Synthetic biology of pseudo-natural products by artificial in vitro biosynthesis

• Project Area: Creation of Complex Functional Molecules by Rational Redesign of Biosynthetic Machineries
• Project/Area Number: 16H06444
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: The University of Tokyo
• Principal Investigator: 菅 裕明 東京大学, 大学院理学系研究科(理学部), 教授 (00361668)
• Co-Investigator(Kenkyū-buntansha): 後藤 佑樹 東京大学, 大学院理学系研究科(理学部), 准教授 (70570604) ; 尾仲 宏康 東京大学, 大学院農学生命科学研究科(農学部), 特任教授 (80315829)
• Project Period (FY): 2016-06-30 – 2021-03-31
• Project Status: Discontinued (Fiscal Year 2020)
• Budget Amount: ¥72,020,000 (Direct Cost: ¥55,400,000、Indirect Cost: ¥16,620,000); Fiscal Year 2020: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000); Fiscal Year 2019: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000); Fiscal Year 2018: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000); Fiscal Year 2017: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000); Fiscal Year 2016: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
• Keywords: 試験管内リデザイン整合性系 / 主鎖修飾型ペプチド / 人工生合成系 / 擬天然物 / 試験管内リデザイン生合成系

Outline of Annual Research Achievements

本研究課題では、生体内には存在し得ない人工生合成系を試験管内で構築すること、さらにこれらを用いて任意の生物活性をもつ天然物様化合物を創製すること により、新機軸の生物活性分子開発に資する『擬天然物合成生物学』の基盤を確立する。具体的には、改変翻訳系と異種由来のペプチド修飾酵素を複数組み合わ せることで、各種主鎖修飾骨格を有する擬天然物ペプチドの試験管内リデザイン生合成系の創製を行う。さらに、この系を用いて、大規模な多様性(一兆種類以 上)をもつ擬天然物のランダム配列ライブラリーを構築し、当該ライブラリーから新規生物活性擬天然物の探索系を構築することで医療に資する化合物の発見も視 野に入れた研究を進める。昨年度までの研究において、人工チオペプチド及びプレニル化トリプトファン含有人工ペプチドの試験管内リデザイン生合成系の構築と高度化に成功してきた。 今年度の研究（4月～7月のみ）では、機械学習を駆使した人工チオペプチドライブラリー基質の設計と構築を達成した。さらに、これまでに開発を進めてきたプレニル化トリプ トファンを含有する人工ペプチドの生物活性評価を推進した。また、これまでに報告されていない新規酵素を含め、3種類のペプチドプレニル化酵素の結晶構造の解明にも成功した。
研究期間を通じた研究の成果として、複数の試験管内リデザイン生合成系の確立および擬天然物ペプチドライブラリーの構築を達成し、擬天然物ペプチドの試験管内生産戦略の有用性を実証した。さらに、いくつかの生物活性擬天然物ペプチドの開発にも成功しており、擬天然物ペプチド創薬戦略の先鞭をつけた。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Univ. of North Carolina at Chapel Hill/National Institutes of Health(米国)
• [Int'l Joint Research] Univ. of North Carolina at Chapel Hill(米国)
• [Int'l Joint Research] National Institutes of Health(米国)
• [Journal Article] Promiscuous Enzymes Cooperate at the Substrate Level En Route to Lactazole A (2020)
  • Author(s): Vinogradov Alexander A.、Shimomura Morito、Kano Naokazu、Goto Yuki、Onaka Hiroyasu、Suga Hiroaki
  • Journal Title: Journal of the American Chemical Society Volume: 142 Issue: 32 Pages: 13886-13897
  • DOI: 10.1021/jacs.0c05541
  • Peer Reviewed
• [Journal Article] Minimal lactazole scaffold for in vitro thiopeptide bioengineering (2020)
  • Author(s): Vinogradov Alexander A.、Shimomura Morito、Goto Yuki、Ozaki Taro、Asamizu Shumpei、Sugai Yoshinori、Suga Hiroaki、Onaka Hiroyasu
  • Journal Title: Nature Communications Volume: 11 Issue: 1 Pages: 2272-2272
  • DOI: 10.1038/s41467-020-16145-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Initiating ribosomal peptide synthesis with exotic building blocks (2020)
  • Author(s): Tsiamantas Christos、Rogers Joseph M.、Suga Hiroaki
  • Journal Title: Chemical Communications Volume: 56 Issue: 31 Pages: 4265-4272
  • DOI: 10.1039/d0cc01291b
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Macrocyclic Peptide Library with a Structurally Constrained Cyclopropane‐containing Building Block Leads to Thiol‐independent Inhibitors of Phosphoglycerate Mutase (2020)
  • Author(s): Okuma Rika、Kuwahara Tomoki、Yoshikane Takafumi、Watanabe Mizuki、Dranchak Patricia、Inglese James、Shuto Satoshi、Goto Yuki、Suga Hiroaki
  • Journal Title: Chemistry - An Asian Journal Volume: 15 Issue: 17 Pages: 2631-2636
  • DOI: 10.1002/asia.202000700
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ribosomal Elongation of Aminobenzoic Acid Derivatives (2020)
  • Author(s): Katoh Takayuki、Suga Hiroaki
  • Journal Title: Journal of the American Chemical Society Volume: 142 Issue: 39 Pages: 16518-16522
  • DOI: 10.1021/jacs.0c05765
  • Peer Reviewed
• [Journal Article] Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids (2020)
  • Author(s): Katoh Takayuki、Sengoku Toru、Hirata Kunio、Ogata Kazuhiro、Suga Hiroaki
  • Journal Title: Nature Chemistry Volume: 12 Issue: 11 Pages: 1081-1088
  • DOI: 10.1038/s41557-020-0525-1
  • Peer Reviewed
• [Journal Article] An aminoacylation ribozyme evolved from a natural tRNA-sensing T-box riboswitch (2020)
  • Author(s): Ishida Satoshi、Terasaka Naohiro、Katoh Takayuki、Suga Hiroaki
  • Journal Title: Nature Chemical Biology Volume: 16 Issue: 6 Pages: 702-709
  • DOI: 10.1038/s41589-020-0500-6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Affinity Maturation of Macrocyclic Peptide Modulators of Lys48‐Linked Diubiquitin by a Twofold Strategy (2020)
  • Author(s): Huang Yichao、Nawatha Mickal、Livneh Ido、Rogers Joseph M.、Sun Hao、Singh Sumeet K.、Ciechanover Aaron、Brik Ashraf、Suga Hiroaki
  • Journal Title: Chemistry A European Journal Volume: 26 Issue: 36 Pages: 8022-8027
  • DOI: 10.1002/chem.202000273
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Exploring the Post-translational Enzymology of PaaA by mRNA Display (2020)
  • Author(s): Fleming, S. R., Himes, P. M., Ghodge, S. V., Goto, Y., Suga, H., Bowers, A. A.
