| Budget Amount *help |
¥62,790,000 (Direct Cost: ¥48,300,000、Indirect Cost: ¥14,490,000)
Fiscal Year 2021: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2020: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2019: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2018: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2017: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Outline of Final Research Achievements |
In organs and tissues in vivo, cellular diversity composed of various cell types is essential for maintaining homeostasis and responding to internal and external perturbations. In this study, using the Drosophila midgut as an in vivo model, we aimed to elucidate the mechanisms that maintain cellular diversity originating from stem cells and their physiological roles in the midgut before and after different perturbations such as 1) nutritional changes, 2) tumor transplantation, and 3) aging. We found characteristic cellular responses in the midgut before and after different perturbations: 1) nutritional changes, 2) tumor transplantation, and 3) aging. By combining genetic analysis with single cell analysis and mathematical modeling, we demonstrated that this interdisciplinary approach is effective for investigating mechanisms and functions of cellular diversity.
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