Elucidation of inflammation cellular society in liver cirrhosis

• Project Area: Preventive medicine through inflammation cellular sociology
• Project/Area Number: 17H06393
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Kanazawa University
• Principal Investigator: KANEKO Shuichi 金沢大学, 医学系, 教授 (60185923)
• Co-Investigator(Kenkyū-buntansha): 本多 政夫 金沢大学, 保健学系, 教授 (00272980) ; 山下 竜也 金沢大学, 先進予防医学研究センター, 准教授 (30334783)
• Project Period (FY): 2017-06-30 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥137,020,000 (Direct Cost: ¥105,400,000、Indirect Cost: ¥31,620,000); Fiscal Year 2021: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000); Fiscal Year 2020: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000); Fiscal Year 2019: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000); Fiscal Year 2018: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000); Fiscal Year 2017: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
• Keywords: 単純性脂肪肝 / 脂肪性肝炎 / 肝硬変 / 肝線維化

Outline of Final Research Achievements

In the transition from simple fatty liver to non-alcoholic liver disease/hepatitis (NAFLD/NASH), it is known that metabolism is altered in each liver lobule zone (metabolic zonation). The present analysis revealed that the genes expressed in the cells constituting the liver change accordingly. Gene X was expressed in the hepatic sinusoidal endothelium bordering hepatic stellate cells, which play an important role in fibrosis. This Gene X changes with the progression of NAFLD/NASH, suggesting that Gene X has an inhibitory effect on the progression of liver fibrosis.

Academic Significance and Societal Importance of the Research Achievements

肝硬変は肝炎ウイルスによる慢性肝炎だけでなく、人口の数割が罹患する非アルコール性脂肪肝、およびアルコール性脂肪肝から脂肪性肝炎を介して発症する。肝硬変にいたると、肝不全や肝癌を併発することが大きな問題となっている。本研究は、これまでに注目されていなかった類洞内皮細胞の肝硬変への役割と、創薬や診断の標的となりうる新規の分子を明らかにしたものである。その学術的意義および社会的意義は大きい。

Research Products

• [Journal Article] Forkhead box protein O1 (FoxO1) knockdown accelerates the eicosapentaenoic acid (EPA)-mediated <i>Selenop</i> downregulation independently of sterol regulatory element-binding protein-1c (SREBP-1c) in H4IIEC3 hepatocytes (2022)
  • Author(s): K Kamoshita, N Tajima-Shirasaki, KA Ishii, T Shirasaki, H Takayama, H Abuduwaili, T Abuduyimiti, HK Oo, X Yao, Q Li, CM Galicia-Medina, S Kaneko, T Takamura.
  • Journal Title: Endocrine Journal Volume: 69 Issue: 8 Pages: 907-918
  • DOI: 10.1507/endocrj.EJ21-0392
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] C C chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice (2021)
  • Author(s): Xu Liang、Chen Yongping、Nagashimada Mayumi、Ni Yinhua、Zhuge Fen、Chen Guanliang、Li Haoran、Pan Tongtong、Yamashita Tatsuya、Mukaida Naofumi、Kaneko Shuichi、Ota Tsuguhito、Nagata Naoto
  • Journal Title: Metabolism Volume: 125 Pages: 154914-154914
  • DOI: 10.1016/j.metabol.2021.154914
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CX3CL1?CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice (2021)
  • Author(s): Nagashimada Mayumi、Sawamoto Kazuki、Ni Yinhua、Kitade Hironori、Nagata Naoto、Xu Liang、Kobori Masuko、Mukaida Naofumi、Yamashita Tatsuya、Kaneko Shuichi、Ota Tsuguhito
  • Journal Title: Endocrinology Volume: - Issue: 6
  • DOI: 10.1210/endocr/bqab064
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice (2021)
  • Author(s): Hasan Nazmul、Nagata Naoto、Morishige Jun-ichi、Islam Md Tarikul、Jing Zheng、Harada Ken-ichi、Mieda Michihiro、Ono Masanori、Fujiwara Hiroshi、Daikoku Takiko、Fujiwara Tomoko、Maida Yoshiko、Ota Tsuguhito、Shimba Shigeki、Kaneko Shuichi、Fujimura Akio、Ando Hitoshi
  • Journal Title: Molecular Metabolism Volume: 49 Pages: 101202-101202
  • DOI: 10.1016/j.molmet.2021.101202
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans (2021)
  • Author(s): Isobe Yuki、Asakura Hiroki、Tsujiguchi Hiromasa、Kannon Takayuki、Takayama Hiroaki、Takeshita Yumie、Ishii Kiyo-aki、Kanamori Takehiro、Hara Akinori、Yamashita Tatsuya、Tajima Atsushi、Kaneko Shuichi、Nakamura Hiroyuki、Takamura Toshinari
  • Journal Title: Frontiers in Nutrition Volume: 8 Pages: 633703-633703
  • DOI: 10.3389/fnut.2021.633703
  • Peer Reviewed / Open Access
• [Journal Article] Serum laminin γ2 monomer as a novel diagnostic and predictive biomarker for hepatocellular carcinoma. (2021)
  • Author(s): T Yamashita, N Koshikawa, T Shimakami, T Terashima, M Nakagawa, K Nio, R Horii, N Iida, K Kawaguchi, K Arai, Y Sakai, T Yamashita, E Mizukoshi, M Honda, A Kitao, S Kobayashi, S Takahara, Y Imai, K Yoshimura, T Murayama, Y Nakamoto, E Yoshida, T Yoshimura, M Seiki, S Kaneko.
