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Next Generation Natural Product Chemistry by Rational Reconstruction of Artificial Biosynthesis Machinery

Planned Research

Project AreaCreation of Complex Functional Molecules by Rational Redesign of Biosynthetic Machineries
Project/Area Number 16H06443
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionThe University of Tokyo

Principal Investigator

Abe Ikuro  東京大学, 大学院薬学系研究科(薬学部), 教授 (40305496)

Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥108,680,000 (Direct Cost: ¥83,600,000、Indirect Cost: ¥25,080,000)
Fiscal Year 2020: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2019: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2018: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2017: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2016: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Keywords生合成リデザイン / 合成生物学 / 生合成工学 / 天然物化学 / 生物分子科学
Outline of Final Research Achievements

The biosynthesis of meroterpenoids is characterized by the construction of complex molecular scaffolds in a relatively short steps, and this is largely due to the existence of multifunctional enzymes that catalyze dramatic multi-step skeletal transformation reactions. In this study, we elucidated the structural basis of these chemically unique enzyme reactions by X-ray crystallography and other methods. Furthermore, based on the crystal structures, we succeeded in creation of complex functional molecules by rational reconstruction of the biosynthetic machineries. In addition, we also succeeded in structure-function analyses of the novel enzymes which are involved in the biosynthesis of related complex natural products.

Academic Significance and Societal Importance of the Research Achievements

合理的な生合成リデザインに基づく物質生産は、地球環境負荷の低減や自然資源の効率的利用に資することができるばかりでなく、合成化学あるいは工学的な物質生産の研究領域の進展に大きく貢献する。また、新奇な反応を触媒する酵素(生体触媒)の立体構造基盤の解明は、有機化学的にも重要で新たな触媒概念の確立などにも道を拓く。将来的にはゲノムから代謝経路まで合理的にデザインすることで、合目的な機能分子の自在な創成が可能になる。従来の有機合成によるプロセスに比べて、クリーンかつ経済的な新しい技術基盤として期待できることから、社会的にも意義があり、医薬品のみならず、エネルギー、新規素材の生産技術の革新に直結する。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (132 results)

All 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (11 results) Journal Article (67 results) (of which Int'l Joint Research: 34 results,  Peer Reviewed: 65 results,  Open Access: 33 results,  Acknowledgement Compliant: 11 results) Presentation (49 results) (of which Int'l Joint Research: 35 results,  Invited: 49 results) Book (4 results) Remarks (1 results)

  • [Int'l Joint Research] 中国科学院/浙江大学/武漢大学(中国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ボストン大学/ペンシルバニア大学/スクリプス研究所(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ボン大学(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] 中国科学院/浙江大学/武漢大学(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ボストン大学/テキサス大学/スクリプス研究所(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ボン大学(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ジナン大学/浙江大学/上海有機化学研究所(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] デンマーク工科大学(デンマーク)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ジナン大学/上海有機化学研究所/武漢大学(中国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ピッツバーグ大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ボン大学(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] One Polyketide Synthase, Two Distinct Products: Trans‐Acting Enzyme‐Controlled Product Divergence in Calbistrin Biosynthesis2021

    • Author(s)
      Tao Hui、Mori Takahiro、Wei Xingxing、Matsuda Yudai、Abe Ikuro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 60 Issue: 16 Pages: 8851-8858

    • DOI

      10.1002/anie.202016525

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemistry of fungal meroterpenoid cyclases2021

    • Author(s)
      Barra Lena、Abe Ikuro
    • Journal Title

      Natural Product Reports

      Volume: 38 Issue: 3 Pages: 566-585

    • DOI

      10.1039/d0np00056f

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enzymology and biosynthesis of the orsellinic acid derived medicinal meroterpenoids2021

    • Author(s)
      Tao Hui、Abe Ikuro
    • Journal Title

      Current Opinion in Biotechnology

      Volume: 69 Pages: 52-59

    • DOI

      10.1016/j.copbio.2020.11.016

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biosynthesis of alkyne-containing natural products2021

    • Author(s)
      Li Xinyang、Lv Jian-Ming、Hu Dan、Abe Ikuro
    • Journal Title

      RSC Chemical Biology

      Volume: 2 Issue: 1 Pages: 166-180

    • DOI

      10.1039/d0cb00190b

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biosynthesis of sulfonamide and sulfamate antibiotics in Actinomycete2021

    • Author(s)
      Awakawa Takayoshi、Barra Lena、Abe Ikuro
    • Journal Title

      Journal of Industrial Microbiology and Biotechnology

      Volume: 48 Issue: 3-4 Pages: 001-001

    • DOI

      10.1093/jimb/kuab001

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microbial soluble aromatic prenyltransferases for engineered biosynthesis2021

    • Author(s)
      Chen He-Ping、Abe Ikuro
    • Journal Title

      Synthetic and Systems Biotechnology

      Volume: 6 Issue: 2 Pages: 51-62

    • DOI

      10.1016/j.synbio.2021.02.001

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids2020

    • Author(s)
      Mitsuhashi Takaaki、Barra Lena、Powers Zachary、Kojasoy Volga、Cheng Andrea、Yang Feng、Taniguchi Yoshimasa、Kikuchi Takashi、Fujita Makoto、Tantillo Dean J.、Porco John A.、Abe Ikuro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 52 Pages: 23772-23781

