| Budget Amount *help |
¥91,520,000 (Direct Cost: ¥70,400,000、Indirect Cost: ¥21,120,000)
Fiscal Year 2021: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
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| Outline of Final Research Achievements |
To analyze the mechanisms by which environmental stress induces chronic inflammation, various omics methods were used. 1) By using mice deficient in Nrf2, an environmental chemical sensor molecule, we investigated the effects of some soft electrophile substances on the central nervous system. We found that acrylamide induces antioxidant proteins in the cerebral cortex and that Nrf2 activation has anti-inflammatory effects. 2) Several new phenotypes were discovered during the breeding of mice deficient in another environmental chemical sensor molecule Ahr. We clarified the mechanism by which intestinal microflora developed in a specific breeding environment promotes Th17 differentiation in Ahr-deficient mice and induces ulcerative colitis-like diseases. Additionally, the mechanism by which Ahr-deficiency results in silencing of the pheromone protein Mup family genes was revealed.
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