10.1016/j.isci.2023.106210

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] オミクロン株の感染拡大について2022

    • Author(s)
      渡辺 登喜子
    • Journal Title

      インフルエンザ:その他の呼吸器感染症

      Volume: 23巻3号

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 本邦のBSL-4施設に適したサスティナブルな陽圧防護服の開発2022

    • Author(s)
      七戸 新太郎
    • Journal Title

      クリーンテクノロジー

      Volume: 第32巻第8号

    • Related Report
      2020 Annual Research Report
  • [Journal Article] ネオウイルス学:自然界におけるウイルスの役割をひもとく2022

    • Author(s)
      渡辺 登喜子
    • Journal Title

      milsil(ミルシル)

      Volume: 第15巻第4号

    • Related Report
      2020 Annual Research Report
  • [Journal Article] オミクロン株について:出現と感染拡大2022

    • Author(s)
      渡辺 登喜子
    • Journal Title

      インフルエンザ:その他の呼吸器感染症

      Volume: 23巻2号

    • Related Report
      2020 Annual Research Report
  • [Journal Article] ウイルス感染症の克服に向けた新展開:総論 古くて新しいウイルス感染症への挑戦状2022

    • Author(s)
      渡辺 登喜子
    • Journal Title

      月刊「細胞」

      Volume: 4月号

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 新型コロナウイルスの懸念される変異株の出現2022

    • Author(s)
      渡辺 登喜子
    • Journal Title

      インフルエンザ:その他の呼吸器感染症

      Volume: 23巻1号

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Mutations in the NA-like protein of bat influenza H18N11 virus enhance virus replication in mammalian cells, mice, and ferrets2020

    • Author(s)
      Zhong G, Fan S, Hatta M, Nakatsu S, Walters KB, Lopes TJS, Wang JI, Ozawa M, Karasin A, Li Y, Tong S, Donis RO, Neumann G, Kawaoka Y.
    • Journal Title

      J Virol

      Volume: - Issue: 5

    • DOI

      10.1128/jvi.01416-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Baloxavir marboxil treatment of nude mice infected with influenza A virus.2020

    • Author(s)
      Kiso M, Yamayoshi S, Murakami J, Kawaoka Y.
    • Journal Title

      J Infect Dis

      Volume: - Issue: 10 Pages: 1699-1702

    • DOI

      10.1093/infdis/jiz665

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] G Protein Pathway Suppressor 1 Promotes Influenza Virus Polymerase Activity by Activating the NF-κB Signaling Pathway.2020

    • Author(s)
      Kuwahara T, Yamayoshi S, Noda T, Kawaoka Y.
    • Journal Title

      mBio

      Volume: 10 Issue: 6

    • DOI

      10.1128/mbio.02867-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multicolor two-photon imaging of in vivo cellular pathophysiology upon influenza virus infection using the two-photon IMPRESS2020

    • Author(s)
      Ueki Hiroshi、Wang I-Hsuan、Zhao Dongming、Gunzer Matthias、Kawaoka Yoshihiro
    • Journal Title

      Nature Protocols

      Volume: 15 Issue: 3 Pages: 1041-1065

    • DOI

      10.1038/s41596-019-0275-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparison of the Pathogenicity in Mice of A(H1N1)pdm09 Viruses Isolated between 2009 and 2015 in Japan2020

    • Author(s)
      Mitake H, Yasuhara A, Lopes TJS, Tagawa-Sakai Y, Shimizu K, Ozawa H, Kawakami C, Morikawa S, Sugaya N, Watanabe T, Kawaoka Y.
    • Journal Title

      Viruses

      Volume: 12 Issue: 2 Pages: 155-155

    • DOI

      10.3390/v12020155

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Villains or heroes? The raison detre of viruses2020

    • Author(s)
      Watanabe Tokiko、Kawaoka Yoshihiro
    • Journal Title

      Clinical & Translational Immunology

      Volume: 9 Issue: 2

    • DOI

      10.1002/cti2.1114

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 新規抗インフルエンザ薬ゾフルーザ感受性低下ウイルスの性状について2020

    • Author(s)
      今井正樹、河岡義裕
    • Journal Title

      東京小児科医会報

      Volume: -

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 鳥インフルエンザA(H5N1)について2020

    • Author(s)
      渡辺登喜子
    • Journal Title

      インフルエンザ その他の呼吸器感染症

      Volume: 21

    • Related Report
      2019 Annual Research Report
  • [Journal Article] エボラウイルス制圧にむけて~エボラワクチン開発研究とシエラレオネでの研究活動~2020

    • Author(s)
      渡辺登喜子、河岡義裕
    • Journal Title

      LABIO21

      Volume: - Pages: 25-29

    • Related Report
      2019 Annual Research Report
  • [Journal Article] C57BL/6J and C57BL/6NJ Mice Are Differentially Susceptible to Inflammation-Associated Disease Caused by Influenza A Virus2019

    • Author(s)
      Eisfeld AJ, Gasper DJ, Suresh M, KawaokaY.
    • Journal Title

      Front Microbiol

      Volume: 9 Pages: 3307-3307

    • DOI

      10.3389/fmicb.2018.03307

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Injectable Excipients as Novel Influenza Vaccine Adjuvants2019

    • Author(s)
      Feng H, Yamashita M, da Silva Lopes TJ, Watanabe T, Kawaoka Y.
    • Journal Title

      Front. Microbiol

      Volume: 10 Pages: 1-9

    • DOI

      10.3389/fmicb.2019.00019

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of Mouse Monoclonal Antibodies Against the HA of A(H7N9) Influenza Virus.2019

    • Author(s)
      Ito M, Yamayoshi S, Murakami K, Saito K, Motojima A, Nakaishi K, Kawaoka Y.
    • Journal Title

      Viruses

      Volume: 11 Issue: 2 Pages: 149-149

    • DOI

      10.3390/v11020149

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic and antigenic characterisation of influenza A(H3N2) viruses isolated in Yokohama during the 2016/17 and 2017/18 influenza seasons2019

    • Author(s)
      Kawakami Chiharu、Yamayoshi Seiya、Akimoto Miki、Nakamura Kazuya、Miura Hideka、Fujisaki Seiichiro、Pattinson David J.、Shimizu Kohei、Ozawa Hiroki、Momoki Tomoko、Saikusa Miwako、Yasuhara Atsuhiro、Usuku Shuzo、Okubo Ichiro、Toyozawa Takahiro、Sugita Shigeo、Smith Derek J.、Watanabe Shinji、Kawaoka Yoshihiro
    • Journal Title

      Eurosurveillance

      Volume: 24 Issue: 6 Pages: 1800467-1800467

    • DOI

      10.2807/1560-7917.es.2019.24.6.1800467

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Plasma lipidome reveals critical illness and recovery from human Ebola virus disease.2019

    • Author(s)
      Kyle JE, Burnum-Johnson KE, Wendler JP, Eisfeld AJ, Halfmann PJ, Watanabe T, Sahr F, Smith RD, Kawaoka Y, Waters KM, Metz TO
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 116 Issue: 9 Pages: 3919-3928

    • DOI

      10.1073/pnas.1815356116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus.2019

    • Author(s)
      4.Yasuhara A, Yamayoshi S, Kiso M, Sakai-Tagawa Y, Koga M, Adachi E, Kikuchi T, Wang IH, Yamada S, Kawaoka Y.
    • Journal Title

      Nat Microbiol.

