| Budget Amount *help |
¥157,430,000 (Direct Cost: ¥121,100,000、Indirect Cost: ¥36,330,000)
Fiscal Year 2020: ¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000)
Fiscal Year 2019: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Fiscal Year 2018: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2017: ¥29,640,000 (Direct Cost: ¥22,800,000、Indirect Cost: ¥6,840,000)
Fiscal Year 2016: ¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
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| Outline of Final Research Achievements |
Specific neuronal connections that underlie information processing in the sensory cortex are initially established without sensory experiences. Subsequently, the connections are refined through sensory experiences to develop appropriate function. We find that layer 4 excitatory neurons that arise from the same neural stem cell preferentially establish reciprocal synaptic connections in mouse barrel cortex. DNA methyltransferase 3b and clustered protocadherin are required for the establishment of lineage-specific reciprocal connections. We also find that synchronized firing occurs selectively in adjacent neurons sharing similar visual preferences in the upper layer of rat visual cortex. This feature-selective synchrony was rudimentary when the eyes opened and became prominent during the first few weeks after eye opening only in the presence of pattern vision. In addition, we find that visual experience is required for maturation of spatial-frequency preference in mouse visual cortex.
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