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Analysis of the molecular mechanism for formation and breakdown of biotissues by mathematical modeling

Planned Research

Project AreaIntegrated analysis and regulation of cellular diversity
Project/Area Number 17H06329
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionTokyo Institute of Technology (2020-2022)
Kanagawa Cancer Center Research Institute (2017-2019)

Principal Investigator

Koshikawa Naohiko  東京工業大学, 生命理工学院, 教授 (70334282)

Co-Investigator(Kenkyū-buntansha) 石渡 通徳  大阪大学, 大学院基礎工学研究科, 教授 (30350458)
中村 直俊  名古屋大学, 理学研究科, 特任准教授 (30554472)
星野 大輔  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 部長代理 (30571434)
朝倉 暢彦  大阪大学, 数理・データ科学教育研究センター, 特任准教授(常勤) (70308584)
室井 敦  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 技師・研究員 (60609402)
板野 景子  大阪大学, データビリティフロンティア機構, 特任研究員(常勤) (00608416)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥178,880,000 (Direct Cost: ¥137,600,000、Indirect Cost: ¥41,280,000)
Fiscal Year 2021: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2020: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2019: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2018: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2017: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Keywords肝細胞がん / 幹細胞性 / 細胞シグナル / 逆相タンパク質アレイ(RPPA) / 数理モデル / 数理シミュレーション / 悪性化進展 / 生物統計 / 肝がん幹細胞 / 上皮間葉転換 / 肝がん / 悪性化進展シグナル / 受容体チロシンキナーゼ / EMT / 上皮組織 / 数理モデル、シミュレーション / 層化解析 / 上皮間葉転換(EMT) / シミュレーション / RPPA / チロシンキナーゼ受容体 / がん / プロテオミクス / 逆相タンパク質アレイ / 数理モデル、 / 層別化解析 / 混合正規分布 / 上皮細胞 / 数理腫瘍学 / 逆走蛋白質アレイ / 上皮間葉移行(EMT) / 間葉上皮移行(MET) / 逆相蛋白質アレイ(RPPA) / 多次元時系列データ / 時系列画像データ / 生体組織の構築と破綻 / 細胞・組織 / プロテオーム / 発生・分化 / 癌 / 生体機能利用
Outline of Final Research Achievements

In this study, we visualized complex cellular signaling regulations such as feedback and crosstalk which were difficult to visualize with the existing simple mathematical model, by simulation using a highly accurate mathematical model, and found key pathways and molecules to acquire the malignant progression of hepatocellular carcinoma (HCC).
Furthermore, we performed RPPA analysis of the cellular signals using HCC tissues and blockade experiments on this pathway by tumor-bearing mice.
Based on this, we discovered that the key pathway that determines the malignant transformation of HCC is a new method for the diagnosis and treatment of HCC. In addition to the basic biological study, the applicability of the RPPA analysis technique to the clinical diagnosis of lymphoma was verified, and we found that the diagnostic accuracy of lymphoma by RPPA analysis was equal to or better than that of the present technique with immunohistostaining.

Academic Significance and Societal Importance of the Research Achievements

このウエット実験での弱点を本領域研究の発足により取り入れた逆相蛋白質アレイ(RPPA)解析は細胞から組織中の蛋白質の発現やリン酸化を含む翻訳後修飾を定量化することが可能となり、多様な細胞シグナル経路の活性化、蛋白質発現などを簡便に高度に定量化する技術の国内最初の確立は生物学と数理科学の融合に大きなインパクトとなった。また、RPPA解析技術は数理科学への情報提供だけでなく、多様な生命科学研究領域に蛋白質の発現や翻訳後修飾の微量定量化情報を提供することでこれら研究領域の新たな発見に繋がるインパクトを与えることが出来た。

Report

(6 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (72 results)

All 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (6 results) Journal Article (25 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 24 results,  Open Access: 22 results) Presentation (34 results) (of which Int'l Joint Research: 5 results,  Invited: 16 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] バンダービルト大学(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Vanderbilt Univ(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] “S. De Bellis” Research Hospital(イタリア)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Vanderbilt University(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Vanderbilt University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Vanderbilt University Medical School(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Chronological change in EPHA2 protein expression Is associated with recurrence of bladder cancer.2022

