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Dynamic regulation of cerebellar neural circuits by "scrap and build" mechanisms

Planned Research

Project AreaDynamic regulation of brain function by Scrap & Build system
Project/Area Number 16H06461
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKeio University

Principal Investigator

柚崎 通介  慶應義塾大学, 医学部(信濃町), 教授 (40365226)

Co-Investigator(Kenkyū-buntansha) 溝口 明  三重大学, 医学系研究科, 産学官連携講座教授 (90181916)
Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Discontinued (Fiscal Year 2020)
Budget Amount *help
¥98,930,000 (Direct Cost: ¥76,100,000、Indirect Cost: ¥22,830,000)
Fiscal Year 2020: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2019: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2018: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2017: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2016: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
Keywords神経科学 / 小脳 / シナプス / 樹状突起 / 発生・分化
Outline of Annual Research Achievements

小脳神経回路においては、発達期から成熟後にかけてさまざまな破壊を伴う創造現象(スクラップ&ビルド)が観察される。まず、幼若プルキンエ細胞の複数の樹状突起は、生後8日目までに1本のみが選択的に強化されて残りは刈り込まれる。これまでに2光子顕微鏡を用いてin vivo小脳において樹状突起の選択的強化と除去を担う分子基盤の解明を進めた。プルキンエ細胞に発現するNMDA受容体の機能はこれまで謎であったが、細胞内Ca上昇とCaMKII活性化を介して、複数の樹状突起を1本化させることが判明した。また生後8日目以降になり、プルキンエ細胞に入力する複数の登上線維が刈り込まれて、1本の登上線維が選択的に強化される。この過程には登上線維が分泌するC1qL1とその受容体であるBai3が必須であることは知られていたが、成熟後にC1qL1-Bai3シグナリングが果たす役割は不明であった。これまでに成熟後にBai3が過剰活性化されると再び複数の登上線維がプルキンエ細胞を支配することを発見した。このような現象は、他の動物種や脳領域においてもさまざまな発達時期において起きることが知られている。これらの他の類似現象との比較を通して、「創造と破壊」が一体どのように連動するのか、発達期と成熟期でどのような原理が連続/非連続的に用いられるのか、といった問いに答えることによってスクラップ&ビルド現象の基本原理の解明を目指した。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Report

(5 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (50 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (19 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 19 results,  Open Access: 15 results,  Acknowledgement Compliant: 3 results) Presentation (25 results) (of which Int'l Joint Research: 22 results,  Invited: 20 results) Book (2 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Visualization of AMPA receptors in living human brain with positron emission tomography.2020

    • Author(s)
      Miyazaki T, Nakajima W, Hatano M, Shibata Y, Kuroki Y, Arisawa T, Mimura M, Yuzaki M, Kato H, Higuchi M, Uchida H, Takahashi T.
    • Journal Title

      Nature Medicine

      Volume: 26 Issue: 2 Pages: 281-288

    • DOI

      10.1038/s41591-019-0723-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors2020

    • Author(s)
      Luo, L.、19名略、Sinclair, J. L.、Stogsdill, J. A.、Traunmuller, L.、Wang, J.、Wortel, J.、 You, W.、 Abumaria, N.、 Beier, K. T.、 Brose, N.、 Burgess, H. A.、 Cepko, C. L.、 Cloutier, J. F.、 Eroglu, C.、 Goebbels, S.、 Kaeser, P. S.、 Kay, J. N.、 Lu, W.、 Luo, L.、 Mandai, K.、15名略、Kawabe, H.、 Craig, A. M.
    • Journal Title

      Neuron

      Volume: 106 Issue: 1 Pages: 37-65

    • DOI

      10.1016/j.neuron.2020.01.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In vivo two-photon imaging of anesthesia-specific alterations in microglial surveillance and photodamage-directed motility in mouse cortex2019

    • Author(s)
      Weilun Sun, Kunimichi Suzuki, Dmytro Toptunov, Stoyan Stoyanov, Michisuke Yuzaki, Leonard Khiroug and Alexander Dityatev
    • Journal Title

      Frontier Neuroscience

      Volume: - Pages: 421-421

    • DOI

      10.3389/fnins.2019.00421

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activity-dependent secretion of synaptic organizer Cbln1 from lysosomes in granule cell axons2019

    • Author(s)
      Ibata K, Kono M, Narumi S, Motohashi J, Kakegawa W, Kohda K, Yuzaki M.
    • Journal Title