    • DOI

      10.1002/anie.202011171

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exploiting a C-N Bond Forming Cytochrome?P450 Monooxygenase for C?S Bond Formation2020

    • Author(s)
      Morita Iori、Mori Takahiro、Mitsuhashi Takaaki、Hoshino Shotaro、Taniguchi Yoshimasa、Kikuchi Takashi、Nagae Kei、Nasu Norihiro、Fujita Makoto、Ohwada Tomohiko、Abe Ikuro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 10 Pages: 3988-3993

    • DOI

      10.1002/anie.201916269

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterochiral coupling in non-ribosomal peptide macrolactamization2020

    • Author(s)
      Matsuda Kenichi、Zhai Rui、Mori Takahiro、Kobayashi Masakazu、Sano Ayae、Abe Ikuro、Wakimoto Toshiyuki
    • Journal Title

      Nature Catalysis

      Volume: 3 Issue: 6 Pages: 507-515

    • DOI

      10.1038/s41929-020-0456-7

    • NAID

      120006941707

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides2020

    • Author(s)
      Kozakai Ryosuke、Ono Takuto、Hoshino Shotaro、Takahashi Hidenori、Katsuyama Yohei、Sugai Yoshinori、Ozaki Taro、Teramoto Kazuya、Teramoto Kanae、Tanaka Koichi、Abe Ikuro、Asamizu Shumpei、Onaka Hiroyasu
    • Journal Title

      Nature Chemistry

      Volume: 12 Issue: 9 Pages: 869-877

    • DOI

      10.1038/s41557-020-0508-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis of biscognienyne B involving an unprecedented cytochrome P450‐dependent alkynylation2020

    • Author(s)
      Abe Ikuro、Lv Jian-Ming、Gao Yao-Hui、Zhao Huan、Awakawa Takayoshi、Liu Ling、Chen Guo-Dong、Yao Xin-Sheng、Hu Dan、Gao Hao
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 32 Pages: 13531-13536

    • DOI

      10.1002/anie.202004364

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases2020

    • Author(s)
      He Haibing、Bian Guangkai、Herbst-Gervasoni Corey J.、Mori Takahiro、Shinsky Stephen A.、Hou Anwei、Mu Xin、Huang Minjian、Cheng Shu、Deng Zixin、Christianson David W.、Abe Ikuro、Liu Tiangang
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 3958-3958

    • DOI

      10.1038/s41467-020-17642-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea2020

    • Author(s)
      Zhang Yue-Hong、Li Yi-Fang、Wang Yongjin、Tan Li、Cao Zhi-Qin、Xie Chao、Xie Guo、Gong Hai-Biao、Sun Wan-Yang、Ouyang Shu-Hua、Duan Wen-Jun、Lu Xiaoyun、Ding Ke、Kurihara Hiroshi、Hu Dan、Zhang Zhi-Min、Abe Ikuro、He Rong-Rong
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 1473-1473

    • DOI

      10.1038/s41467-020-15324-7

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural Diversification of Andiconin-Derived Natural Products by α-Ketoglutarate-Dependent Dioxygenases2020

    • Author(s)
      Bai Tongxuan、Matsuda Yudai、Tao Hui、Mori Takahiro、Zhang Yonghui、Abe Ikuro
    • Journal Title

      Organic Letters

      Volume: 22 Issue: 11 Pages: 4311-4315

    • DOI

      10.1021/acs.orglett.0c01358

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sporormielones A?E, bioactive novel C?C coupled orsellinic acid derivative dimers, and their biosynthetic origin2020

    • Author(s)
      Chen Guo-Dong、Hu Dan、Huang Mei-Juan、Tang Jia、Wang Xiao-Xia、Zou Jian、Xie Jun、Zhang Wei-Guang、Guo Liang-Dong、Yao Xin-Sheng、Abe Ikuro、Gao Hao
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 33 Pages: 4607-4610

    • DOI

      10.1039/d0cc00855a

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis2020

    • Author(s)
      Wang Juan、Zhang Ze-Kun、Jiang Fang-Fang、Qi Bo-Wen、Ding Ning、Hnin Saw Yu Yu、Liu Xiao、Li Jun、Wang Xiao-hui、Tu Peng-Fei、Abe Ikuro、Morita Hiroyuki、Shi She-Po
    • Journal Title

      Organic Letters

      Volume: 22 Issue: 21 Pages: 8725-8729

    • DOI

      10.1021/acs.orglett.0c03339

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Total Synthesis and Structural Revision of Kasumigamide, and Identification of a New Analogue2020

    • Author(s)
      Kuranaga Takefumi、Matsuda Kenichi、Takaoka Masachika、Tachikawa Chisato、Sano Ayae、Itoh Kosei、Enomoto Ayumu、Fujita Kei、Abe Ikuro、Wakimoto Toshiyuki
    • Journal Title

      ChemBioChem

      Volume: 21 Issue: 23 Pages: 3329-3332

    • DOI

      10.1002/cbic.202000409

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases2020

    • Author(s)
      Chen Qingwen、Li Jianxu、Liu Zhixi、Mitsuhashi Takaaki、Zhang Yuting、Liu Haili、Ma Yihua、He Juan、Shinada Tetsuro、Sato Tsutomu、Wang Yong、Liu Hongwei、Abe Ikuro、Zhang Peng、Wang Guodong
    • Journal Title

