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Establishment of Evolutionary Fluctuation-Response Theory and Extension to Developmental and Mutilevel Evolution

Planned Research

Project AreaEvolutionary theory for constrained and directional diversities
Project/Area Number 17H06386
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

Kaneko Kunihiko  東京大学, 大学院総合文化研究科, 名誉教授 (30177513)

Co-Investigator(Kenkyū-buntansha) 藤本 仰一  大阪大学, 大学院理学研究科, 准教授 (60334306)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥88,270,000 (Direct Cost: ¥67,900,000、Indirect Cost: ¥20,370,000)
Fiscal Year 2021: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2020: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2017: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Keywords頑健性 / 可塑性 / 学習 / 進化 / 次元圧縮 / 表現型進化 / ゆらぎ / 安定性 / 発生進化対応 / 表現型可塑性
Outline of Final Research Achievements

(1)Low-dimensional constraint of phenotypic evolution: Through simulations, we showed that the region in which phenotypes of cells can vary after the evolution is bounded in a low dimension, and theoretically explained its universality.
(2) Hierarchical evolution: We analyzed evolution across the molecular-cellular-individual-ecological hierarchy. Especially when selection pressure is applied in the oppsite direction across the hierarchy, there emerges a symmetry breaking between information-carrying and function-carrying elements, which leads to the origin of genes.
(3) Theory of evolutionary developmental correspondence: We performed evolutionary simulations of developmental processes and showed that modes with slow time scales produce evolutionary developmental response. We also identified cross-species universality in organ geometry and the developmental constraints that give rise to it.

Academic Significance and Societal Importance of the Research Achievements

表現型がどの方向に進化しやすく、また進化に制約がかかっていることが理論的に明らかになり、しかもその制約や方向が進化の起こる以前の状態の揺らぎと相関していることが示された。これは遺伝子の変異がでたらめに起きても表現型の進化は予測できることを含意している。また表現型の少数自由度への制約や階層進化理論で見られた役割分業は従来の揺らぎ応答進化理論を超える枠組みであり、生物進化のみならず人間社会の進化の考え方でも大きな意義を持つ。これらの結果により、今後の進化学に大きな影響を与える包括的な進化理論の道が開かれた。

Report

(6 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (225 results)

All 2023 2022 2021 2020 2019 2018 2017 Other

All Journal Article (60 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 58 results,  Open Access: 50 results,  Acknowledgement Compliant: 1 results) Presentation (162 results) (of which Int'l Joint Research: 53 results,  Invited: 35 results) Book (1 results) Remarks (1 results) Funded Workshop (1 results)

  • [Journal Article] Generic optimization by fast chaotic exploration and slow feedback fixation2023

    • Author(s)
      Matsushita Yuuki、Kaneko Kunihiko
    • Journal Title

      Physical Review Research

      Volume: 5 Issue: 2 Pages: 023017-023017

    • DOI

      10.1103/physrevresearch.5.023017

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Avoidance of error catastrophe via proofreading innate to template-directed polymerization2023

    • Author(s)
      Matsubara Yoshiya J.、Takeuchi Nobuto、Kaneko Kunihiko
    • Journal Title

      Physical Review Research

      Volume: 5 Issue: 1 Pages: 013170-013170

    • DOI

      10.1103/physrevresearch.5.013170

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Autotoxin-mediated latecomer killing in yeast communities2022

    • Author(s)
      Oda Arisa H.、Tamura Miki、Kaneko Kunihiko、Ohta Kunihiro、Hatakeyama Tetsuhiro S.
    • Journal Title

      PLOS Biology

      Volume: 20 Issue: 11 Pages: 3001844-3001844

    • DOI

      10.1371/journal.pbio.3001844

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Statistical Trends of Protein Evolution: A Lesson from AlphaFold Database2022

    • Author(s)
      Tang Qian-Yuan、Ren Weitong、Wang Jun、Kaneko Kunihiko
    • Journal Title

      Molecular Biology and Evolution

      Volume: 39 Issue: 10

    • DOI

      10.1093/molbev/msac197

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Heterosis of fitness and phenotypic variance in the evolution of a diploid gene regulatory network2022

    • Author(s)
      Okubo Kenji、Kaneko Kunihiko
    • Journal Title

      PNAS Nexus

      Volume: 1 Issue: 3

    • DOI

      10.1093/pnasnexus/pgac097

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamical systems theory of cellular reprogramming2022

    • Author(s)
      Matsushita Yuuki、Hatakeyama Tetsuhiro S.、Kaneko Kunihiko
    • Journal Title

      Physical Review Research

      Volume: 4 Issue: 2

    • DOI

      10.1103/physrevresearch.4.l022008

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emergence of kinship structures and descent systems: multi-level evolutionary simulation and empirical data analysis2022

    • Author(s)
      Itao Kenji、Kaneko Kunihiko
    • Journal Title

      Proceedings of the Royal Society B: Biological Sciences

      Volume: 289 Issue: 1969 Pages: 1-10

    • DOI

      10.1098/rspb.2021.2641

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Physical Model to Identify the Common Organ Shape Across Species2022

    • Author(s)
      郷達明,藤原基洋,津川暁,藤本仰一
    • Journal Title

      Seibutsu Butsuri

      Volume: 62 Issue: 1 Pages: 7-12

    • DOI

      10.2142/biophys.62.7

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evolution of phenotypic fluctuation under host-parasite interactions2021

    • Author(s)
      Nishiura Naoto、Kaneko Kunihiko
    • Journal Title

      PLOS Computational Biology

      Volume: 17 Issue: 11 Pages: e1008694-e1008694

    • DOI

      10.1371/journal.pcbi.1008694

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exploitation by asymmetry of information reference in coevolutionary learning in prisoner’s dilemma game2021

    • Author(s)
      Fujimoto Yuma, Kaneko Kunihiko
    • Journal Title

      Journal of Physics: Complexity

      Volume: 2 Issue: 4 Pages: 045007-045007

    • DOI

      10.1088/2632-072x/ac301a

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A scaling law of multilevel evolution: how the balance between within- and among-collective evolution is determined2021

    • Author(s)
      Takeuchi Nobuto、Mitarai Namiko、Kaneko Kunihiko
    • Journal Title

      Genetics

      Volume: 220 Issue: 2

    • DOI

      10.1093/genetics/iyab182

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evolution of family systems and resultant socio-economic structures2021

    • Author(s)
      Itao Kenji、Kaneko Kunihiko
    • Journal Title

      Humanities and Social Sciences Communications

      Volume: 8 Issue: 1 Pages: 1-11

    • DOI

      10.1057/s41599-021-00919-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamics-Evolution Correspondence in Protein Structures2021

