| Budget Amount *help |
¥109,330,000 (Direct Cost: ¥84,100,000、Indirect Cost: ¥25,230,000)
Fiscal Year 2020: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2019: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2018: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2017: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
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| Outline of Final Research Achievements |
In this study, we aimed to elucidate the regulatory mechanisms of the developmental clock in brain formation, focusing on the temporal production of neurons in the cerebral cortex and the molecular identity of feedback signal-mediated neuronal production transition. During the production period of deep- and upper-layer neurons, we manipulated gene expression in cortical progenitor cells and revealed that the intracellular localization of transcription factor determines the temporal competence of progenitor cells and the timing of upper-layer neuron production. Furthermore, we analyzed the extrinsic mechanisms that determine the differentiation and positioning of layer subtype neurons in the cerebral cortex, and revealed the interaction between the intrinsic transcriptional regulatory network and extracellular signaling in the spatiotemporal control of brain formation.
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