      Plant Communications

      Volume: 1 Issue: 5 Pages: 100051-100051

    • DOI

      10.1016/j.xplc.2020.100051

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enzymatic Formation of Indolactam Scaffold by C-N Bond‐Forming Cytochrome P450 Oxidases in Teleocidin Biosynthesis2020

    • Author(s)
      Morita Iori、Mori Takahiro、Abe Ikuro
    • Journal Title

      Chemistry A European Journal

      Volume: 27 Issue: 9 Pages: 2963-2972

    • DOI

      10.1002/chem.202003899

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extensive expanding the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy2020

    • Author(s)
      Song Xiaojun、Lv Jianming、Cao Zhiqin、Huang Huiyun、Chen Guodong、Awakawa Takayoshi、Hu Dan、Gao Hao、Abe Ikuro、Yao Xinsheng
    • Journal Title

      Acta Pharmaceutica Sinica B

      Volume: 10 Issue: 6 Pages: 1676-1685

    • DOI

      10.1016/j.apsb.2020.12.007

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular basis for the P450-catalyzed C-N bond formation in indolactam biosynthesis2019

    • Author(s)
      He Fei、Mori Takahiro、Morita Iori、Nakamura Hitomi、Alblova Miroslava、Hoshino Shotaro、Awakawa Takayoshi、Abe Ikuro
    • Journal Title

      Nature Chemical Biology

      Volume: 15 Issue: 12 Pages: 1206-1213

    • DOI

      10.1038/s41589-019-0380-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biomimetic Synthesis of Meroterpenoids by Dearomatization‐Driven Polycyclization2019

    • Author(s)
      Powers Zachary、Scharf Adam、Cheng Andrea、Yang Feng、Himmelbauer Martin、Mitsuhashi Takaaki、Barra Lena、Taniguchi Yoshimasa、Kikuchi Takashi、Fujita Makoto、Abe Ikuro、Porco John A.
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 58 Issue: 45 Pages: 16141-16146

    • DOI

      10.1002/anie.201910710

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural Elucidation of Tenebrathin: Cytotoxic C-5-Substituted γ-Pyrone with a Nitroaryl Side Chain from Streptoalloteichus tenebrarius2019

    • Author(s)
      Hoshino Shotaro、Mitsuhashi Takaaki、Kikuchi Takashi、Wong Chin Piow、Morita Hiroyuki、Awakawa Takayoshi、Fujita Makoto、Abe Ikuro
    • Journal Title

      Organic Letters

      Volume: 21 Issue: 16 Pages: 6519-6522

    • DOI

      10.1021/acs.orglett.9b02443

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multidomain P450 Epoxidase and a Terpene Cyclase from the Ascochlorin Biosynthetic Pathway in Fusarium sp.2019

    • Author(s)
      Quan Zhiyang、Awakawa Takayoshi、Wang Dongmei、Hu Yue、Abe Ikuro
    • Journal Title

      Organic Letters

      Volume: 21 Issue: 7 Pages: 2330-2334

    • DOI

      10.1021/acs.orglett.9b00616

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (+)- and (-)-Preuisolactone A: A Pair of Caged Norsesquiterpenoidal Enantiomers with a Tricyclo[4.4.01,6.02,8]decane Carbon Skeleton from the Endophytic Fungus Preussia isomera2019

    • Author(s)
      Xu Lu-Lin、Chen Hai-Li、Hai Ping、Gao Yuan、Xie Chuan-Dong、Yang Xiao-Long、Abe Ikuro
    • Journal Title

      Organic Letters

      Volume: 21 Issue: 4 Pages: 1078-1081

    • DOI

      10.1021/acs.orglett.8b04123

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] How structural subtleties lead to molecular diversity for the type III polyketide synthases2019

    • Author(s)
      Morita Hiroyuki、Wong Chin Piow、Abe Ikuro
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 41 Pages: 15121-15136

    • DOI

      10.1074/jbc.rev119.006129

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inherent atomic mobility changes in carbocation intermediates during the sesterterpene cyclization cascade2019

    • Author(s)
      Sato Hajime、Mitsuhashi Takaaki、Yamazaki Mami、Abe Ikuro、Uchiyama Masanobu
    • Journal Title

      Beilstein Journal of Organic Chemistry

      Volume: 15 Pages: 1890-1897

    • DOI

      10.3762/bjoc.15.184

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular basis for the plasticity of aromatic prenyltransferases in hapalindole biosynthesis2019

    • Author(s)
      Awakawa Takayoshi、Abe Ikuro
    • Journal Title

      Beilstein Journal of Organic Chemistry

      Volume: 15 Pages: 1545-1551

    • DOI

      10.3762/bjoc.15.157

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aminoacyl sulfonamide assembly in SB-203208 biosynthesis2019

    • Author(s)
      Hu Zhijuan、Awakawa Takayoshi、Ma Zhongjun、Abe Ikuro
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 184-184

    • DOI

      10.1038/s41467-018-08093-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum2019

    • Author(s)
      Araki Yasuko、Awakawa Takayoshi、Matsuzaki Motomichi、Cho Rihe、Matsuda Yudai、Hoshino Shotaro、Shinohara Yasutomo、Yamamoto Masaichi、Kido Yasutoshi、Inaoka Daniel Ken、Nagamune Kisaburo、Ito Kotaro、Abe Ikuro、Kita Kiyoshi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 未定 Issue: 17 Pages: 8269-8274