    • Author(s)
      Tang Qian-Yuan、Kaneko Kunihiko
    • Journal Title

      Physical Review Letters

      Volume: 127 Issue: 9 Pages: 098103-098103

    • DOI

      10.1103/physrevlett.127.098103

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Entangled gene regulatory networks with cooperative expression endow robust adaptive responses to unforeseen environmental changes2021

    • Author(s)
      Inoue Masayo、Kaneko Kunihiko
    • Journal Title

      Physical Review Research

      Volume: 3 Issue: 3 Pages: 033183-033183

    • DOI

      10.1103/physrevresearch.3.033183

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evolution of dominance in gene expression pattern associated with phenotypic robustness2021

    • Author(s)
      Okubo Kenji、Kaneko Kunihiko
    • Journal Title

      BMC Ecology and Evolution

      Volume: 21 Issue: 1 Pages: 110-110

    • DOI

      10.1186/s12862-021-01841-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Forebrain Architecture and Development in Cyclostomes, with Reference to the Early Morphology and Evolution of the Vertebrate Head2021

    • Author(s)
      Sugahara F, Murakami Y, Pascual-Anaya, J. and Kuratani, S
    • Journal Title

      Brain Behav. Evol.

      Volume: in press Issue: 1 Pages: 12-12

    • DOI

      10.1186/s40851-021-00180-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamical systems approach to evolution?development congruence: Revisiting Haeckel's recapitulation theory2021

    • Author(s)
      Kohsokabe Takahiro、Kaneko Kunihiko
    • Journal Title

      Journal of Experimental Zoology Part B: Molecular and Developmental Evolution

      Volume: 338 Issue: 1-2 Pages: 62-75

    • DOI

      10.1002/jez.b.23031

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tissue growth constrains root organ outlines into an isometrically scalable shape2021

    • Author(s)
      Fujiwara Motohiro、Goh Tatsuaki、Tsugawa Satoru、Nakajima Keiji、Fukaki Hidehiro、Fujimoto Koichi
    • Journal Title

      Development

      Volume: 148 Issue: 4 Pages: 196253-196253

    • DOI

      10.1242/dev.196253

    • NAID

      120007028967

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rotation angle of stem cell division plane controls spiral phyllotaxis in mosses.2021

    • Author(s)
      Kamamoto, N., Tano, T., Fujimoto, K. & Shimamura, M.
    • Journal Title

      Journal of Plant Research

      Volume: 134 Issue: 3 Pages: 457-473

    • DOI

      10.1007/s10265-021-01298-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polarity Fluctuation Inhibition by Memory in Collective Cell Motion2021

    • Author(s)
      Katsuyoshi Matsushita, Shunsuke Yabunaka and Koichi Fujimoto
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 90 Issue: 5 Pages: 054801-054801

    • DOI

      10.7566/jpsj.90.054801

    • NAID

      40022563209

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional sensitivity and mutational robustness of proteins2020

    • Author(s)
      Tang Qian-Yuan、Hatakeyama Tetsuhiro S.、Kaneko Kunihiko
    • Journal Title

      Physical Review Research

      Volume: 2 Issue: 3 Pages: 033452-033452

    • DOI

      10.1103/physrevresearch.2.033452

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dimensional Reduction in Evolving Spin-Glass Model: Correlation of Phenotypic Responses to Environmental and Mutational Changes2020

    • Author(s)
      Sakata Ayaka、Kaneko Kunihiko
    • Journal Title

      Physical Review Letters

      Volume: 124 Issue: 21 Pages: 218101-218101

    • DOI

      10.1103/physrevlett.124.218101

    • NAID

      120006847400

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Homeorhesis in Waddington's landscape by epigenetic feedback regulation2020

    • Author(s)
      Matsushita Yuuki、Kaneko Kunihiko
    • Journal Title

      Physical Review Research

      Volume: 2 Issue: 2 Pages: 023083-023083

    • DOI

      10.1103/physrevresearch.2.023083

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reply to Read and Parkin: Our model correctly expresses the ethnographic nature of the cultural incest taboo and kinship structures2020

    • Author(s)
      Itao Kenji、Kaneko Kunihiko
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 17 Pages: 9167-9168

    • DOI

      10.1073/pnas.2003300117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Mechanical Instability in Planar Epithelial Monolayers Leads to Cell Extrusion2020

    • Author(s)
      Satoru Okuda, Koichi Fujimoto
    • Journal Title

      Biophysical Journal

      Volume: 118 Issue: 10 Pages: 2549-2560

    • DOI

      10.1016/j.bpj.2020.03.028

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 細胞競合の力学的理解2020

    • Author(s)
      坪井有寿, 奥田覚, 藤本仰一
    • Journal Title

      医学のあゆみ

      Volume: 274巻5号 Pages: 537-543

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Transition in relaxation paths in allosteric molecules: Enzymatic kinetically constrained model2020

    • Author(s)
      T.S. Hatakeyama, K. Kaneko
    • Journal Title

      Phys. Rev. Research

      Volume: 2 Issue: 1

    • DOI

      10.1103/physrevresearch.2.012005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic Ratchet: Spontaneous Adaptation via Stochastic Gene Expression2020

    • Author(s)
      Y. Himeoka, K. Kaneko
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 459-459

    • DOI

      10.1038/s41598-019-57372-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Advantage of Leakage of Essential Metabolites for Cells2020

    • Author(s)
      J.F. Yamagishi, N. Saito and K. Kaneko
    • Journal Title

      Phys. Rev. Lett.

      Volume: 124 Issue: 4 Pages: 048101-048101

    • DOI

      10.1103/physrevlett.124.048101

    • NAID

      130008156522

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evolution of Kinship Structures Driven by Marriage Tie and Competition2020

    • Author(s)
      K.Itao and K. Kaneko
    • Journal Title

      PNAS

      Volume: 117 (5) Issue: 5 Pages: 2378-2384

    • DOI

      10.1073/pnas.1917716117

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evolutionary dimension reduction in phenotypic space2020

    • Author(s)
      T. U. Sato, K. Kaneko
    • Journal Title

      Phys. Rev. Research

      Volume: 2 (1) Issue: 1 Pages: 013197-013197

    • DOI

      10.1103/physrevresearch.2.013197

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-range Correlation in Protein Dynamics: Confirmation by Structural Data and Normal Mode Analysis2020

    • Author(s)
      Qian-Yuan Tang and Kunihiko Kaneko
    • Journal Title

      PLoS Comp. Biol.