      Volume: 4(6) Issue: 6 Pages: 1024-1034

    • DOI

      10.1038/s41564-019-0401-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of Amino Acid Residues in Influenza A Virus PA-X That Contribute to Enhanced Shutoff Activity2019

    • Author(s)
      Oishi K, Yamayoshi S, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 10 Pages: 432-432

    • DOI

      10.3389/fmicb.2019.00432

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses.2019

    • Author(s)
      Kosuke Takada, Chiharu Kawakami, Shufang Fan, Shiho Chiba, Gongxun Zhong, Chunyang Gu, Kohei Shimizu, Sara Takasaki, Yuko Sakai-Tagawa, Tiago J. S. Lopes, Jayeeta Dutta, Harm van Bakel, Zenab Khan, Divya Kriti, Shinya Yamada, Tokiko Watanabe, Masaki Imai, Yoshihiro Kawaoka
    • Journal Title

      Nature Microbiology

      Volume: 印刷中 Issue: 8 Pages: 1268-1273

    • DOI

      10.1038/s41564-019-0433-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Subclade 2.2.1-Specific Human Monoclonal Antibodies That Recognize an Epitope in Antigenic Site A of Influenza A(H5) Virus HA Detected between 2015 and 20182019

    • Author(s)
      Okuda Moe、Yamayoshi Seiya、Uraki Ryuta、Ito Mutsumi、Hamabata Taiki、Kawaoka Yoshihiro
    • Journal Title

      Viruses

      Volume: 11 Issue: 4 Pages: 321-321

    • DOI

      10.3390/v11040321

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation of Highly Pathogenic H5N1 Influenza Viruses in 2009-2013 in Vietnam2019

    • Author(s)
      Zhong G, Fan S, Lopes TJS, Le MQ, van Bakel H, Dutta J, Smith GJD, Jayakumar J, Nguyen HLK, Hoang PVM, Halfmann P, Hatta M, Su YCF, Neumann G, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 10 Pages: 1411-1411

    • DOI

      10.3389/fmicb.2019.01411

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Serological analysis of Ebola virus survivors and close contacts in Sierra Leone: A cross-sectional study2019

    • Author(s)
      Halfmann Peter J.、Eisfeld Amie J.、Watanabe Tokiko、Maemura Tadashi、Yamashita Makoto、Fukuyama Satoshi、Armbrust Tammy、Rozich Isaiah、N’jai Alhaji、Neumann Gabriele、Kawaoka Yoshihiro、Sahr Foday
    • Journal Title

      PLOS Neglected Tropical Diseases

      Volume: 13 Issue: 8 Pages: e0007654-e0007654

    • DOI

      10.1371/journal.pntd.0007654

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Long-term culture of human lung adenocarcinoma A549 cells enhances the replication of human influenza A viruses.2019

    • Author(s)
      Ujie M, Takada K, Kiso M, Sakai-Tagawa Y, Ito M, Nakamura K, Watanabe S, Imai M, Kawaoka Y.
    • Journal Title

      J Gen Virol

      Volume: 100 Issue: 10 Pages: 1345-1349

    • DOI

      10.1099/jgv.0.001314

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of a distinct lineage of aviadenovirus from crane feces.2019

    • Author(s)
      Mukai Y, Tomita Y, Kryukov K, Nakagawa S, Ozawa M, Matsui T, Tomonaga K, Imanishi T, Kawaoka Y, Watanabe T, Horie M
    • Journal Title

      Virus Genes

      Volume: 55 Issue: 6 Pages: 815-824

    • DOI

      10.1007/s11262-019-01703-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Soluble Recombinant Hemagglutinin Protein of H1N1pdm09 Influenza Virus Elicits Cross-Protection Against a Lethal H5N1 Challenge in Mice.2019

    • Author(s)
      Yamada S, Yasuhara A, Kawaoka Y.
    • Journal Title

      Front Microbiol.

      Volume: 4(10) Pages: 1268-1273

    • DOI

      10.3389/fmicb.2019.02031

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Food Additives as Novel Influenza Vaccine Adjuvants2019

    • Author(s)
      Feng Huapeng、Yamashita Makoto、Wu Li、Jose da Silva Lopes Tiago、Watanabe Tokiko、Kawaoka Yoshihiro
    • Journal Title

      Vaccines

      Volume: 7 Issue: 4 Pages: 127-127

    • DOI

      10.3390/vaccines7040127

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influenza Virus Polymerase Mutation Stabilizes a Foreign Gene Inserted into the Virus Genome by Enhancing the Transcription/Replication Efficiency of the Modified Segment.2019

    • Author(s)
      2.Furusawa Y, Yamada S, da Silva Lopes TJ, Dutta J, Khan Z, Kriti D, van Bakel H, Kawaoka Y.
    • Journal Title

      mBio.

      Volume: 10(5) Issue: 5

    • DOI

      10.1128/mbio.01794-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Glycolipid Adjuvant, 7DW8-5, Enhances the Protective Immune Response to the Current Split Influenza Vaccine in Mice2019

    • Author(s)
      Feng Huapeng、Nakajima Noriko、Wu Li、Yamashita Makoto、Lopes Tiago J. S.、Tsuji Moriya、Hasegawa Hideki、Watanabe Tokiko、Kawaoka Yoshihiro
    • Journal Title

      Frontiers in Microbiology

      Volume: 10 Pages: 2157-2157

    • DOI

      10.3389/fmicb.2019.02157

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oseltamivir is effective against 1918 influenza virus infection of macaques but vulnerable to escape.2019

    • Author(s)
      Feldmann F, Kobasa D, Embury-Hyatt C, Grolla A, Taylor T, Kiso M, Kakugawa S, Gren J, Jones SM, Kawaoka Y, Feldmann H.
    • Journal Title

      mBio

      Volume: 10 Issue: 5

    • DOI

      10.1128/mbio.02059-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of H7N9 avian influenza viruses isolated from duck meat products.2019

    • Author(s)
      Wu L, Mitake H, Kiso M, Ito M, Iwatsuki-Hirimoto K, Yamayoshi S, Lopes TJS, Feng H, Sumiyoshi R, Shibata A, Osaka H, Imai M, Watanabe T, Kawaoka Y.
    • Journal Title

      Transbound Emerg Dis

      Volume: 67 Issue: 2 Pages: 1-7

    • DOI

      10.1111/tbed.13398

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antigenic change in human influenza A(H2N2) viruses detected by using human plasma from aged and younger adult individuals.2019

    • Author(s)
      Matsuzawa Y, Iwatsuki-Horimoto K, Nishimoto Y, Abe Y, Fukuyama S, Hamabata T, Okuda M, Go Y, Watanabe T, Imai M, Arai Y, Fouchier RAM, Yamayoshi S, Kawaoka Y.
    • Journal Title

      Viruses

      Volume: 11

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sensitivity of commercially available influenza rapid diagnostic tests in the 2018-2019 influenza season.2019

    • Author(s)
      Sakai-Tagawa Y, Yamayoshi S, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 10 Pages: 2342-2342

    • DOI

      10.3389/fmicb.2019.02342

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Treatment of highly pathogenic H7N9 virus-infected mice with baloxavir marboxil.2019