  • Journal Title: J Am Chem Soc Volume: 142 Issue: 11 Pages: 5024-5028
  • DOI: 10.1021/jacs.0c01576
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming (2020)
  • Author(s): Vinogradov Alexander A.、Suga Hiroaki
  • Journal Title: Cell Chemical Biology Volume: 27 Issue: 8 Pages: 1032-1051
  • DOI: 10.1016/j.chembiol.2020.07.003
  • Peer Reviewed
• [Journal Article] Methodologies for Backbone Macrocyclic Peptide Synthesis Compatible With Screening Technologies (2020)
  • Author(s): Shinbara Koki、Liu Wenyu、van Neer Renier Herman Pieter、Katoh Takayuki、Suga Hiroaki
  • Journal Title: Frontiers in Chemistry Volume: 8 Pages: 447-447
  • DOI: 10.3389/fchem.2020.00447
  • Peer Reviewed / Open Access
• [Journal Article] Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages (2020)
  • Author(s): Tsiamantas Christos、Kwon Sunbum、Rogers Joseph M.、Douat Cline、Huc Ivan、Suga Hiroaki
  • Journal Title: Angewandte Chemie International Edition Volume: 59 Issue: 12 Pages: 4860-4864
  • DOI: 10.1002/anie.201914654
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chemoenzymatic Posttranslational Modification Reactions for the Synthesis of Ψ[CH 2 NH]‐Containing Peptides (2020)
  • Author(s): Kato Yasuharu、Kuroda Tomohiro、Huang Yichao、Ohta Risa、Goto Yuki、Suga Hiroaki
  • Journal Title: Angewandte Chemie International Edition Volume: 59 Issue: 2 Pages: 684-688
  • DOI: 10.1002/anie.201910894
  • Peer Reviewed
• [Journal Article] In Vitro Biosynthesis of Peptides Containing Exotic Azoline Analogues (2019)
  • Author(s): Goto Yuki、Suga Hiroaki
  • Journal Title: ChemBioChem Volume: 21 Issue: 1-2 Pages: 84-87
  • DOI: 10.1002/cbic.201900521
  • Peer Reviewed
• [Journal Article] De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor (2019)
  • Author(s): Yin Yizhen、Ochi Nobuaki、Craven Timothy W.、Baker David、Takigawa Nagio、Suga Hiroaki
  • Journal Title: Journal of the American Chemical Society Volume: 141 Issue: 49 Pages: 19193-19197
  • DOI: 10.1021/jacs.9b09106
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Optimizing aromatic oligoamide foldamer side-chains for ribosomal translation initiation (2019)
  • Author(s): Tsiamantas Christos、Kwon Sunbum、Douat C?line、Huc Ivan、Suga Hiroaki
  • Journal Title: Chemical Communications Volume: 55 Issue: 51 Pages: 7366-7369
  • DOI: 10.1039/c9cc03547h
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ribosomal Formation of Thioamide Bonds in Polypeptide Synthesis (2019)
  • Author(s): Maini Rumit、Kimura Hiroyuki、Takatsuji Ryo、Katoh Takayuki、Goto Yuki、Suga Hiroaki
  • Journal Title: Journal of the American Chemical Society Volume: 141 Issue: 51 Pages: 20004-20008
  • DOI: 10.1021/jacs.9b11097
  • Peer Reviewed
• [Journal Article] Flexizyme-catalyzed synthesis of 3'-aminoacyl-NH-tRNAs. (2019)
  • Author(s): Katoh T, Suga H.
  • Journal Title: Nucleic Acids Res. Volume: pii Issue: 9 Pages: e54-e54
  • DOI: 10.1093/nar/gkz143
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display (2019)
  • Author(s): Hirose Hisaaki、Hideshima Tomoki、Katoh Takayuki、Suga Hiroaki
  • Journal Title: ChemBioChem Volume: 20 Issue: 16 Pages: 2089-2100
  • DOI: 10.1002/cbic.201900039
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Flexizyme-Enabled Benchtop Biosynthesis of Thiopeptides. (2019)
  • Author(s): Fleming SR, Bartges TE, Vinogradov AA, Kirkpatrick CL, Goto Y, Suga H, Hicks LM, Bowers AA.
  • Journal Title: J Am Chem Soc. Volume: 141 Issue: 2 Pages: 758-762
  • DOI: 10.1021/jacs.8b11521
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines (2019)
  • Author(s): Ozaki Taro、Sugiyama Ryosuke、Shimomura Morito、Nishimura Shinichi、Asamizu Shumpei、Katsuyama Yohei、Kakeya Hideaki、Onaka Hiroyasu
  • Journal Title: Organic & Biomolecular Chemistry Volume: 17 Issue: 9 Pages: 2370-2378
  • DOI: 10.1039/c8ob02846j
  • Peer Reviewed
• [Journal Article] Discovery of Functional Macrocyclic Peptides by Means of the RaPID System (2019)
  • Author(s): Tsiamantas Christos、Otero-Ramirez Manuel E.、Suga Hiroaki
  • Journal Title: Methods Mol Biol Volume: 2001 Pages: 299-315
  • DOI: 10.1007/978-1-4939-9504-2_14
  • ISBN: 9781493995035, 9781493995042
  • Peer Reviewed
• [Journal Article] Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges. (2019)
  • Author(s): Vinogradov AA, Yin Y, Suga H.
  • Journal Title: J Am Chem Soc. Volume: 141 Issue: 10 Pages: 4167-4181
  • DOI: 10.1021/jacs.8b13178
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RiPP生合成経路の改変による人工ペプチド生産 (2019)
  • Author(s): 後藤 佑樹、井上 澄香、菅 裕明
  • Journal Title: Farumashia Volume: 55 Issue: 7 Pages: 662-667
  • DOI: 10.14894/faruawpsj.55.7_662
  • NAID: 130007671606
  • ISSN: 0014-8601, 2189-7026
• [Journal Article] Ribosomal Synthesis of Backbone-Cyclic Peptides Compatible with In Vitro Display. (2019)
  • Author(s): Takatsuji R, Shinbara K, Katoh T, Goto Y, Passioura T, Yajima R, Komatsu Y, Suga H.