  • Journal Title: Hepatology Volume: - Issue: 2 Pages: 760-775
  • DOI: 10.1002/hep.31758
  • Peer Reviewed / Open Access
• [Journal Article] Artificial intelligence/neural network system for the screening of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. (2021)
  • Author(s): T Okanoue, T Shima, Y Mitsumoto, A Umemura, K Yamaguchi, Y Itoh, M Yoneda, A Nakajima, E Mizukoshi, S Kaneko, K Harada.
  • Journal Title: Hepatol Res Volume: - Issue: 5 Pages: 554-569
  • DOI: 10.1111/hepr.13628
  • Peer Reviewed / Open Access
• [Journal Article] LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH (2021)
  • Author(s): Takata Noboru、Ishii Kiyo-aki、Takayama Hiroaki、Nagashimada Mayumi、Kamoshita Kyoko、Tanaka Takeo、Kikuchi Akihiro、Takeshita Yumie、Matsumoto Yukako、Ota Tsuguhito、Yamamoto Yasuhiko、Yamagoe Satoshi、Seki Akihiro、Sakai Yoshio、Kaneko Shuichi、Takamura Toshinari
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 555-555
  • DOI: 10.1038/s41598-020-80689-0
  • Peer Reviewed / Open Access
• [Journal Article] Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability (2020)
  • Author(s): Sakai Yuriko、Arie Hideyuki、Ni Yinhua、Zhuge Fen、Xu Liang、Chen Guanliang、Nagata Naoto、Suzuki Takuya、Kaneko Shuichi、Ota Tsuguhito、Nagashimada Mayumi
  • Journal Title: Journal of Endocrinology Volume: 247 Issue: 2 Pages: 169-181
  • DOI: 10.1530/joe-20-0105
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DPP-4 Inhibition with Anagliptin Reduces Lipotoxicity-Induced Insulin Resistance and Steatohepatitis in Male Mice (2020)
  • Author(s): Sakai Yuriko、Chen Guanliang、Ni Yinhua、Zhuge Fen、Xu Liang、Nagata Naoto、Kaneko Shuichi、Ota Tsuguhito、Nagashimada Mayumi
  • Journal Title: Endocrinology Volume: 161 Issue: 10
  • DOI: 10.1210/endocr/bqaa139
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients. (2020)
  • Author(s): T Seike, E Mizukoshi, K Yamada, H Okada, M Kitahara, T Yamashita, K Arai, T Terashima, N Iida, K Fushimi, T Yamashita, Y Sakai, M Honda, K Harada, S Kaneko.
