| Budget Amount *help |
¥241,800,000 (Direct Cost: ¥186,000,000、Indirect Cost: ¥55,800,000)
Fiscal Year 2020: ¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2019: ¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
Fiscal Year 2018: ¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2017: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2016: ¥60,450,000 (Direct Cost: ¥46,500,000、Indirect Cost: ¥13,950,000)
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| Outline of Final Research Achievements |
Developing neurons often remove existing compartments such as axons, dendrites, and synapses to refine functionally nascent circuits in a compartment-specific manner, yet how neurons selectively eliminate distinct compartments remains elusive. Drosophila sensory neurons provide an excellent model system to investigate the molecular and cellular mechanisms underlying developmental neuronal remodeling, as larval neurons are extensively remodeled to establish adult-specific circuits during metamorphosis. For the past decade, we have studied the mechanisms of developmental dendrite pruning in Drosophila sensory neurons during metamorphosis. Here we show that presynapses/axons as well as dendrites are eliminated in Drosophila sensory neurons during metamorphosis. To understand the molecular mechanisms of the presynapse/axon elimination, we performed a genetic screen and found that the ubiquitin proteasome systems is required for the presynapse/axon elimination as well as dendrite pruning.
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