| Budget Amount *help |
¥90,870,000 (Direct Cost: ¥69,900,000、Indirect Cost: ¥20,970,000)
Fiscal Year 2020: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2018: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
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| Outline of Final Research Achievements |
In this study, we investigated the molecular mechanism by which the antigen peptide-MHC complex modified by haptens as “neo-self”. To explore the mechanisms, we analyzed T cell receptors that react with haptens such as metal. We identified the metal allergy-specific T cell receptors in a mouse model of metal allergy using palladium (Pd). Furthermore, by in vitro cell culture system, we found that the antigen peptide-MHC complex was changed by Pd solution and the expression of MHC was transiently reduced. In other words, we found that the behavior of the antigen peptide-MHC complex induces changes in the repertoire of T cell receptors. Therefore, our findings suggest that the behavior of antigen peptide-MHC complex may be induce the neo-self.
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