菌類が関わる共生・寄生における化学コミュニケーションの解明

• Project Area: Frontier research of chemical communications
• Project/Area Number: 17H06402
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Shizuoka University
• Principal Investigator: 河岸 洋和 静岡大学, グリーン科学技術研究所, 教授 (70183283)
• Co-Investigator(Kenkyū-buntansha): 鈴木 智大 宇都宮大学, バイオサイエンス教育研究センター, 准教授 (10649601) ; 稲井 誠 静岡県立大学, 薬学部, 講師 (20621626) ; 崔 宰熏 静岡大学, 農学部, 准教授 (40731633) ; 菅 敏幸 静岡県立大学, 薬学部, 教授 (10221904)
• Project Period (FY): 2017-06-30 – 2021-03-31
• Project Status: Discontinued (Fiscal Year 2020)
• Budget Amount: ¥76,180,000 (Direct Cost: ¥58,600,000、Indirect Cost: ¥17,580,000); Fiscal Year 2020: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2019: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2018: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2017: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
• Keywords: フェアリーリング / 冬虫夏草 / マコモタケ / キノコ / 植物 / 化学コミュニケーション / 黒穂菌 / 菌類 / 共生 / 寄生

Outline of Annual Research Achievements

「菌類が関わる共生・寄生における化学コミュニケーションの解明」のため，３つの課題を行った。
1）フェアリーリング：　芝生が輪状に周囲より繁茂する現象「フェアリーリング」を形成するコムラサキシメジからシバ成長制御物質AHXとICA，AHXの植物体内での代謝産物AOHが知られている。その後，これら３化合物は全ての植物に内生し，その生合成がプリン代謝における新しい経路によることを明らかにした。今年度は，これらの受容体探索と作用機序の解明を試み，シロイヌナズナの266系統を用いて，フェアリー化合物に感受性の高い系統を調査し，受容体探索に有用な系統を得，それらのEMS変異株の取得に成功した。また，ICAをイネに投与することで，S-ICA ribosyl homocysteine (SIH) がその代謝産物として単離された。ホモシステイン部分の立体化学の確定を目的にこれらの合成を行い，側鎖のホモシステインはL体と決定した。
2）マコモタケ：　イネ科植物マコモに黒穂菌が感染すると共生が始まり，菌糸が蔓延する部分は異常に肥大する。この肥大部分は，マコモタケと称し食されている。マコモタケは，花芽が形成されず実がならない。このことは，未知の制御物質が共生部分の肥大化と不稔を起こすと推定される。今年度は，全生育ステージのマコモタケを使用して，HiSeq Xを用いた遺伝子発現差解析を行いマコモ中の黒穂菌に由来する遺伝子の挙動を明らかにした。
3) 冬虫夏草：　冬虫夏草とは，菌が昆虫などに感染し，最終的に昆虫体内から子実体が発生するものの総称である。感染メカニズムは未だ明らかになっていない。今年度は，冬虫夏草サナギタケより新規レクチン（CmLec4と命名）の精製・構造決定・カイコ蛹中のCmLec4の標的分子の同定に成功した。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] University of Pavia(イタリア)
• [Journal Article] Biosynthesis of the Fairy Chemicals, 2-Azahypoxanthine and Imidazole-4-carboxamide, in the Fairy Ring-Forming FungusLepista sordida (2020)
  • Author(s): Ito Akinobu、Choi Jae-Hoon、Takemura Hirohide、Kotajima Mihaya、Wu Jing、Tokuyama Shinji、Hirai Hirofumi、Asakawa Tomohiro、Ouchi Hitoshi、Inai Makoto、Kan Toshiyuki、Kawagishi Hirokazu
  • Journal Title: Journal of Natural Products Volume: 83 Issue: 8 Pages: 2469-2476
  • DOI: 10.1021/acs.jnatprod.0c00394
  • Peer Reviewed
• [Journal Article] Plant growth regulators and Axl and immune checkpoint inhibitors from the edible mushroom Leucopaxillus giganteus (2020)
  • Author(s): Malya Irine Yunhafita、Wu Jing、Harada Etsuko、Toda Masaaki、D’Alessandro-Gabazza Corina N、Yasuma Taro、Gabazza Esteban C、Choi Jae-Hoon、Hirai Hirofumi、Kawagishi Hirokazu
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: - Issue: 7 Pages: 1-7
  • DOI: 10.1080/09168451.2020.1743170
  • NAID: 120006825989
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A biomimetic synthesis of chaxine and its related compounds (2020)
  • Author(s): Niki, M., Hirata, Y., Nakazaki, A., Wu, J., Kawagishi, H., Nishikawa, T.
