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Repertoire analysis of neo-self-recognizing receptors

Planned Research

Project AreaCreation, function and structure of neo-self
Project/Area Number 16H06499
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionUniversity of Toyama

Principal Investigator

Kishi Hiroyuki  富山大学, 学術研究部医学系, 教授 (60186210)

Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥90,870,000 (Direct Cost: ¥69,900,000、Indirect Cost: ¥20,970,000)
Fiscal Year 2020: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2018: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Keywordsネオ・セルフ / 抗原受容体 / レパトア / 抗原認識 / レパートリー解析 / 単一細胞解析 / TCR / 抗体 / T細胞受容体 / レパトア解析 / 単一細胞 / 単一細胞レベル / 抗原レセプター / 受容体 / 単一リンパ球解析 / 可溶化ネオ・セルフ / 免疫学 / T細胞受容体
Outline of Final Research Achievements

To comprehensively analyze the function of TCRs that are obtained by neo-self-reactive receptor repertoire analysis, we have developed cFIT method and TAP-J method. By using these methods, we have identified various TCRs reacting to self-antigen, tumor cells, or foreign antigen. We have also developed the easy protocol to prepare soluble MHC/peptide complex using animal cells, which un-require refolding of proteins. By using soluble MHC/peptide complex prepared by the method, we have prepared TCR-like antibodies that recognize MHC/peptide complex as TCR does. Furthermore, we have performed many collaborations with researchers in and outside of the innovative area.

Academic Significance and Societal Importance of the Research Achievements

単一細胞解析技術およびNGS解析技術の進歩により、TCRのレパトアの網羅的解析は比較的簡単に行えるようになってきたが、得られたTCRの機能を網羅的に解析する技術はこれまでなかった。本研究成果により、数百個のTCRの機能を解析することが可能になり、様々なサンプルからネオ・セルフ特異的TCRを同定することが可能になった。今後、自己免疫疾患の発症機序の解明や腫瘍の新規治療法の開発などに貢献すると期待される。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (123 results)

All 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (32 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 31 results,  Open Access: 18 results) Presentation (88 results) (of which Int'l Joint Research: 17 results,  Invited: 3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] Dana-Farber Cancer Institute(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Rapid and efficient generation of T-cell receptor-like antibodies using chip-based single-cell analysis.2021

    • Author(s)
      Ozawa T, Kobayashi E, Hamana H, Nakamura T, Lyu F, Hayashi A, Muraguchi A, Kishi H
    • Journal Title

      Eur. J. Immunol.

      Volume: in press Issue: 7 Pages: 1850-1853

    • DOI

      10.1002/eji.202049083

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of decidual regulatory T cells in the induction and maintenance of fetal antigen-specific tolerance: Imbalance between regulatory and cytotoxic T cells in pregnancy complications.2021

    • Author(s)
      Tsuda S, Nakashima A, Morita K, Shima T, Yoneda S, Kishi H, Saito S.
    • Journal Title

      Hum Immunol.

      Volume: S0198-8859 Issue: 5 Pages: 00040-9

    • DOI

      10.1016/j.humimm.2021.01.019

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of SARS-CoV-2 neutralizing antibodies using a vesicular stomatitis virus possessing SARS-CoV-2 spike protein.2021

    • Author(s)
      Tani H, Kimura M, Tan L, Yoshida Y, Ozawa T, Kishi H, Fukushi S, Saijo M, Sano K, Suzuki T, Kawasuji H, Ueno A, Miyajima Y, Fukui Y, Sakamaki I, Yamamoto Y, Morinaga Y
    • Journal Title

      Virology Journal

      Volume: 18 Issue: 1 Pages: 16-16

    • DOI

      10.1186/s12985-021-01490-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of pseudotyped vesicular stomatitis virus bearing the heartland virus envelope glycoprotein.2021

    • Author(s)
      Kimura M, Egawa K, Ozawa T, Kishi H, Shimojima M, Taniguchi S, Fukushi S, Fujii H, Yamada H, Tan L, Sano K, Katano H, Suzuki T, Morikawa S, Saijo M, Tani H.
    • Journal Title

      Virology

      Volume: 556 Pages: 124-132

    • DOI

      10.1016/j.virol.2020.10.006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model2020

    • Author(s)
      Hamamoto Yuta、Ouhara Kazuhisa、Munenaga Syuichi、Shoji Mikio、Ozawa Tatsuhiko、Hisatsune Jyunzo、Kado Isamu、Kajiya Mikihito、Matsuda Shinji、Kawai Toshihisa、Mizuno Noriyoshi、Fujita Tsuyoshi、Hirata Shintaro、Tanimoto Kotaro、Nakayama Koji、Kishi Hiroyuki、Sugiyama Eiji、Kurihara Hidemi
    • Journal Title

      Arthritis Research & Therapy

      Volume: 22 Issue: 1 Pages: 249-249

    • DOI

      10.1186/s13075-020-02348-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Artificial T cell adaptor molecule-transduced TCR-T cells demonstrated improved proliferation only when transduced in a higher intensity.2020

    • Author(s)
      Sakai T, Terakura S, Miyao K, Okuno S, Adachi Y, Umemura K, Julamanee J, Watanabe K, Hamana H, Kishi H, Leitner J, Steinberger P, Nishida T, Murata M, Kiyoi H.
    • Journal Title

      Mol. Ther. Oncolytics

      Volume: 18 Pages: 613-622

    • DOI

      10.1016/j.omto.2020.08.014

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a protective Leishmania antigen dihydrolipoyl dehydrogenase and its responding CD4+ T cells at clonal level.2020

    • Author(s)
      Mou Z, Barazandeh A, Hamana H, Kishi H, Zhang X, Jia P, Ikeogu N, Onyilagha C, Gupta G, Uzonna J.
    • Journal Title