      Neuron

      Volume: 102 Issue: 6 Pages: 1184-1198

    • DOI

      10.1016/j.neuron.2019.03.044

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions.2019

    • Author(s)
      Saegusa S, Fukaya M, Kakegawa W, Tanaka M, Katsumata O, Sugawara T, Hara Y, Itakura M, Okubo T, Sato T, Yuzaki M, Sakagami H
    • Journal Title

      PLoS One

      Volume: 14 Issue: 5 Pages: e0216960-e0216960

    • DOI

      10.1371/journal.pone.0216960

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyaluronan synthesis supports glutamate transporter activity2019

    • Author(s)
      Hayashi MK, Nishioka T, Shimizu H, Takahashi K, Kakegawa W, Mikami T, Hirayama Y, Koizumi S, Yoshida S, Yuzaki M, Tammi M, Sekino Y, Kaibuchi K, Shigemoto-Mogami Y, Yasui M, Sato K.
    • Journal Title

      Journal of Neurochemistry

      Volume: 150 Issue: 3 Pages: 249-263

    • DOI

      10.1111/jnc.14791

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activity-dependent secretion of synaptic organizer Cbln1 from lysosomes in granule cell axons.2019

    • Author(s)
      Ibata K, Kono M, Narumi S, Motohashi J, Kohda K, Yuzaki M.
    • Journal Title

      Neuron

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning2018

    • Author(s)
      Kakegawa Wataru、Katoh Akira、Narumi Sakae、Miura Eriko、Motohashi Junko、Takahashi Akiyo、Kohda Kazuhisa、Fukazawa Yugo、Yuzaki Michisuke、Matsuda Shinji
    • Journal Title

      Neuron

      Volume: 99 Issue: 5 Pages: 985-998

    • DOI

      10.1016/j.neuron.2018.07.034

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Caveolin-1 Promotes Early Neuronal Maturation via Caveolae-Independent Trafficking of N-Cadherin and L1.2018

    • Author(s)
      Shikanai M, Nishimura YV, Sakurai M, Nabeshima YI, Yuzaki M, Kawauchi T.
    • Journal Title

      iScience

      Volume: 7 Pages: 53-67

    • DOI

      10.1016/j.isci.2018.08.014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cote JF. Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.2018

    • Author(s)
      Hamoud N, Tran V, Aimi T, Kakegawa W, Lahaie S, Thibault MP, Pelletier A, Wong GW, Kim IS, Kania A, Yuzaki M, Bouvier M,
    • Journal Title

      Nat Commun

      Volume: 9 Issue: 1

    • DOI

      10.1038/s41467-018-06897-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells2017

    • Author(s)
      Miyazaki T, Yamasaki M, Hashimoto K, Kohda K, Yuzaki M, Shimamoto K, Tanaka K, Kano M, Watanabe M.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 114 Issue: 28 Pages: 7438

    • DOI

      10.1073/pnas.1617330114

    • URL

      https://pure.teikyo.jp/en/publications/c25d18f5-49a3-45de-9d85-d01159c3a02e

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical labelling for visualizing native AMPA receptors in live neurons.2017

    • Author(s)
      Wakayama, S., Kiyonaka, S., Arai, I., Kakegawa, W., Matsuda, S., Ibata, K., Nemoto, Y.L., Kusumi, A., Yuzaki, M., Hamachi, I.
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 14850-14850

    • DOI

      10.1038/ncomms14850

    • NAID

      120006600363

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional interactions between transient receptor potential M8 and transient receptor potential V1 in the trigeminal system: Relevance to migraine pathophysiology2017

    • Author(s)
      Kayama Y, Shibata M, Takizawa T, Ibata K, Shimizu T, Ebine T, Toriumi H, Yuzaki M, Suzuki N.
    • Journal Title

      Cephalalgia

      Volume: 38(5) Issue: 5 Pages: 833-845

    • DOI

      10.1177/0333102417712719

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors2017

    • Author(s)
      Matsushita Misako、Nakatake Yuhki、Arai Itaru、Ibata Keiji、Kohda Kazuhisa、Goparaju Sravan K.、Murakami Miyako、Sakota Miki、Chikazawa-Nohtomi Nana、Ko Shigeru B.H.、Kanai Takanori、Yuzaki Michisuke、Ko Minoru S.H.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 490 Issue: 2 Pages: 296-301

    • DOI

      10.1016/j.bbrc.2017.06.039

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma2017

    • Author(s)
      Shiihashi Gen、Ito Daisuke、Arai Itaru、Kobayashi Yuki、Hayashi Kanehiro、Otsuka Shintaro、Nakajima Kazunori、Yuzaki Michisuke、Itohara Shigeyoshi、Suzuki Norihiro
    • Journal Title