      Volume: 16 (2) Issue: 2 Pages: e1007670-e1007670

    • DOI

      10.1371/journal.pcbi.1007670

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A design principle for floral organ number and arrangement in flowers with bilateral symmetry2020

    • Author(s)
      Nakagawa Aiko、Kitazawa Miho S.、Fujimoto Koichi
    • Journal Title

      Development

      Volume: 147 Issue: 3

    • DOI

      10.1242/dev.182907

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perianth Phyllotaxis Is Polymorphic in the Basal Eudicot Anemone and Eranthis Species2020

    • Author(s)
      Kitazawa Miho S.、Fujimoto Koichi
    • Journal Title

      Frontiers in Ecology and Evolution

      Volume: 8 Pages: 70-70

    • DOI

      10.3389/fevo.2020.00070

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional dynamic by intention recognition in iterated games2019

    • Author(s)
      Fujimoto Yuma、Kaneko Kunihiko
    • Journal Title

      New Journal of Physics

      Volume: 21 Issue: 2 Pages: 023025-023025

    • DOI

      10.1088/1367-2630/ab0459

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Statistical Evolutionary Laws in Music Styles2019

    • Author(s)
      Eita Nakamura, Kunihiko Kaneko
    • Journal Title

      Scientific Reports

      Volume: 9(15993) Issue: 1 Pages: 1-11

    • DOI

      10.1038/s41598-019-52380-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emergence of Exploitation as Symmetry Breaking in Iterated Prisoner's Dilemma2019

    • Author(s)
      Y.Fujimoto, K. Kaneko
    • Journal Title

      Phys.Rev.Research

      Volume: 1 Issue: 3 Pages: 033077-033077

    • DOI

      10.1103/physrevresearch.1.033077

    • NAID

      130008152851

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The origin of the central dogma through conflicting multilevel selection2019

    • Author(s)
      N. Takeuchi, K. Kaneko
    • Journal Title

      Proc. R. Soc. B

      Volume: 286 Issue: 1912 Pages: 20191359-20191359

    • DOI

      10.1098/rspb.2019.1359

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 適応と進化におけるマクロ現象論ーー表現型変化の低次元拘束と揺らぎー応答関係2019

    • Author(s)
      金子邦彦,古澤力
    • Journal Title

      日本物理学会誌

      Volume: 第74巻 第3号 Pages: 137-137

    • NAID

      130007690582

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimal Scaling of Critical Size for Metamorphosis in the Genus Drosophila2019

    • Author(s)
      Hironaka Ken-ichi、Fujimoto Koichi、Nishimura Takashi
    • Journal Title

      iScience

      Volume: 20 Pages: 348-358

    • DOI

      10.1016/j.isci.2019.09.033

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell Motion Alignment as Polarity Memory Effect2019

    • Author(s)
      Katsuyoshi Matsushita, Kazuya Horibe, Naoya Kamamoto and Koichi Fujimoto
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 88 Issue: 10 Pages: 103801-103801

    • DOI

      10.7566/jpsj.88.103801

    • NAID

      40022034090

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curved surface geometry-induced topological change of an excitable planar wave2019

    • Author(s)
      Kazuya Horibe, Ken-ichi Hironaka, Katsuyoshi Matsushita, Koichi Fujimoto
    • Journal Title

      Chaos

      Volume: 29 Issue: 9 Pages: 093120-093120

    • DOI

      10.1063/1.5108838

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental Basis of Determination of Floral Organ Numbers: Theoretical Approaches2019

    • Author(s)
      北沢 美帆, 藤本 仰一
    • Journal Title

      Seibutsu Butsuri

      Volume: 59 Issue: 5 Pages: 266-270

    • DOI

      10.2142/biophys.59.266

    • NAID

      130007718912

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lateral inhibition by a peptide hormone-receptor cascade during Arabidopsis lateral root founder cell formation.2019

    • Author(s)
      Toyokura K, Goh T, Shinohara H, Shinoda A, Kondo Y, Okamoto Y, Uehara T, Fujimoto K, Okushima Y, Ikeyama Y, Nakajima K, Mimura T, Tasaka M, Matsubayashi Y and Fukaki H.
    • Journal Title

      Developmental Cell

      Volume: 48 Issue: 1 Pages: 64-75

    • DOI

      10.1016/j.devcel.2018.11.031

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 適応と進化におけるマクロ現象論――表現型変化の低次元拘束と揺らぎー応答関係2019

    • Author(s)
      金子邦彦,古澤力
    • Journal Title

      日本物理学会誌

      Volume: 74(3) Pages: 137-137

    • NAID

      130007690582

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology2018

    • Author(s)
      Tsuboi Alice、Ohsawa Shizue、Umetsu Daiki、Sando Yukari、Kuranaga Erina、Igaki Tatsushi、Fujimoto Koichi
    • Journal Title

      Current Biology

      Volume: 28 Issue: 13 Pages: 2115-2128

    • DOI

      10.1016/j.cub.2018.05.029

    • NAID

      120006491713

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 前がん細胞が正常細胞の領地へ拡大して占拠するしくみ - 予測と検証.2018

    • Author(s)
      坪井有寿, 藤本仰一
    • Journal Title

      実験医学

      Volume: 36(19) Pages: 3282-3285

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Plant-inspired pipettes2018

    • Author(s)
      Keigo Nakamura, Tetsuya Hisanaga, Koichi Fujimoto, Keiji Nakajima and Hirofumi Wada
    • Journal Title

      Journal of the Royal Society of Interface

      Volume: 15 Issue: 140 Pages: 20170868-20170868

    • DOI

      10.1098/rsif.2017.0868

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A quantitative study of the diversity of stripe-forming processes in an arthropod cell-based field undergoing axis formation and growth2018

    • Author(s)
      Natsuki Hemmi, Yasuko Akiyama-Oda, Koichi Fujimoto, Hiroki Oda
    • Journal Title

      Developmental Biology

      Volume: 437 Issue: 2 Pages: 84-104

    • DOI

      10.1016/j.ydbio.2018.03.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Formation of Dominant Mode by Evolution in Biological Systems2018

    • Author(s)
      C. Furusawa and K. Kaneko
    • Journal Title

      Phys. Rev. E

      Volume: 97 Pages: 042410-042410

    • DOI

      10.1101/125278

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Macroscopic Theory for Evolving Biological Systems Akin to Thermodynamics2018

    • Author(s)
      K. Kaneko and C. Furusawa
    • Journal Title

      Ann. Rev. Biophys

      Volume: 47 Issue: 1 Pages: 273-290

    • DOI

      10.1146/annurev-biophys-070317-033155

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Boundary-Induced Pattern Formation from Uniform Temporal Oscillation2018