  • Journal Title: J Gastroenterol Volume: - Issue: 7 Pages: 701-711
  • DOI: 10.1007/s00535-020-01679-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice (2020)
  • Author(s): Nishikawa Tomoki、Nagata Naoto、Shimakami Tetsuro、Shirakura Takashi、Matsui Chieko、Ni Yinhua、Zhuge Fen、Xu Liang、Chen Guanliang、Nagashimada Mayumi、Yamashita Taro、Sakai Yoshio、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi、Ota Tsuguhito
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 815-815
  • DOI: 10.1038/s41598-020-57784-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans (2019)
  • Author(s): Mohri K, Misu H, Takayama H, Ishii KA, Kikuchi A, Lan F, Enyama Y, Takeshita Y, Saito Y, Kaneko S,Takamura T.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 42 Issue: 3 Pages: 373-378
  • DOI: 10.1248/bpb.b18-00549
  • NAID: 130007607371
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2019-03-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice (2019)
  • Author(s): Ni Yinhua、Zhuge Fen、Nagashimada Mayumi、Nagata Naoto、Xu Liang、Yamamoto Sayo、Fuke Nobuo、Ushida Yusuke、Suganuma Hiroyuki、Kaneko Shuichi、Ota Tsuguhito
  • Journal Title: Free Radical Biology and Medicine Volume: - Pages: 225-234
  • DOI: 10.1016/j.freeradbiomed.2019.11.036
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lycopene Alleviates Obesity‐Induced Inflammation and Insulin Resistance by Regulating M1/M2 Status of Macrophages (2019)
  • Author(s): Chen Guanliang、Ni Yinhua、Nagata Naoto、Zhuge Fen、Xu Liang、Nagashimada Mayumi、Yamamoto Sayo、Ushida Yusuke、Fuke Nobuo、Suganuma Hiroyuki、Kaneko Shuichi、Ota Tsuguhito
  • Journal Title: Molecular Nutrition & Food Research Volume: 63 Issue: 21 Pages: 1900602-1900602
  • DOI: 10.1002/mnfr.201900602
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet (2019)
  • Author(s): Xu Liang、Nagata Naoto、Chen Guanliang、Nagashimada Mayumi、Zhuge Fen、Ni Yinhua、Sakai Yuriko、Kaneko Shuichi、Ota Tsuguhito
  • Journal Title: BMJ Open Diabetes Research & Care Volume: 7 Issue: 1 Pages: e000783-e000783
  • DOI: 10.1136/bmjdrc-2019-000783
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum C16:1n7/C16:0 ratio as a diagnostic marker for non-alcoholic steatohepatitis. (2019)
  • Author(s): K Yamada, E Mizukoshi, T Seike, R Horii, T Terashima, N Iida, M Kitahara, H Sunagozaka, K Arai, T Yamashita, M Honda, T Takamura, K Harada, S Kaneko.
  • Journal Title: J Gastroenterol Hepatol Volume: 34 Issue: 10 Pages: 1829-1835
  • DOI: 10.1111/jgh.14654
  • Peer Reviewed / Open Access
• [Journal Article] Diabetes impairs the angiogenic capacity of human adipose-derived stem cells by reducing the CD271+ subpopulation in adipose tissue (2019)
  • Author(s): Inoue Oto、Usui Soichiro、Takashima Shin-ichiro、Nomura Ayano、Yamaguchi Kosei、Takeda Yusuke、Goten Chiaki、Hamaoka Takuto、Ootsuji Hiroshi、Murai Hisayoshi、Kaneko Shuichi、Takamura Masayuki
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 517 Issue: 2 Pages: 369-375
  • DOI: 10.1016/j.bbrc.2019.07.081
  • Peer Reviewed / Open Access
• [Journal Article] Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages (2019)
  • Author(s): Chen Guanliang、Ni Yinhua、Nagata Naoto、Xu Liang、Zhuge Fen、Nagashimada Mayumi、Kaneko Shuichi、Ota Tsuguhito
  • Journal Title: Laboratory Investigation Volume: - Issue: 9 Pages: 1335-1348
  • DOI: 10.1038/s41374-019-0255-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Adipose tissue‐derived stem cells prevent fibrosis in murine steatohepatitis by suppressing IL‐17‐mediated inflammation (2019)
  • Author(s): Yamato Masatoshi、Sakai Yoshio、Mochida Hatsune、Kawaguchi Kazunori、Takamura Masayuki、Usui Soichiro、Seki Akihiro、Mizukoshi Eishiro、Yamashita Taro、Yamashita Tatsuya、Ishida Kousuke、Nasti Alessandro、Tuyen Ho Thuy Bich、Komura Takuya、Yoshida Keiko、Wada Takashi、Honda Masao、Kaneko Shuichi
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: - Issue: 8 Pages: 1432-1440
  • DOI: 10.1111/jgh.14647
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum aldo-keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis. (2019)
  • Author(s): M Kanno, K Kawaguchi, M Honda, R Horii, H Takatori, T Shimakami, K Kitamura, K Arai, T Yamashita, Y Sakai, T Yamashita, E Mizukoshi, S Kaneko.