  • Journal Title: J Am Chem Soc. Volume: 141 Issue: 6 Pages: 2279-2287
  • DOI: 10.1021/jacs.8b05327
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Artificial Division of Codon Boxes for Expansion of the Amino Acid Repertoire of Ribosomal Polypeptide Synthesis. (2018)
  • Author(s): Iwane Y, Katoh T, Goto Y, Suga H.
  • Journal Title: Methods Mol Biol. Volume: 1728 Pages: 17-47
  • DOI: 10.1007/978-1-4939-7574-7_2
  • ISBN: 9781493975730, 9781493975747
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A. (2018)
  • Author(s): Passioura T, Bhushan B, Tumber A, Kawamura A, Suga H.
  • Journal Title: Bioorg Med Chem. Volume: 26 Issue: 6 Pages: 1225-1231
  • DOI: 10.1016/j.bmc.2018.01.013
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ribosomal synthesis and folding of peptide-helical aromatic foldamer hybrids. (2018)
  • Author(s): Rogers JM, Kwon S, Dawson SJ, Mandal PK, Suga H, Huc I.
  • Journal Title: Nat Chem. Volume: 10 Issue: 4 Pages: 405-412
  • DOI: 10.1038/s41557-018-0007-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Engineering of RiPP pathways for the production of artificial peptides bearing various non-proteinogenic structures (2018)
  • Author(s): Goto Yuki、Suga Hiroaki
  • Journal Title: Current Opinion in Chemical Biology Volume: 46 Pages: 82-90
  • DOI: 10.1016/j.cbpa.2018.06.014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Artificial <i>In Vitro</i> Biosynthesis Systems for the Development of Pseudo-Natural Products (2018)
  • Author(s): Goto Yuki、Suga Hiroaki
  • Journal Title: Bulletin of the Chemical Society of Japan Volume: 91 Issue: 3 Pages: 410-419
  • DOI: 10.1246/bcsj.20170379
  • NAID: 130006507065
  • ISSN: 0009-2673, 1348-0634
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Non-competitive cyclic peptides for targeting enzyme?substrate complexes (2018)
  • Author(s): McAllister T. E.、Yeh T.-L.、Abboud M. I.、Leung I. K. H.、Hookway E. S.、King O. N. F.、Bhushan B.、Williams S. T.、Hopkinson R. J.、M?nzel M.、Loik N. D.、Chowdhury R.、Oppermann U.、Claridge T. D. W.、Goto Y.、Suga H.、Schofield C. J.、Kawamura A.
  • Journal Title: Chemical Science Volume: 9 Issue: 20 Pages: 4569-4578
  • DOI: 10.1039/c8sc00286j
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quality control by trans-editing factor prevents global mistranslation of non-protein amino acid α-aminobutyrate. (2018)
  • Author(s): Bacusmo JM, Kuzmishin AB, Cantara WA, Goto Y, Suga H, Musier-Forsyth K.
  • Journal Title: RNA Biol. Volume: 15 Issue: 4-5 Pages: 576-585
  • DOI: 10.1080/15476286.2017.1353846
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides. (2017)
  • Author(s): Jongkees SAK, Caner S, Tysoe C, Brayer GD, Withers SG, Suga H.
  • Journal Title: Cell Chem Biol. Volume: 16 Pages: 381-390
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5. (2017)
  • Author(s): Song X, Lu LY, Passioura T, Suga H.
  • Journal Title: Org Biomol Chem. Volume: 15 Issue: 24 Pages: 5155-5160
  • DOI: 10.1039/c7ob00012j
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases. (2017)
  • Author(s): Yu H, Dranchak P, Li Z, MacArthur R, Munson MS, Mehzabeen N, Baird NJ, Battalie KP, Ross D, Lovell S, Carlow CK, Suga H, Inglese J.
  • Journal Title: Nat Commun. Volume: 8 Issue: 1 Pages: 14932-14932
  • DOI: 10.1038/ncomms14932
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Logical engineering of D-arm and T-stem of tRNA that enhances d-amino acid incorporation. (2017)
  • Author(s): Katoh T, Iwane Y, Suga H.
  • Journal Title: Nucleic Acids Res. Volume: 45 Issue: 22 Pages: 12601-12610
  • DOI: 10.1093/nar/gkx1129
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides. (2017)
  • Author(s): Jongkees SAK, Umemoto S, Suga H
  • Journal Title: Chem Sci. Volume: 8 Issue: 2 Pages: 1474-1481
  • DOI: 10.1039/c6sc04381j
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Highly selective inhibition of histone demethylases by de novo macrocyclic peptides. (2017)
  • Author(s): Kawamura A, Mnzel M, Kojima T, Yapp C, Bhushan B, Goto Y, Tumber A, Katoh T, King ON, Passioura T, Walport LJ, Hatch SB, Madden S, Muller S, Brennan PE, Chowdhury R, Hopkinson RJ, Suga H, Schofield CJ.
  • Journal Title: Nat Commun Volume: 8 Issue: 1 Pages: 14773-14773
  • DOI: 10.1038/ncomms14773
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficient siRNA Delivery by Lipid Nanoparticles Modified with a Nonstandard Macrocyclic Peptide for EpCAM-Targeting. (2017)
  • Author(s): Sakurai Y, Mizumura W, Murata M, Hada T, Yamamoto S, Ito K, Iwasaki K, Katoh T, Goto Y, Takagi A, Kohara M, Suga H, Harashima H.
  • Journal Title: Mol Pharm Volume: 14 Issue: 10 Pages: 3290-3298
  • DOI: 10.1021/acs.molpharmaceut.7b00362
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo (2017)
  • Author(s): Ozaki, T., Yamashita, K., Goto, Y., Shimomura, M., Hayashi, S., Asamizu, S., Sugai, Y., Ikeda, H., Suga, H., Onaka, H.
  • Journal Title: Nat. Commun. Volume: 8 Issue: 1 Pages: 14207-14207
  • DOI: 10.1038/ncomms14207
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Consecutive Elongation of D-Amino Acids in Translation. (2017)
  • Author(s): Katoh T, Tajima K, Suga H.
