• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Lipid transport via the endoplasmic reticulum communication zones

Planned Research

Project AreaToward an integrative understanding of functional zones in organelles
Project/Area Number 17H06417
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Hanada Kentaro  国立感染症研究所, 品質保証・管理部, 主任研究官 (30192701)

Co-Investigator(Kenkyū-buntansha) 加藤 薫  国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (80356782)
下嶋 美恵  東京工業大学, 生命理工学院, 准教授 (90401562)
Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥114,660,000 (Direct Cost: ¥88,200,000、Indirect Cost: ¥26,460,000)
Fiscal Year 2021: ¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
Fiscal Year 2020: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2019: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2018: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2017: ¥35,230,000 (Direct Cost: ¥27,100,000、Indirect Cost: ¥8,130,000)
Keywordsオルガネラ間脂質輸送 / 小胞体 / ゴルジ体 / 葉緑体 / CERT / PAH / ゲノム編集 / 超解像蛍光顕微鏡 / 脂質輸送 / オルガネラ膜接触部位 / 超解像イメージング
Outline of Final Research Achievements

Lipid transport between organelles is thought to occur efficiently in special intracellular subregions (called organelle communication zones) where different organelles contact each other. However, it remains elusive how the zones for lipid transport are formed and functionally regulated. and the visualization of the zone has not been achieved. In this study, we investigated the ceramide transfer protein CERT, which mediates ceramide transport from the endoplasmic reticulum (ER) to the Golgi apparatus in animal cells, and the phosphatidic acid phosphohydrolase, which is involved in phospholipid transport from the ER to the chloroplast in plant cells. Using high-resolution imaging techniques, we elucidated the molecular mechanisms underlying the formation and regulation of the ER communication zones involved in lipid transport.

Academic Significance and Societal Importance of the Research Achievements

小胞体と他のオルガネラとの連携ゾーンで効率的な脂質転送が起こる仕組みの一端が明らかになった。また、高解像イメージング技術についても、細胞生物学に大変有用ないくつかの新技法を提供した。さらに、CERTの抑制制御不全は人の疾病の原因となり、また、植物におけるPAHの機能不全はリン欠乏をはじめとする様々なストレス応答の不全をもたらすことも明らかになってきた。よって、本研究成果は、人の疾病の診断・治療やストレス耐性型有用植物の作出といった応用に結び付くと期待される。

Report

(6 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (163 results)

All 2023 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (6 results) Journal Article (54 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 45 results,  Open Access: 36 results) Presentation (88 results) (of which Int'l Joint Research: 22 results,  Invited: 30 results) Remarks (15 results)

  • [Int'l Joint Research] University of Cambridge/Birmingham Women’s Hospital/Northern Regional Genetics Laboratory(英国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] ERN-RND/Humboldt-Universitat zu Berlin/Institute of Human Genetics(ドイツ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] EPFL/University of Zurich/University of Bern(スイス)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Stony Brook University Medical Center/Columbia University/Medical University of South Carolina(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Hospital Sant Joan de Deu/Institute of Rare Diseases Research/Valle Hebron Research Institute(スペイン)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Protocol for casein kinase 1γ3 CSNK1G3 gene knockout and recombinant gene expression in cultured HeLa cells2023

    • Author(s)
      Goto Asako、Hanada Kentaro
    • Journal Title

      STAR Protocols

      Volume: 4 Issue: 2 Pages: 102251-102251

    • DOI

      10.1016/j.xpro.2023.102251

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CERT1 mutations perturb human development by disrupting sphingolipid homeostasis2023

    • Author(s)
      Gehin Charlotte、Kentaro Hanada (85名中、78番目)、et al.
    • Journal Title

      Journal of Clinical Investigation

      Volume: 133 Issue: 10

    • DOI

      10.1172/jci165019

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi2023

    • Author(s)
      Mizuike Aya、Sakai Shota、Katoh Kaoru、Yamaji Toshiyuki、Hanada Kentaro
    • Journal Title