      J. Immunol

      Volume: 205 Issue: 5 Pages: 1355-1364

    • DOI

      10.4049/jimmunol.2000338

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiologic Target, Molecular Evolution, and Pathogenic Functions of a Monoclonal Anti-Citrullinated Protein Antibody Obtained From a Patient With Rheumatoid Arthritis.2020

    • Author(s)
      Ozawa T, Ouhara K, Tsuda R, Munenaga S, Kurihara H, Kohno H, Hamana H, Kobayashi E, Taki H, Tobe K, Sugiyama E, Muraguchi A, Kishi H.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 72 Issue: 12 Pages: 2040-2049

    • DOI

      10.1002/art.41426

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The suppressive effect on CD4 T cell alloresponse against endothelial HLA-DR via PD-L1 induced by anti-A/B ligation2020

    • Author(s)
      Iwasaki K, Hamada H, Kishi H, Yamamoto T, Hiramitsu T, Takeda A, Narumi S, Watarai Y, Miwa Y, Kazuharu U, Matsuoka U, Horimi K, Muraguchi A, Kobayashi T.
    • Journal Title

      Clinical and Experimental Immunology

      Volume: 202(2) Issue: 2 Pages: 249-261

    • DOI

      10.1111/cei.13482

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of TCR repertoire and PD-1 expression in decidual and peripheral CD8+ T cells reveals distinct immune mechanisms in miscarriage and preeclampsia.2020

    • Author(s)
      Morita K, Tsuda S, Kobayashi E, Hamana H, Tsuda K, Shima T, Nakashima A, Ushijima A, Kishi H, Saito S.
    • Journal Title

      Front Immunol.

      Volume: 11 Pages: 1082-1082

    • DOI

      10.3389/fimmu.2020.01082

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between T cell receptor clonotype and PD-1 expression of tumor-infiltrating lymphocytes in colorectal cancer.2020

    • Author(s)
      Sukegawa K, Shitaoka K, Hamana H, Kobayashi E, Miyahara Y, Fujii K, Tsuda K, Saeki S, Nagata T, Ozawa T, Saito S, Fujii T, Muraguchi A, Shiku H, Kishi H.
    • Journal Title

      Eur. J. Immunol.

      Volume: 50 Issue: 10 Pages: 1580-1590

    • DOI

      10.1002/eji.201948399

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of a rabbit monoclonal antibody for highly sensitive detection of citrus mosaic virus and related viruses.2020

    • Author(s)
      Miyoshi S, Tokunaga S, Ozawa T, Takeda H, Aono M, Miyoshi T, Kishi H, Muraguchi A, Shimizu S, Nozawa A, Sawasaki T.
    • Journal Title

      PloS One

      Volume: 15 Issue: 4 Pages: e0229196-e0229196

    • DOI

      10.1371/journal.pone.0229196

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-transmissible MV Vector with Segmented RNA Genome Establishes Different Types of iPSCs from Hematopoietic Cells2020

    • Author(s)
      Hiramoto T、Tahara M、Liao J、Soda Y、Miura Y、Kurita R、Hamana H、Inoue K、Kohara H、Miyamoto S、Hijikata Y、Okano S、Yamaguchi Y、Oda Y、Ichiyanagi K、Toh H、Sasaki H、Kishi H、Ryo A、Muraguchi A、Takeda M、Tani K
    • Journal Title

      Molecular Therapy

      Volume: 28 Issue: 1 Pages: 129-141

    • DOI

      10.1016/j.ymthe.2019.09.007

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] T cell receptor (TCR) repertoire analysis of tumor-infiltrating lymphocytes of primary and metastatic tumors in colorectal cancer shows the relationship between TCR clonotype and PD-1 expression.2020

    • Author(s)
      Sukegawa K, Shitaoka K, Hamana H, Kobayashi E, Miyahara Y, Fujii K, Tsuda K, Saeki S, Nagata T, Ozawa T, Saito S, Fujii T, Muraguchi A, Shiku H, Kishi H.
    • Journal Title

      Eur. J. Immunol.

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel and simple method to produce large amounts of recombinant soluble peptide/major histocompatibility complex monomers for analysis of antigen-specific human T cell receptors2019

    • Author(s)
      Lyu Fulian、Ozawa Tatsuhiko、Hamana Hiroshi、Kobayashi Eiji、Muraguchi Atsushi、Kishi Hiroyuki
    • Journal Title

      New Biotechnology

      Volume: 49 Pages: 169-177

    • DOI

      10.1016/j.nbt.2018.11.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Novel HLA Class II-Restricted Neoantigens Derived from Driver Mutations2019

    • Author(s)
      Iiizumi Susumu、Ohtake Junya、Murakami Naoko、Kouro Taku、Kawahara Mamoru、Isoda Fumiko、Hamana Hiroshi、Kishi Hiroyuki、Nakamura Norihiro、Sasada Tetsuro
    • Journal Title

      Cancers

      Volume: 11 Issue: 2 Pages: 266-266

    • DOI

      10.3390/cancers11020266

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isolation of Antigen-Specific, Antibody-Secreting Cells Using a Chip-Based Immunospot Array2018

    • Author(s)
      Kishi Hiroyuki、Ozawa Tatsuhiko、Hamana Hiroshi、Kobayashi Eiji、Muraguchi Atsushi
    • Journal Title

      Methods Mol Biol

      Volume: 1904 Pages: 147-162

    • DOI

      10.1007/978-1-4939-8958-4_6

    • ISBN
      9781493989577, 9781493989584
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Cutting Edge: B cells expressing cyclic citrullinated peptide-specific antigen receptor are tolerized in normal conditions.2018

    • Author(s)
      Yamada H, Ozawa T, Kishi H, Okada S, Nakashima Y, Muraguchi A and Yoshikai Y.
    • Journal Title

