| Budget Amount *help |
¥178,750,000 (Direct Cost: ¥137,500,000、Indirect Cost: ¥41,250,000)
Fiscal Year 2020: ¥32,110,000 (Direct Cost: ¥24,700,000、Indirect Cost: ¥7,410,000)
Fiscal Year 2019: ¥32,110,000 (Direct Cost: ¥24,700,000、Indirect Cost: ¥7,410,000)
Fiscal Year 2018: ¥32,110,000 (Direct Cost: ¥24,700,000、Indirect Cost: ¥7,410,000)
Fiscal Year 2017: ¥32,110,000 (Direct Cost: ¥24,700,000、Indirect Cost: ¥7,410,000)
Fiscal Year 2016: ¥50,310,000 (Direct Cost: ¥38,700,000、Indirect Cost: ¥11,610,000)
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| Outline of Final Research Achievements |
We demonstrated that the misfolded proteins are carried to the cell surface by disease-sensitive HLA molecules, causing an abnormal immune response as “neo-self”. We show that antibodies to HLA class II molecules loaded by various misfold proteins correlate with autoimmune diseases with HLA susceptibility. The immunosuppressive mechanism of malaria was revealed. Furthermore, using advanced molecular imaging with super-resolution microscopy, we have clarified the functional units of signaling molecules for immune cells to recognize their “neo-self”. We demonstrated the PD-1 inhibitory microcluster induced by PD-1-PD-L2 binding to change self-recognition to non-self-one, that is “neo-self”. We further revealed the recognition of the “neo-self” by TCR induced by chimeric antigen receptor signals.
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