Brain information dynamics

• Project Area: Brain information dynamics underlying multi-area interconnectivity and parallel processing
• Project/Area Number: 17H06309
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: The University of Tokyo
• Principal Investigator: MATSUZAKI Masanori 東京大学, 大学院医学系研究科(医学部), 教授 (50353438)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥132,470,000 (Direct Cost: ¥101,900,000、Indirect Cost: ¥30,570,000); Fiscal Year 2021: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000); Fiscal Year 2020: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000); Fiscal Year 2019: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000); Fiscal Year 2018: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000); Fiscal Year 2017: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
• Keywords: ２光子イメージング / 運動野 / 大脳基底核 / 小脳 / マウス / 情報交換 / 感覚連動 / 2光子イメージング / 感覚運動 / 情報変換 / ２光子カルシウムイメージ / 視床 / ２光子カルシウムイメージング

Outline of Final Research Achievements

We used two-photon calcium imaging to measure the activity of thalamocortical axons projecting to layers 1 and 3 in the mouse primary motor cortex (M1). Two types of signals transmitted from the thalamus to M1 became stronger and showed different temporal changes (dynamics) from each other while the mice learned a forelimb lever-pull task. The cerebellum-originated signal was transmitted to layer 3 and was associated with "success rate in the motor task". The basal ganglia-originated signal was transmitted to layer 1 and was associated with "motor kinetics and stability,". We also clarified the pattern of transmission of contextual information from the higher motor cortex to M1 during this task.

Academic Significance and Societal Importance of the Research Achievements

本研究は、脳全体の理解に不可欠な脳領域間ネットワークの視点から運動学習や運動制御のメカニズムの一端を明らかにしたという点で非常に重要であり、パーキンソン病やジストニアなどの運動失調・運動障害疾患の病態理解に将来的に貢献することが期待される。