      Journal of Cell Biology

      Volume: 222 Issue: 7

    • DOI

      10.1083/jcb.202111069

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT2022

    • Author(s)
      Kentaro Hanada, Shota Sakai, Keigo Kumagai
    • Journal Title

      Internal Journal of Molecular Sciences

      Volume: 23 Issue: 4 Pages: 2098-2098

    • DOI

      10.3390/ijms23042098

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperosmotic Stress Induces Phosphorylation of CERT and Enhances Its Tethering Throughout the Endoplasmic Reticulum2022

    • Author(s)
      Shimasaki K, Kumagai K, Sakai S, Yamaji T, Hanada K
    • Journal Title

      Int J Mol Sci

      Volume: 23 Issue: 7 Pages: 4025-4025

    • DOI

      10.3390/ijms23074025

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ligand recognition by the lipid transfer domain of human OSBP is important for entero-virus replication2022

    • Author(s)
      5. Jun Kobayashi#, Minetaro Arita*#, Shota Sakai, Hirotatsu Kojima, Miki Senda, Toshiya Senda, Kentaro Hanada and Ryuichi Kato*
    • Journal Title

      ACS Infectious Diseases

      Volume: 8 Issue: 6 Pages: 1161-1170

    • DOI

      10.1021/acsinfecdis.2c00108

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chlamydial Infection-Dependent Synthesis of Sphingomyelin as a Novel Anti-Chlamydial Target of Ceramide Mimetic Compounds2022

    • Author(s)
      Keigo Kumagai, Shota Sakai, Masaharu Ueno, Michiyo Kataoka, Shu Kobayashi, Kentaro Hanada
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 23 Pages: 14697-14697

    • DOI

      10.3390/ijms232314697

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide2022

    • Author(s)
      Goto A, Sakai s, Mizuike A, Yamaji T, Hanada K
    • Journal Title

      iScience

      Volume: 25 Issue: 7 Pages: 164624-164624

    • DOI

      10.1016/j.isci.2022.104624

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of phalloidin‐negative nuclear actin filaments in U2OS cells expressing cytoplasmic actin‐EGFP2022

    • Author(s)
      Nagasaki Akira、Katoh Kaoru、Hoshi Masamichi、Doi Motomichi、Nakamura Chikashi、Uyeda Taro Q. P.
    • Journal Title

      Genes to Cells

      Volume: 27 Issue: 5 Pages: 317-330

    • DOI

      10.1111/gtc.12930

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modeling Protein Molecules at the Mesoscale: for Structural Study of Artificial Muscle2022

    • Author(s)
      上野 豊, 松田 健人, 加藤 薫, 角五 彰, 葛谷 明紀, 小長谷 明彦
    • Journal Title

      Seibutsu Butsuri

      Volume: 62 Issue: 1 Pages: 58-61

    • DOI

      10.2142/biophys.62.58

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3.2021

    • Author(s)
      Riccardo Rizzo, Domenico Russo, Kazuo Kurokawa, Alfredo Budillon, Franck Perez, Seetharaman Parashuraman, Yusuf A Hannun, Akihiko Nakano, Daniela Corda, Giovanni D’Angelo and Alberto Luini et al.,.
    • Journal Title

      The EMBO Journal

      Volume: 40 Issue: 8

    • DOI

      10.15252/embj.2020107238

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of SYS1 as a Host Factor Required for Shiga Toxin-Mediated Cytotoxicity in Vero Cells2021

    • Author(s)
      Sakuma Chisato、Sekizuka Tsuyoshi、Kuroda Makoto、Hanada Kentaro、Yamaji Toshiyuki
    • Journal Title

      Int J Mol Sci

      Volume: 22 Issue: 9 Pages: 4936-4936

    • DOI

      10.3390/ijms22094936

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intellectual-disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution2021

    • Author(s)
      Norito Tamura, Shota Sakai, Loreto Martorell, Roser Colom, Aya Mizuike, Asako Goto, Juan Dario Ortigoza-Escobar and Kentaro Hanada
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 297 Issue: 5 Pages: 1-10