  • Journal Title: Cell Chem Biol Volume: 24 Issue: 1 Pages: 46-54
  • DOI: 10.1016/j.chembiol.2016.11.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Conformational and chemical selection by a trans-acting editing domain. (2017)
  • Author(s): Danhart EM, Bakhtina M, Cantara WA, Kuzmishin AB, Ma X, Sanford BL, Vargas-Rodriguez O, Ko; M, Goto Y, Suga H, Nakanishi K, Micura R, Foster MP, Musier-Forsyth K.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 114 Issue: 33
  • DOI: 10.1073/pnas.1703925114
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Post-translational Cyclodehydratase, PatD, Tolerates Sequence Variation in the C-terminal Region of Substrate Peptides (2016)
  • Author(s): Y. Goto, H. Suga
  • Journal Title: Chem. Lett. Volume: 45 Issue: 11 Pages: 1247-1249
  • DOI: 10.1246/cl.160562
  • NAID: 130005509442
  • Peer Reviewed / Open Access
• [Journal Article] In vitro biosynthesis systems for elaboration of novel bioacitive peptides (2016)
  • Author(s): Goto Y, Suga H.
  • Journal Title: Peptide Science Volume: 53 Pages: 1-2
• [Presentation] The next generation of RaPID display (2020)
  • Author(s): Hiroaki Suga
  • Organizer: RSC Desktop Seminar
  • Int'l Joint Research / Invited
• [Presentation] 特殊ペプチド医薬品スクリーニングの革命 (2020)
  • Author(s): Hiroaki Suga
  • Organizer: 第10回レギュラトリーサイエンス学会学術大会
  • Invited
• [Presentation] 特殊ペプチドによる創薬革命 (2020)
  • Author(s): Hiroaki Suga
  • Organizer: 第79回日本癌学会学術総会
  • Invited
• [Presentation] 特殊ペプチド創薬からネオバイオロジクス創薬 (2020)
  • Author(s): Hiroaki Suga
  • Organizer: 第24回日本がん分子標的治療学会学術集会
  • Invited
• [Presentation] From Basic Science to Innovation - From genetic code reprogramming to peptide therapeutics (2020)
  • Author(s): Hiroaki Suga
  • Organizer: MIRAI Seminar
  • Int'l Joint Research / Invited
• [Presentation] Artificial in vitro biosynthesis for elaboration of pseudo-natural peptides (2020)
  • Author(s): Yuki Goto
  • Organizer: The 6th International Symposium On Middle Molecular Strategy
  • Int'l Joint Research / Invited
• [Presentation] Artificial in vitro biosynthesis for elaboration of pseudo-natural peptides (2020)
  • Author(s): Yuki Goto
  • Organizer: 7th FIP Pharmaceutical Sciences World Congress (PSWC2020 Virtual)
  • Int'l Joint Research / Invited
• [Presentation] From constrained peptides to neobiologics (2020)
  • Author(s): Hiroaki Suga
  • Organizer: AsiaTIDES: Oligonucleotide & Peptide Therapeutics
  • Int'l Joint Research / Invited
• [Presentation] Displayable Pseudo-Natural Products (2020)
  • Author(s): Hiroaki Suga
  • Organizer: Gordon Research Conferences: Advancing Peptides as Tools, Materials and Therapeutics
  • Int'l Joint Research / Invited
• [Presentation] Revolutionizing the discovery process de novo bioactive peptides and biologics (2019)
  • Author(s): Hiroaki Suga
  • Organizer: 5th Peptides & Proteins Symposium Singapre
  • Int'l Joint Research / Invited
• [Presentation] Revolutionizing the discovery processes of de novo bioactive peptides and biologics (2019)
  • Author(s): Hiroaki Suga
  • Organizer: Bohlmann Lecture Freie University Berlin
  • Int'l Joint Research / Invited
• [Presentation] Worldwide Perspectives on SynCell (2019)
  • Author(s): Hiroaki Suga
  • Organizer: SynCell2019: Defining the Challenges
  • Int'l Joint Research / Invited
• [Presentation] Revolutionizing the discovery processes of de novo bioactive peptides and neobiologics (2019)
  • Author(s): Hiroaki Suga
  • Organizer: 34th William S. Johnson Symposium
  • Int'l Joint Research / Invited
• [Presentation] Peptide therapeutics innovation (2019)
  • Author(s): Hiroaki Suga
  • Organizer: The 78th Annual Meeting of the Japanese Cancer Assocation
  • Int'l Joint Research / Invited
• [Presentation] In vitro pseudo-natural product biosynthesis and selection (2019)
  • Author(s): Hiroaki Suga
  • Organizer: 14th International Symposium on the Genetics of Industrial Microorganisms (GIM) 2019
  • Int'l Joint Research / Invited
• [Presentation] Rvolutionizing the discovery processes of de novo bioactive peptidesand biologics (2019)
  • Author(s): Hiroaki Suga
  • Organizer: 27th International Society of Heterocyclic Chemistry Congress
  • Int'l Joint Research / Invited
• [Presentation] Revolutionizing the discovery process of peptide drug leads by the RaPID system (2019)
  • Author(s): Hiroaki Suga
  • Organizer: 26th International smposium: Synthesis in organic chemistry
  • Int'l Joint Research / Invited
• [Presentation] Revolutionizing the discovery processes of therapeutically valuable peptides and biologics (2019)
  • Author(s): Hiroaki Suga
  • Organizer: 47th IUPAC Chemistry Congress
  • Int'l Joint Research / Invited
• [Presentation] Revolutionizing the Discovery Processes of de novo Bioactive Peptides and Biologics (2019)
  • Author(s): Hiroaki Suga
  • Organizer: 26th American Peptide Symposium
  • Int'l Joint Research / Invited
• [Presentation] The RaPID way to devise biologically active peptides and biologics (2019)
  • Author(s): Hiroaki Suga