  • Journal Title: J Gastroenterol Volume: - Issue: 6 Pages: 549-557
  • DOI: 10.1007/s00535-019-01551-3
  • Peer Reviewed / Open Access
• [Journal Article] Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity. (2019)
  • Author(s): Murai K, Honda M, Shirasaki T, Shimakami T, Omura H, Misu H, Kita Y, Takeshita Y, Ishii KA, Takamura T, Urabe T, Shimizu R, Okada H, Yamashita T, Sakai Y, Kaneko S.
  • Journal Title: Cell Host Microbe Volume: 10;25(4) Issue: 4 Pages: 588-601
  • DOI: 10.1016/j.chom.2019.02.015
  • Peer Reviewed / Open Access
• [Journal Article] Distinct chemotherapy-associated anti-cancer immunity by myeloid cells inhibition in murine pancreatic cancer models. (2019)
  • Author(s): Sakai Y, Miyazawa M, Komura T, Yamada T, Nasti A, Yoshida K, Takabatake H, Yamato M, Yamashita T, Yamashita T, Mizukoshi E, Okuzono M, Ho TTB, Kawaguchi K, Wada T, Honda M, Kaneko S.
  • Journal Title: Cancer Sci Volume: 110 Issue: 3 Pages: 903-912
  • DOI: 10.1111/cas.13944
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characteristics of Immune Response to Tumor‐Associated Antigens and Immune Cell Profile in Patients With Hepatocellular Carcinoma. (2019)
  • Author(s): Y Inada, E Mizukoshi, T Seike, T Tamai, N Iida, M Kitahara, T Yamashita, K Arai, T Terashima, K Fushimi, T Yamashita, M Honda, S Kaneko.
  • Journal Title: Hepatology Volume: 69 Issue: 2 Pages: 653-665
  • DOI: 10.1002/hep.30212
  • Peer Reviewed / Open Access
• [Journal Article] Ribavirin-induced down-regulation of CCAAT/enhancer-binding protein α leads to suppression of lipogenesis (2018)
  • Author(s): Satoh Shinya、Onomura Daichi、Ueda Youki、Dansako Hiromichi、Honda Masao、Kaneko Shuichi、Kato Nobuyuki
  • Journal Title: Biochemical Journal Volume: 476 Issue: 1 Pages: 137-149
  • DOI: 10.1042/bcj20180680
  • Peer Reviewed / Open Access
• [Journal Article] Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population. (2018)
  • Author(s): Oo SM, Misu H, Saito Y, Tanaka M, Kato S, Kita Y, Takayama H, Takeshita Y, Kanamori T, Nagano T, Nakagen M, Urabe T, Matsuyama N, Kaneko S, Takamura T.
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 16727-16727
  • DOI: 10.1038/s41598-018-35067-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Immune responses against tumor-associated antigen-derived cytotoxic T lymphocyte epitopes in cholangiocarcinoma patients. (2018)
  • Author(s): Kida A, Mizukoshi E, Tamai T, Kitahara M, Yamashita T, Arai K, Terashima T, Iida N, Fushimi K, Kaneko S.
  • Journal Title: Liver Int Volume: 38 Issue: 11 Pages: 2040-2050
  • DOI: 10.1111/liv.13885
  • Peer Reviewed / Open Access
• [Journal Article] The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication. (2018)
  • Author(s): Shirasaki T, Honda M, Yamashita T, Nio K, Shimakami T, Shimizu R, Nakasyo S, Murai K, Shirasaki N, Okada H, Sakai Y, Sato T, Suzuki T, Yoshioka K, Kaneko S.
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 13143-13143
  • DOI: 10.1038/s41598-018-31421-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Immune response to human telomerase reverse transcriptase-derived helper T cell epitopes in hepatocellular carcinoma patients (2018)
  • Author(s): Kumagai Masashi、Mizukoshi Eishiro、Tamai Toshikatsu、Kitahara Masaaki、Yamashita Tatsuya、Arai Kuniaki、Terashima Takeshi、Iida Noriho、Fushimi Kazumi、Kaneko Shuichi
  • Journal Title: Liver International Volume: 印刷中 Issue: 9 Pages: 1635-1645
  • DOI: 10.1111/liv.13713
  • Peer Reviewed / Open Access
• [Journal Article] Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid (2018)
  • Author(s): Qin XY, Suzuki H, Honda M, Okada H, Kaneko S, Inoue I, Ebisui E, Hashimoto K, Carninci P, Kanki K, Tatsukawa H, Ishibashi N, Masaki T, Matsuura T, Kagechika H, Toriguchi K, Hatano E, Shirakami Y, Shiota G, Shimizu M, Moriwaki H, Kojima S
  • Journal Title: Proc Natl Acad Sci U S A Volume: 115 Issue: 19 Pages: 4969-4974
  • DOI: 10.1073/pnas.1802279115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells. (2017)
  • Author(s): Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S.