  • Journal Title: J. Org. Chem. Volume: 85 Issue: 7 Pages: 4848-4860
  • DOI: 10.1021/acs.joc.9b03482
  • Peer Reviewed
• [Journal Article] A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis (2020)
  • Author(s): D’Alessandro-Gabazza Corina N、Kobayashi Tetsu、Yasuma Taro、Toda Masaaki、Fujimoto Hajime、Hataji Osamu、Takeshita Atsuro、Nishihama Kota、Okano Tomohito、Okano Yuko、Nishii Yoichi、Tomaru Atsushi、Fujiwara Kentaro、D’Alessandro Valeria Fridman、Yano Yutaka、Cann Isaac、Gabazza Esteban C
  • Journal Title: Nature Communications Volume: 11 Issue: 1 Pages: 1539-1539
  • DOI: 10.1038/s41467-020-15344-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome. (2020)
  • Author(s): Nur EAA, Ohshiro T, Kobayashi K, Wu J, Wahyudin E, Zhang H, Hayashi F, Kawagishi H, Tomoda H.
  • Journal Title: Bioorg Med Chem Lett Volume: 30 Issue: 7 Pages: 126997-126997
  • DOI: 10.1016/j.bmcl.2020.126997
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Are fairy chemicals a new family of plant hormones? (2019)
  • Author(s): Kawagishi, H.
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 95 Issue: 1 Pages: 29-38
  • DOI: 10.2183/pjab.95.003
  • NAID: 130007556026
  • ISSN: 0386-2208, 1349-2896
  • Year and Date: 2019-01-11
  • Peer Reviewed / Open Access
• [Journal Article] The complete mitochondrial genome sequence of the edible mushroom Stropharia rugosoannulata (Strophariaceae, Basidiomycota) (2019)
  • Author(s): Suzuki Tomohiro、Ono Akiko、Choi Jae-Hoon、Wu Jing、Kawagishi Hirokazu、Dohra Hideo
  • Journal Title: Mitochondrial DNA Part B Volume: 4 Issue: 1 Pages: 570-572
  • DOI: 10.1080/23802359.2018.1558120
  • NAID: 120006603032
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Glucose Concentration on Ethanol Fermentation of White-Rot Fungus Phanerochaete sordida YK-624 Under Aerobic Conditions (2019)
  • Author(s): Toshio Mori、Ojiro Kondo、Hirokazu Kawagishi、Hirofumi Hirai
  • Journal Title: Current Microbiology Volume: 76 Issue: 3 Pages: 263-269
  • DOI: 10.1007/s00284-018-01622-3
  • NAID: 120006557909
  • Peer Reviewed
• [Journal Article] Jianqiao Wang, Haruka Ohno, Yuuri Ide, Hirofumi Ichinose, Toshio Mori, Hirokazu Kawagishi, Hirofumi Hirai (2019)
  • Author(s): Identification of the cytochrome P450 involved in the degradation of neonicotinoid insecticide acetamiprid in Phanerochaete chrysosporium
  • Journal Title: Journal of Hazardous Materials Volume: 371 Pages: 494-498
  • DOI: 10.1016/j.jhazmat.2019.03.042
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Erinachromanes A and B and Erinaphenol A from the Culture Broth of Hericium erinaceus (2019)
  • Author(s): Wu Jing、Uchida Kazuki、Ridwan Arif Yanuar、Kondo Mitsuru、Choi Jae-Hoon、Hirai Hirofumi、Kawagishi Hirokazu
  • Journal Title: Journal of Agricultural and Food Chemistry Volume: 67 Issue: 11 Pages: 3134-3139
  • DOI: 10.1021/acs.jafc.8b06050
  • Peer Reviewed
• [Journal Article] Hericium erinaceus improves recognition memory and induces hippocampal and cerebellar neurogenesis in frail mice during aging (2019)
  • Author(s): Ratto, D., Corana, F., Mannucci, B., Priori, E. C., Cobelli, F., Roda, E., Ferrari, B., Occhinegro, A., Iorio, C. D., Luca, F. D., Cesaroni, V., Girometta, C., Bottone, M. G., Savino, E., Kawagishi, H., Rossi, P.
