| Budget Amount *help |
¥58,760,000 (Direct Cost: ¥45,200,000、Indirect Cost: ¥13,560,000)
Fiscal Year 2020: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2019: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2018: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2017: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2016: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Outline of Final Research Achievements |
We performed sequence analysis of genes related to human neuropsychiatric disorders in macaque monkeys and marmosets to identify individuals and families with loss-of-function (LoF) mutations. We analyzed 503 and 1281 neuropsychiatric-related genes in 1231 macaque monkeys and 503 marmosets, respectively, and found that 10 genes in macaques and 18 genes in marmosets had LoF mutations in neuropsychiatric-related genes. As part of the development of cellular individuality analysis technology, we established the single-cell RNA-seq analysis system in the autism marmoset model brain and clarified the expression dynamics in the diseased brain at the single-cell level.
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