| Budget Amount *help |
¥149,370,000 (Direct Cost: ¥114,900,000、Indirect Cost: ¥34,470,000)
Fiscal Year 2020: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2019: ¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2018: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2017: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2016: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
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| Outline of Final Research Achievements |
In this project, we focused on paternal aging as an environmental factor that may affect the "individuality" of the next generation. Using genetically homogeneous wild-type mice, we conducted bioinformatics analysis of epigenetic changes that occur during spermatogenesis and the resulting changes in gene expression in the fetal brain of offspring, and found that hypomethylation in sperm leads to alterations in the neurodevelopmental program of the offspring. In addition, we obtained various behavioral data after individual identification, and conducted mathematical analysis based on the data to model that paternal aging causes more "atypical" development in the next generation of mice, resulting in diversification of individuality.
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