    • Author(s)
      Kiso M, Yamayoshi S, Furusawa Y, Imai M, Kawaoka Y.
    • Journal Title

      Viruses

      Volume: 11 Issue: 11 Pages: 1066-1066

    • DOI

      10.3390/v11111066

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets2019

    • Author(s)
      Imai M、Yamashita M、Sakai-Tagawa Y、Iwatsuki-Horimoto Ki、Kiso M、Murakami J、Yasuhara A、Takada K、Ito M、Nakajima N、Takahashi K、Hasegawa H、Kawaoka Y, et al
    • Journal Title

      Nature Microbiology

      Volume: 5 Issue: 1 Pages: 27-33

    • DOI

      10.1038/s41564-019-0609-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neo-virology: The raison d'etre of viruses.2019

    • Author(s)
      Watanabe T, Suzuki N, Tomonaga K, Sawa H, Matsuura Y, Kawaguchi Y, Takahashi H, Nagasaki K, Kawaoka Y.
    • Journal Title

      Virus Res

      Volume: 274 Pages: 197751-197751

    • DOI

      10.1016/j.virusres.2019.197751

    • NAID

      130006183770

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A型インフルエンザの流行の特徴2019

    • Author(s)
      渡辺登喜子
    • Journal Title

      チャイルドヘルス

      Volume: 9

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 季節性インフルエンザの流行について2019

    • Author(s)
      渡辺登喜子
    • Journal Title

      インフルエンザ その他の呼吸器感染症

      Volume: 20 Pages: 39-43

    • Related Report
      2019 Annual Research Report
  • [Journal Article] インフルエンザ迅速診断キットの性能比較2019

    • Author(s)
      坂井(田川)優子、河岡義裕
    • Journal Title

      インフルエンザ その他の呼吸器感染症

      Volume: 20 Pages: 15-21

    • NAID

      40022107999

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Network-Guided Discovery of Influenza Virus Replication Host Factors.2019

    • Author(s)
      Ackerman EE, Kawakami E, Katoh M, Watanabe T, Watanabe S, Tomita Y, Lopes TJ, Matsuoka Y, Kitano H, Shoemaker JE, Kawaoka Y
    • Journal Title

      MBio

      Volume: 9 Issue: 6

    • DOI

      10.1128/mbio.02002-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 高病原性H7N9鳥インフルエンザウイルスはヒトの間で大流行を起こすのか2019

    • Author(s)
      今井正樹、河岡義裕
    • Journal Title

      臨牀と研究

      Volume: 95 Pages: 1245-1248

    • Related Report
      2018 Annual Research Report
  • [Journal Article] スペイン・インフルエンザ その2 スペイン・インフルエンザの病原性の謎2019

    • Author(s)
      渡辺登喜子.
    • Journal Title

      インフルエンザ その他の呼吸器感染症

      Volume: 20 Pages: 37-40

    • Related Report
      2018 Annual Research Report
  • [Journal Article] エボラ出血熱の重症かメカニズムならびに予後を予測するためのバイオマーカーの同定2019

    • Author(s)
      渡辺登喜子、河岡義裕
    • Journal Title

      感染・炎症・免疫

      Volume: 49 Pages: 65-67

    • Related Report
      2018 Annual Research Report
  • [Journal Article] エボラ出血熱について-エボラウイルス感染者の宿主応答解析から得られた知見-2019

    • Author(s)
      渡辺登喜子、河岡義裕
    • Journal Title

      最新医学

      Volume: 74 Pages: 51-57

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a Feline Influenza A(H7N2) Virus2018

    • Author(s)
      Hatta M, Zhong G, Gao Y, Nakajima N, Fan S, Chiba S, Deering KM, Ito M, Imai M, 他13名
    • Journal Title

      Emerg Infect Dis

      Volume: 24 Issue: 1 Pages: 75-86

    • DOI

      10.3201/eid2401.171240

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast2018

    • Author(s)
      Oishi Kohei、Yamayoshi Seiya、Kawaoka Yoshihiro
    • Journal Title

      Virology

      Volume: 516 Pages: 71-75

    • DOI

      10.1016/j.virol.2018.01.004

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influenza C and D Viruses Package Eight Organized Ribonucleoprotein Complexes2018

    • Author(s)
      Nakatsu Sumiho、Murakami Shin、Shindo Keiko、Horimoto Taisuke、Sagara Hiroshi、Noda Takeshi、Kawaoka Yoshihiro
    • Journal Title

      Journal of Virology

      Volume: 92 Issue: 6

    • DOI

      10.1128/jvi.02084-17

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of the 1+7 configuration of ribonucleoprotein complexes for influenza A virus genome packaging.2018

    • Author(s)
      Noda T, Murakami S, Nakatsu S, Imai H, Muramoto Y, Shindo K, Sagara H, Kawaoka Y.
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 59-59

    • DOI

      10.1038/s41467-017-02517-w

    • NAID

      120006376026

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human protective monoclonal antibodies against the HA stem of group 2 HAs derived from an H3N2 virus-infected human2018

    • Author(s)
      Yamayoshi Seiya、Ito Mutsumi、Uraki Ryuta、Sasaki Tadahiro、Ikuta Kazuyoshi、Kawaoka Yoshihiro
    • Journal Title

      J Infect

      Volume: 76 Issue: 2 Pages: 177-185

    • DOI

      10.1016/j.jinf.2017.12.004

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles2018

    • Author(s)
      Nanbo Asuka、Maruyama Junki、Imai Masaki、Ujie Michiko、Fujioka Yoichiro、Nishide Shinya、Takada Ayato、Ohba Yusuke、Kawaoka Yoshihiro
    • Journal Title

      PLoS Pathog

      Volume: 14 Issue: 1 Pages: e1006848-e1006848

    • DOI

      10.1371/journal.ppat.1006848

    • NAID

      120006416019

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lung-derived exosomal miR-483-3p regulates the innate immune response to influenza virus infection.2018

    • Author(s)
      Maemura T, Fukuyama S, Sugita Y, Lopes TJS, Nakao T, Noda T, Kawaoka Y.
    • Journal Title

      J Infect Dis

      Volume: 217 Issue: 9 Pages: 1372-1382

    • DOI

      10.1093/infdis/jiy035

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans.2018

    • Author(s)
      Yamayoshi S, Kiso M, Yasuhara A, Ito M, Shu Y, Kawaoka Y.
    • Journal Title

      Emerg Infect Dis

      Volume: 24 Issue: 4 Pages: 746-750

    • DOI

      10.3201/eid2404.171509

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulation of alpha2-adrenergic receptors impairs influenza virus infection.2018

    • Author(s)
      Matsui K, Ozawa M, Kiso M, Yamashita M, Maekawa T, Kubota M, Sugano S, Kawaoka Y.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 4631-4631

    • DOI

      10.1038/s41598-018-22927-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the fusion partner cell line SPYMEG for obtaining human monoclonal antibodies against influenza B virus2018

    • Author(s)
      Soni P, Yasuhara A, Takenaga T, Iwatsuki-Horimoto K, Uraki R, Ito M, Sasaki T, Ikuta K, Yamayoshi S, Kawaoka Y.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 6 Pages: 1020-1024