      EBioMedicine

      Volume: 24 Pages: 102-115

    • DOI

      10.1016/j.ebiom.2017.09.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins2016

    • Author(s)
      Matsuda K, Budisantoso T, Mitakidis N, Sugaya Y, Miura E, Kakegawa W, Yamasaki M, Konno K, Uchigashima M, Abe M, Watanabe I, Kano M, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M.
    • Journal Title

      Neuron

      Volume: 90 Issue: 4 Pages: 752

    • DOI

      10.1016/j.neuron.2016.04.001

    • URL

      https://localhost/en/publications/d8d05ba5-11eb-4f5d-8f67-0eb097d2e36e

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells2016

    • Author(s)
      Shigeki Kiyonaka, Ryou Kubota, Yukiko Michibata, Masayoshi Sakakura, Hideo Takahashi, Tomohiro Numata, Ryuji Inoue, Michisuke Yuzaki, Itaru Hamachi
    • Journal Title

      Nat. Chem.

      Volume: 8 Issue: 10 Pages: 958-967

    • DOI

      10.1038/nchem.2554

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural basis for integration of GluD receptors within synaptic organizer complexes.2016

    • Author(s)
      Elegheert, J., Kakegawa, W., Clay, E. J., Shanks, N., Behiels, E., Matsuda, K., Kohda, K., Miura, E., Rossmann, M., Mitakidis, N., Motohashi, J., Chang, T. V., Siebold, C., Greger, H. I., Nakagawa, T., K., Yuzaki, M., Aricescu, R.A.
    • Journal Title

      Science

      Volume: 353 Issue: 6296 Pages: 295-299

    • DOI

      10.1126/science.aae0104

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Roles of Cbln1 in Non-Motor Functions of Mice2016

    • Author(s)
      Otsuka S, Konno K, Abe M, Motohashi J, Kohda K, Sakimura K, Watanabe M, Yuzaki M
    • Journal Title

      Journal of Neuroscience

      Volume: 36 Issue: 46 Pages: 11801-11816

    • DOI

      10.1523/jneurosci.0322-16.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Casting new light on synaptic plasticity using optogenetic tools.2019

    • Author(s)
      Yuzaki M.
    • Organizer
      Symposium on "Molecular Mechanisms of Glutamate Receptor Signaling"
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bridge Over Troubled Synapses: A New Synthetic Synapse Organizer2019

    • Author(s)
      Yuzaki M.
    • Organizer
      The Institut NeuroMyoGene (INMG) Seminar
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synaptic iGluRs: a privilege to be at synapses.2019

    • Author(s)
      Yuzaki M.
    • Organizer
      Jacques Monod Conference on "ligand-gated ion channels from atomic structure to synaptic transmission"
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of iGluRs by Extracellular Scaffolding Proteins2019

    • Author(s)
      Yuzaki M.
    • Organizer
      Gordon Research Conference on Excitatory Synapses and Brain Function
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New tools to modify functional & structural synaptic connectivity2019

    • Author(s)
      Yuzaki M.
    • Organizer
      UK-DRI Synapse Symposium on “Physiology and Pathophysiology in Synapse”
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Casting new light on synaptic plasticity using optogenetic tools2019

    • Author(s)
      Yuzaki M.
    • Organizer
      US-Japan Brain Research Cooperation Program on “Current Trends and Future Directions of Synapse-Circuit Plasticity Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] グルタミン酸受容体の人工的な活性制御を可能とする新規ケモジェネティクス法の開発2019

    • Author(s)
      小島憲人、掛川渉、道籏友紀子、窪田亮、柚崎通介、浜地格、清中茂樹
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Dynamic Roles of C1ql1-Bai3 Signaling in Formation and Elimination of Climbing Fibers in Adult Cerebellum2019

    • Author(s)
      Takahiro Aimi, Wataru Kakegawa and Michisuke Yuzaki
    • Organizer
      Neuro2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Trans-synaptic control of iGluR localization and function through C1q families2019

    • Author(s)
      Keiko Matsuda, M. Abe, M. Watanabe, K. Sakimura, Michisuke Yuzaki
    • Organizer
      CNRS - Jacques Monod conference
    • Related Report
      2019 Annual Research Report
  • [Presentation] Molecular Mechanisms Underlying Dynamic Changes of Synapses in Adult Cerebellum2019

    • Author(s)
      Takahiro Aimi, Wataru Kakegawa and Michisuke Yuzaki
    • Organizer
      Current Trends and Future Directions of Synapse-Circuit Plasticity Research
    • Related Report
      2019 Annual Research Report
  • [Presentation] C1ql1-Bai3 Signaling Dynamically Modulates Climbing Fiber Synapses in Adult Cerebellum2019