      J Immunol

      Volume: 201 Issue: 12 Pages: 3492-3496

    • DOI

      10.4049/jimmunol.1800826

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens2018

    • Author(s)
      Hu Z, Anandappa AJ, Sun J, Kim J, Leet DE, Bozym DJ, Chen C, Williams L, Shukla SA, Zhang W, Tabbaa D, Steelman S, Olive O, Livak KJ, Kishi H, Muraguchi A, Guleria I, Stevens J, Lane WJ, Burkhardt UE, Fritsch EF, Neuberg D, Ott PA, Keskin DB, Hacohen N, Wu CJ
    • Journal Title

      Blood

      Volume: 132 Issue: 18 Pages: 1911-1921

    • DOI

      10.1182/blood-2018-04-843763

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Autoantibodies reactive to PEP08 are clinically related with morbidity and severity of interstitial lung disease in connective tissue diseases.2018

    • Author(s)
      Okumura M, Ozawa T, Hamana H, Norimatsu Y, Tsuda R, Kobayashi E, Shinoda K, Taki H, Tobe K, Imura J, Sugiyama E, Kishi H, Muraguchi A.
    • Journal Title

      Eur J Immunol.

      Volume: 48 Issue: 10 Pages: 1717-1727

    • DOI

      10.1002/eji.201747381

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clonally Expanded Decidual Effector Regulatory T Cells Increase in Late Gestation of Normal Pregnancy, but Not in Preeclampsia, in Humans2018

    • Author(s)
      Tsuda Sayaka、Zhang Xiaoxin、Hamana Hiroshi、Shima Tomoko、Ushijima Akemi、Tsuda Kei、Muraguchi Atsushi、Kishi Hiroyuki、Saito Shigeru
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 1934-1934

    • DOI

      10.3389/fimmu.2018.01934

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of the clinical significance of DCLK1(+) colorectal cancer using novel monoclonal antibodies against DCLK1.2018

    • Author(s)
      Dai T, Hu Y, Lv F, Ozawa T, Sun X, Huang J, Han X, Kishi H, Muraguchi A, Jin A.
    • Journal Title

      Onco Targets Ther.

      Volume: 11 Pages: 5047-5057

    • DOI

      10.2147/ott.s169928

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human monoclonal antibodies against West Nile virus from Japanese encephalitis-vaccinated volunteers.2018

    • Author(s)
      Ozawa T, Masaki H, Takasaki T, Aoyama I, Yumisashi T, Yamanaka A, Konishi E, Ohnuki Y, Muraguchi A, Kishi H.
    • Journal Title

      Antiviral Res

      Volume: 154 Pages: 58-65

    • DOI

      10.1016/j.antiviral.2018.04.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Introduction of genetically modified CD3ζ improves proliferation and persistence of antigen-specific CTLs.2018

    • Author(s)
      Miyao K, Terakura S, Okuno S, Julamanee J, Watanabe K, Hamana H, Kishi H, Sakemura R, Koyama D, Goto T, Nishida T, Murata M, Kiyoi H.
    • Journal Title

      Cancer Immunol Res

      Volume: 6 Issue: 6 Pages: 733-744

    • DOI

      10.1158/2326-6066.cir-17-0538

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Tumoricidal TCRs from Tumor-Infiltrating Lymphocytes by Single-Cell Analysis2018

    • Author(s)
      Shitaoka Kiyomi、Hamana Hiroshi、Kishi Hiroyuki、Hayakawa Yoshihiro、Kobayashi Eiji、Sukegawa Kenta、Piao Xiuhong、Lyu Fulian、Nagata Takuya、Sugiyama Daisuke、Nishikawa Hiroyoshi、Tanemura Atsushi、Katayama Ichiro、Murahashi Mutsunori、Takamatsu Yasushi、Tani Kenzaburo、Ozawa Tatsuhiko、Muraguchi Atsushi
    • Journal Title

      Cancer Immunology Research

      Volume: 6 Issue: 4 Pages: 378-388

    • DOI

      10.1158/2326-6066.cir-17-0489

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack2018

    • Author(s)
      Espinoza J. Luis、Elbadry Mahmoud I.、Chonabayashi Kazuhisa、Yoshida Yoshinori、Katagiri Takamasa、Harada Kenichi、Nakagawa Noriharu、Zaimoku Yoshitaka、Imi Tatsuya、Hassanein Hassan A.、Khalifa A. Noreldin Amal、Takenaka Katsuto、Akashi Koichi、Hamana Hiroshi、Kishi Hiroyuki、Akatsuka Yoshiki、Nakao Shinji
    • Journal Title

      Blood Adv

      Volume: 2 Issue: 4 Pages: 390-400

    • DOI

      10.1182/bloodadvances.2017013342

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bladder cancer-associated cancer-testis antigen-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes induced CD4+ T cells expressing converged T-cell receptor genes in vitro2018

    • Author(s)
      Tsuruta Miki、Ueda Shohei、Yew Poh Yin、Fukuda Isao、Yoshimura Sachiko、Kishi Hiroyuki、Hamana Hiroshi、Hirayama Masatoshi、Yatsuda Junji、Irie Atsushi、Senju Satoru、Yuba Eiji、Kamba Tomomi、Eto Masatoshi、Nakayama Hideki、Nishimura Yasuharu
    • Journal Title

      OncoImmunology

      Volume: 7 Issue: 4 Pages: 1415687-1415687

    • DOI

      10.1080/2162402x.2017.1415687

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Highly functional T-cell receptor repertoires are abundant in stem memory T cells and highly shared among individuals2017

    • Author(s)
      Miyama Takahiko、Kawase Takakazu、Kitaura Kazutaka、Chishaki Ren、Shibata Masashi、Oshima Kumi、Hamana Hiroshi、Kishi Hiroyuki、Muraguchi Atsushi、Kuzushima Kiyotaka、Saji Hiroh、Shin-I Tadasu、Suzuki Ryuji、Ichinohe Tatsuo
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 668-668