  • Organizer: 20th Tetrahedron Symposium
  • Int'l Joint Research / Invited
• [Presentation] From Constrained Peptides to NeoBiologics (2019)
  • Author(s): Hiroaki Suga
  • Organizer: The 8thChemical Protein Synthesis (CPS) Meeting 2019
  • Int'l Joint Research / Invited
• [Presentation] De novo discovery of bioactive pseudo-natural peptides from biosynthetic libraries (2019)
  • Author(s): Hiroaki Suga
  • Organizer: 30th Anniversary Today-Unistra Symposium on Complexity
  • Int'l Joint Research / Invited
• [Presentation] Revolutionizing the discovery process of macrocyclic peptides for therapeutic use (2019)
  • Author(s): Hiroaki Suga
  • Organizer: 21st GFPP Meeting
  • Int'l Joint Research / Invited
• [Presentation] Revolutionizing the discovery process of bioactive peptides (2019)
  • Author(s): Hiroaki Suga
  • Organizer: RU Lemieux Lecture on Biotechnology
  • Int'l Joint Research / Invited
• [Presentation] Unnatural Amino Acids for Exotic Macrocyclic Peptides and Targeting IL6R as a Case Study (2019)
  • Author(s): Hiroaki Suga
  • Organizer: Drug Discovery Chemistry
  • Int'l Joint Research / Invited
• [Presentation] 微生物相互作用と「ものづくり」～東京大学微生物潜在酵素（天野エンザイム）寄付講座の歩み～ (2019)
  • Author(s): 尾仲 宏康
  • Organizer: 天野エンザイム社内講演会
  • Invited
• [Presentation] リホゾーム翻訳型ペプチドの生合成の多様性 (2019)
  • Author(s): 尾仲 宏康
  • Organizer: 第8回食品薬学シンポジウムシンポジウム②【天然薬物学研究のこれから】
  • Invited
• [Presentation] GNAT superfamily enzyme plays a key role in the biosynthesis of polyketide/peptide hybrid lipopeptides (2019)
  • Author(s): Hiroyasu Onaka
  • Organizer: 1st Japan-Germany-Switzerland Workshop for Enzyme Technology and Bioprocess Development
  • Int'l Joint Research / Invited
• [Presentation] Combined-culture: co-culture with MACB induced potential secondary metabolism in actinomycetes (2019)
  • Author(s): Hiroyasu Onaka
  • Organizer: Guest lecture at Gadjah Mada University, Yogyakarta, Indonesia
  • Int'l Joint Research / Invited
• [Presentation] 複合培養：物理的接触を利用した放線菌抗生物質生産手法 (2019)
  • Author(s): 尾仲 宏康
  • Organizer: 早稲田大学 理工学術院セミナー
  • Invited
• [Presentation] 物理的接触が引き起こす放線菌抗生物質生産 (2019)
  • Author(s): 尾仲 宏康
  • Organizer: 微生物ウィーク2019 シンポジウム
  • Invited
• [Presentation] Introduction (2019)
  • Author(s): Hiroyasu Onaka
  • Organizer: The 4th A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products
  • Int'l Joint Research / Invited
• [Presentation] 物理的接触が介在する放線菌二次代謝誘導 (2019)
  • Author(s): 尾仲 宏康
  • Organizer: 環境バイオテクノロジー学会2019年度大会年会シンポジウム
  • Invited
• [Presentation] Combined-culture: co-culture with MACB induced potential secondary metabolism in actinomycetes (2019)
  • Author(s): Hiroyasu Onaka
  • Organizer: ISCE 2019 Annual Meeting
  • Int'l Joint Research / Invited
• [Presentation] ペプチド薬剤を作る人工生合成システム (2019)
  • Author(s): 後藤 佑樹
  • Organizer: 第9回 CSJ化学フェスタ2019
  • Invited
• [Presentation] 試験管内人工生合成系で擬天然物を創る (2019)
  • Author(s): 後藤 佑樹
  • Organizer: 理研 Chemical Probe 第二回合同合宿セミナー
  • Invited
• [Presentation] 試験管内人工生合成系で擬天然物ペプチドを創る (2019)
  • Author(s): 後藤 佑樹
  • Organizer: 第71回日本生物工学会大会
  • Invited
• [Presentation] 試験管内人工生合成系で擬天然物ペプチドを創る (2019)
  • Author(s): 後藤 佑樹
  • Organizer: 日本遺伝学会第91回大会
  • Invited
• [Presentation] Artificial in vitro biosynthesis for elaboration of pseudo-natural peptides (2019)
  • Author(s): Yuki Goto
  • Organizer: 10th RSC-CSJ Joint Symposium
  • Int'l Joint Research / Invited
• [Presentation] 試験管内人工生合成系で擬天然物をつくる (2019)
  • Author(s): 後藤 佑樹
  • Organizer: 第7回慶應有機化学若手シンポジウム
  • Invited
• [Presentation] 擬天然ペプチドのリボソーム型生体外発現に関する最近の研究成果 (2019)
  • Author(s): H Suga
  • Organizer: AsiaTIDES: Oligonucleotide & Peptide Therapeutics
  • Int'l Joint Research / Invited
• [Presentation] Macrocyclic pseudo-natural peptides for anti-cancer therapies (2019)
  • Author(s): H Suga
  • Organizer: 11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Biology to Precision Medicine
  • Int'l Joint Research / Invited
• [Presentation] From constrained peptides to biologics (2019)
  • Author(s): H Suga
  • Organizer: The Festival of Biologics San Diego
  • Int'l Joint Research / Invited
• [Presentation] Combined-culture: Potential secondary metabolism is promoted by co-culture with mycolic acid containing bacteria (2019)
  • Author(s): H Onaka
  • Organizer: 2nd China-Japan Joint Symposium on Natural Product Biosynthesis
  • Int'l Joint Research / Invited
• [Presentation] RiPPs型生合成リデザインによる迅速多様な中分子創薬に向けた修飾ペプチド創製手法 (2019)
  • Author(s): 尾仲宏康
  • Organizer: 2019年度日本農芸化学会シンポジウム生合成マシナリからリデザインへ
  • Invited
• [Presentation] 試験管内人工生合成系で擬天然物をつくる (2019)
  • Author(s): 後藤佑樹
  • Organizer: 鹿児島大学理学部先端科学講演会
  • Invited
• [Presentation] 中分子創薬を見据えた擬天然ペプチド開発戦略 (2019)
  • Author(s): 後藤佑樹
  • Organizer: 技術情報協会セミナー「環状ペプチドの探索法と構造・配座解析」
  • Invited
• [Presentation] 生合成系を改造して擬天然物を創る (2019)
  • Author(s): 後藤佑樹
  • Organizer: 東京工業大学LiHub 創薬技術革新G ワークショップ「創薬関連研究の最先端」
  • Invited
• [Presentation] 翻訳反応を改造して擬天然物をつくる (2019)
  • Author(s): 後藤佑樹
  • Organizer: 新潟大学UGCE連携教育研究センター第9回シンポジウム
  • Invited
• [Presentation] Development of tunable and selective protein modifiers based on macrocyclic peptides (2019)
