| Budget Amount *help |
¥265,460,000 (Direct Cost: ¥204,200,000、Indirect Cost: ¥61,260,000)
Fiscal Year 2020: ¥50,960,000 (Direct Cost: ¥39,200,000、Indirect Cost: ¥11,760,000)
Fiscal Year 2019: ¥51,870,000 (Direct Cost: ¥39,900,000、Indirect Cost: ¥11,970,000)
Fiscal Year 2018: ¥50,960,000 (Direct Cost: ¥39,200,000、Indirect Cost: ¥11,760,000)
Fiscal Year 2017: ¥51,870,000 (Direct Cost: ¥39,900,000、Indirect Cost: ¥11,970,000)
Fiscal Year 2016: ¥59,800,000 (Direct Cost: ¥46,000,000、Indirect Cost: ¥13,800,000)
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| Outline of Final Research Achievements |
The function of the transcription factor NF-kB, which regulates gene expression, is tightly regulated in order to maintain human health. This regulation requires the coordinated action of multiple NF-kB activating proteins on a ubiquitin-linked scaffold. In this study, we succeeded in simulating the complex dynamics of the scaffold and activation proteins using mathematical science, considering time and intracellular space, and proposed a new mechanism of NF-kB regulation. In addition, we clarified new mechanisms of leukemia, neurological diseases, and malignant transformation of breast cancer caused by abnormal NF-kB activation.
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