  • Journal Title: Nutrients Volume: 11 Issue: 4 Pages: 715-715
  • DOI: 10.3390/nu11040715
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome sequence analysis of the fairy ring-forming fungus Lepista sordida and gene candidates for interaction with plants (2019)
  • Author(s): Takano Tomoyuki、Yamamoto Naoki、Suzuki Tomohiro、Dohra Hideo、Choi Jae-Hoon、Terashima Yurika、Yokoyama Koji、Kawagishi Hirokazu、Yano Kentaro
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 5888-5888
  • DOI: 10.1038/s41598-019-42231-9
  • NAID: 120006825988
  • Peer Reviewed / Open Access
• [Journal Article] Effect on growth, sugar consumption, and aerobic ethanol fermentation of homologous expression of the sugar transporter gene Pshxt1 in the white rot fungus Phanerochaete sordida YK-624 (2019)
  • Author(s): Mori, T., Kondo, O., Masuda, A., Kawagishi, H., Hirai, H.
  • Journal Title: J. Biosci. Bioeng. Volume: 128 Issue: 5 Pages: 537-543
  • DOI: 10.1016/j.jbiosc.2019.04.016
  • NAID: 120006729386
  • Peer Reviewed
• [Journal Article] A Fairy Chemical, Imidazole-4-carboxamide, is Produced on a Novel Purine Metabolic Pathway in Rice (2019)
  • Author(s): Takemura Hirohide、Choi Jae-Hoon、Matsuzaki Nobuo、Taniguchi Yuki、Wu Jing、Hirai Hirofumi、Motohashi Reiko、Asakawa Tomohiro、Ikeuchi Kazutada、Inai Makoto、Kan Toshiyuki、Kawagishi Hirokazu
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 9899-9899
  • DOI: 10.1038/s41598-019-46312-7
  • NAID: 120006733893
  • Peer Reviewed / Open Access
• [Journal Article] Biotransformation and detoxification of the neonicotinoid insecticides nitenpyram and dinotefuran by Phanerochaete sordida YK-624 (2019)
  • Author(s): Wang, J., Tanaka, Y., Ohno, H., Jia, J., Mori, T., Xiao, T., Yan, B., Kawagishi, H., Hirai, H.
  • Journal Title: Environ. Pollut. Volume: 252 Pages: 856-862
  • DOI: 10.1016/j.envpol.2019.06.022
  • NAID: 120006643229
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Draft genome sequence of Buttiauxella sp. A111 that converts 2-azahypoxanthine to 2-aza-8-oxohypoxanthine (2019)
  • Author(s): Choi, J-H., Moriuchi, R., Sukprasitchai, A., Tokuyama, S., Kawagishi, H., Dohra, H.
  • Journal Title: Microbiol. Res. Announc. Volume: 8 Issue: 29
  • DOI: 10.1128/mra.00664-19
  • Peer Reviewed
• [Journal Article] Ribosides and Ribotide of a Fairy Chemical, Imidazole-4-carboxamide, as Its Metabolites in Rice (2019)
  • Author(s): Choi Jae-Hoon、Matsuzaki Nobuo、Wu Jing、Kotajima Mihaya、Hirai Hirofumi、Kondo Mitsuru、Asakawa Tomohiro、Inai Makoto、Ouchi Hitoshi、Kan Toshiyuki、Kawagishi Hirokazu
  • Journal Title: Organic Letters Volume: 21 Issue: 19 Pages: 7841-7845
  • DOI: 10.1021/acs.orglett.9b02833
  • Peer Reviewed
• [Journal Article] Efficient reconstitution of Basidiomycota diterpene erinacine gene cluster in Ascomycota host Aspergillus oryzae based on genomic DNA sequences (2019)
  • Author(s): Liu, C., Minami, A., Ozaki, T., Wu, J., Kawagishi, H., Maruyama, J., Oikawa, H.