    • DOI

      10.1038/s41598-017-03855-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of an HLA class I allele closely involved in the auto-antigen presentation in acquired aplastic anemia2017

    • Author(s)
      Zaimoku Y, Takamatsu H, Hosomichi K, Ozawa T, Nakagawa N, Imi T, Maruyama H, Katagiri T, Kishi H, Tajima A, Muraguchi A, Kashiwase K, Nakao S
    • Journal Title

      Blood

      Volume: 印刷中 Issue: 21 Pages: 2908-2916

    • DOI

      10.1182/blood-2016-11-752378

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association Between High-Avidity T-Cell Receptors, Induced by α-Fetoprotein-Derived Peptides, and Anti-Tumor Effects in Patients With Hepatocellular Carcinoma2017

    • Author(s)
      Nakagawa H, Mizukoshi E, Kobayashi E, Tamai T, Hamana H, Ozawa T, Kishi H, Kitahara M, Yamashita T, Arai K, Terashima T, Iida N, Fushimi K, Muraguchi A, Kaneko S
    • Journal Title

      Gastroenterology

      Volume: 152 Issue: 6 Pages: 1395-1406

    • DOI

      10.1053/j.gastro.2017.02.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain2016

    • Author(s)
      Kawasaki Y, Sakimura A, Park CM, Tomaru R, Tanaka T, Ozawa T, Zhou Y, Narita K, Kishi H, Muraguchi A, Sakurai H
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 31502-31502

    • DOI

      10.1038/srep31502

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel, rapid and efficient method of cloning functional antigen-specific T-cell receptors from single human and mouse T-cells2016

    • Author(s)
      Hamana H, Shitaoka K, Kishi H, Ozawa T, Muraguchi A
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 474 Issue: 4 Pages: 709-714

    • DOI

      10.1016/j.bbrc.2016.05.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大腸がん浸潤リンパ球におけるTCRクロノタイプとPD-1の発現2020

    • Author(s)
      岸 裕幸,下岡清美,小林栄治,宮原慶裕,津田 桂,佐伯しおり,長田拓哉,村口 篤,珠玖 洋
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒト大腸がん組織浸潤T細胞の腫瘍反応性とその認識抗原の解析2020

    • Author(s)
      宮原慶裕,山根真妃子,平糠和志,藤井啓介,問山裕二,北嶋貴仁,井上靖浩,浜名 洋,中村徳弘,井上正宏,岸 裕幸,珠玖 洋
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マウス難治性癌モデルにおける腫瘍抗原ペプチドワクチン療法と免疫チェックポイント阻害剤の併用療法の奏功2020

    • Author(s)
      上田翔平,入江 厚,千住 覚,伊藤甲雄,浜名 洋,小笠原康悦,岸 裕幸,江藤正俊,西村泰治
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マウス内在性ウィルスのエンベロープタンパク質由来の新しいエピトープの同定2020

    • Author(s)
      下岡清美,浜名 洋,保田朋波流,岸 裕幸
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of a novel tumor antigen-specific TCR cloning system using a microarray chip2020

    • Author(s)
      KOBAYASHI Eiji, OZAWA Tatsuhiko, HAMANA hiroshi, MURAGUCHI Atsushi, KISHI Hiroyuki
    • Organizer
      第24回日本がん免疫学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ISAAC法を用いたTCR様抗体の迅速作製とその応用2020

    • Author(s)
      小澤龍彦,小林栄治,浜名 洋,村口 篤,岸 裕幸
    • Organizer
      第24回日本がん免疫学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Jurkat細胞を用いたTCRのネオアンチゲン反応性解析2020

    • Author(s)
      浜名 洋,宮原慶裕,下岡清美,祐川健太,小林栄治,小澤龍彦,村口 篤,藤井 努,珠玖 洋,岸 裕幸
    • Organizer
      第24回日本がん免疫学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒト大腸がん浸潤T細胞中の腫瘍反応性T細胞とその認識抗原の解析2020

    • Author(s)
      宮原慶裕,山根真妃子,藤井啓介,問山裕二,北嶋貴仁,井上靖浩,浜名 洋,井上正宏,岸 裕幸,珠玖 洋
    • Organizer
      第24回日本がん免疫学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 正常妊娠と異常妊娠における脱落膜CD8+T細胞のTCRレパートリーとPD-1の発現についての検討2020

    • Author(s)
      森田恵子,津田さやか,小林栄治,浜名 洋,津田 桂,島 友子,中島彰俊,岸 裕幸,齋藤 滋
    • Organizer
      第28回日本胎盤学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 新規マラリアワクチン候補PfRiprにより誘導されるウサギモノクローナル抗体の評価2020

    • Author(s)
      徳永 聡,長岡ひかる,小澤龍彦,岸 裕幸,村口 篤,坪井敬文,高島英造,澤崎達也
    • Organizer
      第43回日本分子生物学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] TCR-T細胞療法へ向けた単一T細胞解析2020

    • Author(s)
      岸 裕幸
    • Organizer
      第50回日本皮膚免疫アレルギー学会総会学術大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] The identification of a common loss-function mutation across different HLA class alleles frequently detected in patients with acquired aplastic anemia.2019

    • Author(s)
      Mizumaki H, Hosomichi K, Tanabe M, Yoroidaka T, Imi T, Hosokawa K, Katagiri T, Takamatsu H, Ozawa T, Azuma F, Kishi H, Tajima A, Nakao S.
    • Organizer
      24th Congress of European Hematology Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel TCR cloning system of peptide-specific T cells using immunospot array assay on a chip(T-ISAAC) technology.2019

    • Author(s)
      Kobayashi E, Ozawa T, Hamana H, Shitaoka K, Muraguchi A, Kishi H.
    • Organizer
      International Conference on Lymphocyte Engineering 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TCR repertoire analysis of PD-1- or PD-1+ tumor infiltrating lymphocytes in colorectal cancer and breast cancer: TCR property affects their phenotype.2019

