| Budget Amount *help |
¥72,020,000 (Direct Cost: ¥55,400,000、Indirect Cost: ¥16,620,000)
Fiscal Year 2020: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2019: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2018: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2017: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2016: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
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| Outline of Final Research Achievements |
In this study, we analyzed the functions of aminoglycoside, macrolactam, and fosfomycin biosynthetic enzymes. In the aminoglycoside antibiotics, we demonstrated that the biosynthesis of the aminoglycoside antibiotic kanamycin proceeds stepwise. In macrolactam antibiotics, we are the first to elucidate protein-protein interactions between the acyl carrier protein of polyketide synthase and other domains by using a covalent bond-forming probe. Furthermore, based on this information, we succeeded in obtaining analogs of incednin and hitachimycin belonging to macrolactam antibiotics. In addition, we were able to clarify the biosynthetic pathway of fosfomycin in streptomyces.
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