| Budget Amount *help |
¥207,740,000 (Direct Cost: ¥159,800,000、Indirect Cost: ¥47,940,000)
Fiscal Year 2020: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2019: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2018: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2017: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2016: ¥55,900,000 (Direct Cost: ¥43,000,000、Indirect Cost: ¥12,900,000)
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| Outline of Final Research Achievements |
Based on the crystal structure of HLA-DP5 complexed with a 13-residue peptide (NF-pCj1) containing a 4-residue N-terminal flanking region (NF) derived from a cedar pollen antigen Cry j 1, the functionally-important hexameric structure of HLA-DP5 was elucidated, and it was clarified that this clustering significantly enhances TCR activation. Furthermore, the multimeric structure on the TCR side that binds to the hexameric structure of HLA-DP5 was clarified. Thus, it was concluded that the formation of this TCR multimeric structure is universal to the HLA-II・TCR complex leading to T cell activation, and is the structural entity on which “neo-self” is based.
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