    • Author(s)
      Kishi H.
    • Organizer
      17th International Congress of Immunology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of T-cell receptors specific to antigens presented by HLA-B4002 and B5401 in acquired aplastic anemia.2019

    • Author(s)
      Hosokawa K, Kobayashi E, Akatsuka Y, Espinoza L, Nakagawa N, Tanabe M, Tsuji N, Yoroidaka T, Mizumaki H, Mai A.T.N., Katagiri T, Shitaoka K, Hamana H, Kishi H, Nakao S.
    • Organizer
      61st Annual Meetings of American Society of Hematology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 患者HLA遺伝子導入乳がん細胞株を用いた乳がん患者TIL中の腫瘍反応性TCRの探索.2019

    • Author(s)
      浜名 洋,下岡 清美,祐川 健太,佐伯しおり,長田任一哉,小林 栄治,小澤 龍彦,藤井 努,村口 篤,岸 裕幸.
    • Organizer
      第23回日本がん免疫学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 腫瘍浸潤CD8+ T細胞におけるPD-1の発現はTCRレパトアに規定される.2019

    • Author(s)
      祐川 健太,佐伯しおり,下岡 清美,浜名 洋,宮原 慶裕,小林 栄治,長田任一哉,小澤 龍彦,藤井 努,珠玖 洋,村口 篤,岸 裕幸.
    • Organizer
      第23回日本がん免疫学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Clonally expanded populations of cytotoxic T cell in TILs and peripheral blood in endometrial cancer patients.2019

    • Author(s)
      津田 桂,浜名 洋,中島 彰俊,森田 恵子,津田さやか,島 友子,下岡 清美,小林 栄治,小澤 龍彦,村口 篤,岸 裕幸.
    • Organizer
      第23回日本がん免疫学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 腫瘍浸潤CD8+ T細胞のTCRとPD-1の発現との関連:大腸癌における考察.2019

    • Author(s)
      岸 裕幸,祐川 健太,下岡 清美,浜名 洋,小林 栄治,津田 桂,長田任一哉,佐伯しおり,小澤 龍彦,齋藤 滋,藤井 努,村口 篤.
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 腫瘍反応性TIL由来TCRおよびその認識抗原を用いた個別化がん免疫療法の展望.2019

    • Author(s)
      宮原 慶裕,問山 裕二,北嶋 貴仁,浜名 洋,楠 正人,井上 正宏,岸 裕幸,珠玖 洋.
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Identification of T cell receptors specific to antigens presented by HLA-B4002 in aplastic anemia.2019

    • Author(s)
      Hosokawa K, Kobayashi E, Akatsuka Y, Espinoza L, Nakagawa N, Tanabe M, Tsuji N, Yoroidaka T, Mizukami H, Mai A. T. N, Katagiri T, Shitaoka K, Hamana H, Kishi H, Nakao S.
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ISAAC法を用いたTCR様抗体の迅速単離法の開発.2019

    • Author(s)
      小澤 龍彦,呂 福蓮,村口 篤,岸 裕幸.
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Screening of tumor-reactive TCRs from TILs of breast cancer patients using a patients' HLA-transduced breast cancer cell line.2019

    • Author(s)
      Hamana H, Shitaoka K, Sukegawa K, Saeki S, Nagata T, Kobayashi E, Ozawa T, Fujii T, Muraguchi A, Kishi H.
    • Organizer
      第49回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Common TCR-beta repertoire was found in both decidual and peripheral CD8+ T cells in normal term pregnancy.2019

    • Author(s)
      Morita K, Kobayashi E, Tsuda S, Shitaoka K, Ozawa T, Hamana H, Saito S, Kishi H.
    • Organizer
      第49回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cloning of tumor antigen-specific TCRs using immunospot array assay on a chip (T-ISAAC) technology.2019

    • Author(s)
      Kobayashi E, Ozawa T, Hamana H, Shitaoka K, Muraguchi A, Kishi H.
    • Organizer
      第49回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A new epitope is identified derived from envelope protein of an endogenous murine leukemia virus.2019

    • Author(s)
      Shitaoka K, Hamana H, Muraguchi A, Kishi H.
    • Organizer
      第49回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] TCR repertoire analysis of cytotoxic T cells in tumor-infiltrated lymphocytes and peripheral blood lymphocytes in endometrial cancers.2019

    • Author(s)
      Tsuda K, Hamana H, Nakashima A, Tsuda S, Shima T, Shitaoka K, Kobayashi E, Ozawa T, Kishi H.
    • Organizer
      第49回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] CTL lines specific for a wild type tumor antigen exert tumor regulatory activity in vivo.2019

    • Author(s)
      Kasai M, Komatsu T, Sakaguti N, Kishi H, Udaka K.
    • Organizer
      第49回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] NKG2D as a marker of active tumor-antigen specific CD8+ T cells during antitumor immune response.2019

    • Author(s)
      Ucche S, Mojic M, Shitaoka K, Kishi H, Muraguchi A, Tahara H, Hayakawa Y.
    • Organizer
      第49回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Toward the repertoire analysis of neo-self recognizing receptors.2018

    • Author(s)
      Kishi H.
    • Organizer
      The 1st International Symposium on NEO-SELF
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clonally expanded populations of cytotoxic T cell in tumor infiltrated lymphocyte and peripheral blood in endometrial cancer.2018

    • Author(s)
      Tsuda K, Kishi H, Nakashima A, Hamana H, Ushijima A, Tsuda S, Shima T, Shitaoka K, Kobayashi E, Ozawa T, Yoshino O, Saito S.
    • Organizer
      17th Biennial Meeting of the International Gynecologic Cancer Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clonally expanded decidual effector Treg cells increase in late gestation of normal pregnancy, but not in preeclampsia in human.2018