    • Author(s)
      T,Kohsokabe and K. Kaneko
    • Journal Title

      Chaos

      Volume: 28 Issue: 4 Pages: 045110-045110

    • DOI

      10.1063/1.5013280

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cooperative reliable response from sloppy gene-expression dynamics2018

    • Author(s)
      M. Inoue, K. Kaneko
    • Journal Title

      EPL

      Volume: 124 Issue: 3 Pages: 38002-38002

    • DOI

      10.1209/0295-5075/124/38002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spiral phyllotaxis underlies constrained variation in Anemone (Ranunculaceae) tepal arrangement.2018

    • Author(s)
      Miho S. Kitazawa、Koichi Fujimoto
    • Journal Title

      J. Plant Res.

      Volume: 未定 Issue: 3 Pages: 1-10

    • DOI

      10.1007/s10265-018-1025-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hierarchical prisoner's dilemma in hierarchical game for resource competition2017

    • Author(s)
      Yuma Fujimoto, Takahiro Sagawa, and Kunihiko Kaneko
    • Journal Title

      New Journal of Physics

      Volume: 19 Issue: 7 Pages: 073008-073008

    • DOI

      10.1088/1367-2630/aa7152

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Theory for Transitions Between Exponential and Stationary Phases: Universal Laws for Lag Time2017

    • Author(s)
      Himeoka Yusuke、Kaneko Kunihiko
    • Journal Title

      Physical Review X

      Volume: 7 Issue: 2 Pages: 021049-021049

    • DOI

      10.1103/physrevx.7.021049

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Robustness of spatial patterns in buffered reaction-diffusion systems and its reciprocity with phase plasticity2017

    • Author(s)
      Tetsuhiro S. Hatakeyama, Kunihiko Kaneko
    • Journal Title

      Physical Review E Rapid Communications

      Volume: 95 Issue: 3 Pages: 030201-030201

    • DOI

      10.1103/physreve.95.030201

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Conceptualizing the origin of life in terms of evolution2017

    • Author(s)
      Takeuchi N.、Hogeweg P.、Kaneko K.
    • Journal Title

      Philosophical Transactions of the Royal Society A

      Volume: 375 Issue: 2109 Pages: 20160346-20160346

    • DOI

      10.1098/rsta.2016.0346

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The origin of a primordial genome through spontaneous symmetry breaking2017

    • Author(s)
      Takeuchi Nobuto、Hogeweg Paulien、Kaneko Kunihiko
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 250-250

    • DOI

      10.1038/s41467-017-00243-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stronger selection can slow down evolution driven by recombination on a smooth fitness landscape2017

    • Author(s)
      Ueda Masahiko、Takeuchi Nobuto、Kaneko Kunihiko
    • Journal Title

      PLoS One

      Volume: 12 Issue: 8 Pages: e0183120-e0183120

    • DOI

      10.1371/journal.pone.0183120

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Dynamical systems theory of robust cell differentiation and reprogramming2022

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      Net Bio Med 2022
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Universal biology in adaptation and evolution: dimensional reduction and fluctuation-response relationship2022

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      2nd Biology for Physics Conference "Biological Evolution and Nonequilibrium Physics: Close Encounters"
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Harnessing Complexity through Evolutionary Dimensional Reduction2022

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      Evolution of Complexity from the Statistical Physics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Universal Biology in Adaptation and Evolution: Dimensional Reduction, and Fluctuation-Response Relationship2022

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      IBS-BIMAG Colloquium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The direction of protein evolution: A lesson from AlphaFold Database2022

    • Author(s)
      唐乾元A, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 二倍体遺伝子発現制御ネットワークにおけるヘテロシスの進化と適応度地形2022

    • Author(s)
      大窪健児, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 速い遺伝子制御ダイナミクスと遅いエピジェネティック制御との相互作用による細胞分化とリプログラミングの力学系理論2022

    • Author(s)
      松下優貴, 畠山哲央, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 鋳型指示重合に内在する校正効果によるエラーカタストロフの回避2022

    • Author(s)
      松原嘉哉, 竹内信人, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 贈与関係による階層構造の生成2022

    • Author(s)
      板尾健司, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Heterosis Related to Fitness and Phenotypic Variance in the Evolution of Diploid Gene Regulatory Network2022

    • Author(s)
      Kenji Okubo
    • Organizer
      Fifth Bangalore School on Population Genetics and Evolution
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative modeling of multicellular mechanics promoting pathogenesis and organogenesis2022

    • Author(s)
      Koichi Fujimoto
    • Organizer
      International Symposium on Evolutionary Genomics and Bioinformatics 2022
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The advantage of leakage of essential metabolites and resultant symbiosis of diverse microbes2021

    • Author(s)
      山岸純平, 斉藤稔, 金子邦彦
    • Organizer
      日本生物物理学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 多階層進化モデルによる社会構造の生成2021

    • Author(s)
      板尾健司
    • Organizer
      統計物理と統計科学のセミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 婚姻交換による親族構造形成のダイナミクス2021

    • Author(s)
      板尾健司、金子邦彦
    • Organizer
      日本人類学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Microbial Potlatch: The advantage of leakage of essential metabolites and resultant symbiosis of diverse species2021

    • Author(s)
      山岸純平, 斉藤稔, 金子邦彦
    • Organizer
      国際生物物理学大会
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 親族構造と出自様式の多階層進化2021

    • Author(s)
      板尾健司, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アロステリック効果の進化モデルと次元圧縮仮説2021

    • Author(s)
      坂田綾香, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 遺伝子発現制御系の進化における発現パターン顕性2021

    • Author(s)
      大窪健児, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 細胞集団系における低次元摂動応答2021

    • Author(s)
      山岸純平, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] The Dynamics-Evolution Correspondence in Protein Structures2021

    • Author(s)
      唐乾元, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Universal Biology in Adaptation and Evolution: Dimensional Reduction, and Fluctuation-Response Relationship2021

    • Author(s)
      金子邦彦
    • Organizer
      Statistical Physics of Complex Systems
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Relevance of Noise to Adaption and Evolution2021

    • Author(s)
      金子邦彦
    • Organizer
      Storchastic Resonance 40
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞配置と器官配置の周期を構成し変調するメリステム動態の理論生物学2021

    • Author(s)
      藤本仰一,鎌本直也,北沢美帆,嶋村正樹
    • Organizer
      日本植物学会第83回大会 シンポジウム「異分野協調と周期の変調で解き明かす植物の発生メカニズム」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 細胞から個体に至る動植物の形を定量し生まれる仕組みを探る数理2021

