| Budget Amount *help |
¥109,330,000 (Direct Cost: ¥84,100,000、Indirect Cost: ¥25,230,000)
Fiscal Year 2020: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2019: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2018: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2017: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
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| Outline of Final Research Achievements |
In this study, we attempted to elucidate the molecular mechanisms that define species-specificity in development using tissue induction systems from pluripotent stem cells. We established mouse and human cerebral and retinal organoid systems and performed sequential single-cell RNA-seq to compare the dynamics of cell differentiation during development. As a result, we identified novel cells that specifically contribute to the mouse retinal formation process and their roles in morphogenesis. In addition, we identified a novel neural progenitor cell type that specifically exists in the process of human retinal tissue formation. In addition, we developed the means to induce limb bud tissue from pluripotent stem cells.
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