    • Author(s)
      Tsuda S, Kishi H, Xiaoxin Z, Shima T, Hamana H, Tsuda K, Ushijima A, Muraguchi A, Saito S.
    • Organizer
      The 38th Annual Meeting of the American Society for Reproductive Immunology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウス腫瘍細胞株をモデルとした高免疫原性変異抗原の同定とワクチン治療への応用.2018

    • Author(s)
      宮原慶裕,藤井啓介,金関貴幸,鳥越俊彦,山口 類,井元清哉,宮野 悟,浜名 洋,岸 裕幸,珠玖 洋.
    • Organizer
      第22回日本がん免疫学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] T-ISAAC法を用いたペプチド特異的T細胞のTCRレパトア解析.2018

    • Author(s)
      小林栄治,村口 篤,岸 裕幸.
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] TILでクローナルなT細胞受容体は,腫瘍に対して細胞障害性を示し,腫瘍関連抗原を認識する.2018

    • Author(s)
      下岡清美,浜名 洋,小林栄治,早川芳弘,村口 篤,岸 裕幸.
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒト大腸がん組織に浸潤する腫瘍反応性CD8陽性T細胞の表現型および遺伝子解析.2018

    • Author(s)
      宮原慶裕,藤井啓介,問山裕二,北嶋貴仁,井上靖浩,浜名 洋,遠藤洋子,楠 正人,井上正宏,岸 裕幸,珠玖 洋.
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] CTLとTh細胞を共に活性化できる膀胱癌関連抗原に由来する長鎖ペプチドの同定.2018

    • Author(s)
      鶴田未季,平山正敏,Poh Yin Yew,吉村祥子,岸 裕幸,浜名 洋,千住 覚,入江 厚,矢津田旬二,神波大己,江藤正俊,中山秀樹,西村泰治.
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒトの妊娠高血圧腎症と胎児染色体正常流産症例では脱落膜effector制御性T細胞のクローナリティと数が異なる.2018

    • Author(s)
      津田さやか,Zhang Xiaoxin,浜名 洋,島 友子,牛島明美,津田 桂,村口 篤,岸 裕幸,齋藤 滋.
    • Organizer
      第39回日本妊娠高血圧学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 効率的な大腸癌免疫療法の確立に向けた腫瘍浸潤リンパ球レパートリー解析.2018

    • Author(s)
      祐川健太,浜名 洋,下岡清美,小林栄治,北條荘三,奧村知之,長田拓哉,村口 篤,岸 裕幸,藤井 努.
    • Organizer
      第29回日本消化器癌発生学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 制御性T細胞のsingle-cell TCRレパートリー解析により示唆された流産と妊娠高血圧腎症の免疫学的病態の相違.2018

    • Author(s)
      津田さやか,チャン シャオシン,浜名 洋,島 友子,牛島明美,津田 桂,村口 篤,岸 裕幸,齋藤 滋.
    • Organizer
      第33回日本生殖免疫学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 子宮体癌患者における末梢血CD8T細胞のTCRレパートリー解析.2018

    • Author(s)
      津田 桂,岸 裕幸,中島彰俊,浜名 洋,牛島明美,津田さやか,島 友子,下岡清美,小林栄治,小澤龍彦,吉野 修,齋藤 滋.
    • Organizer
      第33回日本生殖免疫学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 酵母表面ディスプレイ法を用いたTCRの抗原ペプチド/MHCライブラリーの作製とそのスクリーニング.2018

    • Author(s)
      小澤龍彦,大貫 燿,浜名 洋,小林栄治,呂 福蓮,村口 篤,岸 裕幸.
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] hysiological target and molecular evolution of ACPA obtained from RA patients.2018

    • Author(s)
      Ozawa T, Tsuda R, Hamana H, Kobayashi E, Taki H, Muraguchi A, Kishi H.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] TCR repertoire analysis of peptide-specific T cells using immunospot array assay on a chip (T-ISAAC) technology.2018

    • Author(s)
      Kobayashi E, Ozawa T, Hamana H, Shitaoka K, Muraguchi A, Kishi H.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A rapid and simple protocol for cDNA cloning of tumor antigen-specific TCR.2018

    • Author(s)
      Hamana H, Ozawa T, Kobayashi E, Shitaoka K, Muraguchi A, Kishi H.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The development of antigen detection system using yeast surface display library.2018

    • Author(s)
      Ohnuki Y, Ozawa T, Hamana H, Kobayashi E, Lyu F, Muraguchi A, Kishi H.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Tumor infiltrating lymphocyte repertoire analysis of colon cancer.2018

    • Author(s)
      Sukegawa K, Hamana H, Shitaoka K, Kobayashi E, Saeki S, Nagata T, Fujii T, Muraguchi A, Kishi H.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Clonally expanded populations of cytotoxic T cell in tumor infiltrated lymphocyte and peripheral blood in uterine endometrial cancer.2018

    • Author(s)
      Tsuda K, Kishi H, Nakashima A, Hamana H, Tsuda S, Shima T, Shitaoka K, Kobayashi E, Ozawa T, Muraguchi A, Saito S.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of TCR-antigen identification system using “cis-interaction” of TCR and peptide/MHC complex on a T cell.2018

    • Author(s)
      Yamaguchi S, Kishi H, Shitaoka K, Hamana H, Kobayashi E, Ozawa T, Muraguchi A.
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Time-scale analysis of interplay between immunogenic tumor and immune response.2017

    • Author(s)
      Mojic M, Shitaoka K, Kishi H, Muraguchi A, Tahara H, Hayakawa Y.
    • Organizer
      5th Annual Meeting of the International Cytokine and Interferon Society (ICIS)2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Human Anti-HLA-Bw4 and B61 Monoclonal Antibodies Kill Malignant B Cells Via CDC/ADCC While Sparing Normal Peripheral Blood Cells.2017

