| Co-Investigator(Kenkyū-buntansha) |
高木 聡 公益財団法人がん研究会, がん化学療法センター 基礎研究部, 研究員 (20582240)
田崎 創平 北海道大学, 理学研究院, 准教授 (50713020)
竹本 愛 公益財団法人がん研究会, がん化学療法センター 基礎研究部, 研究員 (20706494)
片山 量平 公益財団法人がん研究会, がん化学療法センター 基礎研究部, 部長 (60435542)
|
|---|
| Budget Amount *help |
¥308,620,000 (Direct Cost: ¥237,400,000、Indirect Cost: ¥71,220,000)
Fiscal Year 2021: ¥58,500,000 (Direct Cost: ¥45,000,000、Indirect Cost: ¥13,500,000)
Fiscal Year 2020: ¥58,500,000 (Direct Cost: ¥45,000,000、Indirect Cost: ¥13,500,000)
Fiscal Year 2019: ¥58,500,000 (Direct Cost: ¥45,000,000、Indirect Cost: ¥13,500,000)
Fiscal Year 2018: ¥58,500,000 (Direct Cost: ¥45,000,000、Indirect Cost: ¥13,500,000)
Fiscal Year 2017: ¥74,620,000 (Direct Cost: ¥57,400,000、Indirect Cost: ¥17,220,000)
|
|---|
| Outline of Final Research Achievements |
In this research project, we aimed to analyze the molecular mechanisms of heterogenous multicellular interaction and organ maintenance, and to develop new molecular-targeting drugs for diseases caused by abnormal cellular interactions. In osteosarcoma, we discovered that interaction with platelets promotes its tumor growth and metastasis, and found a drug to overcome it. From single-cell analysis of patient-derived lung tumors harboring treatment-resistant phenotype, we revealed the existence of drug-resistant persister cells in the therapeutic drug-treated tumors. We also found new resistance mechanisms against cancer immunotherapy. In the system of angiogenesis, we constructed a mathematical model that can simultaneously analyze cell-level phenomena and macrovascular network formation from a mathematical model of the vascular endothelial cell motion and the phase fields of surrounding microenvironment and vascular morphology.
|
