| Budget Amount *help |
¥255,580,000 (Direct Cost: ¥196,600,000、Indirect Cost: ¥58,980,000)
Fiscal Year 2020: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2019: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2018: ¥44,070,000 (Direct Cost: ¥33,900,000、Indirect Cost: ¥10,170,000)
Fiscal Year 2017: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2016: ¥77,740,000 (Direct Cost: ¥59,800,000、Indirect Cost: ¥17,940,000)
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| Outline of Final Research Achievements |
In mammalian cells, a wide array of extracellular stimuli generates intracellular signals that converge on a limited number of protein kinase cascades, commonly referred to as MAPK pathways. In mammals, there are at least three subfamilies of MAPKs, named p38, JNK, and ERK. While the classical ERK MAPK is mainly activated by mitogenic stimuli, two relatively newly identified MAPKs, p38 and JNK, are preferentially activated by various environmental stresses. Perturbation of these critical signaling systems is involved in a variety of life-threatening diseases, including cancers and autoimmune diseases. In this study, we investigated the regulatory mechanisms and roles of these signaling pathways in cell fate decisions by combining experimental approaches using molecular biology and multi-omics techniques with theoretical approaches based on mathematical science. We also analyzed abnormalities of these signaling pathways in human diseases including cancer and inflammation.
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