  • Author(s): Y Goto
  • Organizer: 3rd ETH Zurich-UTokyo Strategic Partnership Symposium
  • Int'l Joint Research / Invited
• [Presentation] The RaPID discovery of bioactive pseudo-natural peptides (2018)
  • Author(s): H Suga
  • Organizer: CHI's 13th Annual Drug Discovery Chemistry
  • Int'l Joint Research / Invited
• [Presentation] The RaPID way to discover bioactive pseudo-natural peptides with macrocyclic scaffold (2018)
  • Author(s): H Suga
  • Organizer: The Protein Society Annual Symposium
  • Int'l Joint Research / Invited
• [Presentation] The RaPID way to discover bioactive macrocyclic peptides expressed under the reprogrammed genetic code (2018)
  • Author(s): H Suga
  • Organizer: 2018 Genetic Code Espansion Conference
  • Int'l Joint Research / Invited
• [Presentation] Revolutionizing the discovery process of peptide drug leads (2018)
  • Author(s): H Suga
  • Organizer: Nature Conference on Chemical Biology
  • Int'l Joint Research / Invited
• [Presentation] The RaPID Discovery of Bioactive Pseudo-Natural Peptides (2018)
  • Author(s): H Suga
  • Organizer: 1st Japanese-German Symposium Biosynthesis and Function of Natural Products
  • Int'l Joint Research
• [Presentation] Revolutionizing the discovery process of bioactive peptides (2018)
  • Author(s): H Suga
  • Organizer: Basel Life 2018
  • Int'l Joint Research / Invited
• [Presentation] The RaPID System That Has Revolutionized the Discovery Process of Peptide Therapeutics (2018)
  • Author(s): H Suga
  • Organizer: ACS Publications Symposium: Innovation at the Frontier of Chemistry and Life Science
  • Int'l Joint Research / Invited
• [Presentation] The RaPID way to discover bioactive pseudo-natural macrocycles (2018)
  • Author(s): H Suga
  • Organizer: 10th International Peptide Symposium
  • Int'l Joint Research / Invited
• [Presentation] 微生物による「ものづくり」のイノベーション：微生物の潜在能力発掘・応用のための新手法の開発と実践 (2018)
  • Author(s): 尾仲宏康
  • Organizer: (公財）発酵研究所第12回助成研究報告会
  • Invited
• [Presentation] 微生物を用いたものづくり ～抗生物質をワンポット試験管内反応でつくる～ (2018)
  • Author(s): 尾仲宏康
  • Organizer: 東京大学大学院農学生命科学研究科微生物潜在機能探索寄付講座最終報告会および記念講演会
  • Invited
• [Presentation] RiPPs biosynthesis by in vitro reconstitution system (2018)
  • Author(s): H Onaka
  • Organizer: The 3rd A3 Foresight Symposium on Chemical & Synthetic Biology of Natural Products
  • Int'l Joint Research / Invited
• [Presentation] 微生物を用いたものづくり ～抗生物質をワンポット試験管内反応でつくる～ (2018)
  • Author(s): 尾仲宏康
  • Organizer: ライフサイエンス技術部会反応分科会講演会
  • Invited
• [Presentation] In vitro reconstitution of RiPPs biosynthesis coupled by in vitrotranslation and post-translation modifications (2018)
  • Author(s): H Onaka
  • Organizer: 3rd Europian Conference on Natural Products, DECHEMA
  • Int'l Joint Research / Invited
• [Presentation] Combined-culture: potential secondary metabolism is promoted by co-culture with mycolic acid containing bacteria (2018)
  • Author(s): H Onaka
  • Organizer: The Japanese-German Symposium
  • Int'l Joint Research / Invited
• [Presentation] Combined-culture: Physical contact with mycolic acid containing bacteria promotes potential secondary metabolism of actinomycetes (2018)
  • Author(s): H Onaka
  • Organizer: OSU seminar, Oregon Sttes University
  • Invited
• [Presentation] 複合培養法による休眠遺伝子の効率的な覚醒をめざして (2018)
  • Author(s): 尾仲宏康
  • Organizer: バイオインダストリー協会 “未来へのバイオ技術” 勉強会「微生物・覚醒」
  • Invited
• [Presentation] 共有結合を介して標的に結合する高選択性中分子化合物の汎用創製手法の確立 (2018)
  • Author(s): 後藤佑樹
  • Organizer: 第21回生命化学研究会
  • Invited
• [Presentation] mRNAディスプレイ法によるペプチド修飾酵素基質の網羅的変異導入解析 (2018)
  • Author(s): 後藤佑樹
  • Organizer: 第91回日本生化学会大会物理、化学の力で生物を理解する」シンポジウム
  • Invited
• [Presentation] In vitro biosynthesis system for peptides with diverse modified backbones (2018)
  • Author(s): Y Goto
  • Organizer: 6.Asian Synthetic Biology Association 2018
  • Int'l Joint Research / Invited
• [Presentation] In vitro biosynthesis system for peptides with diverse modified backbones (2018)
  • Author(s): Y Goto
  • Organizer: 4th International Conference on Circular Proteins and Peptides 2018
  • Int'l Joint Research / Invited
• [Presentation] 試験管内リデザイン生合成系で擬天然物を創る (2018)
  • Author(s): 後藤佑樹
  • Organizer: 「細胞を創る」研究会 11.0
  • Invited
• [Presentation] In vitro biosynthetic system for peptides with diverse modified backbones (2017)
  • Author(s): Yuki Goto
  • Organizer: 第97回日本化学会春季年会Asian International Symposium -Natural Products Chemistry, Chemical Biology/ Biofunctional Chemistry and Biotechnology-
  • Place of Presentation: 慶應義塾大学（神奈川県横浜市）
  • Year and Date: 2017-03-18
  • Int'l Joint Research / Invited
• [Presentation] Development of novel bioactive molecules using artificial in vitro biosynthesis systems (2017)
  • Author(s): Yuki Goto
  • Organizer: 日本化学会進歩賞受賞講演 第97回日本化学会春季年会
  • Place of Presentation: 慶應義塾大学（神奈川県横浜市）
  • Year and Date: 2017-03-17
  • Invited
• [Presentation] Artificial in vitro biosynthetic systems aiming at development of de novo natural product-like peptides (2017)
  • Author(s): Yuki Goto
  • Organizer: The 23rd Peptide Forum
