| Budget Amount *help |
¥108,680,000 (Direct Cost: ¥83,600,000、Indirect Cost: ¥25,080,000)
Fiscal Year 2020: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2019: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2018: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2017: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2016: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
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| Outline of Final Research Achievements |
The biosynthesis of meroterpenoids is characterized by the construction of complex molecular scaffolds in a relatively short steps, and this is largely due to the existence of multifunctional enzymes that catalyze dramatic multi-step skeletal transformation reactions. In this study, we elucidated the structural basis of these chemically unique enzyme reactions by X-ray crystallography and other methods. Furthermore, based on the crystal structures, we succeeded in creation of complex functional molecules by rational reconstruction of the biosynthetic machineries. In addition, we also succeeded in structure-function analyses of the novel enzymes which are involved in the biosynthesis of related complex natural products.
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