    • DOI

      10.1292/jvms.18-0146

    • NAID

      130007412681

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The marmoset as an animal model of influenza: infection with A(H1N1)pdm09 and highly pathogenic A(H5N1) viruses via the conventional or tracheal spray route.2018

    • Author(s)
      Iwatsuki-Horimoto K, Nakajima N, Kiso M, Takahashi K, Ito M, Inoue T, Horiuchi M, Okahara N, Sasaki E, Hasegawa H, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 9 Pages: 844-844

    • DOI

      10.3389/fmicb.2018.00844

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diversity of influenza A(H5N1) Viruses in infected humans, Northern Vietnam, 2004-2010.2018

    • Author(s)
      Imai H, Dinis JM, Zhong G, Moncla LH, Lopes TJS, McBride R, Thompson AJ, Peng W, Le MTQ, Hanson A, Lauck M, Sakai-Tagawa Y, Yamada S, Eggenberger J, O'Connor DH, Suzuki Y, Hatta M, Paulson JC, Neumann G, Friedrich TC, Kawaoka Y.
    • Journal Title

      Emerg Infect Dis

      Volume: 24 Issue: 7 Pages: 1128-1238

    • DOI

      10.3201/eid2407.171441

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In vivo imaging of the pathophysiological changes and neutrophil dynamics in influenza virus-infected mouse lungs.2018

    • Author(s)
      Ueki H, Wang IH, Fukuyama S, Katsura H, da Silva Lopes TJ, Neumann G, Kawaoka Y.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of an influenza rapid diagnostic kit specific for the H7 subtype.2018

    • Author(s)
      Iwatsuki-Horimoto K, Shi J, Wang X, Sakai-Tagawa Y, Ito M, Murakami K, da Silva Lopes TJ, Nakaishi K, Yamayoshi S, Watanabe S, Chen H, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 9 Pages: 1346-1346

    • DOI

      10.3389/fmicb.2018.01346

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strain-specific contribution of eukaryotic elongation factor 1 gamma to the translation of influenza A virus proteins.2018

    • Author(s)
      Sammaibashi S, Yamayoshi S, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 9 Pages: 1446-1446

    • DOI

      10.3389/fmicb.2018.01446

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-terminal acetylation by NatB is required for the shutoff activity of influenza A virus PA-X.2018

    • Author(s)
      Oishi K, Yamayoshi S, Kozuka-Hata H, Oyama M, Kawaoka Y.
    • Journal Title

      Cell Rep

      Volume: 24 Issue: 4 Pages: 851-860

    • DOI

      10.1016/j.celrep.2018.06.078

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA.2018

    • Author(s)
      Furusawa Y, Yamada S, Kawaoka Y.
    • Journal Title

      Front Microbiol

      Volume: 9 Pages: 1675-1675

    • DOI

      10.3389/fmicb.2018.01675

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in the ease with which mutant viruses escape from human monoclonal antibodies against the HA stem of influenza A virus.2018

    • Author(s)
      Yamayoshi S, Yasuhara A, Ito M, Uraki R, Kawaoka Y.
    • Journal Title

      J Clin Virol

      Volume: 108 Pages: 105-111

    • DOI

      10.1016/j.jcv.2018.09.016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex at 3.6 A resolution.2018

    • Author(s)
      Sugita Y, Matsunami H, Kawaoka Y, Noda T, Wolf M.
    • Journal Title

      Nature

      Volume: 563 Issue: 7729 Pages: 137-140

    • DOI

      10.1038/s41586-018-0630-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation and Characterization of Human Monoclonal Antibodies That Recognize the Influenza A(H1N1)pdm09 Virus Hemagglutinin Receptor-Binding Site and Rarely Yield Escape Mutant Viruses2018

    • Author(s)
      Yasuhara Atsuhiro、Yamayoshi Seiya、Ito Mutsumi、Kiso Maki、Yamada Shinya、Kawaoka Yoshihiro
    • Journal Title

      Frontiers in Microbiology

      Volume: 9 Pages: 2660-2660

    • DOI

      10.3389/fmicb.2018.02660

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] スペインかぜ その1 100年前に起こった疫学史上最悪の出来事2018

    • Author(s)
      渡辺登喜子
    • Journal Title

      インフルエンザ その他の呼吸器感染症

      Volume: 19 Pages: 49-52

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 新興再興感染症に対するワクチン開発~エボラワクチン開発における最近の進展~.2018

    • Author(s)
      渡辺登喜子、河岡義裕
    • Journal Title

      BIO Clinica

      Volume: 32 Pages: 25-29

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virulence.2018

    • Author(s)
      Zhong G, Le MQ, Lopes TJS, Halfmann P, Hatta M, Fan S, Neumann G, Kawaoka Y.
    • Journal Title

      J Virol

      Volume: 92 Issue: 4

    • DOI

      10.1128/jvi.01557-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.2018

    • Author(s)
      Menachery VD, Sch?er A, Burnum-Johnson KE, Mitchell HD, Eisfeld AJ, Walters KB,
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 115 Issue: 5

    • DOI

      10.1073/pnas.1706928115

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Experimental infection of Cynomolgus Macaques with highly pathogenic H5N1 influenza virus through the aerosol route2018

    • Author(s)
      Watanabe Tokiko、Iwatsuki-Horimoto Kiyoko、Kiso Maki、Nakajima Noriko、Takahashi Kenta、Jose da Silva Lopes Tiago、Ito Mutsumi、Fukuyama Satoshi、Hasegawa Hideki、Kawaoka Yoshihiro
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 4801-4801

    • DOI

      10.1038/s41598-018-23022-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] エボラ出血熱に対するワクチン開発の進展2018

    • Author(s)
      今井正樹、渡辺登喜子、河岡義裕
    • Journal Title

      医学のあゆみ

      Volume: 264 Pages: 419-422

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 鳥インフルエンザウイルスのヒトへの感染と伝播の可能性2018

    • Author(s)
      渡邉真治、今井正樹
    • Journal Title

      インフルエンザ

      Volume: 62 Pages: 37-42

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Multi-platform ’Omics Analysis of Human Ebola Virus Disease Pathogenesis2017

    • Author(s)
      Eisfeld Amie J.、Halfmann Peter J. et al
    • Journal Title

      Cell Host&Microbe

      Volume: 22 Issue: 6 Pages: 817-829

    • DOI

      10.1016/j.chom.2017.10.011

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Combination Therapy With Neuraminidase and Polymerase Inhibitors in Nude Mice Infected With Influenza Virus2017

    • Author(s)
      Kiso Maki、Lopes Tiago J S、Yamayoshi Seiya、Ito Mutsumi、Yamashita Makoto、Nakajima Noriko、Hasegawa Hideki、Neumann Gabriele、Kawaoka Yoshihiro
    • Journal Title

      The Journal of Infectious Diseases

      Volume: 217 Issue: 6 Pages: 887-896

    • DOI

      10.1093/infdis/jix606

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Syrian hamster as an animal model for the study of human influenza virus infection2017

    • Author(s)
      Iwatsuki-Horimoto Kiyoko、Nakajima Noriko、Ichiko Yurie、Sakai-Tagawa Yuko、Noda Takeshi、Hasegawa Hideki、Kawaoka Yoshihiro
    • Journal Title