  • Place of Presentation: 東京大学（東京都文京区）
  • Year and Date: 2017-01-18
  • Int'l Joint Research / Invited
• [Presentation] A RaPID Way to Discover Bioactive Pseudo-Natural Peptides (2017)
  • Author(s): H Suga
  • Organizer: Symposium and celebrations of the 25th anniversary of the Leibniz-Institut fur Molekulare Pharmakologie
  • Int'l Joint Research / Invited
• [Presentation] Translation-coupled in vitro reconstitution of pseudo-natural peptide biosynthesis (2017)
  • Author(s): H Suga
  • Organizer: 9th US-Japan Seminar on the Biosynthesis of Naural Products
  • Int'l Joint Research / Invited
• [Presentation] A RaPID Way to Discover Pseudo-natural Peptides and Products for Therapeutic Uses (2017)
  • Author(s): H Suga
  • Organizer: Dutch Peptide Symposium 2017
  • Int'l Joint Research / Invited
• [Presentation] One-Pot Synthesis and Screening of Pseudo-Natural Peptides and Products (2017)
  • Author(s): H Suga
  • Organizer: The Bioorganic Chemistry Gordon Research Conference
  • Int'l Joint Research / Invited
• [Presentation] The RaPID Discovery of Pseudo-Natural Peptides (2017)
  • Author(s): H Suga
  • Organizer: 25th American Peptide Symposium
  • Int'l Joint Research / Invited
• [Presentation] A RaPID way to discover pseudo-natural peptides and products (2017)
  • Author(s): H Suga
  • Organizer: Benzon Symposium; New Paradigms of Protein Engineering & Applications in Modern Medicine
  • Int'l Joint Research / Invited
• [Presentation] A RaPID Way to Discover Pseudo-natural Peptides (2017)
  • Author(s): H Suga
  • Organizer: 7th Symposium on Advances in Synthetic and Medicinal Chemistry
  • Int'l Joint Research / Invited
• [Presentation] Inorporation of nonproteinogenic amino acids into polypeptides from protein functional studies to drug discovery (2017)
  • Author(s): H Suga
  • Organizer: The Ins-and-Outs of Membrane Biolog
  • Int'l Joint Research / Invited
• [Presentation] RaPID Way to Discover Pseudo-natural Peptides for Therapeutic Uses (2017)
  • Author(s): H Suga
  • Organizer: GDCh Scientific Forum Chemistry 2017
  • Int'l Joint Research / Invited
• [Presentation] A RaPID way to discover pseudo-natural peptides and products for therapeutic uses (2017)
  • Author(s): H Suga
  • Organizer: 14th Horizons in Molecular Biology
  • Int'l Joint Research / Invited
• [Presentation] A RaPID way to discover bioactive pseudo-natural peptides (2017)
  • Author(s): H Suga
  • Organizer: 26th French-Japanese Symposium on Medicinal & Fine Chemistry
  • Int'l Joint Research / Invited
• [Presentation] A RaPID way to discover pseudo-natural peptides for therapeutic uses (2017)
  • Author(s): H Suga
  • Organizer: 11th International Symposium on Bioorganic Chemistry
  • Int'l Joint Research / Invited
• [Presentation] The RaPID discovery of bioactive pseudo-natural peptides (2017)
  • Author(s): H Suga
  • Organizer: Nanoscience Days 2017
  • Int'l Joint Research / Invited
• [Presentation] Genetic code reprogramming assisted by flexizymes and pseudo-natural peptide discovery (2017)
  • Author(s): H Suga
  • Organizer: AARS2017 (2017 IUBMB Focused Meeting on Aminoacyl-tRNA Synthetases)
  • Int'l Joint Research / Invited
• [Presentation] 複合培養、微生物コミュニケーションを利用した天然物探索法 (2017)
  • Author(s): 尾仲 宏康
  • Organizer: 日本薬学会第138年会
  • Invited
• [Presentation] 中分子創薬に向けたRiPPs型生合成機構による迅速多様な修飾ペプチド創製手法 (2017)
  • Author(s): 尾仲 宏康
  • Organizer: 2018年度日本農芸化学会
  • Invited
• [Presentation] RiPPs biosynthesis by in vitro translation-coupled post-translational modification (2017)
  • Author(s): 尾仲 宏康
  • Organizer: 1st China-Japan Joint Symposium on Natural Product Biosynthesis
  • Int'l Joint Research / Invited
• [Presentation] RiPPs (ribosomally synthesized and post-translationally modified peptides) biosynthesis coupled by in vitro translation and post-translation modifications (2017)
  • Author(s): H Onaka
  • Organizer: 19th German-Japanese workshop on enzyme technology, Rostock
  • Int'l Joint Research / Invited
• [Presentation] マイクロファクトリー:微生物によるものづくり、酒から薬まで (2017)
  • Author(s): 尾仲 宏康
  • Organizer: 石川県立大学セミナー
  • Invited
• [Presentation] 無細胞翻訳系と翻訳後修飾反応を介したRiPPs試験管内完全合成 (2017)
  • Author(s): 尾仲 宏康
  • Organizer: 石川県立大学セミナー
  • Invited
• [Presentation] マイクロファクトリー:微生物によるものづくり、酒から薬まで (2017)
  • Author(s): 尾仲 宏康
  • Organizer: 田産研第26回バイオテクノロジー教室講演会
  • Invited
• [Presentation] In vitro reconstitution of RiPPs biosynthesis by translational-coupled post-translational modification (2017)
  • Author(s): H Onaka
  • Organizer: ASP meeting
  • Int'l Joint Research / Invited
• [Presentation] 天然ペプチド生合成系を利用した新規ペプチド薬剤の開発 (2017)
  • Author(s): 尾仲 宏康
  • Organizer: 低・中分子創薬推進プラットフォーム特別講演
  • Invited
• [Presentation] 多段階連続酵素反応によるペプチド系抗生物質の試験管内完全合成と翻訳後修飾酵素群の基質認識の解明 (2017)
  • Author(s): 尾仲 宏康
  • Organizer: 第18回酵素応用シンポジウム研究奨励賞受賞講演
  • Invited
• [Presentation] In vitro reconstitution of RiPPs biosynthesis by translational-coupled post-translational modification (2017)
  • Author(s): H Onaka
  • Organizer: 9th US-JAPAN seminar on the biosynthesis of natural products