    • Author(s)
      藤本仰一
    • Organizer
      第23回日本進化学会 夏の学校
    • Related Report
      2021 Annual Research Report
  • [Presentation] Heterosis, Phenotypic Variance and Dominance in Diploid Gene Regulatory Network2021

    • Author(s)
      大窪健児
    • Organizer
      AsiaEvo Conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evolution of kinship structures driven by marriage tie and competition.2021

    • Author(s)
      Kenji Itao and Kunihiko Kaneko
    • Organizer
      International Conference on Computational Social Science
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multi-level evolution of families and societies reveals the universality in anthropological phenomena2021

    • Author(s)
      Kenji Itao
    • Organizer
      Mathematical geographical modelling for environmental humanities(数理地理モデリング研究会2021年ワークショップ)
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Evolution of kinship structures driven by marriage tie and competition.2021

    • Author(s)
      Kenji Itao and Kunihiko Kaneko
    • Organizer
      Human Behavior & Evolution Society 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Macroscopic Theory for Adaptation and Evolution: Multilevel Consistency, Dimensional Reduction, and Fluctuation-Response Relationship2021

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      Solvay Workshop on ‘Nonlinear Phenomena and Complex Systems'
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evolution of kinship structures driven by marriage tie and competition.2021

    • Author(s)
      Kenji Itao and Kunihiko Kaneko
    • Organizer
      Cultural Evolution Society Conference 2021 Sapporo
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 農村社会における家族形態の生成と社会構造の進化2021

    • Author(s)
      板尾健司、金子邦彦
    • Organizer
      第76回 日本物理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 多倍数体における顕性の数理モデル2021

    • Author(s)
      大窪健児、金子邦彦
    • Organizer
      第76回 日本物理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] RNA構造の進化に与えるホストパラサイト相互作用の影響2021

    • Author(s)
      西浦直人, 竹内信人, 金子邦彦
    • Organizer
      第76回 日本物理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 細胞のリプログラミングの力学系理論2021

    • Author(s)
      松下優貴, 畠山哲央, 金子邦彦
    • Organizer
      第76回 日本物理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Long-range correlation in protein dynamics: Confirmation by structural data and normal mode analysis2021

    • Author(s)
      唐乾元, 金子邦彦学生
    • Organizer
      第76回 日本物理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 協同的な遺伝子発現制御ネットワークの特性解析2021

    • Author(s)
      井上雅世, 金子邦彦
    • Organizer
      第76回 日本物理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 細胞内代謝系の非最適制御のミクロ経済学2021

    • Author(s)
      山岸純平, 畠山哲央
    • Organizer
      第76回 日本物理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 進化的次元縮減:適応と進化のマクロ現象論2021

    • Author(s)
      金子邦彦
    • Organizer
      第8回 統計物理学懇談会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ホストパラサイト相互作用での表現型進化2020

    • Author(s)
      西浦直人、金子邦彦
    • Organizer
      第22回 日本進化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 表現型拘束とその進化に対する制約2020

    • Author(s)
      佐藤匠哉, 金子邦彦
    • Organizer
      第22回 日本進化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Cellular Potlatch II:代謝物の利己的な漏出と取り込みによる多種共生2020

    • Author(s)
      山岸純平, 斉藤稔, 金子邦彦
    • Organizer
      日本物理学会 2020年秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 内部共生系における遺伝子水平伝播の階層的ゲノム進化モデル2020

    • Author(s)
      青木さくら、竹内信人、金子邦彦
    • Organizer
      日本物理学会 2020年秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 多階層選択モデルにおけるスケーリング則:協力または裏切りの進化2020

    • Author(s)
      竹内信人, 御手洗菜美子, 金子邦彦
    • Organizer
      日本物理学会 2020年秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 遺伝子制御ネットワークモデルにおける遺伝的同化の例2020

    • Author(s)
      西浦直人, 金子邦彦
    • Organizer
      日本物理学会 2020年秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 表現型拘束に起因する進化トレードオフ関係2020

    • Author(s)
      佐藤匠哉, 金子邦彦
    • Organizer
      日本物理学会 2020年秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Functional Sensitivity and Mutational Robustness of Proteins2020

    • Author(s)
      唐乾元, 畠山哲央, 金子邦彦
    • Organizer
      日本物理学会 2020年秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 遺伝子制御ダイナミクスとエピジェネティック制御による適応進化2020

    • Author(s)
      松下優貴、金子邦彦
    • Organizer
      日本物理学会 2020年秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 2倍体遺伝子発現制御系の固定点分類2020

    • Author(s)
      大窪健児、金子邦彦
    • Organizer
      日本物理学会 2020年秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 情報の非対称性による囚人のジレンマでの搾取の発生2020

    • Author(s)
      藤本悠雅, 金子邦彦
    • Organizer
      日本物理学会 2020年秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 多階層進化モデルによる家族形態の生成2020

    • Author(s)
      板尾健司、金子邦彦
    • Organizer
      日本物理学会 2020年秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 家族形態の規定する経済的な社会構造の特徴2020

    • Author(s)
      板尾健司、金子邦彦
    • Organizer
      日本物理学会 2020年秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ホストパラサイト相互作用による表現型可塑性の進化2020

    • Author(s)
      西浦直人、金子邦彦
    • Organizer
      第58回 日本生物物理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Universal Biology in Adaptation and Evolution: Multilevel Consistency, Dimension Reduction, and Fluctuation-Response Relationship2020

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      Statistical Biological Physics: From Single Molecule to Cell
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 農村社会における家族形態の生成と社会構造の進化2020

    • Author(s)
      板尾健司、金子邦彦
    • Organizer
      第13回 日本人間行動進化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 必須代謝物の漏出による細胞の成長促進2020

    • Author(s)
      山岸純平, 斉藤稔, 金子邦彦
    • Organizer
      第75回 日本物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 情報の非対称性による囚人のジレンマでの搾取の発生2020

    • Author(s)
      藤本悠雅, 金子邦彦
    • Organizer
      第75回 日本物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 遅いモード存在下における抗生物質耐性進化の低自由度表現2020

    • Author(s)
      佐藤匠哉, 金子邦彦
    • Organizer
      第75回 日本物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 発現エラーの大きな遺伝子から機能的な発現制御ネットワークをつくる方法2020

    • Author(s)
      井上雅世, 金子邦彦
    • Organizer
      第75回 日本物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ホスト-パラサイト相互作用における成長と耐性のトレードオフ2020

    • Author(s)
      西浦直人, 金子邦彦
    • Organizer
      第75回 日本物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 内部共生系における変異と進化2020

    • Author(s)
      青木さくら, 金子邦彦
    • Organizer
      第75回 日本物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The surface geometry of living things induces a topological change of a chemical traveling wave during morphogenesis2020