      Journal of Virology

      Volume: 92 Issue: 4

    • DOI

      10.1128/jvi.01693-17

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response.2017

    • Author(s)
      Zhao D,Liang L,Wang S,Nakao T,Li Y,Liu L,Guan Y,Fukuyama S,Bu Z,Kawaoka Y,Chen H
    • Journal Title

      Journal of Virology

      Volume: 91 Issue: 7

    • DOI

      10.1128/jvi.02215-16

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Evaluation of seasonal influenza vaccinese for H1N1pdm09 and type B viruses based on a replication-incompetent PB2-KO virus.2017

    • Author(s)
      Ui H, Yamayoshi S, Uraki R, Kiso M, Oishi K, Murakami S, Mimori S, Kawaoka Y.
    • Journal Title

      Vaccine

      Volume: 4;35(15) Issue: 15 Pages: 1892-1897

    • DOI

      10.1016/j.vaccine.2017.02.041

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] M2SR, a novel live influenza vaccine, protects mice and ferrets against highly pathogenic avian influenza.2017

    • Author(s)
      Hatta Y, Boltz D, Sarawar S, Kawaoka Y, Neumann G, Bilsel P.
    • Journal Title

      Vaccine

      Volume: 35 Issue: 33 Pages: 4177-4183

    • DOI

      10.1016/j.vaccine.2017.06.039

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets2017

    • Author(s)
      Imai Masaki、Watanabe Tokiko et al
    • Journal Title

      Cell Host&Microbe

      Volume: 22 Issue: 5 Pages: 615-626

    • DOI

      10.1016/j.chom.2017.09.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Emergence of Oseltamivir-Resistant H7N9 Influenza Viruses in Immunosuppressed Cynomolgus Macaques2017

    • Author(s)
      Kiso Maki et al.
    • Journal Title

      The Journal of Infectious Diseases

      Volume: 216 Issue: 5 Pages: 582-593

    • DOI

      10.1093/infdis/jix296

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reactivity and sensitivity of commercially available influenza rapid diagnostic tests in Japan.2017

    • Author(s)
      Sakai-Tagawa Y, Yamayoshi S, Kawakami C, Le MQ, Uchida Y, Saito T, Nidom CA, Humaira I, Toohey-Kurth K, Arafa AS, Liu MT, Shu Y, Kawaoka Y.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 14483-14483

    • DOI

      10.1038/s41598-017-14536-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diversity of antigenic mutants of influenza A(H1N1)pdm09 virus escaped from human monoclonal antibodies.2017

    • Author(s)
      Yasuhara A, Yamayoshi S, Soni P, Takenaga T, Kawakami C, Takashita E, Sakai-Tagawa Y, Uraki R, Ito M, Iwatsuki-Horimoto K, Sasaki T, Ikuta K, Yamada S, Kawaoka Y.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 17735-17735

    • DOI

      10.1038/s41598-017-17986-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NS1 is the fluid for “flu-transmission”2017

    • Author(s)
      Watanabe Tokiko、Imai Masaki、Kawaoka Yoshihiro
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 114 Issue: 42 Pages: 11012-11014

    • DOI

      10.1073/pnas.1715239114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 季節性インフルエンザウイルスの抗原変異株の出現予測2017

    • Author(s)
      今井正樹、渡邉真治、河岡義裕
    • Journal Title

      インフルエンザ

      Volume: 61 Pages: 31-34

    • NAID

      40021350846

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Complete and incomplete genome packaging of influenza A and B viruses2016

    • Author(s)
      Nakatsu S, Sagara H, Sakai-Tagawa Y, Sugaya N, Noda T, Kawaoka Y
    • Journal Title

      MBio

      Volume: 7(5) Issue: 5

    • DOI

      10.1128/mbio.01248-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Microminipig as an Animal Model for Influenza A Virus Infection2016

    • Author(s)
      Iwatsuki-Horimoto K, Nakajima N, Shibata M, Takahashi K, Sato Y, Kiso M, Yamayoshi S, Ito M, Enya S, Otake M, Kangawa A, da Silva Lopes TJ, Ito H, Hasegawa H, Kawaoka Y.
    • Journal Title

      Journal of Virology

      Volume: 91 Issue: 2 Pages: 1-9

    • DOI

      10.1128/jvi.01716-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Risk assessment of recent Egyptian H5N1 influenza viruses2016

    • Author(s)
      Arafa AS, Yamada S, Imai M, Watanabe T et al
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 38388-38388

    • DOI

      10.1038/srep38388

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of high-yield influenza B virus vaccine viruses.2016

    • Author(s)
      Ping J, Lopes TJ, Neumann G, Kawaoka Y.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 113 Issue: 51

    • DOI

      10.1073/pnas.1616530113

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A Broadly Reactive Human Anti-hemagglutinin Stem Monoclonal Antibody That Inhibits Influenza A Virus Particle Release.2016

    • Author(s)
      Yamayoshi S, Uraki R, Ito M, Kiso M, Nakatsu S, Yasuhara A, Oishi K, Sasaki T, Ikuta K,Kawaoka Y.
    • Journal Title

      EBioMedicine

      Volume: 17 Pages: 182-191

    • DOI

      10.1016/j.ebiom.2017.03.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] インフルエンザウイルスの抗原変異とその予測2016

    • Author(s)
      渡辺登喜子、今井正樹、河岡義裕
    • Journal Title

      医学のあゆみ

      Volume: 260 Pages: 17034-17038

    • Related Report
      2016 Annual Research Report
    • Open Access
  • [Journal Article] 新学術領域「ネオウイルス学:生命源流から超個体、そしてエコ・スフィアーへ」 Neo-Virology: the raison d’etre of viruses ~ウイルスのレゾンデートルを探る!~2016

    • Author(s)
      渡辺登喜子、河岡義裕
    • Journal Title

      学会誌「ウイルス」

      Volume: 66 Pages: 155-162

    • Related Report
      2016 Annual Research Report
    • Open Access / Acknowledgement Compliant
  • [Presentation] ハムスターモデルにおける新型コロナウイルスの少量感染系の確立2023

    • Author(s)
      高田光輔、大場靖子、澤洋文、渡辺登喜子
    • Organizer
      獣医学会微生物分科会
    • Related Report
      2020 Annual Research Report
  • [Presentation] SARS-CoV-2に対する抗ウイルス活性を有する海洋天然物の探索と作用機序解明2023

    • Author(s)
      安齋 樹、岩崎 有紘、小野 慎子、鳥居 志保、松浦 善治、末永 聖武、渡辺 登喜子
    • Organizer
      日本薬学会第143年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 新型コロナウイルス感染マウスにおける宿主応答解析2022

    • Author(s)
      七戸 新太郎
    • Organizer
      第69回日本ウイルス学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Emerging zoonotic viral diseases including COVID-192022

    • Author(s)
      Tokiko Watanabe
    • Organizer
      Virtual Symposium on Infectious Diseases and Drug Development
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ワンヘルスと人獣共通感染症 ー人、動物、環境、そしてウイルスー2022

    • Author(s)
      渡辺登喜子
    • Organizer
      第5回山口大学・環境DNA研究センターシンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Identification of a novel bat alphacoronavirus in Sierra Leone by using multiple degenerate primers2022

