| Co-Investigator(Kenkyū-buntansha) |
早川 芳弘 富山大学, 学術研究部薬学・和漢系, 教授 (10541956)
安田 周祐 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10643398)
堀中 真野 (友杉 真野 / 堀中真野) 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (80512037)
飯泉 陽介 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20533178)
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| Budget Amount *help |
¥137,020,000 (Direct Cost: ¥105,400,000、Indirect Cost: ¥31,620,000)
Fiscal Year 2021: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2020: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2019: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2018: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2017: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
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| Outline of Final Research Achievements |
As a result of SASP inhibitor screening, we have newly found several natural compounds with SASP inhibitory activity. We found that oridonin, a terpenoid that is isolated from various Isodon plants, inhibited the activity of NF-κB and p38 in senescent cells induced by DNA damage. Furthermore, we have newly identified a binding protein of a known SASP inhibitor and found their involvement in SASP inhibitory activity.
We also identified compounds that activate NK cells, which attack cells that caused SASP, by screening, and clarified the mechanism of NK cell activation. We identified a number of natural compounds with NF-κB inhibitory activity against SASP and clarified their metastasis inhibitory effects in vivo.
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