| Budget Amount *help |
¥75,400,000 (Direct Cost: ¥58,000,000、Indirect Cost: ¥17,400,000)
Fiscal Year 2021: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2020: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2019: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2018: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2017: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
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| Outline of Final Research Achievements |
Endoplasmic reticulum transmembrane transcription factor OASIS is characterized by accumulation at the collapsed nuclear envelope (nuclear-endoplasmic reticulum linkage zone). In this research, we aimed to elucidate the zone structure and the repair mechanism of the collapsed nuclear envelope. As a result, it was found that multiple factors in addition to OASIS are accumulated in the zone, and they cooperatively promote the repair of the nuclear envelope. Oasis itself is not directly involved in its repair, but it has been found to play an important function in creating a repair environment by suppressing the cell cycle. Furthermore, in glioblastoma, we found that the OASIS gene promoter region received DNA methylation, and succeeded in developing a method to stop the growth of cancer cells by inducing DNA demethylation by epigenome editing.
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