    • Author(s)
      K. Horibe,K. Hironaka,K. Matsushita,K. Fujimoto
    • Organizer
      EMBL-IBEC Winter Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The surface geometry of cerebral cortex induces topological changes of cortical traveling waves2020

    • Author(s)
      K. Horibe,K. Hironaka,K. Matsushita,K. Fujimoto
    • Organizer
      4th HBP Student Conference on Interdisciplinary Brain Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transition in relaxation paths in allosteric molecules: enzymatic kinetically constrained model2019

    • Author(s)
      Tetsuhiro Hatakeyama
    • Organizer
      Statistical Physics of Complex Systems
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dimension-Reduction Theory for Direction and Constraint in Phenotypic Evolution2019

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      From Molecular Basis to Predictability and Control of Evolution
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Microeconomics of Metabolism: Overflow metabolism as Giffen behavior2019

    • Author(s)
      Jumpei Yamagishi
    • Organizer
      Advances in Complex Systems - From Ecology to Economics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Dynamical Emergence of Incest Taboo and Kinship Structure2019

    • Author(s)
      板尾健司,金子邦彦
    • Organizer
      第21回 日本進化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of Speciation in Intracellular Symbiosis and its Evolutionary Dynamics2019

    • Author(s)
      青木さくら,金子邦彦
    • Organizer
      第21回 日本進化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Evolution of Group Mendelian Dominance in Diploid Gene Regulatory Network2019

    • Author(s)
      大窪健児,金子邦彦
    • Organizer
      第21回 日本進化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 婚姻交換による親族構造の形成と分岐2019

    • Author(s)
      板尾健司, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 大型前方後円墳の順位規模則2019

    • Author(s)
      大窪健児
    • Organizer
      日本物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 対称性の破れとしての囚人のジレンマにおける搾取の発生2019

    • Author(s)
      藤本悠雅, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 表現型可塑性が主導する種分化2019

    • Author(s)
      西浦直人, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] エピジェネティック制御と遺伝子制御ダイナミクス;Waddington 地形の実現2019

    • Author(s)
      松下優貴, 金子邦彦
    • Organizer
      日本物理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 囚人のジレンマの学習における搾取関係の発生2019

    • Author(s)
      Yuma Fujimoto
    • Organizer
      日本数理生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Functional Sensitivity and Mutational Robustness of Proteins2019

    • Author(s)
      Qianyuan Tang, Tetsuhiro Hatakeyama, Kunihiko Kaneko
    • Organizer
      第57回 日本生物物理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Theoretical approach to evolution of intracellular symbiosis2019

    • Author(s)
      Sakura Aoki, Kunihiko Kaneko
    • Organizer
      第57回 日本生物物理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Group Mendelian Dominance in Diploid Gene Regulatory Network2019

    • Author(s)
      Kenji Okubo, Kunihiko Kaneko
    • Organizer
      第57回 日本生物物理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cooperative architecture for functional network from sloppy gene expression dynamics2019

    • Author(s)
      Masayo Inoue, Kunihiko Kaneko
    • Organizer
      第57回 日本生物物理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] How does cell division generate phyllotactic pattern in bryophytes?2019

    • Author(s)
      Naoya Kamamoto,Katsuyoshi Matsushita,Mitsuyasu Hasebe,Koichi Fujimoto
    • Organizer
      日本植物学会第83回大会 国際シンポジウム Beyond Fibonacci patterns and the golden angle: phyllotactic variations and their cellular origin
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞競合の多細胞力学:勝者細胞の優先的拡大と敗者細胞の逸脱方向の調節ロジック2019

    • Author(s)
      坪井 有寿, 奥田 覚, 藤本 仰一
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Elucidation of spatiotemporal control of tentacle formation in cnidarians; Evo-Devo study focusing on Moon Jelly2019

    • Author(s)
      Sarper Safiye Esra, Hirai Tamami, Kuratani Shigeru, Fujimoto Koichi
    • Organizer
      日本発生学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 刺胞動物を中心に考えるEvo-Devo研究2019

    • Author(s)
      Sarper Safiye Esra, Kamamoto Naoya, Hirai Tamami, Kuratani Shigeru, Fujimoto Koichi
    • Organizer
      日本刺胞動物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 器官配置の時空間ダイナミクス;タテジマイソギンチャクの隔膜形成に基づく研究2019

    • Author(s)
      Sarper Safiye Esra, Kamamoto Naoya, Hirai Tamami, Kuratani Shigeru, Fujimoto Koichi
    • Organizer
      日本動物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Microeconomic Metabolism: an exact mapping between q-bio and microeconomics2019

    • Author(s)
      Jumpei Yamagishi
    • Organizer
      Winter q-bio
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 婚姻交換による親族構造形成のダイナミクス2019

    • Author(s)
      板尾健司, 金子邦彦
    • Organizer
      日本物理学会 第74回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 平均選好と近縁選好の転移2019

    • Author(s)
      藤本悠雅, 金子邦彦
    • Organizer
      日本物理学会 第74回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mutational Robustness and Controllability of Proteins2019

    • Author(s)
      唐乾元, 金子邦彦
    • Organizer
      日本物理学会 第74回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ミクロ経済学としての代謝制御の理解:オーバーフロー代謝とギッフェン財を例として2019

    • Author(s)
      山岸純平, 畠山哲央
    • Organizer
      日本物理学会 第74回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] エピジェネティック制御を含んだ遺伝子ダイナミクス:多重状態の生成と安定化2019

    • Author(s)
      松下優貴, 金子邦彦
    • Organizer
      日本物理学会 第74回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 進化による宿主-共生体間の分業の発生2019

    • Author(s)
      青木さくら, 金子邦彦
    • Organizer
      日本物理学会 第74回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 二倍体遺伝子発現制御系のダイナミクスと集合的メンデル顕性2019

    • Author(s)
      大窪健児, 金子邦彦
    • Organizer
      日本物理学会 第74回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 種間相互作用における多様性進化と種分化2019

    • Author(s)
      西浦直人, 金子邦彦
    • Organizer
      日本物理学会 第74回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 相克的階層進化におけるスケーリング則2019

    • Author(s)
      竹内信人, 御手洗菜美子, 金子邦彦
    • Organizer
      日本物理学会 第74回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 遺伝子制御ネットワークの進化と低次元構造2019

    • Author(s)
      佐藤匠哉, 金子邦彦
    • Organizer
      日本物理学会 第74回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] スピングラス模型における固有モードの進化2019