    • Author(s)
      Koizumi M, Sato S, Yoshihara M, Nakamura Y, Terao H, Okubo Y, Washimi K, Yoshioka E, Yokose T, Kishida T, Koshikawa N, Miyagi Y.
    • Journal Title

      Anticancer Research

      Volume: 12 Pages: 5783-5794

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteolytic cleavage of membrane proteins by <scp>membrane type‐1 MMP</scp> regulates cancer malignant progression2022

    • Author(s)
      Ikeda Kazuki、Kaneko Ryo、Tsukamoto Eiki、Funahashi Nobuaki、Koshikawa Naohiko
    • Journal Title

      Cancer Science

      Volume: 114 Issue: 2 Pages: 348-356

    • DOI

      10.1111/cas.15638

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel LAMC2 fusion protein has tumor‐promoting properties in ovarian carcinoma2021

    • Author(s)
      Daisuke Hoshino、Kato Hisamori、Fukumura Kazuhiro、Mayeda Akila、Miyagi Yohei、Seiki Motoharu、Koshikawa Naohiko
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 12 Pages: 4957-4967

    • DOI

      10.1111/cas.15149

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum laminin γ2 monomer as a novel diagnostic and predictive biomarker for hepatocellular carcinoma.2021

    • Author(s)
      T Yamashita, N Koshikawa, T Shimakami, T Terashima, M Nakagawa, K Nio, R Horii, N Iida, K Kawaguchi, K Arai, Y Sakai, T Yamashita, E Mizukoshi, M Honda, A Kitao, S Kobayashi, S Takahara, Y Imai, K Yoshimura, T Murayama, Y Nakamoto, E Yoshida, T Yoshimura, M Seiki, S Kaneko.
    • Journal Title

      Hepatology

      Volume: - Issue: 2 Pages: 760-775

    • DOI

      10.1002/hep.31758

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of Cancer Stem Cell Markers EpCAM and CD90 Is Correlated with Anti- and Pro-Oncogenic EphA2 Signaling in Hepatocellular Carcinoma2021

    • Author(s)
      Asakura Nobuhiko、Nakamura Naotoshi、Muroi Atsushi、Nojima Yosui、Yamashita Taro、Kaneko Shuichi、Ikeda Kazuki、Koshikawa Naohiko、Suzuki Takashi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 16 Pages: 8652-8652

    • DOI

      10.3390/ijms22168652

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 肝細胞がんのシグナル伝達と生物統計による層別化2021

    • Author(s)
      朝倉暢彦、室井 敦、越川直彦、鈴木 貴
    • Journal Title

      Precision medicine

      Volume: 13 Pages: 1224-1230

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Membrane type 1 matrix metalloproteinase regulates anaplastic thyroid carcinoma cell growth and invasion into the collagen matrix2020

    • Author(s)
      Yoshida Tatsuya、Suganuma Nobuyasu、Sato Shinya、Toda Soji、Nakayama Hirotaka、Masudo Katsuhiko、Okubo Yoichiro、Hayashi Hiroyuki、Yokose Tomoyuki、Koshikawa Naohiko、Rino Yasushi、Iwasaki Hiroyuki、Miyagi Yohei、Masuda Munetaka、Hoshino Daisuke
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 529 Issue: 4 Pages: 1195-1200

    • DOI

      10.1016/j.bbrc.2020.06.043

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] NH2‐terminal fragment of ZF21 protein suppresses tumor invasion via inhibiting the interaction of ZF21 with FAK2020

    • Author(s)
      Makoto Nagano, Daisuke Hoshino, Jiro Toshima, Motoharu Seiki, Naohiko Koshikawa
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 12 Pages: 4393-4404

    • DOI

      10.1111/cas.14665

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient2020

    • Author(s)
      Osumi Hiroki、Muroi Atsushi、Sakahara Mizuho、Kawachi Hiroshi、Okamoto Takuya、Natsume Yasuko、Yamanaka Hitomi、Takano Hiroshi、Kusama Daisuke、Shinozaki Eiji、Ooki Akira、Yamaguchi Kensei、Ueno Masashi、Takeuchi Kengo、Noda Tetsuo、Nagayama Satoshi、Koshikawa Naohiko、Yao Ryoji
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 17455-17455

