| Budget Amount *help |
¥99,190,000 (Direct Cost: ¥76,300,000、Indirect Cost: ¥22,890,000)
Fiscal Year 2020: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2019: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2018: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2017: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2016: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
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| Outline of Final Research Achievements |
Takumi found Neuroligin 1 mutation related to synapse formation from genetic analysis of autistic families. The model mouse with the point mutation was produced, and the social behavior was abnormal. An integrated analysis of 15q dup mice as an autism model mouse showed abnormalities in serotonin neurons mainly in the raphe nucleus, E/I imbalance in the somatosensory cortex. These abnormalities were improved by serotonin replacement therapy during the developmental stage. When fMRI under mouse arousal was constructed and 15q dup mice were analyzed, the neuronal functional connectivity was reduced. Our collaborator, Mandai, elucidates the mechanisms by which afadin regulates synaptic formation and synaptic transmission. αN-catenin, a membrane-lining protein of cadherin, NGL -3, an adhesion molecule, and MAGUIN, a molecule in the postsynaptic density, were involved in these mechanisms.
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