    • DOI

      10.1073/pnas.1819254116

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity2019

    • Author(s)
      Cao Zhiqin、Li Shaoyang、Lv Jianming、Gao Hao、Chen Guodong、Awakawa Takayoshi、Abe Ikuro、Yao Xinsheng、Hu Dan
    • Journal Title

      Acta Pharmaceutica Sinica B

      Volume: 9 Issue: 2 Pages: 433-442

    • DOI

      10.1016/j.apsb.2018.10.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture with mycolic acid-containing bacteria2018

    • Author(s)
      Hoshino Shotaro、Onaka Hiroyasu、Abe Ikuro
    • Journal Title

      Journal of Industrial Microbiology & Biotechnology

      Volume: 46 Issue: 3-4 Pages: 363-374

    • DOI

      10.1007/s10295-018-2100-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution2018

    • Author(s)
      Awakawa Takayoshi、Fujioka Takuma、Zhang Lihan、Hoshino Shotaro、Hu Zhijuan、Hashimoto Junko、Kozone Ikuko、Ikeda Haruo、Shin-Ya Kazuo、Liu Wen、Abe Ikuro
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 3534-3534

    • DOI

      10.1038/s41467-018-05877-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural and computational bases for dramatic skeletal rearrangement in anditomin biosynthesis2018

    • Author(s)
      Nakashima, Y., Mitsuhashi, T., Matsuda, Y., Senda, M., Sato, H., Yamazaki, M., Uchiyama, M., Senda, T. & Abe, I.
    • Journal Title

      JACS

      Volume: 140 Issue: 30 Pages: 9743-9750

    • DOI

      10.1021/jacs.8b06084

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation2018

    • Author(s)
      Matsuda Yudai、Bai Tongxuan、Phippen Christopher B. W.、Nodvig Christina S.、Kjaerbolling Inge、Vesth Tammi C.、Andersen Mikael R.、Mortensen Uffe H.、Gotfredsen Charlotte H.、Abe Ikuro、Larsen Thomas O.
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 2587-2587

    • DOI

      10.1038/s41467-018-04983-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elucidation and Heterologous Reconstitution of Chrodrimanin B Biosynthesis2018

    • Author(s)
      Bai Tongxuan、Quan Zhiyang、Zhai Rui、Awakawa Takayoshi、Matsuda Yudai、Abe Ikuro
    • Journal Title

      Organic Letters

      Volume: 20 Issue: 23 Pages: 7504-7508

    • DOI

      10.1021/acs.orglett.8b03268

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Computational Studies on Biosynthetic Carbocation Rearrangements Leading to Quiannulatene: Initial Conformation Regulates Biosynthetic Route, Stereochemistry, and Skeleton Type2018

    • Author(s)
      Sato Hajime、Mitsuhashi Takaaki、Yamazaki Mami、Abe Ikuro、Uchiyama Masanobu
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 45 Pages: 14752-14757

    • DOI

      10.1002/anie.201807139

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystalline Sponge Method Enabled the Investigation of a Prenyltransferase-terpene Synthase Chimeric Enzyme, Whose Product Exhibits Broadened NMR Signals2018

    • Author(s)
      Mitsuhashi Takaaki、Kikuchi Takashi、Hoshino Shotaro、Ozeki Masahiro、Awakawa Takayoshi、Shi She-Po、Fujita Makoto、Abe Ikuro
    • Journal Title

      Organic Letters

      Volume: 20 Issue: 18 Pages: 5606-5609

    • DOI

      10.1021/acs.orglett.8b02284

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis2018

    • Author(s)
      Nakashima Yu、Mori Takahiro、Nakamura Hitomi、Awakawa Takayoshi、Hoshino Shotaro、Senda Miki、Senda Toshiya、Abe Ikuro
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41467-017-02371-w

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular insights into the Mg2+-dependent allosteric control of indole prenylation by aromatic prenyltransferase AmbP12018

    • Author(s)
      Abe Ikuro、Awakawa Takayoshi、Mori Takahiro、Nakashima Yu、Zhai Rui、Wong Chin Piow、Hillwig Matthew、Liu Xinyu
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 印刷中 Issue: 23 Pages: 6810-6813

    • DOI

      10.1002/anie.201800855

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage2018

    • Author(s)
      2.Wang, G.-Q., Chen, G.-D., Qin, S.-Y., Hu, D., Awakawa, T., Li, S.-Y., Lv, J.-M., Wang, C.-X., Yao, X.-S., Abe, I., Gao, H.
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1838-1838

    • DOI

      10.1038/s41467-018-04298-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways2018

    • Author(s)
      Nakamura Hitomi、Matsuda Yudai、Abe Ikuro
    • Journal Title

      Nat Prod Rep

      Volume: 35 Issue: 7 Pages: 633-645

    • DOI

      10.1039/c7np00055c

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chimeric Terpene Synthases Possessing both Terpene Cyclization and Prenyltransfer Activities2018