    • Author(s)
      Shintaro Shichinohe, Kosuke Takada, Pascal Hingamp, Yuriko Tomita, Tadashi Maemura, Alhaji U. N'jai, Tohru Suzuki, Yoshihiro Kawaoka, Hisashi Endo, Hiroyuki Ogata, Tokiko Watanabe
    • Organizer
      20th Awaji International Forumon Infection and Immunity
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genomic diversity of SARS-CoV-2 can be accelerated by an amino acid substitution in the non-structural protein 142022

    • Author(s)
      Kosuke Takada, Mahoko Takahashi Ueda, Shintaro Shichinohe, Tokiko Watanabe and So Nakagawa
    • Organizer
      The 23rd Annual Meeting of the RNA Society of Japan
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of a low-volume SARS-CoV-2 infection system in the hamster model2022

    • Author(s)
      Kosuke Takada, Yasuko Orba, Hirofumi Sawa, Tokiko Watanabe
    • Organizer
      20th Awaji International Forumon Infection and Immunity
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ハムスターモデルにおける新型コロナウイルスの少量感染系の確立2022

    • Author(s)
      高田光輔、大場靖子、澤洋文、渡辺登喜子
    • Organizer
      第69回日本ウイルス学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Characterization of an antibody that neutralizes a wide range of SARS-CoV-2 variants2022

    • Author(s)
      Itsuki Anzai, Junso Fujita, Chikako Ono, Yoichiro Kosaka, Yuki Miyamoto, Shintaro Shichinohe, Kosuke Takada, Shiho Torii, Shuhei Taguwa, Koichiro Suzuki, Fumiaki Makino, Tadahiro Kajita, Tsuyoshi Inoue, Keiichi Namba, Tokiko Watanabe, Yoshiharu Matsuura
    • Organizer
      20th Awaji International Forumon Infection and Immunity
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SARS-CoV-2の増殖に関わる宿主因子の同定と機能解析2022

    • Author(s)
      安齋 樹、足達 俊吾、河岡 義裕、渡辺 登喜子
    • Organizer
      第69回日本ウイルス学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] エボラ出血熱の制圧に向けたワクチン開発研究2020

    • Author(s)
      渡辺登喜子
    • Organizer
      9th Negative Strand Virus-Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] 鶏卵での増殖過程でHAの抗原性変化を伴わないH3N2インフルエンザウイルスの作出2020

    • Author(s)
      山田晋弥、千葉志穂、安原敦洋、高田光輔、柳本周、Ryan McBride、 Charli Worth、Andrew J. Thompson、Tiago J.S. Lopes、山吉誠也、James C. Paulson、河岡義裕
    • Organizer
      9th Negative Strand Virus-Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] インフルエンザウイルス感染肺における免疫細胞応答の生体イメージング解析2020

    • Author(s)
      植木紘史, 河岡義裕.
    • Organizer
      9th Negative Strand Virus-Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヌードマウスにおけるインフルエンザ感染と抗インフルエンザ薬及び抗体の併用効果2020

    • Author(s)
      木曽真紀、山吉誠也、河岡義裕
    • Organizer
      9th Negative Strand Virus-Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] Human monoclonal antibodies that recognize the HA of both influenza B lineages2020

    • Author(s)
      Yamayoshi S, Yasuhara A, Kiso M, Kawaoka Y
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Antigenic variants of influenza B viruses isolated in Japan during the 2017-2018 and 2018-2019 influenza seasons2020

    • Author(s)
      Sari Kato, Yuko Sakai-Tagawa, Masaki Imai and Yoshihiro Kawaoka
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Challenges in Influenza2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      The 2nd Joint Meeting of Veterinary Science in East Asia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Animal Models for the development of next-generation Influenza vaccines2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      ISIRV Influenza Vaccine Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pathogens and Transmission of Negative Strand RNA Viruses2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Virus and Cells Research Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Centers of Excellence for Influenza Research and Surveillance
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Working with deadly viruses?シ喘attling Ebola and Influenza2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Conference of Research Workers in Animal Diseases
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New approaches to the development of effective influenza vaccines2019

    • Author(s)
      Tokiko Watanabe
    • Organizer
      The 7th International Conference & Exhibition on Influenza Vaccines for The World.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] deltaVP30 vaccine for control of Ebola virus disease2019

    • Author(s)
      Watanabe T and Kawaoka Y
    • Organizer
      BARDA Industry Day
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新興感染症-インフルエンザならびにエボラ出血熱-2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      第66回日本実験動物学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新興感染症-インフルエンザならびにエボラ出血熱-2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      第40回阿蘇シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新興感染症-インフルエンザならびにエボラ出血熱-2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      第7回アフリカ開発会議
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Neo-Virology: The raison detre of viruses2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新興感染症-インフルエンザならびにエボラ出血熱-2019

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      第125回日本小児科学会甲信地方会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] インフルエンザウイルス感染個体における生体イメージング2019

    • Author(s)
      植木紘史, 河岡義裕
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Genetic and antigenic analyses of influenza B viruses isolated in Japan during the 2017-2018 and 2018-2019 influenza seasons.2019

    • Author(s)
      Sari Kato, Yuko Sakai-Tagawa, Yoshihiro Kawaoka, Masaki Imai.
    • Organizer
      Options X for the Control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The marmoset as an animal model of influenza.2019

    • Author(s)
      Iwatsuki-Horimoto K, Nakajima N, Kiso M, Takahashi K, Ito M, Inoue T, Horiuchi M, Okahara N, Sasaki E, Hasegawa H, Kawaoka Y.
    • Organizer
      Options X for the Control of Influenza.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The marmoset as an animal model of influenza.2019

    • Author(s)
      Iwatsuki-Horimoto K, Nakajima N, Kiso M, Takahashi K, Ito M, Inoue T, Horiuchi M, Okahara N, Sasaki E, Hasegawa H, Kawaoka Y
    • Organizer
      Asian-African Research Forum on Emerging and Reemerging Infections 2019.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Subclade 2.2.1-specific human monoclonal antibodies that recognize an epitope in antigenic site A of influenza A (H5) virus HA detected between 2015 and 20182019

    • Author(s)
      Moe Okuda, Seiya Yamayoshi, Ryuta Uraki, Mutsumi Ito, Taiki Hamabata, and Yoshihiro Kawaoka
    • Organizer
      Options X for the control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo imaging of the pathophysiological changes and dynamics of immune cells in influenza virus-infected mouse lung2019

    • Author(s)
      Hiroshi Uek, I-Hsuan Wang, Satoshi Fukuyama, Hiroaki Katsura, Tiago Jose da Silva Lopes, Gabriele Neumann, and Yoshihiro Kawaoka
    • Organizer
      Focus on Microscopy 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Two-photon imaging of the in vivo dynamics of immune cells and cellular pathophysiology in influenza virus-infected lung2019

    • Author(s)
      Hiroshi Uek, I-Hsuan Wang, Satoshi Fukuyama, Hiroaki Katsura, Tiago Jose da Silva Lopes, Gabriele Neumann, and Yoshihiro Kawaoka
    • Organizer
      17th International Congress of Immunology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Long-Term Cultured Human Lung Adenocarcinoma A549 Cells Show Enhanced Susceptibility to Human Influenza A Viruses2019

    • Author(s)
      Ujie M, Imai, M, Nakamura K, Watanabe S, Kawaoka Y, Long-Term Cultured Human Lung Adenocarcinoma A549 Cells Show Enhanced Susceptibility to Human Influenza A Viruses
    • Organizer
      OPTIONS X for the Control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses.2019

