| Budget Amount *help |
¥66,170,000 (Direct Cost: ¥50,900,000、Indirect Cost: ¥15,270,000)
Fiscal Year 2020: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2019: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2018: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2017: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2016: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
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| Outline of Final Research Achievements |
In this research project, we trained monkeys to perform a “response inhibition” task in which the animals were required to cancel a planned motor action based on information about the salience of a visual cue, and a “decision-making” task in which the animals were required to decide whether to choose an option based on information about the value of the option. We recorded neuronal activity from dopamine neurons and neurons in dopamine-related brain regions while the monkeys were performing the tasks. In the response inhibition experiment, we found that the nigrostriatal dopamine pathway plays a crucial role in canceling a motor action by signaling salience information. In the decision-making experiment, we found that dopamine neurons are involved in the “value-to-choice transformation” process in which option’s value information is transformed into monkey’s choice command about whether to choose the option.
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