| Budget Amount *help |
¥92,690,000 (Direct Cost: ¥71,300,000、Indirect Cost: ¥21,390,000)
Fiscal Year 2020: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2018: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
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| Outline of Final Research Achievements |
In this study, we developed various innovative methods to comprehensively understand gene polymorphisms, gene expression, and transcriptional regulation in HLA and its related genomic regions to elucidate the neo-self phenomenon. We also collected HLA polymorphism and expression information in Japanese population. Furthermore, we identified novel molecular mechanisms involved in qualitative and quantitative abnormalities of the HLA and its related genes by elucidating the pathophysiology of HLA-related diseases, cancers, and adverse drug reactions.
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