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System-level analysis of signal transduction mechanisms by high-resolution proteomics

Planned Research

Project AreaIntegrative understanding of biological signaling networks based on mathematical science
Project/Area Number 16H06578
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionThe University of Tokyo

Principal Investigator

Oyama Masaaki  東京大学, 医科学研究所, 准教授 (30422398)

Co-Investigator(Kenkyū-buntansha) 秦 裕子  東京大学, 医科学研究所, 技術専門員 (80401256)
Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
Fiscal Year 2020: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2019: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2018: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2016: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywordsプロテオーム / シグナル伝達 / 癌
Outline of Final Research Achievements

In this study, we established an analytical platform to perform global ubiquitination and acetylation proteome analyses of human cancer cells using high-resolution nanoflow liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) system. We also developed a bioinformatical platform named 'Post Translational Modification mapper (PTMapper)' to reconstruct regulatory protein-protein interaction relations at the protein modification level towards systematic network analysis based on PTM-oriented quantitative activation data,

Academic Significance and Societal Importance of the Research Achievements

シグナル伝達系は細胞の運命決定を担う最も重要な生命制御システムの一つであり、リン酸化やユビキチン化・アセチル化をはじめとする多様なタンパク質翻訳後修飾による複雑かつ精細な相互作用ネットワークがその動的な駆動力として機能している。本研究によってシグナル伝達制御を担う主要翻訳後修飾に関する大規模同定・定量分析プラットフォームが確立され、被修飾部位ごとの詳細な活性変動を基盤とする次世代の数理モデル・統計モデル解析研究に資するプロテオーム情報基盤を構築することができた。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (50 results)

All 2021 2020 2019 2018 2017 2016 Other

All Journal Article (23 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 23 results,  Open Access: 21 results,  Acknowledgement Compliant: 1 results) Presentation (22 results) (of which Int'l Joint Research: 8 results,  Invited: 6 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Comparative whole-genome and proteomics analyses of the next seed bank and the original master seed bank of MucoRice-CTB 51A line, a rice-based oral cholera vaccine2021

    • Author(s)
      Sasou Ai、Yuki Yoshikazu、Honma Ayaka、Sugiura Kotomi、Kashima Koji、Kozuka-Hata Hiroko、Nojima Masanori、Oyama Masaaki、Kurokawa Shiho、Maruyama Shinichi、Kuroda Masaharu、Tanoue Shinjiro、Takamatsu Narushi、Fujihashi Kohtaro、Goto Eiji、Kiyono Hiroshi
    • Journal Title

      BMC Genomics

      Volume: 22 Issue: 1 Pages: 59-59

    • DOI

      10.1186/s12864-020-07355-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CADM1 suppresses c-Src activation by binding with Cbp on membrane lipid rafts and intervenes colon carcinogenesis2020

    • Author(s)
      Tsuboi Yumi、Oyama Masaaki、Kozuka-Hata Hiroko、Ito Akihiko、Matsubara Daisuke、Murakami Yoshinori
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 529 Issue: 3 Pages: 854-860

    • DOI

      10.1016/j.bbrc.2020.05.103

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prohibitin-1 Contributes to Cell-to-Cell Transmission of Herpes Simplex Virus 1 via the MAPK/ERK Signaling Pathway2020

    • Author(s)
      Watanabe Mizuki、Arii Jun、Takeshima Kosuke、Fukui Ayano、Shimojima Masayuki、Kozuka-Hata Hiroko、Oyama Masaaki、Minamitani Takeharu、Yasui Teruhito、Kubota Yuji、Takekawa Mutsuhiro、Kosugi Isao、Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 95 Issue: 3

    • DOI

      10.1128/jvi.01413-20

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osmostress enhances activating phosphorylation of Hog1 MAP kinase by mono-phosphorylated Pbs2 MAP2K.2020

