| Budget Amount *help |
¥72,020,000 (Direct Cost: ¥55,400,000、Indirect Cost: ¥16,620,000)
Fiscal Year 2020: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2019: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2018: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2017: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2016: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
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| Outline of Final Research Achievements |
Our research aims include chemical modification (polycationic modification) of small molecule compounds with bacterial polycationic peptides to improve the water solubility and the cell membrane permeability simultaneously. New small compounds generated by biosynthetic re-design and known small compounds were our target molecules for the polycationic modification approach, and biosynthetic studies were performed to generate new peptide compounds in this study. In addition, we identified novel bacterial polycationic peptides and demonstrated their biosynthetic mechanisms. The polycationic modification of known compounds were achieved with clickable ε-poly-α-L-lysine and ε-oligo-β-L-lysine, which were produced by microbial transformation and enzymatic reaction, respectively.
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