    • DOI

      10.1038/s41598-020-74530-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts2020

    • Author(s)
      Sato A, Kakinuma S, Miyoshi M, Kamiya A, Tsunoda T, Kaneko S, Tsuchiya J, Shimizu T, Takeichi E, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Koshikawa N, Seiki S, Nakauchi H, Asahina Y, Watanabe M.
    • Journal Title

      Hepatology Communications

      Volume: 4 Issue: 2 Pages: 235-254

    • DOI

      10.1002/hep4.1459

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effectiveness of dispatcher instructions-dependent or independent bystander cardiopulmonary resuscitation on neurological survival among patients with out-of-hospital cardiac arrest2020

    • Author(s)
      Hatakeyama Toshihiro、Kiguchi Takeyuki、Kobayashi Daisuke、Nakamura Naotoshi、Nishiyama Chika、Hayashida Sumito、Kiyohara Kosuke、Kitamura Tetsuhisa、Kawamura Takashi、Iwami Taku
    • Journal Title

      Journal of Cardiology

      Volume: 75 Issue: 3 Pages: 315-322

    • DOI

      10.1016/j.jjcc.2019.08.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extension of Sinkhorn Method: Optimal Movement Estimation of Agents Moving at Constant Velocity2019

    • Author(s)
      Okada Daigo、Nakamura Naotoshi、Wada Takuya、Iwasaki Ayako、Yamada Ryo
    • Journal Title

      Transactions of the Japanese Society for Artificial Intelligence

      Volume: 34 Issue: 5 Pages: D-J13_1-7

    • DOI

      10.1527/tjsai.D-J13

    • NAID

      130007700234

    • ISSN
      1346-0714, 1346-8030
    • Year and Date
      2019-09-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unique Biological Activity and Potential Role of Monomeric Laminin-γ2 as a Novel Biomarker for Hepatocellular Carcinoma: A Review2019

    • Author(s)
      Yasuda Hiroshi、Nakagawa Masatoshi、Kiyokawa Hirofumi、Yoshida Eisaku、Yoshimura Toru、Koshikawa Naohiko、Itoh Fumio、Seiki Motoharu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 1 Pages: 226-226

    • DOI

      10.3390/ijms20010226

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Utility of a reverse phase protein array to evaluate multiple biomarkers in diffuse large B‐cell lymphoma2019

    • Author(s)
      Suzuki M、Muroi A、Nojima M、Numata A、Takasaki H、Sakai R、Yokose T、Miyagi Y、Koshikawa N.
    • Journal Title

      Proteomics Clinical Applications

      Volume: 14 Issue: 1 Pages: 1900091-1900091

    • DOI

      10.1002/prca.201900091

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ease of hand rotation during active exploration of views of a 3-D object modulates view generalization2019

    • Author(s)
      Sasaoka Takafumi、Asakura Nobuhiko、Inui Toshio
    • Journal Title

      Experimental Brain Research

      Volume: 237 Issue: 4 Pages: 939-951

    • DOI

      10.1007/s00221-019-05474-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal Sensorimotor Integration in Adults Who Stutter: A Behavioral Study by Adaptation of Delayed Auditory Feedback2019

    • Author(s)
      Iimura Daichi、Asakura Nobuhiko、Sasaoka Takafumi、Inui Toshio
    • Journal Title

      Frontiers in Psychology

      Volume: 10 Pages: 2440-2440

    • DOI

      10.3389/fpsyg.2019.02440

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LAVENDER: latent axes discovery from multiple cytometry samples with non-parametric divergence estimation and multidimensional scaling reconstruction2019

    • Author(s)
      Nakamura Naotoshi、Okada Daigo、Setoh Kazuya、Kawaguchi Takahisa、Higasa Koichiro、Tabara Yasuharu、Matsuda Fumihiko、Yamada Ryo
    • Journal Title

      bioRxiv

      Volume: 1 Pages: 673434-673434

    • DOI

      10.1101/673434

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] On the maximizing problem associated with Sobolev type embeddings under inhomogeneous constraints2018