    • Author(s)
      Tatebayashi K, Yamamoto K, Tomida T, Nishimura A, Takayama T, Oyama M, Kozuka-Hata H, Adachi-Akahane S, Tokunaga Y, Saito H
    • Journal Title

      EMBO J

      Volume: 39 Issue: 5

    • DOI

      10.15252/embj.2019103444

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] System-Wide Analysis of Protein Acetylation and Ubiquitination Reveals a Diversified Regulation in Human Cancer Cells2020

    • Author(s)
      Kozuka-Hata Hiroko、Kitamura Aya、Hiroki Tomoko、Aizawa Aiko、Tsumoto Kouhei、Inoue Jun-ichiro、Oyama Masaaki
    • Journal Title

      Biomolecules

      Volume: 10 Issue: 3 Pages: 411-411

    • DOI

      10.3390/biom10030411

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Widespread Family of Heat-Resistant Obscure (Hero) Proteins Protect Against Protein Instability and Aggregation2020

    • Author(s)
      Tsuboyama K, Osaki T, Matsuura-Suzuki E, Kozuka-Hata H, Okada Y, Oyama M, Ikeuchi Y, Iwasaki S, Tomari Y
    • Journal Title

      PLOS Biology

      Volume: 18 Issue: 3 Pages: 3000632-3000632

    • DOI

      10.1371/journal.pbio.3000632

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery of a Vertebrate-Specific Factor that Processes Flagellar Glycolytic Enolase during Motile Ciliogenesis2020

    • Author(s)
      Narita Keishi、Nagatomo Hiroaki、Kozuka-Hata Hiroko、Oyama Masaaki、Takeda Sen
    • Journal Title

      iScience

      Volume: 23 Issue: 4 Pages: 100992-100992

    • DOI

      10.1016/j.isci.2020.100992

    • URL

      https://pure.teikyo.jp/en/publications/ca2c94fe-eb98-437a-b0ce-41a7ee9865be

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infected Erythrocytes2019

    • Author(s)
      Takano R, Kozuka-Hata H, Kondoh D, Bochimoto H, Oyama M, Kato K
    • Journal Title

      iScience

      Volume: 19 Pages: 703-714

    • DOI

      10.1016/j.isci.2019.07.035

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts2019

    • Author(s)
      Aoki M, Koga K, Miyazaki M, Hamasaki M, Koshikawa N, Oyama M, Kozuka-Hata H, Seiki M, Toole BP, Nabeshima K
    • Journal Title

      BMC Cancer

      Volume: 19 Issue: 1 Pages: 912-912

    • DOI

      10.1186/s12885-019-6127-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel ASXL1?OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies2018

    • Author(s)
      Inoue D, Fujino T, Sheridan P, Zhang YZ, Nagase R, Horikawa S, Li Z, Matsui H, Kanai A, Saika M, Yamaguchi R, Kozuka-Hata H, Kawabata KC, Yokoyama A, Goyama S, Inaba T, Imoto S, Miyano S, Xu M, Yang FC, Oyama M, Kitamura T.
    • Journal Title

      Leukemia

      Volume: 印刷中 Issue: 6 Pages: 1327-1337

    • DOI

      10.1038/s41375-018-0083-3

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Regulation of Herpes Simplex Virus 2 Protein Kinase UL13 by Phosphorylation and Its Role in Viral Pathogenesis.2018

    • Author(s)
      Koyanagi N, Kato A, Takeshima K, Maruzuru Y, Kozuka-Hata H, Oyama M, Arii J, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 92 Issue: 17

    • DOI

      10.1128/jvi.00807-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of the Phosphorylation of Herpes Simplex Virus 1 UL51 at a Specific Site in Viral Replication and Pathogenicity.2018

    • Author(s)
      Kato A, Oda S, Watanabe M, Oyama M, Kozuka-Hata H, Koyanagi N, Maruzuru Y, Arii J, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 92 Issue: 18