    • Author(s)
      Mitsuhashi Takaaki、Abe Ikuro
    • Journal Title

      ChemBioChem

      Volume: 19 Issue: 11 Pages: 1106-1114

    • DOI

      10.1002/cbic.201800120

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Tryptophan Prenyltransferase with Broad Substrate Tolerance from Bacillus subtilis subsp. natto2018

    • Author(s)
      Abe Ikuro、Sugita Tomotoshi、Okada Masahiro、Nakashima Yu、Tian Tian
    • Journal Title

      ChemBioChem

      Volume: 19 Issue: 13 Pages: 1396-1399

    • DOI

      10.1002/cbic.201800174

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 酵素の立体構造を基盤にした新規生体触媒の開発2018

    • Author(s)
      森貴裕, 阿部郁朗
    • Journal Title

      化学

      Volume: 73 Pages: 32-36

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 多段階反応を触媒する酸化酵素のエンジニアリング2018

    • Author(s)
      中嶋優、阿部郁朗
    • Journal Title

      現代化学

      Volume: -

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Two Distinct Substrate Binding Modes for the Normal and Reverse Prenylation of Hapalindoles by the Prenyltransferase AmbP32017

    • Author(s)
      Wong Chin Piow、Awakawa Takayoshi、Nakashima Yu、Mori Takahiro、Zhu Qin、Liu Xinyu、Abe Ikuro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 2 Pages: 560-563

    • DOI

      10.1002/anie.201710682

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis2017

    • Author(s)
      Mori Takahiro、Iwabuchi Taiki、Hoshino Shotaro、Wang Hang、Matsuda Yudai、Abe Ikuro
    • Journal Title

      Nature Chemical Biology

      Volume: 13 Issue: 10 Pages: 1066-1073

    • DOI

      10.1038/nchembio.2443

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis2017

    • Author(s)
      Lv Jian-Ming、Hu Dan、Gao Hao、Kushiro Tetsuo、Awakawa Takayoshi、Chen Guo-Dong、Wang Chuan-Xi、Abe Ikuro、Yao Xin-Sheng
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 1644-1644

    • DOI

      10.1038/s41467-017-01813-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides2017

    • Author(s)
      Zhang, L., Hashimoto, T., Qin, B., Hashimoto, J., Kozone, I., Kawahara, T., Okada, M., Awakawa, T., Ito, T., Asakawa, Y., Ueki, M., Takahashi, S., Osada, H., Wakimoto, T., Ikeda, H., Shin-ya, K., Abe, I.
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 56 Issue: 7 Pages: 1740-1745

    • DOI

      10.1002/anie.201611371

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mechanistic Characterization of Two Chimeric Sesterterpene Synthases from Penicillium2017

    • Author(s)
      Mitsuhashi Takaaki、Rinkel Jan、Okada Masahiro、Abe Ikuro、Dickschat Jeroen S.
    • Journal Title

      Chemistry - A European Journal

      Volume: 23 Issue: 42 Pages: 10053-10057

    • DOI

      10.1002/chem.201702766

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mycolic Acid Containing Bacterium Stimulates Tandem Cyclization of Polyene Macrolactam in a Lake Sediment Derived Rare Actinomycete2017

    • Author(s)
      Hoshino Shotaro、Okada Masahiro、Awakawa Takayoshi、Asamizu Shumpei、Onaka Hiroyasu、Abe Ikuro
    • Journal Title

      Organic Letters

      Volume: 19 Issue: 18 Pages: 4992-4995

    • DOI

      10.1021/acs.orglett.7b02508

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Chimeric αβγ Diterpene Synthases Possessing both Type?II Terpene Cyclase and Prenyltransferase Activities2017

    • Author(s)
      Mitsuhashi Takaaki、Okada Masahiro、Abe Ikuro
    • Journal Title

      ChemBioChem

      Volume: 18 Issue: 21 Pages: 2104-2109

    • DOI

      10.1002/cbic.201700445

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combinatorial Biosynthesis of (+)-Daurichromenic Acid and Its Halogenated Analogue2017

    • Author(s)
      Okada Masahiro、Saito Kai、Wong Chin Piow、Li Chang、Wang Dongmei、Iijima Miu、Taura Futoshi、Kurosaki Fumiya、Awakawa Takayoshi、Abe Ikuro
    • Journal Title

      Organic Letters

      Volume: 19 Issue: 12 Pages: 3183-3186

    • DOI

      10.1021/acs.orglett.7b01288

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 2-Alkylquinolone alkaloid biosynthesis in the medicinal plantEvodia rutaecarpainvolves collaboration of two novel type III polyketide synthases2017

    • Author(s)
      Matsui Takashi、Kodama Takeshi、Mori Takahiro、Tadakoshi Tetsuhiro、Noguchi Hiroshi、Abe Ikuro、Morita Hiroyuki
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 22 Pages: 9117-9135

    • DOI

      10.1074/jbc.m117.778977

    • NAID

      120006559815

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of pyridinium with three indole moieties as an antimicrobial agent2017

    • Author(s)
      Okada, M., Sugita, T., Wong, C. P., Wakimoto, T., Abe, I.
    • Journal Title

      J. Nat. Prod.,

      Volume: 80 Issue: 4 Pages: 1205-1209

    • DOI

      10.1021/acs.jnatprod.6b01152

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification and Characterization of Daurichromenic Acid Synthase Active in Anti-HIV Biosynthesis2017

