| Budget Amount *help |
¥97,500,000 (Direct Cost: ¥75,000,000、Indirect Cost: ¥22,500,000)
Fiscal Year 2020: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2019: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2018: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2017: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2016: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
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| Outline of Final Research Achievements |
Focusing on the "Proton motive force" which has been a weak point of structural biology, we have been able to advance structural analysis including hydrogen atoms by combining theoretical chemical calculations with X-ray structural analysis, NMR, and cryo-electron microscopy. By using this approach, we were able to identify the structural basis for the photosynthetic function, and for some of them, we were able to find out the bottleneck of supramolecular complex responsible for the photosynthetic reaction. Specifically, the structural basis of the proton transport pathway of the photosystem II complex, the pH-dependent interaction of the cytochrome b6f complex with FNR, the molecular mechanism of the Fd-dependent quinone reduction of the NDH complex, and the regulatory system mediated by the strong reducing power of ferredoxin were clarified. Our collaborative research with <A01> and <A02> groups has also yielded certain results.
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