| Budget Amount *help |
¥94,380,000 (Direct Cost: ¥72,600,000、Indirect Cost: ¥21,780,000)
Fiscal Year 2020: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2019: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2018: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2017: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2016: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
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| Outline of Final Research Achievements |
We focused on the insulin signaling pathway and conducted mathematical analysis and multi-omics analysis at the individual level. In the mathematical analysis, we developed the first mathematical model of hormone action in vivo and revealed that the insulin signaling pathway in the liver processes information encoded into the blood insulin patterns and its mechanism. Using the model, we also predicted the insulin signaling pathway responses in type 2 diabetes mellitus conditions, and the model deepened our understanding on T2DM mechanisms. In the multi-omics analysis, we obtained time-series data across four omics layers, such as metabolome, phospho-proteome, expression proteome, and transcriptome. Also, we found that insulin action is coordinately regulated at different timing by reconstructing the trans-omic network across multi-omic layers.
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