Research Products

• [Journal Article] Neuronal representations of reward-predicting cues and outcome history with movement in the frontal cortex (2021)
  • Author(s): Kondo Masashi、Matsuzaki Masanori
  • Journal Title: Cell Reports Volume: 34 Issue: 5 Pages: 108704-108704
  • DOI: 10.1016/j.celrep.2021.108704
  • Peer Reviewed / Open Access
• [Journal Article] Non-action Learning: Saving Action-Associated Cost Serves as a Covert Reward (2020)
  • Author(s): Tanimoto Sai、Kondo Masashi、Morita Kenji、Yoshida Eriko、Matsuzaki Masanori
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 14
  • DOI: 10.3389/fnbeh.2020.00141
  • Peer Reviewed / Open Access
• [Journal Article] Structural dynamics and stability of corticocortical and thalamocortical axon terminals during motor learning (2020)
  • Author(s): Hasegawa Ryota、Ebina Teppei、Tanaka Yasuhiro R.、Kobayashi Kenta、Matsuzaki Masanori
  • Journal Title: PLOS ONE Volume: 15 Issue: 6 Pages: e0234930-e0234930
  • DOI: 10.1371/journal.pone.0234930
  • Peer Reviewed / Open Access
• [Journal Article] Arm movements induced by noninvasive optogenetic stimulation of the motor cortex in the common marmoset (2019)
  • Author(s): Ebina Teppei、Obara Keitaro、Watakabe Akiya、Masamizu Yoshito、Terada Shin-Ichiro、Matoba Ryota、Takaji Masafumi、Hatanaka Nobuhiko、Nambu Atsushi、Mizukami Hiroaki、Yamamori Tetsuo、Matsuzaki Masanori
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 116 Issue: 45 Pages: 22844-22850
  • DOI: 10.1073/pnas.1903445116
  • Peer Reviewed / Open Access
• [Journal Article] Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity (2019)
  • Author(s): Kato Daisuke、Wake Hiroaki、Lee Philip R.、Tachibana Yoshihisa、Ono Riho、Sugio Shouta、Tsuji Yukio、Tanaka Yasuyo H.、Tanaka Yasuhiro R.、Masamizu Yoshito、Hira Riichiro、Moorhouse Andrew J.、Tamamaki Nobuaki、Ikenaka Kazuhiro、Matsukawa Noriyuki、Fields R. Douglas、Nabekura Junichi、Matsuzaki Masanori
  • Journal Title: Glia Volume: 68 Issue: 1 Pages: 193-210
  • DOI: 10.1002/glia.23713
  • NAID: 120006775953
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Super-wide-field two-photon imaging with a micro-optical device moving in post-objective space (2018)
  • Author(s): Terada SI, Kobayashi K, Ohkura M, Nakai J, Matsuzaki M
  • Journal Title: Nat Commun Volume: 9 Issue: 1 Pages: 3550-3550
  • DOI: 10.1038/s41467-018-06058-8
  • Peer Reviewed / Open Access
• [Journal Article] Thalamocortical Axonal Activity in Motor Cortex Exhibits Layer-Specific Dynamics during Motor Learning (2018)
  • Author(s): Tanaka Yasuyo H.、Tanaka Yasuhiro R.、Kondo Masashi、Terada Shin-Ichiro、Kawaguchi Yasuo、Matsuzaki Masanori
  • Journal Title: Neuron Volume: 100 Issue: 1 Pages: 244-258
  • DOI: 10.1016/j.neuron.2018.08.016
  • NAID: 40021939701
  • Peer Reviewed / Open Access
• [Journal Article] In vivo wide-field calcium imaging of mouse thalamocortical synapses with an 8?K ultra-high-definition camera (2018)
  • Author(s): Yoshida Eriko、Terada Shin-Ichiro、Tanaka Yasuyo H.、Kobayashi Kenta、Ohkura Masamichi、Nakai Junichi、Matsuzaki Masanori
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 8324-8324
  • DOI: 10.1038/s41598-018-26566-3
  • Peer Reviewed / Open Access
• [Journal Article] Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks (2018)
  • Author(s): Ebina T, Masamizu Y, Tanaka YR, Watakabe A, Hirakawa R, Hirayama Y, Hira R, Terada S, Koketsu D, Hikosaka K, Mizukami H, Nambu A, Sasaki E, Yamamori Y, Matsuzaki M
  • Journal Title: Nat Commun Volume: 9 Issue: 1 Pages: 1879-1879
  • DOI: 10.1038/s41467-018-04286-6
  • Peer Reviewed / Open Access
• [Journal Article] Two-photon calcium imaging of the medial prefrontal cortex and hippocampus without cortical invasion. (2017)
  • Author(s): Kondo M, Kobayashi K, Ohkura M, Nakai J, Matsuzaki M
  • Journal Title: eLife Volume: 6:e26839 Pages: 1-20
  • DOI: 10.7554/elife.26839
  • Peer Reviewed / Open Access
• [Presentation] 自動インジェクションロボットの開発による＞10,000細胞広域カルシウムイメージング (2021)
  • Author(s): 野村 晋ノ介
  • Organizer: 第44回日本神経科学大会
• [Presentation] 運動学習過程における皮質間・視床皮質間投射軸索終末構造のダイナミクスと安定化 (2020)
  • Author(s): 長谷川 亮太
  • Organizer: 第43回日本神経科学大会
• [Presentation] Frontal cortical activity with long-range input (2019)
  • Author(s): 松崎政紀
  • Organizer: SfN2019
  • Int'l Joint Research
• [Presentation] Motor information flow between the mouse motor cortices (2019)
  • Author(s): 松崎政紀
  • Organizer: 第42回日本分子生物学会年会
  • Invited
• [Presentation] Wide-field imaging of neural activity with high spatial resolution. (2019)
  • Author(s): 松崎政紀
  • Organizer: FAOPS2019
  • Int'l Joint Research
• [Presentation] マウス前頭皮質の深部・広域２光子イメージング (2018)
  • Author(s): 松崎政紀
  • Organizer: 第41回日本神経科学大会
• [Presentation] マーモセット上肢運動課題実行中の ２光子イメージングに向けて (2018)
  • Author(s): 松崎政紀
  • Organizer: 7th Annual Meeting of Japan Society for Marmoset Research
• [Presentation] Dynamics of thalamocortical activity in the primary motor cortex during motor learning (2017)
  • Author(s): 松崎政紀
  • Organizer: 第４０回日本神経科学大会
• [Presentation] Wide, deep, multi-color, subcellular-resolution imaging from any angle (2017)
  • Author(s): 松崎政紀
  • Organizer: 第４０回日本神経科学大会
• [Presentation] 行動課題実行中の小動物における大脳神経 細胞活動の広域深部２光子イメージング (2017)
  • Author(s): 松崎政紀
  • Organizer: 第44回日本神経内分泌学会学術集会
  • Invited
• [Presentation] Marmoset forelimb-movement tasks for two-photon Ca2+ imaging (2017)
  • Author(s): 松崎政紀
  • Organizer: 7th NIPS/CIN Joint Symposium
  • Int'l Joint Research
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~Matsuzaki-Lab/pub/index.html