    • Author(s)
      Iijima Miu、Munakata Ryosuke、Takahashi Hironobu、Kenmoku Hiromichi、Nakagawa Ryuichi、Kodama Takeshi、Asakawa Yoshinori、Abe Ikuro、Yazaki Kazufumi、Kurosaki Fumiya、Taura Futoshi
    • Journal Title

      Plant Physiology

      Volume: 174 Issue: 4 Pages: 2213-2230

    • DOI

      10.1104/pp.17.00586

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3,5-Dimethylorsellinic Acid Derived Meroterpenoids from Penicillium chrysogenum MT-12, an Endophytic Fungus Isolated from Huperzia serrata2017

    • Author(s)
      Qi Bowen、Liu Xiao、Mo Ting、Zhu Zhixiang、Li Jun、Wang Juan、Shi Xiaoping、Zeng Kewu、Wang Xiaohui、Tu Pengfei、Abe Ikuro、Shi Shepo
    • Journal Title

      Journal of Natural Products

      Volume: 80 Issue: 10 Pages: 2699-2707

    • DOI

      10.1021/acs.jnatprod.7b00438

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discovery of key dioxygenases that diverged the paraherquonin and acetoxydehydroaustin pathways in Penicillium brasilianum2016

    • Author(s)
      Matsuda, Y., Iwabuchi,T., Fujimoto, T., Awakawa,T., Nakashima, Y., Mori, T., Zhang, H., Hayashi, F., Abe, I.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 138 Issue: 38 Pages: 12671-12677

    • DOI

      10.1021/jacs.6b08424

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoids biosynthesis2016

    • Author(s)
      Okada, M., Matsuda, Y., Mitsuhashi, T., Hoshino, S., Mori, T., Nakagawa, K., Quan, Z., Qin, B., Zhang, H., Hayashi, F., Kawaide, H., Abe, I.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 138 Issue: 31 Pages: 10011-10018

    • DOI

      10.1021/jacs.6b05799

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Astellifadiene: Structure Determination by NMR Spectroscopy and Crystalline Sponge Method, and Elucidation of its Biosynthesis2016

    • Author(s)
      Matsuda, Y., Mitsuhashi,T., Lee, S., Hoshino, M., Mori, T., Okada, M., Zhang, H., Hayashi, F., Fujita, M., Abe, I.
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 55 Issue: 19 Pages: 5785

    • DOI

      10.1002/anie.201601448

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An unusual chimeric diterpene synthase from Emericella varicolor and its functional conversion into a sesterterpene synthase by domain swapping2016

    • Author(s)
      B. Qin, Y. Matsuda, T. Mori, M. Okada, Z. Quan, T. Mitsuhashi, T. Wakimoto, I. Abe
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 55 Issue: 5 Pages: 1658-1661

    • DOI

      10.1002/anie.201509263

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases2016

    • Author(s)
      T. Mori, L. Zhang, T. Awakawa, S. Hoshino, M. Okada, H. Morita, I. Abe
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 10849-10851

    • DOI

      10.1038/ncomms10849

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural insight into the enzymatic formation of bacterial stilbene2016

    • Author(s)
      Mori, T., Awakawa, T., Shimomura, K., Saito, Y., Yang, D., Morita, H., Abe, I.
    • Journal Title

      Cell Chem. Biol.

      Volume: 23 Issue: 12 Pages: 1468-1479

    • DOI

      10.1016/j.chembiol.2016.10.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Biosynthesis of fungal meroterpenoids2016

    • Author(s)
      Matsuda, Y., Abe, I.
    • Journal Title

      Nat. Prod. Rep.

      Volume: 33 Issue: 1 Pages: 26-53

    • DOI

      10.1039/c5np00090d

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Calyculin: Nature’s way of making the sponge-derived cytotoxin2016

    • Author(s)
      T. Wakimoto, Y. Egami, I. Abe
    • Journal Title

      Nat. Prod. Rep.

      Volume: 未定 Issue: 6 Pages: 751-760

    • DOI

      10.1039/c5np00123d

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Unusual chemistries in fungal meroterpenoid biosynthesis2016

    • Author(s)
      Matsuda, Y., Awakawa, T., Mori, T., Abe, I.
    • Journal Title

      Curr. Opin. Chem. Biol.

      Volume: 31 Pages: 1-7

    • DOI

      10.1016/j.cbpa.2015.11.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 非ヘム鉄-αケトグルタル酸依存性酸化酵素に関する研究2020

    • Author(s)
      阿部郁朗
    • Organizer
      第22回 生体触媒シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Unusual Enzyme Reactions in Fungal Meroterpenoid Biosynthesis2020

    • Author(s)
      Ikuro Abe
    • Organizer
      3rd International Conference on Natural Product Discovery and Development in the Genomic Era
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2019

    • Author(s)
      Ikuro Abe
    • Organizer
      2019 International Conference on Metabolic Sciences
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Enzyme Reactions in Natural Product Biosynthesis2019

    • Author(s)
      Ikuro Abe
    • Organizer
      Design, Evolution and Application of Enzymes, Academia Sinica
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2019

    • Author(s)
      Ikuro Abe
    • Organizer
      5th Sino-Italian Symposium on Bioactive Natural Products
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2019

    • Author(s)
      Ikuro Abe
    • Organizer
      International Plant Cell Technology Industry Summit 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2019