    • Author(s)
      坂田綾香, 金子邦彦
    • Organizer
      日本物理学会 第74回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Multilevel Consistency, Dimension Reduction, and Slow Dynamics in Biology2019

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      Evolving life: the evolution with tradeoffs, frustration in selection and growing complexity
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell competition for space is controlled by apoptosis-induced change of local epithelial topology.2018

    • Author(s)
      Koichi Fujimoto, Alice Tsuboi
    • Organizer
      2018 ICTS Workshop on Cellular Dynamics and Microbiome Studies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Competition for space is controlled by apoptosis-induced change of local epithelial topology2018

    • Author(s)
      Koichi Fujimoto, Alice Tsuboi
    • Organizer
      Quantitative Life Science Workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evo-Devoの数理;発展と未来.2018

    • Author(s)
      藤本仰一
    • Organizer
      日本進化学会第20会大会(招待講演)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Constrained variation in organ arrangements of basal eudicot flowers2018

    • Author(s)
      Miho S. Kitawaza, Koichi Fujimoto
    • Organizer
      The 1st AsiaEvo Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 形の空間にみる制約された揺らぎと多様性:花器官配置の数理解析2018

    • Author(s)
      北沢美帆、藤本仰一
    • Organizer
      日本植物学会第82回大会 シンポジウム「植物の確率論的ふるまいにもとづく戦略」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Constrained variation of floral organ arrangement in basal eudicots: a correlation with species diversity of the organ number.2018

    • Author(s)
      Koichi Fujimoto, Miho S. Kitazawa
    • Organizer
      Euro Evo Devo
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phenotypic evolvability2018

    • Author(s)
      Kuhihiko Kaneko
    • Organizer
      1st AsiaEvo Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evolution of intracellular symbiosis: Theoretical approach2018

    • Author(s)
      S Aoki, K Kaneko
    • Organizer
      1st AsiaEvo Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Emergence of Low-dimensional Structure in Evolution of Highdimensional Cell Model2018

    • Author(s)
      T Sato, K Kaneko
    • Organizer
      1st AsiaEvo Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Is a macroscopic description of biological systems possible?2018

    • Author(s)
      Kuhihiko Kaneko
    • Organizer
      Physics of Living Matter
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Reproduction of a Set of Diverse Molecules, Minority Control, and Arrival of Evolvability2018

    • Author(s)
      金子邦彦
    • Organizer
      Workshop "Puzzles and Solutions in Astrobiology"
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evolution and Genetics of Gene Regulatory Network in Diploid Recombination2018

    • Author(s)
      Kenji Okubo, Kunihiko Kaneko
    • Organizer
      25th International Congress on Sexual Plant Reproduction
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The origin of the central dogma of molecularbiology throughconflicting multilevel evolution2018

    • Author(s)
      Nobuto Takeuchi
    • Organizer
      Science of Early Life
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Phenotypic robustness, fluctuations and plasticity2018

    • Author(s)
      Kuhihiko Kaneko
    • Organizer
      7th Euro Evo Devo
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The origin of the central dogma through conflicting multilevel evolution2018

    • Author(s)
      Nobuto Takeuchi
    • Organizer
      Evolution - Genetic Novelty/Genomic Variations by RNA Networks and Viruses
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 遺伝情報の起源、揺らぎ、進化2018

    • Author(s)
      金子邦彦, 竹内信人
    • Organizer
      日本進化学会 第20回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Complex-Systems Approach to an Ecosystem of Interacting Cells: Differentiation, Symbiosis, and Diversification2018

    • Author(s)
      Kuhihiko Kaneko
    • Organizer
      Research meeting: Principles of Microbial Ecosystems 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 二倍体の遺伝子発現制御系進化による集合的メンデル遺伝の形成2018

    • Author(s)
      大窪健児, 金子邦彦
    • Organizer
      日本物理学会 2018年秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 重合過程が鋳型高分子の進化に及ぼす影響2018

    • Author(s)
      松原嘉哉, 竹内信人, 金子邦彦
    • Organizer
      日本物理学会 2018年秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Epigenetic Spin Glass II:アトラクタの刈り込みのメカニズム2018

    • Author(s)
      松下優貴, 金子邦彦
    • Organizer
      日本物理学会 2018年秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Functional Sensitivity and Evolutionary Robustness of Proteins2018

    • Author(s)
      唐乾元, 金子邦彦
    • Organizer
      日本物理学会 2018年秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 多環境下における触媒反応ネットワーク進化による次元削減2018

    • Author(s)
      佐藤匠哉, 金子邦彦
    • Organizer
      日本物理学会 2018年秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ホストパラサイト共進化系における遺伝子型-表現型対応の進化2018

    • Author(s)
      西浦直人, 金子邦彦
    • Organizer
      日本物理学会 2018年秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 進化による細胞内共生機構の獲得2018

    • Author(s)
      青木さくら, 金子邦彦
    • Organizer
      日本物理学会 2018年秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cellular Potlatch:代謝物の漏出による細胞の成長率増加およびその多種共生への寄与2018

    • Author(s)
      山岸純平, 斉藤稔, 金子邦彦
    • Organizer
      日本物理学会 2018年秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞分化への現象論的アプローチ:エピジェティクスによる安定細胞タイプの形成2018

    • Author(s)
      松下優貴, 金子邦彦
    • Organizer
      第56回日本生物物理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 対称性の自発的破れにより生起する分子生物学のセントラルドグマ2018

    • Author(s)
      竹内信人, 金子邦彦
    • Organizer
      第56回日本生物物理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Emergence of low-dimensional structure in evolution of high-dimensional cell model and its significance for phenotypic evolution2018

    • Author(s)
      Takuya Sato
    • Organizer
      第46回 内藤コンファレンス「生物進化の仕組みと多様性」
    • Related Report
      2018 Annual Research Report
  • [Presentation] Theoretical approach to evolution of intracellular symbiosis2018

    • Author(s)
      Sakura Aoki
    • Organizer
      第46回 内藤コンファレンス「生物進化の仕組みと多様性」
    • Related Report
      2018 Annual Research Report
  • [Presentation] Evolution and Genetics of Gene Regulatory Network in Diploid Recombination2018

    • Author(s)
      Kenji Okubo
    • Organizer
      第46回 内藤コンファレンス「生物進化の仕組みと多様性」
    • Related Report
      2018 Annual Research Report
  • [Presentation] Multilevel consistency, dimension reduction, and slow dynamics in biology2018

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      Quantitative Life Science Workshop2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dimension Reduction and Relevance of Slow Modes in Biological Dynamical Systems2018

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      Dynamics Days Asia Pacific
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional Sensitivity and Evolutionary Robustness of Proteins2018