    • DOI

      10.1016/j.jbc.2021.101338

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protein lactylation induced by neural excitation2021

    • Author(s)
      Hagihara Hideo、Shoji Hirotaka、Otabi Hikari、Toyoda Atsushi、Katoh Kaoru、Namihira Masakazu、Miyakawa Tsuyoshi
    • Journal Title

      Cell Reports

      Volume: 37 Issue: 2 Pages: 109820-109820

    • DOI

      10.1016/j.celrep.2021.109820

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microscopy of Diffuse Nematic-Isotropic Transition in Main-Chain Nematic Liquid-Crystal Elastomers2021

    • Author(s)
      Ohzono Takuya、Katoh Kaoru、Terentjev Eugene M.
    • Journal Title

      Macromolecules

      Volume: 54 Issue: 8 Pages: 3678-3688

    • DOI

      10.1021/acs.macromol.1c00356

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Internal constraints and arrested relaxation in main-chain nematic elastomers2021

    • Author(s)
      Ohzono Takuya、Katoh Kaoru、Minamikawa Hiroyuki、Saed Mohand O.、Terentjev Eugene M.
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 787-787

    • DOI

      10.1038/s41467-021-21036-3

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 非天然骨格を有する新規CERT阻害薬の創成:産学官連携による成果創出2021

    • Author(s)
      中尾 直樹、小林 修、花田 賢太郎
    • Journal Title

      Farumashia

      Volume: 57 Issue: 12 Pages: 1108-1112

    • DOI

      10.14894/faruawpsj.57.12_1108

    • NAID

      130008123338

    • ISSN
      0014-8601, 2189-7026
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood group P1 antigen?bearing glycoproteins are functional but less efficient receptors of Shiga toxin than conventional glycolipid-based receptors2020

    • Author(s)
      Morimoto K, Suzuki N, Tanida I, Kakuta S, Furuta Y, Uchiyama Y, Hanada K, Suzuki Y, Yamaji T.
    • Journal Title

      J Biol Chem

      Volume: 295 Issue: 28 Pages: 9490-9501

    • DOI

      10.1074/jbc.ra120.013926

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT2020

    • Author(s)
      Murakami Hiroaki、Tamura Norito、Enomoto Yumi、Shimasaki Kentaro、Kurosawa Kenji、Hanada Kentaro
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 12 Pages: e0243980-e0243980

    • DOI

      10.1371/journal.pone.0243980

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sphingolipid Metabolism at the ER-Golgi Contact Zone and Its Impact on Membrane Trafficking2020

    • Author(s)
      Goto Asako、Mizuike Aya、Hanada Kentaro
    • Journal Title

      Contact

      Volume: 3 Pages: 1-13

    • DOI

      10.1177/2515256420959514

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RCB-mediated chlorophagy caused by oversupply of nitrogen suppresses phosphate-starvation stress in plants2020

    • Author(s)
      Yoshitake Yushi、Nakamura Sakuya、Shinozaki Daiki、Izumi Masanori、Yoshimoto Kohki、Ohta Hiroyuki、Shimojima Mie
    • Journal Title

      Plant Physiology

      Volume: 185 Pages: 318-330

    • DOI

      10.1093/plphys/kiaa030

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modeling a Microtubule Filaments Mesh Structure from Confocal Microscopy Imaging2020

    • Author(s)
      Ueno Yutaka、Matsuda Kento、Katoh Kaoru、Kuzuya Akinori、Kakugo Akira、Konagaya Akihiko
    • Journal Title

      Micromachines

      Volume: 11 Issue: 9 Pages: 844-844

    • DOI

      10.3390/mi11090844

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration2020

    • Author(s)
      Yamaguchi Hirofumi、Honda Shinya、Torii Satoru、Shimizu Kimiko、Katoh Kaoru、Miyake Koichi、Miyake Noriko、Fujikake Nobuhiro、Sakurai Hajime Tajima、Arakawa Satoko、Shimizu Shigeomi
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 5311-5311