  • Journal Title: J. Am. Chem. Soc. Volume: 141 Issue: 39 Pages: 15519-15523
  • DOI: 10.1021/jacs.9b08935
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Array of bioactive metabolites in Italian Hericium erinaceus mycelium, primordium and sporophore (2019)
  • Author(s): Corana, F., Cesaroni, V., Mannucci, B., Baiguera, R. M., Picco M. A., Savino, E., Ratto, D., Priori, C., Kawagishi, H., Girometta, C. E., Rossi, P.
  • Journal Title: Molecules Volume: 24 Issue: 19 Pages: 3511-3511
  • DOI: 10.3390/molecules24193511
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The complete mitochondrial genome sequence of the medicinal fungus Inonotus obliquus (Hymenochaetaceae, Basidiomycota) (2019)
  • Author(s): Agnestisia, R., Ono, A., Nakamura, L., Chino, R., Nodera, K., Aiso-Sanada, H., Nezu, I., Ishiguri, F., Suzuki, T., Yokota, S.
  • Journal Title: Mitochondrial DNA Part B. Volume: 4 Issue: 2 Pages: 3504-3506
  • DOI: 10.1080/23802359.2019.1675548
  • Peer Reviewed / Open Access
• [Journal Article] Transdermal delivery of nobiletin using ionic liquids (2019)
  • Author(s): Hattori Tadashi、Tagawa Hiroki、Inai Makoto、Kan Toshiyuki、Kimura Shin-ichiro、Itai Shigeru、Mitragotri Samir、Iwao Yasunori
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 20191-20191
  • DOI: 10.1038/s41598-019-56731-1
  • Peer Reviewed / Open Access
• [Journal Article] Piperidine and azetidine formation by direct cyclization of diols with N-nonsubstituted sulfonamide under the Mitsunobu conditions utilizing (cyanomethylene)tributylphosphorane (CMBP) and its application to the synthesis of lupinine (2019)
  • Author(s): Kaku, H., Sonoda, Y., Hishida, H., Taniguchi, Y., Kubo, A., Hamaguchi, T., Horikawa, M., Inai, M., Kitamura, K., Tsunoda, T.
  • Journal Title: Heterocycles Volume: 98 Issue: 11 Pages: 1525-1535
  • DOI: 10.3987/com-19-14171
  • NAID: 40022127977
  • Peer Reviewed
• [Journal Article] Diastereodivergent and Regiodivergent Total Synthesis of Princepin and Isoprincepin in Both (7″R,8″R) and (7″S,8″S) Isomers (2019)
  • Author(s): Kobayashi Manami、Ueno Hiroya、Yoshida Naoto、Ouchi Hitoshi、Asakawa Tomohiro、Yoshimura Fumihiko、Inai Makoto、Kan Toshiyuki
  • Journal Title: The Journal of Organic Chemistry Volume: 84 Issue: 21 Pages: 14227-14240
  • DOI: 10.1021/acs.joc.9b01965
  • Peer Reviewed
• [Journal Article] Concise Synthesis of TAN1251C (2019)
  • Author(s): Nagasaka Y, Asakawa T, Shintaku S, Masuda A, Matsumura K, Inai M, Ishikawa Y, Egi M, Hamashima Y, Kan T.