    • Author(s)
      Michinori Ishiwata, Hidemitsu Wadade
    • Journal Title

      Applicable Analysis (in press)

      Volume: in press Issue: 10 Pages: 1-19

    • DOI

      10.1080/00036811.2018.1491971

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Existence and non-existence of maximizers for the Moser-Trudinger type inequalities under inhomogeneous constraints2018

    • Author(s)
      Norihisa Ikoma, Michinori Ishiwata, Hidemitsu Wadade
    • Journal Title

      Mathematische Annalen (in press)

      Volume: in press Issue: 1-2 Pages: 831-851

    • DOI

      10.1007/s00208-018-1709-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Proteolytic Cleavage Sites of EphA2 by Membrane Type 1 Matrix Metalloproteinase on the Surface of Cancer Cells2018

    • Author(s)
      Kikuchi K, Kozuka-Hata H, Oyama M, Seiki M, Koshikawa N
    • Journal Title

      Methods Mol Biol

      Volume: 1731 Pages: 29-37

    • DOI

      10.1007/978-1-4939-7595-2_3

    • ISBN
      9781493975945, 9781493975952
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activated EphA2 processing by MT1-MMP is involved in malignant transformation of ovarian tumours in vivo2018

    • Author(s)
      Takahashi Y, Hamasaki M, Aoki M, Koga K, Koshikawa N, Miyamoto S, Nabeshima K.
    • Journal Title

      Anticancer Res

      Volume: 38 Issue: 7 Pages: 4257-4266

    • DOI

      10.21873/anticanres.12722

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study on the tumor-induced angiogenesis using mathematical models2017

    • Author(s)
      Suzuki Takashi、Minerva Dhisa、Nishiyama Koichi、Koshikawa Naohiko、Chaplain Mark Andrew Joseph
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 1 Pages: 15-23

    • DOI

      10.1111/cas.13395

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum monomeric laminin-γ2 as a novel biomarker for hepatocellular carcinoma.2017

    • Author(s)
      Kiyokawa H, Yasuda H, Oikawa R, Okuse C, Matsumoto N, Ikeda H, Watanabe T, Yamamoto H, Itoh F, Otsubo T, Yoshimura T, Yoshida E, Nakagawa M, Koshikawa N, Seiki M.
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 7 Pages: 1432-1439

    • DOI

      10.1111/cas.13261

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a fully automated chemiluminescence immunoassay for urine monomeric laminin-γ2 as a promising diagnostic tool of non-muscle invasive bladder cancer2017

    • Author(s)
      Nakagawa Masatoshi、Karashima Takashi、Kamada Masayuki、Yoshida Eisaku、Yoshimura Toru、Nojima Masanori、Inoue Keiji、Shuin Taro、Seiki Motoharu、Koshikawa Naohiko
    • Journal Title

      Biomark Res.

      Volume: 5 Issue: 1 Pages: 1-9

    • DOI

      10.1186/s40364-017-0109-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Specific detection of soluble EphA2 fragments in blood as a new biomarker for pancreatic cancer2017

    • Author(s)
      Koshikawa Naohiko、Minegishi Tomoko、Kiyokawa Hirofumi、Seiki Motoharu
    • Journal Title

      Cell Death Dis

      Volume: 8 Issue: 10 Pages: e3134-e3134

    • DOI

      10.1038/cddis.2017.545

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ラミニンγ2単鎖をバイオマーカーとした肝発がん、遠隔転移の予測を可能とする新たな診断法の構築2022

    • Author(s)
      越川直彦
    • Organizer
      第72回日本電気泳動学会シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] EphA2-EGFRシグナルのAKTへの収斂により制御される肝細胞がんの転移能2022

    • Author(s)
      中村直俊、朝倉暢彦、池田一貴、野島陽水、鈴木貴、越川直彦
    • Organizer
      第81回日本癌学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Identification of LAMC2-fusion gene as an oncoprotein produced by chromosomal translocation2022

    • Author(s)
      Naohiko Koshikawa, Daisuke Hoshino, Yohei Miyagi
    • Organizer
      第81回日本癌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ラミニンγ2単鎖により誘導される肝発がんの新規分子メカニズム2022