    • Author(s)
      Takamatsu H, Ozawa T, Zaimoku Y, Tsuji A, Hanamura I, Kuroda J, Tanaka H, Kawai S, Kishi H, Nakao S.
    • Organizer
      ASH the 59th Annual Meeting and Exposition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 乳がん浸潤リンパ球の迅速・簡便TCRレパートリー解析.2017

    • Author(s)
      浜名 洋,長田拓哉,下岡清美,祐川健太,小澤龍彦,村口 篤,岸 裕幸.
    • Organizer
      第21回日本がん免疫学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト大腸がんにおける腫瘍浸潤CD8+T細胞のクロナリティと腫瘍反応性の解析.2017

    • Author(s)
      藤井啓介,宮原慶裕,問山裕二,井上靖浩,浜名 洋,遠藤洋子,楠 正人,井上正宏,岸 裕幸,珠玖 洋.
    • Organizer
      第21回日本がん免疫学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 単一細胞TCRレパトア解析による,HLA及び抗原に依存しない,腫瘍特異的TCRの取得.2017

    • Author(s)
      岸 裕幸
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト大腸がんにおける腫瘍浸潤CD8+T細胞のクロナリティと腫瘍反応性の解析.2017

    • Author(s)
      藤井啓介,宮原慶裕,問山裕二,井上靖浩,浜名 洋,遠藤洋子,楠 正人,井上正宏,岸 裕幸,珠玖 洋.
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] びまん性大細胞型B細胞リンパ腫における腫瘍浸潤CD8+Tリンパ球の解析.2017

    • Author(s)
      村橋睦了,浜名 洋,岸 裕幸,山口 類,宮野 悟,緒方久修,岡崎利彦,佐々木秀法,宮本将平,谷憲三朗,大西秀哉,高松 泰,中西洋一.
    • Organizer
      第9回血液疾患免疫療法学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 再生不良性貧血患者骨髄中のCD8陽性単一T細胞解析によるHLA-B5401拘束性CTLの同定.2017

    • Author(s)
      中川紀温,Mahmoud I. Elbadry,赤塚美樹,下岡清美,浜名 洋,吉田善紀,井美達也,材木義隆,石山 謙,岸 裕幸,中尾眞二.
    • Organizer
      第9回血液疾患免疫療法学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 自己免疫性出血病XIII/13症例より作製したヒト単クローン抗体のエピトープ解析.2017

    • Author(s)
      尾崎 司,惣宇利正善,小澤龍彦,村口 篤,一瀬白帝.
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TCR repertoire analysis of antigen-specific T cells using immunospot array assay on a chip (T-ISAAC) technology.2017

    • Author(s)
      Kobayashi E, Ozawa T, Hamana H, Lyu F, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] T cell receptor (TCR) gene cloning from tumor infiltrating lymphocytes of breast cancer patients toward TCR gene therapy.2017

    • Author(s)
      Hamana H, Nagata T, Shitaoka K, Sukegawa K, Ozawa T, Kobayashi E, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Majority of tumor infiltrating lymphocytes in B16F10 melanoma recognized tumor-associated antigens, but not melanoma-associated antigens or neoantigens.2017

    • Author(s)
      Shitaoka K, Hamana H, Kobayashi E, Ozawa T, Hayakawa Y, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A novel method to produce high amounts of recombinant MHC/peptide complexes for isolation of antigen-specific human TCRs.2017

    • Author(s)
      Lyu F, Ozawa T, Hamana H, Kobayashi E, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The model of antigen detection system using yeast surface display library.2017

    • Author(s)
      Ohnuki Y, Ozawa T, Hamana H, Kobayashi E, Lyu F, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] T cell receptor repertoire of PD-1+CD137+ and PD1-CD137- tumor infiltrating lymphocytes in various cancers.2017

    • Author(s)
      Takahashi Y, Nagata T, Sukegawa K, Hamana H, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Production of Ro52/TRIM21 autoantibodies that react to PEP08 epitope in Ro52 clinically relate to the morbidity and severity of interstitial lung disease in connective tissue disease.2017

    • Author(s)
      Okumura M, Ozawa T, Taki H, Muraguchi A, Kishi H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Tumor-specific CTL’s reduced clonality and proliferation index, not the inhibitory immune checkpoint expression, as hallmarks of B16 melanoma immune evasion.2017

    • Author(s)
      Mojic M, Shitaoka K, Kishi H, Muraguchi A, Tahara H, Hayakawa Y.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Phenotypic and clonality analysis of tumor-reactive CD8+ T cells among TILs in human colorectal tumor tissue.2017

    • Author(s)
      Fujii K, Miyahara Y, Toiyama Y, Inoue Y, Hamana H, Endo Y, Kusunoki M, Inoue M, Kishi H, Shiku H.
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TCR repertoire of CD4+CD25+CD137+Foxp3+ tumor infiltrating lymphocytes in mice2016

    • Author(s)
      Kishi H, Hamana H, Shitaoka K, Lyu F, Ozawa T, Muraguchi A
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Single-T-cell manipulation method using microwell array chip (T-ISAAC) allows rapid and efficient cloning of antigen-specific TCRs2016

    • Author(s)
      Ozawa T, Kishi H, Hamana H, Tajiri K, Muraguchi A
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] A rapid and easy system for cDNAs cloning of antigen specific TCRs from single human and mouse T-cells within 4 days2016

    • Author(s)
      Hamana H, Kishi H, Shitaoka K, Ozawa T, Muraguchi A
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] T cell receptor obtained from tumor-infiltrating lymphocytes without using tumor-specific antigens exhibits cytotoxicity to tumors in vitro and in vivo2016

    • Author(s)
      Shitaoka K, Kishi H, Hamana H, Hayakawa Y, Ozawa T, Muraguchi A
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] TCR repertoire analysis of OVA-specific T-cells infiltrating into OVA-expressing-melanoma during tumor progression2016