  • Journal Title: HETEROCYCLES Volume: 99 Issue: 2 Pages: 1095-1116
  • DOI: 10.3987/com-18-s(f)78
  • Peer Reviewed
• [Journal Article] Practical Synthesis of Polymethylated Flavones: Nobiletin and Its Desmethyl Derivatives (2019)
  • Author(s): Asakawa Tomohiro、Sagara Hiroto、Kanakogi Masaki、Hiza Aiki、Tsukaguchi Yuta、Ogawa Takahiro、Nakayama Miho、Ouchi Hitoshi、Inai Makoto、Kan Toshiyuki
  • Journal Title: Organic Process Research & Development Volume: 23 Issue: 4 Pages: 595-602
  • DOI: 10.1021/acs.oprd.9b00091
  • Peer Reviewed
• [Journal Article] N-Glucosides of fairy chemicals, 2-azahypoxanthine and 2-aza-8-oxohypoxanthine, in rice (2018)
  • Author(s): Choi, J-H., Wu, J., Sawada, A., Takemura, H., Yogosawa, K., Hirai, H., Kondo, M., Sugimoto, K., Asakawa, T., Inai, M., Kan, T., and Kawagishi, H.
  • Journal Title: Org. Lett. Volume: 20 Issue: 1 Pages: 312-314
  • DOI: 10.1021/acs.orglett.7b03736
  • Peer Reviewed
• [Journal Article] シバAgrostis stolonifera由来のコムラサキシメジ菌糸体に対する生育抑制物質 (2018)
  • Author(s): 崔宰熏，呉静，伏見圭司，平井浩文，河岸洋和
  • Journal Title: 日本きのこ学会誌 Volume: 25 Pages: 141-144
  • NAID: 40021483515
  • Peer Reviewed
• [Journal Article] A novel plant growth regulator from Pholiota lubrica (2018)
  • Author(s): Ridwan Arif Yanuar、Matoba Ryuta、Wu Jing、Choi Jae-Hoon、Hirai Hirofumi、Kawagishi Hirokazu
  • Journal Title: Tetrahedron Letters Volume: 59 Issue: 26 Pages: 2559-2561
  • DOI: 10.1016/j.tetlet.2018.05.045
  • NAID: 120006545324
  • Peer Reviewed
• [Journal Article] Discovery of Plant Growth Stimulants by C?H Arylation of 2-Azahypoxanthine (2018)
  • Author(s): Kitano Hiroyuki、Choi Jae-Hoon、Ueda Ayaka、Ito Hideto、Hagihara Shinya、Kan Toshiyuki、Kawagishi Hirokazu、Itami Kenichiro
  • Journal Title: Organic Letters Volume: 20 Issue: 18 Pages: 5684-5687
  • DOI: 10.1021/acs.orglett.8b02407
  • Peer Reviewed
• [Journal Article] Fairy chemicals ? a candidate for a new family of plant hormones and possibility of practical use in agriculture (2018)
  • Author(s): Kawagishi Hirokazu
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 82 Issue: 5 Pages: 752-758
  • DOI: 10.1080/09168451.2018.1445523
  • NAID: 120006600392
  • Peer Reviewed
• [Journal Article] Bioactive compounds from the edible mushroom Cortinarius caperatus (2018)
  • Author(s): Ridwan, Y. A., Wu, J., Choi, J-H., Hirai, H., and Kawagishi, H.
  • Journal Title: Mycoscience Volume: 59 Issue: 2 Pages: 172-175
  • DOI: 10.1016/j.myc.2017.08.015
  • NAID: 120006533592
  • Peer Reviewed
• [Journal Article] The medicinal mushroom Grifola Gargal ameliorates Allergic bronchial asthma (2018)
  • Author(s): Harada, E., D’Alessandro-Gabazza, C. N., Toda, M., Morizono, T., Totoki, T., Yasuma, T., Nishihama, K., Kobayashi, T. Sumiya, Kawagishi, H., and Gabazza. E. C.
  • Journal Title: J. Med. Food Volume: 21 Issue: 2 Pages: 136-145
  • DOI: 10.1089/jmf.2017.4016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] きのこが産生する生体機能性物質に関する研究 (2018)
  • Author(s): 河岸洋和
  • Journal Title: 日本きのこ学会誌 Volume: 25 Pages: 122-128
  • NAID: 130007703206
  • Peer Reviewed
• [Journal Article] Plant growth regulators from the fruiting bodies of Tricholoma flavovirens (2017)
  • Author(s): Qiu, W., Kobori, H., Wu, J., Choi－H., Hira, H., and Kawagishi, H.