    • DOI

      10.1128/jvi.01035-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis2018

    • Author(s)
      Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T
    • Journal Title

      Nat Commun

      Volume: 9 Issue: 1 Pages: 2733-2733

    • DOI

      10.1038/s41467-018-05085-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] N-terminal acetylation by NatB is required for the shutoff activity of influenza A virus PA-X.2018

    • Author(s)
      Oishi K, Yamayoshi S, Kozuka-Hata H, Oyama M, Kawaoka Y.
    • Journal Title

      Cell Rep

      Volume: 24 Issue: 4 Pages: 851-860

    • DOI

      10.1016/j.celrep.2018.06.078

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Proteolytic Cleavage Sites of EphA2 by Membrane Type 1 Matrix Metalloproteinase on the Surface of Cancer Cells2018

    • Author(s)
      Kikuchi K, Kozuka-Hata H, Oyama M, Seiki M, Koshikawa N
    • Journal Title

      Methods Mol Biol

      Volume: 1731 Pages: 29-37

    • DOI

      10.1007/978-1-4939-7595-2_3

    • ISBN
      9781493975945, 9781493975952
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Shotgun proteomics deciphered age/division of labor-related functional specification of three honeybee (Apis mellifera L.) exocrine glands2018

    • Author(s)
      Fujita T, Kozuka-Hata H, Hori Y, Takeuchi J, Kubo T, Oyama M
    • Journal Title

      PLoS One

      Volume: 13 Issue: 2 Pages: e0191344-e0191344

    • DOI

      10.1371/journal.pone.0191344

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive Identification of Nuclear and Cytoplasmic TNRC6A-Associating Proteins2017

    • Author(s)
      Suzawa M, Noguchi K, Nishi K, Kozuka-Hata H, Oyama M, Ui-Tei K
    • Journal Title

      J Mol Biol

      Volume: 429 Issue: 21 Pages: 3319-3333

    • DOI

      10.1016/j.jmb.2017.04.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysosomal targeting of SIDT2 via multiple YxxΦ motifs is required for SIDT2 function in the process of RNautophagy2017

    • Author(s)
      Contu Viorica Raluca、Hase Katsunori、Kozuka-Hata Hiroko、Oyama Masaaki、Fujiwara Yuuki、Kabuta Chihana、Takahashi Masayuki、Hakuno Fumihiko、Takahashi Shin-Ichiro、Wada Keiji、Kabuta Tomohiro
    • Journal Title

      Journal of Cell Science

      Volume: 130 Issue: 17 Pages: 2843-2853

    • DOI

      10.1242/jcs.202481

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells2017

    • Author(s)
      Saitoh SI, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K and Miyake K
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 1592-1592

    • DOI

      10.1038/s41467-017-01687-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody.2016

    • Author(s)
      Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, Kiyono H.
    • Journal Title

      Regul Toxicol Pharmacol

      Volume: 76 Pages: 128-136

    • DOI

      10.1016/j.yrtph.2016.01.023

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] USP7 and TDP-43: Pleiotropic regulation of Cryptochrome protein stability paces the oscillation of the mammalian circadian clock.2016

    • Author(s)
      Arisa Hirano, Tomoki Nakagawa, Hikari Yoshitane, Masaaki Oyama, Hiroko Kozuka-Hata, Darin Lanjakornsiripoan, and Yoshitaka Fukada
    • Journal Title

      PLOS ONE

      Volume: 11 Issue: 4 Pages: e0154263-e0154263

    • DOI

      10.1371/journal.pone.0154263

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Quantitative phosphoproteomics-based molecular network description for high-resolution kinase-substrate interactome analysis.2016

    • Author(s)
      Narushima, Y., Kozuka-Hata, H., Tsumoto, K., Inoue, J. and Oyama, M.
    • Journal Title

