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Understanding the map-based navigation system in the hippocampus of rats

Planned Research

Project AreaSystems Science of Bio-navigation
Project/Area Number 16H06543
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionDoshisha University

Principal Investigator

Takahashi Susumu  同志社大学, 脳科学研究科, 教授 (20510960)

Co-Investigator(Kenkyū-buntansha) 苅部 冬紀  同志社大学, 研究開発推進機構, 准教授 (60312279)
Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥101,270,000 (Direct Cost: ¥77,900,000、Indirect Cost: ¥23,370,000)
Fiscal Year 2020: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2018: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2017: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2016: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Keywords場所細胞 / ナビゲーション / 認知科学 / 神経科学 / 脳・神経
Outline of Final Research Achievements

In this study, we developed a maze in which the components of the maze including runways, sensors, movable walls, feeders, and treadmills, can be flexibly reconfigured. In addition, we constructed a logger system that can wirelessly record neuronal activities even outside the laboratory. Using these tools, we have advanced the understanding of spatial navigation in rodents and discovered grid cells in the medial pallium of Streaked shearwaters. Moreover, we discovered head direction cells in the telencephalon of salmonids (trout). We contributed to the development of DeepHL, an animal trajectory analysis method, and were able to discover those characteristic behaviors, which can identify movement disorders, appear in the maximum distance traveled at a certain time. These results have facilitated the understanding of navigation in the research field of Systems Science of Bionavigation.

Academic Significance and Societal Importance of the Research Achievements

本研究で開発した再構成可能な迷路や無線神経活動ロガーは、それぞれ独創性を備えた技術である。そのような認知神経科学、情報工学、実験心理学という異なる研究分野に加え、本領域内の共同研究により生態学、制御工学、データ科学分野を、ナビゲーション機能をシステム的に理解するという一つの具体的な目標の実現に向け融合させたという点で、本計画研究は世界的にも例のない極めて独創的な試みと言える。
本研究の成果は、移動障害を行動から検知する見守りシステムや、認知障害発症を予測する早期発見システムの開発に繋がる。更にはカーナビゲーション経路の最適化や、交通渋滞の緩和への応用も期待できる。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (48 results)

All 2021 2020 2019 2018 2017 2016

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 8 results,  Acknowledgement Compliant: 2 results) Presentation (33 results) (of which Int'l Joint Research: 13 results,  Invited: 3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Wireless logging of extracellular neuronal activity in the telencephalon of free-swimming salmonids2021

    • Author(s)
      Susumu Takahashi, Takumi Hombe, Riku Takahashi, Kaoru Ide, Shinichiro Okamoto, Ken Yoda, Takashi Kitagawa and Yuya Makiguchi
    • Journal Title

      Animal Biotelemetry

      Volume: 9 Issue: 1 Pages: 9-9

    • DOI

      10.1186/s40317-021-00232-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deep learning-assisted comparative analysis of animal trajectories with DeepHL2020

    • Author(s)
      Takuya Maekawa, Kazuya Ohara, Yizhe Zhang, Matasaburo Fukutomi, Sakiko Matsumoto, Kentarou Matsumura, Hisashi Shidara, Shuhei J. Yamazaki, Ryusuke Fujisawa, Kaoru Ide, Naohisa Nagaya, Koji Yamazaki, Shinsuke Koike, Takahisa Miyatake, Koutarou D. Kimura, Hiroto Ogawa, Susumu Takahashi, and Ken Yoda
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 5316-5316

    • DOI

      10.1038/s41467-020-19105-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Reconfigurable Maze Provides Flexible, Scalable, Reproducible, and Repeatable Tests2020

    • Author(s)
      Hoshino Satoshi、Takahashi Riku、Mieno Kana、Tamatsu Yuta、Azechi Hirotsugu、Ide Kaoru、Takahashi Susumu
    • Journal Title

      iScience

      Volume: 23 Issue: 1 Pages: 100787-100787

    • DOI

      10.1016/j.isci.2019.100787

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reinforcement schedules differentially affect learning in neuronal operant conditioning in rats2020

    • Author(s)
      Song Kichan、Takahashi Susumu、Sakurai Yoshio
    • Journal Title

      Neuroscience Research

      Volume: 153 Pages: 62-67

    • DOI

      10.1016/j.neures.2019.04.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat2019

    • Author(s)
      Karube F, Takahashi S, Kobayashi K, Fujiyama F
    • Journal Title

      Elife

      Volume: 8 Pages: 1-25

    • DOI

      10.7554/elife.49511

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced Theta and High-Gamma Coupling during Late Stage of Rule Switching Task in Rat Hippocampus2019

    • Author(s)
      Nakazono Tomoaki、Takahashi Susumu、Sakurai Yoshio
    • Journal Title

      Neuroscience

      Volume: 412 Pages: 216-232

    • DOI

      10.1016/j.neuroscience.2019.05.053

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Hippocampal Ensemble Code for Spatial Navigation and Episodic Memory2018