  • Journal Title: Biosci. Biotechnol. Biochem. Volume: 81 Issue: 3 Pages: 441-444
  • DOI: 10.1080/09168451.2016.1249453
  • NAID: 120006380813
  • Peer Reviewed
• [Journal Article] Cytotoxic compounds against cancer cells from Bombyx mori inoculated with Cordyceps militaris (2017)
  • Author(s): 1.Qiu, W., Wu, J., Choi, J.-H., Hira, H., Nishida, H., and Kawagishi, H.
  • Journal Title: Biosci. Biotechnol. Biochem. Volume: 印刷中 Issue: 6 Pages: 1224-1226
  • DOI: 10.1080/09168451.2017.1289075
  • NAID: 120006395368
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Plant growth regulators from the edible mushroom Leccinum extremiorientale (2017)
  • Author(s): Ito, A., Wu, J., Ozawa, N., Choi, J-H., Hirai, H., and Kawagishi, H.
  • Journal Title: Mycoscience Volume: 58 Issue: 6 Pages: 383-386
  • DOI: 10.1016/j.myc.2017.04.008
  • NAID: 120006492731
  • Peer Reviewed
• [Journal Article] Plant growth inhibitors from the culture broth of fairy ring-forming fungus Lepista sordida (2017)
  • Author(s): Ito, A., Choi, J-H., Wu, J., Tanaka, H., Hirai, H., and Kawagishi, H.
  • Journal Title: Mycoscience Volume: 58 Issue: 6 Pages: 387-390
  • DOI: 10.1016/j.myc.2017.05.001
  • NAID: 120006492725
  • Peer Reviewed
• [Journal Article] Gram-scale, stereoselective synthesis and biological evaluation of (+)-armillariol C (2017)
  • Author(s): Motati, D. R., Kobori, H., Mori, T., Wu, J. Kawagishi, H., and Watkins, E.
  • Journal Title: J. Nat. Prod. Volume: 80 Issue: 9 Pages: 2561-2565
  • DOI: 10.1021/acs.jnatprod.7b00484
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] High-quality draft genome sequence of Burkholderia contaminans CH-1, a Gram-negative bacterium that metabolizes 2-azahypoxanthine, a plant growth-regulating compound (2017)
  • Author(s): Choi, J-H., Moriuchia, R., Sugiurac, H., Kawagishi, H, and Dohra, H.
  • Journal Title: Genome Announc. Volume: 5 Issue: 41
  • DOI: 10.1128/genomea.01148-17
  • NAID: 120006376296
  • Peer Reviewed / Open Access
• [Journal Article] キノコの毒 (2017)
  • Author(s): 橋本貴美子，河岸洋和
  • Journal Title: CLINICAL NEUROSCIENCE Volume: 35 Pages: 1427-1431
  • Peer Reviewed
• [Journal Article] フェアリー化合物は植物ホルモンか？ (2017)
  • Author(s): 河岸洋和
  • Journal Title: 植物の生長調節 Volume: 52 Pages: 78-84
  • NAID: 130006308104
  • Peer Reviewed
• [Presentation] キノコからの医薬候補物質の探索とその将来性 (2019)
  • Author(s): 河岸洋和
  • Organizer: 第８回食品薬学シンポジウム
  • Invited
• [Presentation] フェアリー化合物の化学，そして農業への応用の可能性 フェアリー化合物は新しい植物ホルモン？ (2018)
  • Author(s): 河岸洋和
  • Organizer: 日本農薬学会第43回大会
  • Invited
• [Presentation] フェアリー化合物は新しい植物ホルモンか？ (2018)
  • Author(s): 河岸洋和
  • Organizer: 日本ケミカルバイオロジー学会第13回年会
  • Invited
• [Presentation] スギヒラタケ急性脳症の化学的解明の試み (2018)
  • Author(s): 河岸洋和
  • Organizer: 日本学術振興会第170委員会・第189委員会合同シンポジウム
  • Invited
• [Presentation] Fairy chemicals -a candidate for a new family of plant hormones and for new agrochemicals- (2018)
  • Author(s): Hirokazu Kawagishi