      Bioinformatics

      Volume: 印刷中 Issue: 14 Pages: 2083-2088

    • DOI

      10.1093/bioinformatics/btw164

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein.2016

    • Author(s)
      Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T, Enomoto A, Kondo K, Tanaka S, Hara Y, Koshikawa S, Sagara H, Miura T, Yokobori S, Miyagawa K, Suzuki Y, Kubo T, Oyama M, Kohara Y, Fujiyama A, Arakawa K, Katayama T, Toyoda A and Kunieda T
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 12808-12808

    • DOI

      10.1038/ncomms12808

    • NAID

      120005971035

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Integrative network analysis of cancer cell signaling by high-resolution proteomics2020

    • Author(s)
      Masaaki Oyama, Hiroko Kozuka-Hata
    • Organizer
      JSPS Core-to-Core Program
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高精度翻訳後修飾プロテオミクスによるシグナルネットワーク解析2020

    • Author(s)
      尾山 大明、秦 裕子
    • Organizer
      第71回日本電気泳動学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] High-resolution proteomic analysis of EGF-regulated ubiquitination dynamics in human cancer cells2020

    • Author(s)
      Hiroko Kozuka-Hata, Tomoko Hiroki, Aya Kitamura, Aiko Aizawa, Naoaki Miyamura, Kouhei Tsumoto, Jun-ichiro Inoue, Masaaki Oyama
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ヒトがん細胞におけるEGF刺激依存的プロテオームダイナミクスの高深度動態解析2020

    • Author(s)
      秦 裕子、廣木 朋子、北村 亜矢、相澤 愛子、宮村 尚明、津本 浩平、井上 純一郎、尾山 大明
    • Organizer
      第16回日本臨床プロテオゲノミクス研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 翻訳後修飾プロテオミクスによるがん化シグナルネットワーク解析2019

    • Author(s)
      秦 裕子、北村 亜矢、廣木 朋子、相澤 愛子、津本 浩平、井上 純一郎、尾山 大明
    • Organizer
      第15回日本臨床プロテオゲノミクス研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] リシンアセチル化及びユビキチン化が規定する細胞応答ネットワークの時系列プロテオーム解析2019

    • Author(s)
      秦 裕子、北村 亜矢、廣木 朋子、相澤 愛子、宮村 尚明、小嶋 由希子、津本 浩平、井上 純一郎、 尾山 大明
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Pulsed SILAC法を用いた癌細胞内タンパク質ターンオーバーのプロテオーム解析2019

    • Author(s)
      尾山 大明、秦 裕子
    • Organizer
      数理腫瘍学研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Proteome-wide analysis of lysine acetylation and ubiquitination reveals critical signaling regulation in cancer cells2019

    • Author(s)
      秦 裕子
    • Organizer
      第2回ユビキチン研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Integrative analysis of cancer cell signaling networks by post-translational modification-directed proteomics2019

    • Author(s)
      Masaaki Oyama
    • Organizer
      1st International symposium on interdisciplinary approaches to integrative understanding of biological signaling networks
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Proteome-wide analysis of lysine acetylation and ubiquitination reveals critical signaling regulation in cancer cells2019

    • Author(s)
      Hiroko Kozuka-Hata
    • Organizer
      1st International symposium on interdisciplinary approaches to integrative understanding of biological signaling networks
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Integrative network analysis of phosphorylation-dependent signaling dynamics in cancer cells2019

    • Author(s)
      Masaaki Oyama
    • Organizer
      Core to Core meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] System-wide analysis of lysine modification sites based on large-scale cellular proteome data2019

    • Author(s)
      Hiroko Kozuka-Hata
    • Organizer
      Core to Core meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Systematic discovery of cancer biomarkers by integrative post-translational modification-directed proteomics2018

    • Author(s)
      Masaaki Oyama and Hiroko Kozuka-Hata
    • Organizer
      Mass Spectrometry and Proteomics 2018 (MSP2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 大規模ユビキチン化及びアセチル化プロテオーム解析によるシグナル伝達制御機構の解明2018