    • Author(s)
      舟橋伸昭、岡田光、山下太郎、清木元治、金子周一、越川直彦
    • Organizer
      第81回日本癌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 肝発がんにおける胆管上皮細胞由来ラミニンγ2単鎖が肝細胞の機能に及ぼす影響2022

    • Author(s)
      舟橋伸昭、越川直彦
    • Organizer
      第31回 日本がん転移学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新規ラミニンγ2融合遺伝子による悪性化進展の分子機序の解明2022

    • Author(s)
      越川直彦、宮城洋平
    • Organizer
      第26回 日本がん分子標的治療学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新たな肝細胞がんを予測する新たなバイオマーカーとしての血清ラミニンγ2モノマー2021

    • Author(s)
      越川直彦、山下太郎、中川将利、吉田栄作、吉村徹、金子周一、清木元治
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 肝発がんにおけるLn-γ2mの機能解析2021

    • Author(s)
      舟橋伸昭、岡田光、山下太郎、金子周一、清木元治、越川直彦
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] EphA2およびEGFRを介した肝細胞がん進展の数理モデリング2021

    • Author(s)
      中村直俊、室井敦、朝倉暢彦、野島陽水、榎本将士、鈴木貴、越川直彦
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] がん幹細胞マーカーによる肝細胞がんの分類とEphA2シグナル伝達2021

    • Author(s)
      朝倉暢彦、室井敦、中村直俊、野島陽水、越川直彦、鈴木貴
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ラミニンγ2単鎖が肝発がんに及ぼす新たな機能の解析2021

    • Author(s)
      舟橋伸昭、越川直彦
    • Organizer
      第30回日本がん転移学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Biostatistical analysis for malignant signaling pathways of hepatocellular carcinoma.2020

    • Author(s)
      Koshikawa, N, Muroi A, Asakura N, Enomoto M, Ishiwata M, Suzuki T
    • Organizer
      5th Core to Core Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞表層でのプロテオリシスよるがん悪性化進展制御の解明とその産物の臨床応用2020

    • Author(s)
      越川直彦
    • Organizer
      横浜市大院・医学研究科大学院セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] On the profile decomposition of a volume functional2020

    • Author(s)
      Michinori Ishiwata
    • Organizer
      Variational analysis of critical problems on nonlinear partial differantial equation
    • Related Report
      2019 Annual Research Report
  • [Presentation] 数理モデルを用いたがんの悪性化進展制御の解明、第92回 日本生化学会大会2019

    • Author(s)
      室井敦、榎本将士、森達樹、石渡道徳、星野大輔、鈴木貴、越川直彦
    • Organizer
      第92回 日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 数理モデルと逆相蛋白質アレイデータによる肝細胞がん悪性化シグナル経路の解析2019

    • Author(s)
      鈴木貴、榎本将士、朝倉暢彦、室井敦、越川直彦
    • Organizer
      第92回 日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 逆相蛋白質アレイおよび数理モデルを用いた肝細胞がん悪性化制御シグナルの解析2019

    • Author(s)
      室井敦、榎本将士、朝倉暢彦、森達樹、星野大輔、石渡道徳、鈴木貴、越川直彦
    • Organizer
      第19回日本蛋白質化学学会年会、第71回日本細胞生物学会大会 合同年次大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] An application of the profile-decomposition method to parabolic problems2019

    • Author(s)
      石渡 通徳
    • Organizer
      第 699 回「応用解析」研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 距離に基づく細胞間不均一性の解析2019

    • Author(s)
      中村直俊
    • Organizer
      第11回光塾
    • Related Report
      2019 Annual Research Report
  • [Presentation] EphA2とEGFRを介した肝細胞がん悪性化シグナルの数理モデル2019

    • Author(s)
      中村直俊
    • Organizer
      新学術領域・数理シグナル・若手ワークショップ
    • Related Report
      2019 Annual Research Report
  • [Presentation] 実空間や情報空間の『形』を観る方法の開発2019

