| Co-Investigator(Kenkyū-buntansha) |
角田 郁生 近畿大学, 医学部, 教授 (00261529)
岡田 斉 近畿大学, 医学部, 教授 (20280620)
坂井 和子 近畿大学, 医学部, 講師 (20580559)
上嶋 一臣 近畿大学, 医学部, 講師 (70411593)
櫻井 俊治 近畿大学, 医学部, 講師 (90397539)
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| Budget Amount *help |
¥76,180,000 (Direct Cost: ¥58,600,000、Indirect Cost: ¥17,580,000)
Fiscal Year 2021: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2020: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2019: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2018: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2017: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
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| Outline of Final Research Achievements |
Host-microbe interactions in inflammatory bowel disease were investigated. Activation of ribonucleoprotein complex biosynthesis and cytokine signaling pathway mediated by the gut microbiota affected DNA repair, IFN-γ signaling, etc. in the colonic mucosa and was associated with response to immune checkpoint inhibitors and immune-related colitis. Immune checkpoint inhibitor-induced immune-associated colitis showed functional similarities in gut tissue and microbial composition with ulcerative colitis, but decreased Bacteroides species resulted in an enhanced fatty acid transport system and immune cell reorganization in both diseases.
The gut microbiota is involved in pathogenesis of multiple sclerosis and curcumin monoglucuronide modulated microbiota and the pathogenesis histologically.
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