    • Author(s)
      小塚(秦) 裕子、北村 亜矢、廣木 朋子、相澤 愛子、津本 浩平、井上 純一郎、尾山 大明
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高精度プロテオミクスによるシグナル伝達制御機構の数理ネットワーク解析2018

    • Author(s)
      尾山 大明、秦 裕子
    • Organizer
      数理腫瘍学研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Comprehensive network analysis of cancer cell signaling through systematic integration of post-translational modification dynamics2017

    • Author(s)
      Masaaki Oyama and Hiroko Kozuka-Hata
    • Organizer
      12th International Symposium of the Institute Network
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大規模細胞プロテオームデータを用いた包括的ユビキチン結合モチーフ解析2017

    • Author(s)
      小塚(秦) 裕子、廣木 朋子、北村 亜矢、市倉 慎也、津本 浩平、井上 純一郎、尾山 大明
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高精度プロテオミクスによるシグナル伝達制御機構の数理ネットワーク解析2017

    • Author(s)
      尾山 大明
    • Organizer
      新学術領域「数理シグナル」 第一回公開シンポジウム「数理シグナル」学術領域の創出
    • Place of Presentation
      東京大学医科学研究所附属病院棟8階 大会議室
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 大規模翻訳後修飾情報に基づくインタラクトーム解析2017

    • Author(s)
      尾山 大明
    • Organizer
      新学術領域「数理シグナル」 第一回公開シンポジウム「数理シグナル」学術領域の創出
    • Place of Presentation
      東京大学医科学研究所白金ホール
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膠芽腫幹細胞情報伝達系の数理システム解析2017

    • Author(s)
      秦 裕子
    • Organizer
      新学術領域「数理シグナル」 第一回公開シンポジウム「数理シグナル」学術領域の創出
    • Place of Presentation
      東京大学医科学研究所白金ホール
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高深度定量リン酸化プロテオミクスと大規模インタラクトーム情報を基盤とする膠芽腫幹細胞情報伝達系の統合ネットワーク解析2016

    • Author(s)
      秦 裕子、成島 悠太、廣木 朋子、那須 亮、津本 浩平、井上 純一郎、秋山 徹、尾山 大明
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Phosphoproteomics-based Network Analysis of Cancer Cell Signaling Regulation2016

    • Author(s)
      Masaaki Oyama
    • Organizer
      The 8th Asia Oceania Human Proteome Organization (AOHUPO) Congress
    • Place of Presentation
      Fleur De Chine Hotel, Sun Moon Lake, Taiwan
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] in silico創薬におけるスクリーニングの高速化・高精度化技術2018

    • Author(s)
      尾山 大明、秦 裕子
    • Total Pages
      540
    • Publisher
      技術情報協会
    • ISBN
      9784861046889
    • Related Report
      2017 Annual Research Report
  • [Book] Applications of RNA-Seq and Omics Strategies - From Microorganisms to Human Health2017

    • Author(s)
      Hiroko Kozuka‐Hata and Masaaki Oyama
    • Total Pages
      318
    • Publisher
      IntechOpen
    • ISBN
      9789535135043
    • Related Report
      2017 Annual Research Report
  • [Book] 実験医学増刊 生命科学で使える はじめての数理モデルとシミュレーション2017

    • Author(s)
      尾山 大明、秦 裕子
    • Total Pages
      239
    • Publisher
      羊土社
    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京大学医科学研究所附属疾患プロテオミクスラボラトリー

    • URL

      https://www.ims.u-tokyo.ac.jp/mpl/top.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 東京大学大学院新領域創成科学研究科メディカル情報生命専攻疾患蛋白質工学分野

    • URL

      http://www.cbms.k.u-tokyo.ac.jp/lab/oyama.html

    • Related Report
      2020 Annual Research Report

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Published: 2016-07-04   Modified: 2022-01-27  

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