    • Author(s)
      Takahashi Susumu
    • Journal Title

      Advances in Neurobiology

      Volume: 21 Pages: 49-70

    • DOI

      10.1007/978-3-319-94593-4_3

    • ISBN
      9783319945910, 9783319945934
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hippocampal-prefrontal theta phase synchrony in planning of multi-step actions based on memory retrieval2017

    • Author(s)
      Ishino, S., Takahashi, S., Ogawa, M. and Sakurai, Y.
    • Journal Title

      European Journal of Neuroscience

      Volume: 45 Issue: 10 Pages: 1313-1324

    • DOI

      10.1111/ejn.13547

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 場所記憶の想起によるナビゲーション2017

    • Author(s)
      髙橋晋,増田明,井出薫
    • Journal Title

      生物の科学 遺伝

      Volume: 71 Pages: 539-544

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 脳内ナビゲーション・システム―海馬の場所細胞―2017

    • Author(s)
      髙橋晋,井出薫
    • Journal Title

      日本ロボット学会誌

      Volume: 35 Pages: 43-47

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 脳内ナビゲーション・システム―海馬の場所細胞―2017

    • Author(s)
      髙橋晋、井出薫
    • Journal Title

      日本ロボット学会誌

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Similarity in neuronal firing regimes across mammalian species2016

    • Author(s)
      Yasuhiro Mochizuki, ..., Ichiro Fujita, et al.
    • Journal Title

      Journal of Neuroscience

      Volume: 36 Issue: 21 Pages: 5736-5747

    • DOI

      10.1523/jneurosci.0230-16.2016

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations.2016

    • Author(s)
      Oh Y-M, Karube F, Takahashi S, Kobayashi K, Takada M, Uchigashima M, Watanabe M, Nishizawa K, Kobayashi K, *Fujiyama F
    • Journal Title

      Brain Struct Funct

      Volume: 印刷中 Issue: 5 Pages: 2359-2378

    • DOI

      10.1007/s00429-016-1346-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 大脳基底核の機能と構造2016

    • Author(s)
      藤山文乃、髙橋晋、苅部冬紀
    • Journal Title

      Clinical Neuroscience

      Volume: 35 Pages: 268-270

    • Related Report
      2016 Annual Research Report
  • [Presentation] Similarity of the function between time cell and place cell2020

    • Author(s)
      三重野 華菜, 星野 諭, 井出 薫, 髙橋 晋
    • Organizer
      第43回日本神経科学大会(web開催)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Deciphering the code in the medial pallium of migratory seabirds2020

    • Author(s)
      髙橋 晋
    • Organizer
      第43回日本神経科学大会(web開催)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 歩行する海鳥および遊泳するサケ科魚類の脳における空間ナビゲーションの神経相関2019

    • Author(s)
      井出 薫, 本部 拓未, 岡本 慎一郎, 松本 祥子, 依田 憲, 牧口 祐也, 髙橋 晋
    • Organizer
      NEURO2019 (第42回日本神経科学大会、第62回日本神経化学会大会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 再構成可能な迷路は記憶学習研究のための繰り返し精度の高い再現性を有するテストを提供する2019

    • Author(s)
      髙橋 晋, 星野 諭, 井出 薫
    • Organizer
      NEURO2019 (第42回日本神経科学大会、第62回日本神経化学会大会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス用に開発された再構成可能な迷路における移動軌跡の解析2019

    • Author(s)
      高橋 陸, 玉津 裕太, 井出 薫, 髙橋 晋
    • Organizer
      NEURO2019 (第42回日本神経科学大会、第62回日本神経化学会大会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 同一実験室内における様々な迷路上での場所細胞の神経活動2019

    • Author(s)
      三重野 華菜, 星野 諭, 井出 薫, 髙橋 晋
    • Organizer
      第97回 日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Patterned silencing of parvalbumin neurons in rodent visual cortex2019

    • Author(s)
      増田明、高橋晋
    • Organizer
      APCV2019, Osaka
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cell-type specific cortical stimulations by red-shift light with lens optics2019

    • Author(s)
      増田明、高橋晋
    • Organizer
      The Eye and Chip 2019, Michigan
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visual restoration based on optogenetic silencing of parvalbumin neurons in visual cortex2019

    • Author(s)
      増田明、高橋晋
    • Organizer
      CiNet Conference: Brain-Machine Interface, Osaka
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 空間ナビゲーションに関する海馬の場所細胞研究とその未来2019

    • Author(s)
      髙橋 晋
    • Organizer
      第66回日本生態学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The Next Phase for Tracking and Predicting the Navigational Behavior Using Machine Learning2019

    • Author(s)
      髙橋 晋、星野 諭、井出 薫
    • Organizer
      International Workshop on Behavior analysis and Recognition for knowledge Discovery (BiRD 2019)in conjunction with the IEEE International Conference on Pervasive Computing and Communications
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 空間ナビゲーションのための再構成迷路システム2018