    • Author(s)
      Qianyuan Tang
    • Organizer
      APEF 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Emergence of low-dimensional structure in high-dimensional cell model and convergent evolution in phenotypic space2018

    • Author(s)
      Takuya Sato
    • Organizer
      APEF 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Peripherally localized cell proliferation contributes smooth boundary formation along the central xylem axis in Arabidopsis root vascular tissue2018

    • Author(s)
      藤原基洋、宮島俊介、中島敬二、藤本仰一
    • Organizer
      第59回 日本植物生理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Universality in Phenotypic Adaptation and Evolution: Fluctuationresponse, Genetic Assimilation, and Dimension Reduction2018

    • Author(s)
      金子邦彦
    • Organizer
      Non-equilibrium dynamics and information processing in biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Macroscopic Theory of Phenotypic Adaptation and Evolution: Fluctuation-Response, Genetic Assimilation, and Dimension Reduction2018

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      Evolution of Diversity
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Robustness and Genetic Load of Gene Regulatory Network in Recombining Diploids2018

    • Author(s)
      Kenji Okubo
    • Organizer
      Evolution of Diversity
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamical phase transition in population genetics models with evolving mutation rate2018

    • Author(s)
      Masahiko Ueda
    • Organizer
      Evolution of Diversity
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Promotion of cellular growth by leakage of chemical components and its impact on symbiosis2018

    • Author(s)
      Jumpei Yamagishi
    • Organizer
      Evolution of Diversity
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Kinetically slowing-down in the allosteric biomolecules2018

    • Author(s)
      Tetsuhiro Hatakeyama
    • Organizer
      Information transmission in biological systems
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 対称性の自発的破れによって生起する分子生物学の基本原理:セントラル・ドグマはもはやドグマではない2018

    • Author(s)
      竹内信人, 金子邦彦
    • Organizer
      物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 遺伝的アルゴリズムを用いた進化発生関係の探求:breeding-trueな適応度関数を用いて2018

    • Author(s)
      香曽我部隆裕, 金子邦彦
    • Organizer
      物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 触媒反応ネットワークにおける遅いモードの出現と表現型進化2018

    • Author(s)
      佐藤匠哉, 金子邦彦
    • Organizer
      物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 組み替えを含む二倍体の遺伝子発現制御系進化における頑健性2018

    • Author(s)
      大窪健児, 金子邦彦
    • Organizer
      物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ホスト-パラサイト間の相互作用における表現型可塑性の進化2018

    • Author(s)
      西浦直人, 金子邦彦
    • Organizer
      物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 触媒反応ダイナミクスを介した細胞内共生進化2018

    • Author(s)
      青木さくら, 金子邦彦
    • Organizer
      物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 花器官配置の制約された揺らぎ:花器官数の多様化との相関2017

    • Author(s)
      藤本仰一、北沢美帆
    • Organizer
      第19回 日本進化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Localized cell proliferation and growth regulate root vascular bundle cell patterning2017

    • Author(s)
      Motohiro Fujiwara,Shunsuke Miyashima,Keiji Nakajima,Koichi Fujimoto
    • Organizer
      Taiwan-Japan Plant Biology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Macroscopic Theory of Phenotypic Adaptation and Evolution: Fluctuation-response, Genetic Assimilation, and Deep Linearity2017

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      117th Statistical Mechanics Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] From a set of catalytic reactions to reproduction of cells: Perspective from Universal Biology2017

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      The Origin of Life Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Origin of a Genome Through Spontaneous Symmetry Breaking: A Computational Modeling Study2017

    • Author(s)
      Takeuchi N., Hogeweg P., Kaneko K.
    • Organizer
      18th International Conference on the Origin of Life
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 遅い遺伝子発現による発生の時間制御と進化-発生対応2017

    • Author(s)
      香曽我部隆裕
    • Organizer
      脳構築における発生時計と場の連携
    • Related Report
      2017 Annual Research Report
  • [Presentation] Universality in Biology?: (I) Consistency Principle for Complex Systems-Biology (II) Robustness, Plasticity in Adaptation and Evolution2017

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      EON Workshop on Universal Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Central Dogma is no longer a dogma: Explaining the fundamental principle of molecular biology through multilevel evolution2017

    • Author(s)
      Nobuto Takeuchi
    • Organizer
      第19回 日本進化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 遅い遺伝子発現による発生時間制御と進化可能性2017

    • Author(s)
      香曽我部隆裕,金子邦彦
    • Organizer
      第19回 日本進化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Stronger selection can slow down evolution driven by recombination on a smooth fitness landscape2017

    • Author(s)
      Masahiko Ueda
    • Organizer
      30th Marian Smoluchowski Symposium on Statistical Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 進化による低次元主要モード形成2017

    • Author(s)
      金子邦彦, 古澤力
    • Organizer
      日本物理学会 秋季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 進化ゆらぎ応答関係の固有モード解析2017

    • Author(s)
      佐藤匠哉, 金子邦彦
    • Organizer
      日本物理学会 秋季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 組み替えを行う二倍体の遺伝子発現制御系進化2017

    • Author(s)
      大窪健児, 金子邦彦
    • Organizer
      日本物理学会 秋季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 表現型可塑性と多様性進化2017

    • Author(s)
      西浦直人, 金子邦彦
    • Organizer
      日本物理学会 秋季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 構成成分の漏出による細胞の成長率増加2017

    • Author(s)
      山岸純平, 斉藤稔, 金子邦彦
    • Organizer
      日本物理学会 秋季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 遅い変数と発生の進化可能性2017

    • Author(s)
      香曽我部隆裕, 金子邦彦
    • Organizer
      日本物理学会 秋季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ネットワークのデザイン原理と構成要素の応答性2017

    • Author(s)
      井上雅世, 金子邦彦
    • Organizer
      日本物理学会 秋季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マルチレベルクローン干渉2017

    • Author(s)
      上田仁彦, 金子邦彦
    • Organizer
      日本物理学会 秋季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Universality in Biology? Fluctuation-response relationship and Deep Linearity in Adaptation and Evolution2017

    • Author(s)
      Kunihiko Kaneko
    • Organizer
      ENS-UTokyo symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 普遍生物学2019

    • Author(s)
      金子 邦彦
    • Total Pages
      322
    • Publisher
      東京大学出版会
    • ISBN
      9784130626200
    • Related Report
      2019 Annual Research Report
  • [Remarks] 原著論文のプレスリリース

    • URL

      http://resou.osaka-u.ac.jp/ja/research/2018/20180615_2

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] Evolutionary dynamics to shape phenotype and direction in evolution. EuroEvoDevo 2018.2018

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-07-04   Modified: 2024-01-30  

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