| Budget Amount *help |
¥87,230,000 (Direct Cost: ¥67,100,000、Indirect Cost: ¥20,130,000)
Fiscal Year 2020: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2019: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
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| Outline of Final Research Achievements |
Basal ganglia circit-specific reversible neurotransmission blocking revealed that the direct pathway of the nucleus accumbens is specifically involved in sign-tracking behavior in the reward/goal-directed behavioral task. In addition, the direct and indirect pathways of the nucleus accumbens regulate circuit-specific gene expression in the medial prefrontal cortex. The mutant DISC1 transgenic mouse model of psychiatric disorders showed molecular pathology specific in the indirect pathway in the nucleus accumbens, indicating a role for basal ganglia in the pathogenesis of psychiatric disorders.
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