    • Author(s)
      K. Takada, C. Kawakami, S. Fan, S. Chiba, G. Zhong, C. Gu, K. Shimizu, S. Takasaki, Y. Sakai-Tagawa, T. J. S. Lopes, J. Dutta, H. van Bakel, Z. Khan, D. Kriti, S. Yamada, T. Watanabe, M. Imai, Y. Kawaoka.
    • Organizer
      Options X for the control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus2019

    • Author(s)
      Atsuhiro Yasuhara, Seiya Yamayoshi, Maki Kiso, Yuko Sakai-Tagawa, Michiko Koga, Eisuke Adachi, Tadashi Kikuchi, I-Hsuan Wang, Shinya Yamada, and Yoshihiro Kawaoka
    • Organizer
      Options X for the control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The antigenic change in the hemagglutinin of A(H7N9) influenza virus2019

    • Author(s)
      Ito M, Yamayoshi S, Murakami K, Saito K, Motojima A, Nakaishi K, and Kawaoka Y
    • Organizer
      Options X for the control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanisms of deletion and stabilization of foreign gene inserted into influenza virus genome.2019

    • Author(s)
      Yuri Furusawa, Shinya Yamada, Tiago Jose da Silva Lopes, Jayeeta Dutta, Zenab Khan, Divya Kriti, Harm van Bakel, Yoshihiro Kawaoka
    • Organizer
      Options X for the Control of Influenza
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of Ebola virus disease: vaccine development and our project in Sierra Leone2018

    • Author(s)
      Tokiko Watanabe
    • Organizer
      The 17th Awaji International Forum on Infection and Immunity
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Research of zoonotic diseases: Control of Ebola virus disease.2018

    • Author(s)
      Tokiko Watanabe
    • Organizer
      Workshop on Environmental Viruses
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A hightly pathogenic avian H7N9 influenza virus isolated from a human is lethal in some ferrets infected via respiratory droplets.2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      10th International Symposium on Avian Influenza
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flu-Vision: Imaging systems for analyzing influenza virus infection2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Philipps University Marburg Current Topics in Influenza and Filovirus Research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Centenary of the 1918 Spanish Influenza, the Worst Pandemic in the Recent History of the World2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Influenza Virus Virulence factors, International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flu-vision, total imaging systems for analyzing influenza virus infection.2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Nature Conference on Viral Infection and Immune Response
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human Ebola Virus Disease Pathogenesis Revealed by Multi`Platform Omics Analysis,2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Keystone Symposia in Hong Kong
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of N-terminal acetylation by NatB in the shutoff activity of PA-X.2018

    • Author(s)
      Yamayoshi S, Oishi K, Kawaoka Y.
    • Organizer
      The 7th China-Japan Bilateral Symposium on All Influenza virus
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human monoclonal antibodies against influenza virus2018

    • Author(s)
      Yamayoshi S, Kawaoka Y
    • Organizer
      MEDLAB Asia Pacific & Asia Health Exhibition & Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Animal Models for Influenza Research.2018

    • Author(s)
      Iwatsuki-Horimoto K.
    • Organizer
      Symposium “Zoonosis Research in Veterinary Science” at University of Tokyo
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] スペイン風邪から100年2018

    • Author(s)
      河岡義裕
    • Organizer
      インフルエンザ研究者交流の会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] エボラ出血熱の制圧に向けて. ワクチン開発とシエラレオネでの研究活動2018

    • Author(s)
      渡辺登喜子
    • Organizer
      プラチナ勉強会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 新興感染症-インフルエンザウイルスならびにエボラ出血熱-2018

    • Author(s)
      河岡義裕
    • Organizer
      横浜市医師会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 新興感染症-インフルエンザウイルスならびにエボラ出血熱-2018

    • Author(s)
      河岡義裕
    • Organizer
      小児感染症専門医育成フォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] インフルエンザ並びにエボラ出血熱2018

    • Author(s)
      河岡義裕
    • Organizer
      第161回日本獣医学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] インフルエンザ2018

    • Author(s)
      河岡義裕
    • Organizer
      小児感染症学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] エボラ出血熱の制圧に向けて~ワクチン開発とシエラレオネでの研究活動2018

    • Author(s)
      渡辺登喜子
    • Organizer
      北海道大学獣医学研究談話会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] エボラウイルスに挑む!2018

    • Author(s)
      渡辺登喜子
    • Organizer
      AMED感染症研究事業 市民向けシンポジウム「みるみる興味が湧いてくる!感染症研究の世界」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] インフルエンザウイルスの宿主への適応戦略2018

    • Author(s)
      渡辺登喜子
    • Organizer
      日本大学動物医科学研究センターセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Identification of amino acids that enhance virus replication in mammalian hosts in the PB2 and PA proteins of a highly pathogenic H7N9 influenza virus isolated from a human2018

    • Author(s)
      Yamayoshi S, Kiso M, Yasuhara A, Ito M, Kawaoka Y.
    • Organizer
      8th Orthomyxovirus research conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] N-terminal acetylation by NatB is required for the shutoff activity of influenza A virus PA-X2018

    • Author(s)
      Kohei Oishi, Seiya Yamayoshi, Hiroko Kozuka-Hata, Masaaki Oyama and Yoshihiro Kawaoka
    • Organizer
      The 17th Awaji International Forum on Infection and Immunity
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo imaging captures the pathophysiological changes and dynamics of immune cells in influenza virus-infected mouse lung.2018

    • Author(s)
      H. Ueki, IH. Wang, S. Fukuyama, H. Katsura, T. Lopes, M. Gunzer, G. Neumann, and Y. Kawaoka
    • Organizer
      The 2018 Negative Strand RNA Virus
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The potential of human monoclonal antibodies that recognize the influenza A(H1N1)pdm09 virus hemagglutinin receptor-binding site as anti-influenza agents.2018

    • Author(s)
      Atsuhiro Yasuhara, Seiya Yamayoshi, Maki Kiso, Shinya Yamada, Yoshihiro Kawaoka
    • Organizer
      The 2018 Negative Strand RNA Virus
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses.2018

    • Author(s)
      Kosuke Takada, Chiharu Kawakami, Shufang Fan, Shiho Chiba, Gongxun Zhong, Chunyang Gu, Kohei Shimizu, Sara Takasaki, Yuko Sakai-Tagawa, Tiago J. S. Lopes, Jayeeta Dutta, Harm van Bakel, Zenab Khan, Divya Kriti, Shinya Yamada, Tokiko Watanabe, Masaki Imai, Yoshihiro Kawaoka.
    • Organizer
      Influenza and Other Infections Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of amino acids that enhance virus replication in mammalian hosts in the PB2 and PA proteins of a highly pathogenic H7N9 influenza virus isolated from a human2018

    • Author(s)
      Yamayoshi S, Kiso M, Yasuhara A, Ito M, Shu Y, Kawaoka Y.
    • Organizer
      17th Negative Strand Virus Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amino acid substitutions in the PB2 protein of an H5N1 avian influenza virus enhance its replication efficiency and pathogenicity in mammalian hosts.2018