    • Author(s)
      Ikuro Abe
    • Organizer
      9th International Conference on Biotechnology and Bioengineering
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 放線菌由来生物活性二次代謝産物の生合成研究2019

    • Author(s)
      阿部郁朗
    • Organizer
      第34回日本放線菌学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Engineered Biosynthesis of Fungal Meroterpenoids2019

    • Author(s)
      Ikuro Abe
    • Organizer
      14th International Meeting on Biosynthesis, Function and Synthetic Biology of Isoprenoids (TERPNET 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 微生物由来薬用天然物の生合成リデザイン2019

    • Author(s)
      阿部郁朗
    • Organizer
      東京大学微生物科学イノベーション連携研究機構、微生物ウイーク2019、オープニングシンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 希少有用二次代謝産物の合成生物学2019

    • Author(s)
      阿部郁朗
    • Organizer
      第40回糸状菌遺伝子研究会例会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2019

    • Author(s)
      Ikuro Abe
    • Organizer
      Fusion Conference, 2nd Synthetic Biology for Natural Products Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 人工生合成マシナリーの合理的再構築による次世代天然物化学2019

    • Author(s)
      阿部郁朗
    • Organizer
      科学研究費補助金 新学術領域研究(研究領域提案型)生物合成系の再設計による複雑骨格機能分子の革新的創成科学、第6回公開シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2019

    • Author(s)
      Ikuro Abe
    • Organizer
      Biosystems Design 5.0 Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 天然有機化合物の生合成に関する研究2019

    • Author(s)
      阿部郁朗
    • Organizer
      日本薬学会 第 139 年会、薬学会賞受賞講演
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Unusual Enzyme Reactions in Natural Product Biosynthesis2019

    • Author(s)
      Ikuro Abe
    • Organizer
      2nd China-Japan Joint Symposium on Natural Product Biosynthesis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Enzyme Reactions in Fungal Meroterpenoid Biosynthesis2018

    • Author(s)
      Ikuro Abe
    • Organizer
      第 20 回生体触媒化学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 二次代謝酵素が担う多様な反応と精密構造に基づく酵素リデザイン2018

    • Author(s)
      阿部郁朗
    • Organizer
      第 23 回東京大学生物工学センターシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Unusual Enzyme Reactions in Fungal Meroterpenoid Biosynthesis2018

    • Author(s)
      Ikuro Abe
    • Organizer
      KSP-JSP-CSP Joint Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Enzyme Reactions in Natural Products Biosynthesis2018

    • Author(s)
      Ikuro Abe
    • Organizer
      Qingdao International Technology Transfer Conference, Synthetic Biology Workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生薬有効成分の生合成研究2018

    • Author(s)
      阿部郁朗
    • Organizer
      日本生薬学会 第 65 回年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Unusual Enzyme Reactions in Fungal Meroterpenoid Biosynthesis2018

    • Author(s)
      Ikuro Abe
    • Organizer
      1st German-Japanese Joint Symposium on the Biosynthesis of Natural Products
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2018

    • Author(s)
      Ikuro Abe
    • Organizer
      European Conference on Natural Products
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Enzyme Reactions in Fungal Meroterpenoid Biosynthesis2018

    • Author(s)
      Ikuro Abe
    • Organizer
      Int Forum on Natural Products
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structure-guided Engineering of Multifunctional Oxygenases in Complex Natural Products Biosynthesis2018

    • Author(s)
      Ikuro Abe
    • Organizer
      2nd Joint AFOB-EFB Symposium on Biocatalysis, Geneva, Switzerland
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2018

    • Author(s)
      Ikuro Abe
    • Organizer
      24th International Union of Biochemistry and Molecular Biology (IUBMB) and 15th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Congress (IUBMB SEOUL 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 人工生合成マシナリーの合理的再構築による次世代天然 物化学2018

    • Author(s)
      阿部郁朗
    • Organizer
      科学研究費補助金 新学術領域研究(研究領域提案型)生物合成系 の再設計による複雑骨格機能分子の革新的創成科学、第4回公開シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Engineered Biosynthesis of Fungal Meroterpenoids2018

    • Author(s)
      Ikuro Abe
    • Organizer
      The 1st Mini-symposium: Frontiers in Terpenoids Biosynthesis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 酵素工学を基盤とする生合成リデザイン2018

    • Author(s)
      阿部郁朗
    • Organizer
      東京大学大学院農学生命科学研究科 微生物潜在酵素(天野エンザ イム)寄付講座開設記念シンポジウム 微生物酵素による「ものづくり」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2018

    • Author(s)
      Ikuro Abe
    • Organizer
      34th International Conference on Natural Products 2018 (ICNP 2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Enzyme Reactions in Fungal Meroterpenoid Biosynthesis2018

    • Author(s)
      Ikuro Abe
    • Organizer
      8th CMDD Symposium on Marine Natural Products
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Enzyme Reactions in Fungal Meroterpenoid Biosynthesis2018

    • Author(s)
      Ikuro Abe
    • Organizer
      The Society for Industrial Microbiology (SIMB), “2nd International Conference on Natural Product Discovery and Development in the Genomic Era”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2018

    • Author(s)
      Ikuro Abe
    • Organizer
      2018 Synthetic Biotechnology Training Course, Beijing
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Redesigning Complex Natural Products Biosynthesis2017