    • Author(s)
      Lyu F, Shitaoka K, Hamana H, Hayakawa Y, Kishi H, Muraguchi A
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of novel human anti-HLA-monoclonal antibodies for clinical applications using peripheral blood B cells derived from anti-HLA antibody-positive donors2016

    • Author(s)
      Takamatsu H, Zaimoku Y, Ozawa T, Kawai S, Tanaka H, Kishi H, Muraguchi A, Nakao S
    • Organizer
      58th ASH Annual Meeting & Exposition
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ISAAC法を用いた抗原特異的T細胞検出法の開発2016

    • Author(s)
      小澤龍彦,岸 裕幸,浜名 洋,田尻和人,呂 福蓮,村口 篤
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腫瘍浸潤リンパ球の単一細胞解析による腫瘍特異的TCRの同定および治療への応用(担癌マウスモデル)2016

    • Author(s)
      岸 裕幸,村口 篤
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] CT26腫瘍局所浸潤CD8+T細胞のTCRレパトア解析と認識エピトープの同定2016

    • Author(s)
      藤井啓介,宮原慶裕,村岡大輔,下岡清美,浜名 洋,岸 裕幸,珠玖 洋
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 関節リウマチ患者由来モノクローナル抗CCP抗体の取得と抗原の解析2016

    • Author(s)
      岸 裕幸,津田玲奈,小澤龍彦,村口 篤
    • Organizer
      第28回日本神経免疫学会学術集会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Rapid generation of monoclonal antibodies using lymphocyte-microarray chip2016

    • Author(s)
      Ozawa T, Kishi H
    • Organizer
      第68回日本生物工学会大会国際シンポジウム
    • Place of Presentation
      ANAクラウンプラザホテル富山(富山県富山市)
    • Year and Date
      2016-09-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cis-interaction of TCRs and antigen/MHC class I complexes on CD8+ T cells causes their activation2016

    • Author(s)
      Kishi H, Jin A, Hamana H, Shitaoka K, Tajiri K, Kobayashi E, Kusano S, Yokoyama S, Ozawa T, Nagai T, Obata T, Hatakeyama S, Horii M, Hu Y, Zhang F, Muraguchi A
    • Organizer
      2016 International Congress of Immunology
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A rapid and efficient single-cell manipulation method using microwell array chip (ISAAC) technology for screening antigen-specific cytokines-secreting T-cells2016

    • Author(s)
      Ozawa T, Kishi H, Hamana H, Tajiri K, Lyu F, Muraguchi A
    • Organizer
      2016 International Congress of Immunology
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A rapid and easy system for screening of antigen-specific TCRs2016

    • Author(s)
      Hamana H, Kishi H, Shitaoka K, Piao X, Ozawa T, Muraguchi A
    • Organizer
      2016 International Congress of Immunology
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of tumor-specific T cell receptors of primary tumor-infiltrating lymphocytes (TILs) from B16F10 melanoma-bearing mice at single cell levels2016

    • Author(s)
      Shitaoka K, Hamana H, Kishi H, Ozawa T, Muraguchi A
    • Organizer
      2016 International Congress of Immunology
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of West Nile virus-neutralizing human monoclonal antibodies derived from the individuals vaccinated with inactivated Japanese encephalitis virus by ISAAC technology2016

    • Author(s)
      Masaki H., Ozawa T., Takasaki T., Aoyama I., Yumisashi T., Konishi E., Kishi H., and Muraguchi A
    • Organizer
      2016 International Congress of Immunology
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The flanking region of cedar pollen peptide in complex with HLA-DP5 facilitates T-cell activation2016

    • Author(s)
      Kusano S., Ueda S., Hamana H., Kishi H., Ohsawa N., WakiyamaM., Muraguchi A., Yoshikai Y., Yamada H., Yamamoto K., Kukimoto-Niino M., Nishimura Y., Shirouzu M., Sasazuki T., and Yokoyama S
    • Organizer
      2016 International Congress of Immunology
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] びまん性大細胞型B細胞リンパ腫における腫瘍浸潤CD8+Tリンパ球由来T細胞受容体および腫瘍微小環境の解析2016

    • Author(s)
      村橋睦了,浜名 洋,松本太一,鍋島一樹,猪狩洋介,佐々木秀法,原 周司,谷 憲三朗,岸 裕幸,高松 泰
    • Organizer
      第14回日本臨床腫瘍学会学術集会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] B16F10メラノーマ浸潤リンパ球の単一細胞解析による,がん特異的T細胞の同定およびTCR遺伝子治療の試み2016

    • Author(s)
      下岡清美,浜名 洋,呂 福蓮,小澤龍彦,早川芳弘,岸 裕幸,村口 篤
    • Organizer
      第20回日本がん免疫学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-07-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] CT26腫瘍局所浸潤CD8+T細胞のTCRレパトア解析と認識エピトープの同定2016

    • Author(s)
      藤井啓介,宮原慶裕,村岡大輔,下岡清美,浜名 洋,岸 裕幸,珠玖 洋
    • Organizer
      第20回日本がん免疫学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-07-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 次世代シーケンサーとsingle cell sortingを用いた同種抗原反応性T細胞の網羅的解析2016

    • Author(s)
      川瀬孝和,坂本 葵,樗木 錬,美山貴彦,柴田真志,田中清人,北浦一孝,大島久美,浜名 洋,岸 裕幸,葛島清隆,佐治博夫,鈴木隆二,一戸辰夫
    • Organizer
      第20回日本がん免疫学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-07-27
    • Related Report
      2016 Annual Research Report
  • [Remarks] 富山大学大学院医学薬学研究部 免疫学講座

    • URL

      http://www.med.u-toyama.ac.jp/immuno/top.html

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] TCR様抗体の製造方法およびその利用2019

    • Inventor(s)
      小澤龍彦,岸裕幸,村口篤
    • Industrial Property Rights Holder
      小澤龍彦,岸裕幸,村口篤
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-202428
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2016-07-04   Modified: 2022-01-27  

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