    • Author(s)
      星野 諭、井出 薫、髙橋 晋
    • Organizer
      第62回システム制御情報学会研究発表講演会 (SCI’18)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 行動中マウスの運動皮質におけるパルブアルブミン発現インターニューロンの発火操作2018

    • Author(s)
      井出 薫、小林 憲太、苅部 冬紀、藤山 文乃、髙橋 晋
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 多種の迷路を構成可能な小動物用の新規迷路システムの開発2018

    • Author(s)
      星野 諭、井出 薫、髙橋 晋
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 自由行動中の海鳥脳からの神経活動記録2018

    • Author(s)
      髙橋 晋、松本 祥子、井出 薫、依田 憲
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Precisely patterned optogenetic stimulation with mini-LED array and lens optics in rodent visual cortex2018

    • Author(s)
      Akira Masuda, Susumu Takahashi
    • Organizer
      Brain Stimulation
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optogenetic intervention to parvalbumin-expressing interneurons in the motor cortex of behaving mice2018

    • Author(s)
      井出 薫、小林 憲太、苅部 冬紀、尾原 和也、前川 卓也、藤山 文乃、髙橋 晋
    • Organizer
      International Symposium on Systems Science of Bio-Navigation 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The reconfigurable maze enables various tests to study neural mechanisms of spatial navigation2018

    • Author(s)
      星野 諭、井出 薫、髙橋 晋
    • Organizer
      International Symposium on Systems Science of Bio-Navigation 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural activity in the brain of rats, seabirds and salmonid fish during spatial navigation2018

    • Author(s)
      Susumu Takahashi
    • Organizer
      International Symposium on Systems Science of Bio-Navigation 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of the Reconfigurable maze-various shapes of maze in a single environment2018

    • Author(s)
      星野 諭、井出 薫、髙橋 晋
    • Organizer
      Society for Neuroscience 2018 meetings(SfN2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 再構成迷路の開発2018

    • Author(s)
      星野諭、井出薫、高橋晋
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Memory of places in rats2017

    • Author(s)
      Takahashi, S.
    • Organizer
      IEEE ICMA 2017 Conference, Tutorial Workshops on Systems Science of Bio-navigation
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Place sequence recognition and processing in the hippocampal place cell activity2017

    • Author(s)
      Takahashi, S.
    • Organizer
      第40回日本神経科学大会(幕張)
    • Related Report
      2017 Annual Research Report
  • [Presentation] sing a novel PV-cre rat model to characterize pallidonigral cells and terminations2017

    • Author(s)
      呉 胤美, 苅部 冬紀, 高橋晋, 小林 憲太, 高田 昌彦, 小林 和人, 藤山 文乃
    • Organizer
      第122回 日本解剖学会 総会・全国学術集会
    • Place of Presentation
      長崎大学(長崎県長崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] パーキンソン病モデルマウスの一次運動野における光遺伝学を活用した神経細胞活動の操作2016

    • Author(s)
      高橋晋, 小林 憲太, 苅部 冬紀, 藤山 文乃
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 淡蒼球外節から黒質緻密部ドーパミンニューロンへの抑制性入力を解明する2016

    • Author(s)
      呉 胤美, 苅部 冬紀, 高橋晋, 小林 憲太, 高田 昌彦, 小林 和人, 藤山 文乃
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 報酬確率学習課題中の海馬における神経表象2016

    • Author(s)
      高橋 裕美, 廣川 純也, 高橋晋, 櫻井 芳雄
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウス淡蒼球外節におけるNeurokinin-1受容体陽性細胞の形態学的・電気生理学的性質を解明する2016

    • Author(s)
      水谷 和子, 苅部 冬紀, 高橋晋, 小林 憲太, 藤山 文乃
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ラットの海馬・前頭前野における再学習中の神経機構2016

    • Author(s)
      町野友理, 高橋晋, 櫻井芳雄
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ラット皮質における随意的発火調節のニューロン集団間での転移2016

    • Author(s)
      宋 基燦, 高橋晋, 櫻井芳雄
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Learning stages in a rule switching task affects theta-gamma couplings in rat hippocampus2016

    • Author(s)
      Nakazono, T., Takahashi, S., Sakurai, Y.
    • Organizer
      Society for Neuroscience meeting
    • Place of Presentation
      SanDiego, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Volitional modulation of neuronal activities among multiple neuron groups via neuronal operant conditioning2016

    • Author(s)
      Song, K., Takahashi, S., Sakurai, Y.
    • Organizer
      Society for Neuroscience meeting
    • Place of Presentation
      SanDiego, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hippocampal-prefrontal interaction during original task learning and relearning2016

    • Author(s)
      Machino, Y., Takahashi, S., Sakurai, Y.
    • Organizer
      Society for Neuroscience meeting
    • Place of Presentation
      SanDiego, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 小動物実験用迷路組立キット2017

    • Inventor(s)
      髙橋晋
    • Industrial Property Rights Holder
      髙橋晋
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-252076
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2016-07-04   Modified: 2022-01-27  

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