| Budget Amount *help |
¥178,880,000 (Direct Cost: ¥137,600,000、Indirect Cost: ¥41,280,000)
Fiscal Year 2021: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2020: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2019: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2018: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2017: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
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| Outline of Final Research Achievements |
We studied the molecular mechanisms through which highly diverse populations of cells are generated from single cells, mainly focusing on cancer cells. We identified the transcription factor PRRX1 and a TNF receptor superfamily protein as molecules involved in differentiation of glioblastoma initiating cells and studied their functions. We also investigated the mechanisms involved in malignant transformation of pancreatic and renal cancers by serial orthotopic transplantation of cancer cells into mice. In renal cell carcinoma, we found that lung metastasis is accelerated by the neutrophil-mediated aggravation of inflammation in tumor tissues. We further studied the mechanism of differentiation of non-cancer cells, such as mouse ES cells. In addition, we established a method for three-dimensional visualization of blood and lymphatic vessels and cancer cells by using tissue clearing technology, studied interactions of these cells, and introduced mathematical analysis in the system.
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