  • Organizer: 6th Biennial International Conference on New Developments in Drug Discovery from Natural Products and Traditional Medicines
  • Int'l Joint Research / Invited
• [Presentation] キノコと植物をつなぐ活性分子 (2018)
  • Author(s): 河岸洋和
  • Organizer: 日本農芸化学会2018年度大会（名古屋）シンポジウム 「アグリケミストリー：生命をつなぐ活性分子とその応用」
  • Invited
• [Presentation] フェアリーリングを引き起こす小さな分子 (2018)
  • Author(s): 河岸洋和
  • Organizer: 日本薬学会第138年会シンポジウム 「天然物パワー５：生物現象を制御する天然分子」
  • Invited
• [Presentation] フェアリーリングの化学的解明とそのフェアリーの農業への応用への可能性 (2017)
  • Author(s): 河岸洋和
  • Organizer: 糸状菌遺伝子研究会第38回例会
  • Invited
• [Presentation] キノコが農業を変える？ フェアリー化合物の発見とその応用展開 (2017)
  • Author(s): 河岸洋和
  • Organizer: 第4 1 回九州紙パルプ研究会講演会
  • Invited
• [Presentation] フェアリー化合物を用いた新規植物成長調節剤の創製 (2017)
  • Author(s): 河岸洋和
  • Organizer: 第6回JACI/GSCシンポジウム（
  • Invited
• [Presentation] フェアリーリングの謎を化学で解く (2017)
  • Author(s): 河岸洋和
  • Organizer: Visionary 農芸化学100 シンポジウム 天然物化学領域 第1回「生命現象に介在する天然物の化学」
  • Invited
• [Book] Green Science and Technology (2019)
  • Author(s): Park, E. Y., Saito, T., Kawagishi, H. and Hara, M.
  • Total Pages: 343
  • Publisher: CRC press
  • ISBN: 9780367415136
• [Book] Natural Products and Drug Discover (2018)
  • Author(s): Hirokazu Kawagishi
  • Total Pages: 776
  • Publisher: Elsevier
  • ISBN: 9780081020814
• [Book] 天然有機分子の構築 (2018)
  • Author(s): 河岸洋和
  • Total Pages: 148
  • Publisher: 共立出版
  • ISBN: 9784320044678
• [Book] ケミカルバイオロジー化合物集 ―研究展開のヒント― (2018)
  • Author(s): 河岸洋和
  • Total Pages: 304
  • Publisher: 株式会社オーム社
  • ISBN: 9784274507090
• [Remarks]
  • URL: https://www.agr.shizuoka.ac.jp/c/biochem/index.html
• [Remarks]
  • URL: http://www.agr.shizuoka.ac.jp/c/biochem/index.html
• [Patent(Industrial Property Rights)] 動物細胞の細胞賦活剤 (2019)
  • Inventor(s): 青島央江，河岸洋和
  • Industrial Property Rights Holder: ビタミンＣ６０バイオリサーチ株式会社，静岡大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2019-105950
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 抗癌剤耐性抑制剤 (2019)
  • Inventor(s): 原田栄津子，ガバザエステバン，河岸洋和
  • Industrial Property Rights Holder: 株式会社岩出菌学研究所，三重大学，静岡大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2019-105950
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 抗癌剤耐性抑制剤 (2019)
  • Inventor(s): 原田栄津子，ガバザエステバン，河岸洋和
  • Industrial Property Rights Holder: 株式会社岩出菌学研究所，三重大学，静岡大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2019-151529
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 抗癌剤耐性抑制剤 (2018)
  • Inventor(s): 河岸洋和 ガバザ エステバン 西川俊夫 原田栄津子
  • Industrial Property Rights Holder: 岩出菌学研究所 静岡大学 三重大学 名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] ヤマブシタケ由来新規化合物 (2018)
  • Inventor(s): 河岸洋和 原田栄津子
  • Industrial Property Rights Holder: 岩出菌学研究所 静岡大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] 植物病害防除剤 (2018)
  • Inventor(s): 平田(山口) 久笑 河岸洋和 崔宰熏 田中薫
  • Industrial Property Rights Holder: 石原産業株式会社 静岡大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Overseas