    • Author(s)
      中村直俊
    • Organizer
      日本応用数理学会研究部会連合会発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] びまん性大細胞B細胞性リンパ腫における新規診断補助ツールとしての逆相蛋白質アレイの有用性について2019

    • Author(s)
      鈴木理樹、室井敦、野島寛、酒井リカ、横瀬智之、宮城洋平、越川直彦
    • Organizer
      第78回日本癌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞表層でのプロテオリシスよるがん悪性化進展制御の解明とその産物の臨床応用2019

    • Author(s)
      越川直彦
    • Organizer
      宮崎大学大学院特別セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Membrane type-1 matrix metalloproteinase (MT1-MMP) によるがん悪性化進展制御の解明とがん臨床への応用2019

    • Author(s)
      越川直彦
    • Organizer
      第854回千葉県がんセンター研究所 集演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Mathematical modeling for EphA2 and EGF-receptor and their downstream signal pathways involved in malignant progression of hepatocellular carcinoma2019

    • Author(s)
      Koshikawa, N
    • Organizer
      4th Core to Core Meeting at Inria, Bordeaux, France
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] MT1-MMPによるEphA2の限定分解(プロセシング)を介したがん悪性化進展制御の分子機序の解明2018

    • Author(s)
      越川直彦
    • Organizer
      第50回 日本結合組織学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 悪性がんのバイオマーカーとしてのラミニンγ2単鎖2018

    • Author(s)
      越川直彦
    • Organizer
      第27回日本がん転移学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Bounds of Sobolev norm for solutions of semiline ar parabolic equations with critical Sobolev exponent2018

    • Author(s)
      Michinori Ishiwata
    • Organizer
      UK-Japan Workshop on Analysis of Nonlinear Partial Differential Equations
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sobolev embedding involving variable exponent2018

    • Author(s)
      Michinori Ishiwata
    • Organizer
      The 12th AIMS Conference on Dynamical Systems, Differential Equations and Applications
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 膜型MMP1(MT1-MMP)とその周辺分子を標的としたがん治療・診断の新戦略2018

    • Author(s)
      越川直彦
    • Organizer
      藤田保健衛生大学 医学セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Analysis of MT1-MMP-mediated signaling network in vivo using reverse phase protein assay (RPPA) and mathematical modeling2017

    • Author(s)
      Koshikawa N
    • Organizer
      2nd Core to Core Meeting at Vanderbilt University
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エクソソームは細胞膜突起構造を増強し、浸潤活性を惹起する2017

    • Author(s)
      星野大輔、清木元治、越川直彦
    • Organizer
      第76回日本癌学会学術総会 シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] EphA2プロテオリシスによるがん悪性化シグナル制御の解明2017

    • Author(s)
      越川直彦、清木元治
    • Organizer
      第21回日本がん分子標的治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新たな肝細胞がんの早期診断法の開発2017

    • Author(s)
      越川直彦
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] 膜タンパク質工学ハンドブック2020

    • Author(s)
      室井 敦、星野大輔、清木元治、越川直彦
    • Total Pages
      7
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2020 Annual Research Report
  • [Book] 膜タンパク質工学ハンドブック2020

    • Author(s)
      津本浩平、浜窪隆雄
    • Total Pages
      624
    • Publisher
      NTS Inc
    • Related Report
      2019 Annual Research Report
  • [Book] がん生物学イラストレイテッド 第2版2019

    • Author(s)
      渋谷 正史:湯浅 保仁
    • Total Pages
      504
    • Publisher
      羊土社
    • ISBN
      9784758120968
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 東京工業大学生命理工学院 越川研究室

    • URL

      http://koshikawalab.bio.titech.ac.jp

    • Related Report
      2020 Annual Research Report
  • [Remarks] 神奈川県立がんセンター臨床研究所 がん生物学部 ホームページ

    • URL

      http://kcch.kanagawa-pho.jp/kccri/organization/seibutsu.html

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] EphA2 N末端フラグメント抗体2018

    • Inventor(s)
      越川直彦、清木元治
    • Industrial Property Rights Holder
      東京大学、神奈川県立病院機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-534429
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] 4th Core to Core Meeting at Inria, Bordeaux, France2019

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-07-04   Modified: 2024-01-30  

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