    • Author(s)
      Takahiro Aimi, Wataru Kakegawa and Michisuke Yuzaki
    • Organizer
      The 9th FAOPS Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 補体ファミリーによるシナプス調節機構の解明に向けて2018

    • Author(s)
      柚崎 通介
    • Organizer
      第41回日本神経科学大会シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New Approaches to Old Problems: Towards Understanding Cerebellar LTD/LTP2018

    • Author(s)
      Michisuke Yuzaki
    • Organizer
      The 75th Fujihara Seminar
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] How to Scrap & Build Synapses: New Tools to Modify Function & Structure2018

    • Author(s)
      Michisuke Yuzaki
    • Organizer
      Cold Spring Harbor Asia Conferences
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Where's the receptor?-Finding NMDA receptor responsible for cerebellar LTD2018

    • Author(s)
      Kono M., Kakegawa W., Yuzaki M.
    • Organizer
      SRCA2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bridge Over Troubled Synapses: Functional & Structural Insights. Symposium on the innovative progress of neuroscientific research through the use of advanced animal models.2018

    • Author(s)
      Michisuke Yuzaki
    • Organizer
      Brain Research Institute,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bridge over troubled synapses: unexpected roles of complement proteins in the CNS2017

    • Author(s)
      Michisuke Yuzaki
    • Organizer
      Keio-NUS symposium
    • Place of Presentation
      ケントリッジ(シンガポール)
    • Year and Date
      2017-01-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bridge Over Troubled Synapse: C1q Proteins, GluD Receptors, and Beyond.2017

    • Author(s)
      Michisuke Yuzaki
    • Organizer
      Special Lecture, Society for Neuroscience,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Transsynaptic modulation by extracellular protein scaffolds (ESPs).2017

    • Author(s)
      Michisuke Yuzaki
    • Organizer
      The 40th Annual Meeting of the Japan Neuroscience Society,
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Expanding synaptic roles of the C1q complement family proteins.2017

    • Author(s)
      Michisuke Yuzaki
    • Organizer
      Center for Functional Connectomics Seminar, (Korea Institute of Science and Technology)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exocytosis from lysosome-like organelle at synapses,2017

    • Author(s)
      Michisuke Yuzaki
    • Organizer
      French-Japan Scientific Meeting on Neurobiology of Disease & Aging
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bridge Over Troubled Synapses: Unexpected Roles of Complement Proteins in the CNS2017

    • Author(s)
      Michisuke Yuzaki
    • Organizer
      NUS-Keio Joint Scientific Symposium on Frontiers of Translational Medicine.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Bridge Over Troubled Synapses: Gaps Filled by C1q Proteins2016

    • Author(s)
      Michisuke Yuzaki
    • Organizer
      JSPS Core-to-Core Program & OIST Joint Symposium “Nanoscopic Synaptic Function,”
    • Place of Presentation
      Rizzan Sea-Park Hotel (沖縄県国頭郡恩納村)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 補体ファミリー分子によるシナプス形成と除去機構2016

    • Author(s)
      Michisuke Yuzaki
    • Organizer
      第39回日本神経科学学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synaptic Menage a Trois: A Bridge Over Troubled Synapses2016

    • Author(s)
      Michisuke Yuzaki
    • Organizer
      第47回生理研国際シンポジウム
    • Place of Presentation
      Okazaki Conference Center (愛知県岡崎市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 老年精神医学雑誌2020

    • Author(s)
      柚崎通介
    • Total Pages
      110
    • Publisher
      ワールドプランニング
    • Related Report
      2019 Annual Research Report
  • [Book] Clinical Neuroscience2019

    • Author(s)
      掛川渉、松田信爾、柚崎通介
    • Total Pages
      148
    • Publisher
      中外医学社
    • Related Report
      2019 Annual Research Report
  • [Remarks] Yuzaki Lab

    • URL

      http://www.yuzaki-lab.org/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] Yuzaki-Lab

    • URL

      http://www.yuzaki-lab.org/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 慶應義塾大学医学部生理学 柚﨑研究室

    • URL

      http://www.yuzaki-lab.org/

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 人口興奮性シナプスコネクタとその脊髄損傷処置への使用2019

    • Inventor(s)
      柚崎通介,鈴木邦道
    • Industrial Property Rights Holder
      柚崎通介,鈴木邦道
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2020
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2016-07-04   Modified: 2021-12-27  

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