  • Journal Title: Eur J Immunol. Volume: 47 Issue: 12 Pages: 2163-2174
  • DOI: 10.1002/eji.201646835
  • NAID: 120006454989
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor α. (2017)
  • Author(s): S Satoh, K Mori, D Onomura, Y Ueda, H Dansako, M Honda, S Kaneko, M Ikeda, N Kato.
  • Journal Title: Hepatol Commun Volume: 1 Issue: 6 Pages: 550-563
  • DOI: 10.1002/hep4.1065
  • Peer Reviewed / Open Access
• [Journal Article] Corrigendum to 'Weight-adjusted lean body mass and calf circumference are protective against obesity-associated insulin resistance and metabolic abnormalities'. (2017)
  • Author(s): T Takamura, Y Kita, M Nakagen, M Sakurai, Y Isobe, Y Takeshita, K Kawai, T Urabe, S Kaneko.
  • Journal Title: Heliyon Volume: 3 Issue: 7 Pages: e00363-e00363
  • DOI: 10.1016/j.heliyon.2017.e00363
  • Peer Reviewed / Open Access
• [Journal Article] Weight-adjusted lean body mass and calf circumference are protective against obesity-associated insulin resistance and metabolic abnormalities. (2017)
  • Author(s): Takamura T, Kita Y, Nakagen M, Sakurai M, Isobe Y, Takeshita Y, Kawai K, Urabe T, Kaneko S.
  • Journal Title: Heliyon. Volume: 3 Issue: 7 Pages: e00347-e00347
  • DOI: 10.1016/j.heliyon.2017.e00347
  • Peer Reviewed / Open Access
• [Journal Article] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet (2017)
  • Author(s): Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S.
  • Journal Title: Oncotarget Volume: 8 Issue: 25 Pages: 39978-39993
  • DOI: 10.18632/oncotarget.18116
  • Peer Reviewed / Open Access
• [Journal Article] SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice. (2017)
  • Author(s): L Xu, N Nagata, M Nagashimada, F Zhuge, Y Ni, G Chen, E Mayoux, S Kaneko, T Ota.
  • Journal Title: EBioMedicine Volume: 20 Pages: 137-149
  • DOI: 10.1016/j.ebiom.2017.05.028
  • NAID: 120006452382
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes. (2017)
  • Author(s): Tajima-Shirasaki N, Ishii KA, Takayama H, Shirasaki T, Iwama H, Chikamoto K, Saito Y, Iwasaki Y, Teraguchi A, Lan F, Kikuchi A, Takeshita Y, Murao K, Matsugo S, Kaneko S, Misu H, Takamura T.
  • Journal Title: J Biol Chem. Volume: 292 Issue: 26 Pages: 10791-10800
  • DOI: 10.1074/jbc.m116.747006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reply to the Letter to the Editor by Li et al.: Bioinformatics Analysis in Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E. (2017)
  • Author(s): M Kobori, Y Takahashi, M Sakurai, Y Ni, G Chen, M Nagashimada, S Kaneko, T Ota.
  • Journal Title: Int J Mol Sci Volume: 18 Issue: 5 Pages: 994-994
  • DOI: 10.3390/ijms18050994
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Remarks] 予防を科学する炎症細胞社会学 | 文部科学省科学研究費補助金「新学術領域研究（領域提案型）
  • URL: http://inflammationcellularsociology.org/
• [Remarks] 予防を科学する炎症細胞社会学 | 文部科学省科学研究費補助金「新学術領域研究（領域提案型）」
  • URL: http://inflammationcellularsociology.org/
• [Patent(Industrial Property Rights)] 肝硬変の診断方法、非アルコール性脂肪肝炎及び肝細胞がんの合併症の診断方法並びに非アルコール性脂肪肝炎及び食道胃静脈瘤の合併症の診断方法 (2018)
  • Inventor(s): 金子周一、本多政夫、川口和紀
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] 非アルコール性脂肪性肝炎治療剤 (2018)
  • Inventor(s): 金子周一、酒井佳夫
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] 線維化抑制剤 (2017)
  • Inventor(s): 金子周一、本多政夫、岡田光
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017