    • Author(s)
      Takeaki Imamura, Shinya Yamada, Kiyoko Iwatsuki-Horimoto, Reviany V. Nidom, Setyarina Indrasari, Kuncoro P. Santoso, Chairul.A Nidom, Yoshihiro Kawaoka
    • Organizer
      XVII International Meeting on Negative Strand Viruses
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Host Factor Nucleoporin 93 Is Involved in The Nuclear Export of Influenza Virus RNA.2018

    • Author(s)
      Yuri Furusawa, Shinya Yamada, Yoshihiro Kawaoka.
    • Organizer
      The 17th Awaji International Forum on Infection and Immunity,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスモデルにてアジュバント効果を示す食品添加物の探索2018

    • Author(s)
      渡辺登喜子、Huapeng Feng, 山下誠、河岡義裕
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Differences in the ease with which mutant viruses escape from human monoclonal antibodies against the HA stem of influenza A virus2018

    • Author(s)
      S. Yamayoshi, A. Yasuhara, M. Ito, R. Uraki, Y. Kawaoka
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マーモセットのインフルエンザ感染霊長類モデル動物としての検証2018

    • Author(s)
      岩附研子、中島典子、木曽真紀、高橋健太、伊藤睦美、井上貴史、堀内真千子、岡原則夫、佐々木えりか、長谷川秀樹、河岡義裕
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Understanding influenza A virus budding by direct visualization of viral ribonucleoproteins at the plasma membrane.2018

    • Author(s)
      I-Hsuan Wang, Jiro Usukura, and Yoshihiro Kawaoka
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2光子励起顕微鏡を用いたインフルエンザウイルス感染マウスにおける肺の生体イメージングの試み2018

    • Author(s)
      植木紘史, J. IH. Wang, 福山聡, 桂廣亮, Lopes TJS, Gabriele Neumann, 河岡義裕
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2光子励起顕微鏡法を用いたインフルエンザウイルス感染肺の病態生理学的変化の観察2018

    • Author(s)
      植木紘史, I-Hsuan Wang, 福山聡, 桂廣亮, Lopes TJS, Gabriele Neumann, 河岡義裕
    • Organizer
      第26回日本血管生物医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] In vivo imaging of the pathophysiological changes and dynamics of immune cells in influenza virus-infected mouse lung.2018

    • Author(s)
      Hiroshi Ueki, Satoshi Fukuyama, Gabriele Neumann, and Yoshihiro Kawaoka
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Injectable excipients as novel influenza vaccine adjuvants.2018

    • Author(s)
      Huapeng Feng, Makoto Yamashita, Tiago Jose da Silva Lopesa, Tokiko Watanabe, Yoshihiro Kawaoka
    • Organizer
      66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Characterization of a highly pathogenic avian H7N9 influenza virus2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      20th International Conference on Emerging Infectious Diseases in the Pacific Rim
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Animal Models for Influenza Research2018

    • Author(s)
      Kiyoko Iwatsuki-Horimoto
    • Organizer
      A New Paradigm for Laboratory Influenza Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Influenza Basics and Applications of Reverse Genetics2018

    • Author(s)
      Shinya Yamada
    • Organizer
      A New Paradigm for Laboratory Influenza Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of a novel influenza rapid diagnostic kit specific for the H7 subtype.2017

    • Author(s)
      Iwatsuki-Horimoto K.
    • Organizer
      The Sixth China-Japan Bilateral Symposium on All Influenza Viruses.
    • Place of Presentation
      Chinese Academy of Sciences (Beijing, China)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] インフルエンザウイルスの宿主への適応戦略2017

    • Author(s)
      渡辺登喜子
    • Organizer
      農研機構動物衛生研究部門 水曜会(第700回特別記念講演)
    • Place of Presentation
      農研機構動物衛生研究部門
    • Year and Date
      2017-02-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Flu-vision:total imaging systems for analyzing influenza virus infection.2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      CAS-IMSUT Workshop on Infectious Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Understanding Antiviral Targets2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Understanding Antiviral Targets
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flu-vision:total imaging systems for analyzing influenza virus infection2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Transmission of respiratory viruses:from basic science to evidence based options for control Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flu-vision:total imaging systems for analyzing influenza virus infection2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      IMS-JSI2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A broadly reactive anti-HA stem monoclonal antibody that inhibits influenza A virus particle release2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      CAS-IMSUT Workshop on Infectious Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Animal Models in influenza Research2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      NIAID-Sponsored Workshop on Pathway to a Universal Influenza Vaccine.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Flu-vision:total imaging systems for analyzing influenza virus infection.2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      The 6th ESWI Influenza Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Working with deadly viruses:Battling Ebola and Influenza2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      第29回世界病理臨床検査医学会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A highly pathogenic avian H7N9 influenza virus isolated from a human is lethal in some ferrets infected via respiratory droplets.2017

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Hanoi GARAD 2018 Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] インフルエンザ研究の最前線2017

    • Author(s)
      河岡義裕
    • Organizer
      第120回日本小児科学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] インフルエンザ研究の最前線2017

    • Author(s)
      河岡義裕
    • Organizer
      第16回みちのくウイルス塾
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] インフルエンザウイルス感染マウスの生体イメージング研究2017

    • Author(s)
      福山聡, 植木紘史, 仲尾朋美, 三竹博道, Dongming Zhao, 桂廣亮, 今井正樹, 野田岳志, 河岡義裕.
    • Organizer
      第 32 回中国四国ウイルス研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] インフルエンザウイルスの宿主への適応戦略 Host adaptation of influenza A viruses.2017

    • Author(s)
      渡辺登喜子
    • Organizer
      東海医学会講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 海外でアウトブレイク発生!我々にどのような対応ができるか2017

    • Author(s)
      渡辺登喜子
    • Organizer
      ピース・ウィンズ・ジャパン(NPO団体)勉強会.
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] インフルエンザ制圧を目指したウイルスと宿主とのインタラクトーム解析2017

    • Author(s)
      渡辺登喜子
    • Organizer
      第49回日本小児感染症学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 潜んでいた悪者が世に現れるとき2017

    • Author(s)
      渡辺登喜子
    • Organizer
      第7回微生物学連盟フォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] サルモデルにおけるインフルエンザウイルスのエアロゾル感染系の確立2016

    • Author(s)
      渡辺登喜子、岩附研子、木曽真紀、伊藤睦美、河岡義裕
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 近年のヒト分離H3N2インフルエンザウイルスに対するハムスターの感受性2016

    • Author(s)
      岩附研子、中島典子、長谷川秀樹、河岡義裕
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Book] 猛威をふるう「ウイルス・感染症」にどう立ち向かうのか2018

    • Author(s)
      河岡 義裕、今井 正樹
    • Total Pages
      141
    • Publisher
      ミネルヴァ書房
    • ISBN
      9784623080816
    • Related Report
      2017 Annual Research Report
  • [Remarks] 大阪大学微生物病研究所 分子ウイルス分野 渡辺研究室

    • URL

      https://watanabe-lab.biken.osaka-u.ac.jp

    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] アジュバントおよび該アジュバントを含むワクチン2018

    • Inventor(s)
      河岡義裕・渡辺登喜子・山下誠・ホアパンフェン
    • Industrial Property Rights Holder
      河岡義裕・渡辺登喜子・山下誠・ホアパンフェン
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-059532
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-07-04   Modified: 2024-01-30  

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