    • Author(s)
      阿部郁朗
    • Organizer
      PSJ-AAPS Joint Symposium, Creation of Complex Functional Molecules by Rational Redesign of Biosynthetic Machineries
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2017-03-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 複雑骨格天然物の生合成マシナリーの解明と再設計2017

    • Author(s)
      阿部郁朗
    • Organizer
      日本農芸化学会2017年度京都大会シンポジウム、農芸化学から発信する次世代型天然物化学2017
    • Place of Presentation
      京都女子大(京都府・京都市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2017

    • Author(s)
      阿部郁朗
    • Organizer
      The 2nd International Conference on Herbal and Traditional Medicine (HTM2017)
    • Place of Presentation
      Bangkok (Thailand)
    • Year and Date
      2017-01-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 薬用天然物の生合成リデザイン2017

    • Author(s)
      阿部郁朗
    • Organizer
      理研シンポジウム、高磁場・高感度NMR利活用促進のための天然物分野における日中連携シンポジウム2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 放線菌由来生物活性二次代謝産物の生合成研究2017

    • Author(s)
      阿部郁朗
    • Organizer
      公益財団法人日本感染症医薬品協会、メディカルサイエンス・セミナー、住木・梅澤記念賞受賞講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 複雑骨格薬用天然物の合成生物学2017

    • Author(s)
      阿部郁朗
    • Organizer
      JST-ACCEL「革新的分子構造解析」公開シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Molecular Basis for the Unusual Ring Reconstruction in Fungal Meroterpenoid Biogenesis2017

    • Author(s)
      Ikuro Abe
    • Organizer
      3rd Sino-Italian Symposium on Bioactive Natural Products & 1st International Forum for Drug Discovery Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Enzyme Reactions in Fungal Meroterpenoid Biosynthesis2017

    • Author(s)
      Ikuro Abe
    • Organizer
      1st China-Japan Joint Symposium on Natural Product Biosynthesis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 薬用天然物の生合成工学に関する研究2017

    • Author(s)
      阿部郁朗
    • Organizer
      日本生薬学会 第64回年会、生薬学会賞受賞講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Engineered Biosynthesis of Fungal Meroterpenoids2017

    • Author(s)
      Ikuro Abe
    • Organizer
      The American Society of Pharmacognosy Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structure-guided Engineered Biosynthesis of Fungal Meroterpenoid2017

    • Author(s)
      Ikuro Abe
    • Organizer
      13th International Meeting on Biosynthesis, Function and Synthetic Biology of Isoprenoids (TERPNET 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Enzymes Involved in the Complex Natural Products Biosynthesis2017

    • Author(s)
      Ikuro Abe
    • Organizer
      9th US-Japan Seminar on Natural Product Biosynthesis, UCLA Lake Arrowhead Conference Center
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biosynthesis of Fungal Meroterpenoids2016

    • Author(s)
      阿部郁朗
    • Organizer
      Czech-Japan Joint Workshop, Innovative Technologies for the Discovery of Natural Products
    • Place of Presentation
      Prague (Czech Republic)
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Engineered Biosynthesis of Medicinal Natural Products2016

    • Author(s)
      阿部郁朗
    • Organizer
      2016 Mogan Mountain International Summit on Green Pharmaceuticals
    • Place of Presentation
      Hangzhou (China)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biosynthesis of Fungal Meroterpenoids2016

    • Author(s)
      阿部郁朗
    • Organizer
      13th International Symposium on the Genetics of Industrial Microorganisms (GIM2016)
    • Place of Presentation
      Wuhan (China)
    • Year and Date
      2016-10-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multifunctional Oxygenases Involved in Complex Natural Products Biosynthesis2016

    • Author(s)
      阿部郁朗
    • Organizer
      Cytochrome P450 Biodiversity & Biotechnology 2016
    • Place of Presentation
      Vancouver (Canada)
    • Year and Date
      2016-07-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] Comprehensive Natural Products III: Chemistry and Biology, Vol. 12020

    • Author(s)
      Yudai Matsuda, Ikuro Abe
    • Total Pages
      33
    • Publisher
      Elsevier
    • Related Report
      2019 Annual Research Report
  • [Book] Progress in the Chemistry of Organic Natural Products2020

    • Author(s)
      Takaaki Mitsuhashi, Ikuro Abe
    • Total Pages
      79
    • Publisher
      Springer
    • Related Report
      2019 Annual Research Report
  • [Book] Encyclopedia of Inorganic and Bioinorganic Chemistry2020

    • Author(s)
      Yu Nakashima, Takahiro Mori, and Ikuro Abe
    • Total Pages
      8
    • Publisher
      John Wiley & Sons, Ltd.
    • Related Report
      2019 Annual Research Report
  • [Book] Encyclopedia of Inorganic and Bioinorganic Chemistry2019

    • Author(s)
      Takahiro Mori, and Ikuro Abe
    • Total Pages
      8
    • Publisher
      John Wiley & Sons, Ltd.
    • Related Report
      2019 Annual Research Report
  • [Remarks] 東京大学大学院薬学系研究科天然物化学教室

    • URL

      http://www.f.u-tokyo.ac.jp/~tennen/head.htm

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report 2016 Annual Research Report

URL: 

Published: 2016-07-04   Modified: 2022-02-28  

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