| Co-Investigator(Kenkyū-buntansha) |
S Youssefian 京都大学, 医学研究科, 教授 (00210576)
手塚 徹 京都大学, スーパーグローバルコース医学生命系ユニット, 特定講師 (50312319)
土生 敏行 武庫川女子大学, 食物栄養科学部, 准教授 (70346071)
小林 果 三重大学, 医学系研究科, 講師 (70542091)
原田 浩二 京都大学, 医学研究科, 准教授 (80452340)
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| Budget Amount *help |
¥91,520,000 (Direct Cost: ¥70,400,000、Indirect Cost: ¥21,120,000)
Fiscal Year 2021: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
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| Outline of Final Research Achievements |
We previously identified that RNF213 is a major susceptibility gene for moyamoya disease (MMD) and its founder variant p.R4810K is a risk factor for not only MMD but also several other vascular occlusive diseases. The environmental factors and molecular mechanisms of MMD pathogenesis are largely unknown. To clarify them, in this project, we carried out epidemiological studies focusing on immunological factors in MMD, and elucidated cellular functions of RNF213. Specifically, we analyzed (1) RNF213-mediated signaling pathways involved in vascular occlusion, (2) relevance between mitotic failure and RNF213, (3) roles of RNF213 in response to endoplasmic reticulum (ER) stress, and (4) involvement of viral infection and gut microbiota in MMD pathogenesis.
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