  • Int'l Joint Research / Invited
• [Presentation] Dissection of Goadsporin Biosynthesis by in vitro Reconstitution Leading to Designer Analogs Expressed in vivo (2017)
  • Author(s): H Onaka
  • Organizer: 18th International Symposium on the Biology of Actinomycetes Workshop 1-1
  • Int'l Joint Research / Invited
• [Presentation] 無細胞翻訳系と翻訳後修飾反応を介したRiPPs試験管内完全合成 (2017)
  • Author(s): 尾仲 宏康
  • Organizer: 東大薬学部特別講演会
  • Invited
• [Presentation] 調節可能な共有結合性阻害能を示す環状ペプチドの創製 (2017)
  • Author(s): 後藤 佑樹
  • Organizer: 日本化学会第98春季年会
  • Invited
• [Presentation] 試験管内人工生合成系で擬天然物を創る (2017)
  • Author(s): 後藤 佑樹
  • Organizer: Waters ペプチド医薬品分析セミナー
  • Invited
• [Presentation] 人工生合成系を活用して擬天然物を創製する (2017)
  • Author(s): 後藤 佑樹
  • Organizer: 2017疾患関連分子の認識技術の革新シンポジウム
  • Invited
• [Presentation] 擬天然物の創製を指向した試験管内人工生合成系 (2017)
  • Author(s): 後藤 佑樹
  • Organizer: 北陸先端科学技術大学院大学マテリアルサイエンス系セミナー
  • Invited
• [Presentation] 人工生合成系を活用した擬天然物の創製戦略 (2017)
  • Author(s): 後藤 佑樹
  • Organizer: 環境微生物系学会合同大会2017微生物を使った「ものづくり」最前線～代謝物から酵素まで～シンポジウム
  • Invited
• [Presentation] 特殊ペプチドがもつ中分子創薬に向けたポテンシャル (2017)
  • Author(s): 後藤 佑樹
  • Organizer: 構造活性フォーラム2017
  • Invited
• [Presentation] A RaPID way to discover pseudo-natural products & peptides for therapeutic uses (2016)
  • Author(s): Hiroshi Suga
  • Organizer: The 1st international PSL Chemical Biology Symposium
  • Place of Presentation: Paris, France
  • Year and Date: 2016-12-09
  • Int'l Joint Research / Invited
• [Presentation] In vitro biosynthetic system for peptides with diverse modified backbones (2016)
  • Author(s): Yuki Goto, Yasuharu Kato, Hiroaki Suga
  • Organizer: Asian Chemical Biology Conference 2016
  • Place of Presentation: 高雄、台湾
  • Year and Date: 2016-12-01
  • Int'l Joint Research
• [Presentation] Artificial in vitro biosynthetic systems for elaboration of natural product-like peptides (2016)
  • Author(s): Yuki Goto
  • Organizer: 日本ペプチド学会奨励賞受賞講演 第53回ペプチド討論会
  • Place of Presentation: 京都テルサ（京都府京都市）
  • Year and Date: 2016-10-28
  • Int'l Joint Research / Invited
• [Presentation] n vitro synthetic biology of the ribosome and genetic code: From basic science to applied research (2016)
  • Author(s): Hiroshi Suga
  • Organizer: Symposium on the Genetics of Industrial Microorganisms GIM2016
  • Place of Presentation: Wuhan, China
  • Year and Date: 2016-10-19
  • Int'l Joint Research / Invited
• [Presentation] 放線菌における潜在的二次代謝能の覚醒による新規抗生物質探索手法の確立及びその作用機構の解明 (2016)
  • Author(s): 尾仲宏康
  • Organizer: 住木梅澤記念賞受賞講演
  • Place of Presentation: 学士会館（東京都千代田区）
  • Year and Date: 2016-10-18
  • Invited
• [Presentation] A RaPID way to discover pseudo-natural peptides for therapeutic uses (2016)
  • Author(s): Hiroshi Suga
  • Organizer: Gold Medal Awardee Lecture, Max-Bergmann Conference 2016
  • Place of Presentation: Ilsenburg, Germany
  • Year and Date: 2016-10-11
  • Int'l Joint Research / Invited
• [Presentation] 擬天然物創製を目指した人工生合成系の開発 (2016)
  • Author(s): 後藤佑樹
  • Organizer: 第89回日本生化学会大会 「ペプチド機能設計と生化学のインタープレイ：分子相互作用制御と生体応答」シンポジウム
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-09-25
  • Invited
• [Presentation] A RaPID way to discover pseudo-natural peptides for therapeutic uses (2016)
  • Author(s): Hiroshi Suga
  • Organizer: EMBO Conference-Chemical Biology
  • Place of Presentation: Heidelberg, Germany
  • Year and Date: 2016-09-02
  • Int'l Joint Research / Invited
• [Presentation] 人工生合成系を用いた擬天然物創製 (2016)
  • Author(s): 後藤佑樹
  • Organizer: 神戸大学 バイオプロダクション次世代農工連携拠点 第6回合成生物工学シンポジウム
  • Place of Presentation: 神戸大学（兵庫県神戸市）
  • Year and Date: 2016-07-28
  • Invited
• [Presentation] Artificial in vitro biosynthetic systems for elaboration of pseudo-natural products (2016)
  • Author(s): 後藤佑樹
  • Organizer: 第１２回生合成若手勉強会
  • Place of Presentation: 東京大学（東京都文京区）
  • Year and Date: 2016-07-23
• [Presentation] A RaPID way to discover bioactive pseudo-naturla peptides (2016)
  • Author(s): Hiroshi Suga
  • Organizer: Banyu-Sapporo Symposium
  • Place of Presentation: 北海道大学（北海道札幌市）
  • Year and Date: 2016-07-02
  • Invited
• [Book] ペプチド創薬の最前線 (2019)
  • Author(s): 木曽良明
  • Total Pages: 265
  • Publisher: シーエムシー出版
  • ISBN: 9784781314174
• [Book] 遺伝暗号リプログラミングによる人工翻訳系の創製、人工細胞の創製とその応用 (2017)
  • Author(s): 黒田知宏, 後藤佑樹, 菅裕明
  • Total Pages: 215
  • Publisher: シーエムシー出版
• [Book] 擬天然物創製を見据えた人工生合成系の開発, 化学工業 (2016)
  • Author(s): 後藤佑樹
  • Total Pages: 799
  • Publisher: 化学工業社
• [Book] 特殊ペプチド創薬～第三の創薬シーズの可能性を拓く～、現代化学 (2016)
  • Author(s): 山田光博, 梅本詩織, 後藤佑樹, 菅裕明
  • Total Pages: 80
  • Publisher: 東京化学同人
• [Remarks] 天然ペプチド骨格の合理的な設計手法の開発～天然物資源からの創薬研究がより簡便にスピーディーに～
  • URL: http://www.s.u-tokyo.ac.jp/ja/press/2017/5251/
• [Remarks] 天然ペプチド骨格の合理的な設計手法の開発～天然物資源からの創薬研究がより簡便にスピーディーに～
  • URL: http://www.a.u-tokyo.ac.jp/topics/2016/20170203.html
• [Patent(Industrial Property Rights)] 化合物ライブラリー及び化合物ライブラリーの製造方法 (2018)
  • Inventor(s): 菅 裕明,後藤 佑樹,尾仲 宏康,ヴィノグラドフ アレクサンダー
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] ペプチドライブラリーの製造方法 (2018)
  • Inventor(s): 菅 裕明,後藤 佑樹,阿部 郁朗,岡田 正弘,井上 澄香
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018