    • DOI

      10.1038/s41467-020-18892-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coefficient of variation as an image-intensity metric for cytoskeleton bundling.2020

    • Author(s)
      Higaki T, Akita K, Katoh K
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 22187-22187

    • DOI

      10.1038/s41598-020-79136-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three‐Component, One‐Pot Tandem Sonogashira/Suzuki‐Miyaura Coupling Reactions for the Synthesis of a Library of Ceramide‐Transport Protein Inhibitors Designed In Silico2020

    • Author(s)
      Ueno Masaharu、Miyoshi Norikazu、Hanada Kentaro、Kobayashi Shu
    • Journal Title

      Asian Journal of Organic Chemistry

      Volume: 9 Issue: 2 Pages: 267-273

    • DOI

      10.1002/ajoc.201900689

    • NAID

      120007001416

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structure, functions and regulation of CERT, a lipid‐transfer protein for the delivery of ceramide at the ER?Golgi membrane contact sites2019

    • Author(s)
      Kumagai Keigo、Hanada Kentaro
    • Journal Title

      FEBS Letters

      Volume: 593 Issue: 17 Pages: 2366-2377

    • DOI

      10.1002/1873-3468.13511

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of monoclonal antibodies recognizing each extracellular loop domain of occludin2019

    • Author(s)
      Shimizu Yoshimi、Shirasago Yoshitaka、Suzuki Takeru、Hata Tomoyuki、Kondoh Masuo、Hanada Kentaro、Yagi Kiyohito、Fukasawa Masayoshi
    • Journal Title

      The Journal of Biochemistry

      Volume: 166 Issue: 4 Pages: 297-308

    • DOI

      10.1093/jb/mvz037

    • NAID

      40022023629

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A CRISPR Screen Using Subtilase Cytotoxin Identifies SLC39A9 as a Glycan-Regulating Factor2019

    • Author(s)
      Yamaji Toshiyuki、Hanamatsu Hisatoshi、Sekizuka Tsuyoshi、Kuroda Makoto、Iwasaki Norimasa、Ohnishi Makoto、Furukawa Jun-ichi、Yahiro Kinnosuke、Hanada Kentaro
    • Journal Title

      iScience

      Volume: 15 Pages: 407-420

    • DOI

      10.1016/j.isci.2019.05.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chlamydia trachomatis‐infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 22019

    • Author(s)
      Tachida Yuriko、Kumagai Keigo、Sakai Shota、Ando Shuji、Yamaji Toshiyuki、Hanada Kentaro
    • Journal Title

      FEBS Letters

      Volume: 594 Issue: 3 Pages: 519-529

    • DOI

      10.1002/1873-3468.13632

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organelle contacts: Sub‐organelle zones to facilitate rapid and accurate inter‐organelle trafficking of lipids2019

    • Author(s)
      Hanada Kentaro
    • Journal Title

      Traffic

      Volume: 21 Issue: 1 Pages: 189-196

    • DOI

      10.1111/tra.12716

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autophagy-Mediated Regulation of Lipid Metabolism and Its Impact on the Growth in Algae and Seed Plants2019

    • Author(s)
      Yoshitake Yushi、Ohta Hiroyuki、Shimojima Mie
    • Journal Title

      Frontiers in Plant Science

      Volume: 10 Pages: 709-709

    • DOI

      10.3389/fpls.2019.00709

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lipid remodeling under acidic conditions and its interplay with low Pi stress in Arabidopsis2019

    • Author(s)
      Murakawa Masato、Ohta Hiroyuki、Shimojima Mie
    • Journal Title

      Plant Molecular Biology

      Volume: 101 Issue: 1-2 Pages: 81-93

    • DOI

      10.1007/s11103-019-00891-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional Correlation between Subcellular Localizations of Japanese Encephalitis Virus Capsid Protein and Virus Production2019

    • Author(s)
      Ishida Kotaro、Goto Simon、Ishimura Marina、Amanuma Misato、Hara Yumiko、Suzuki Ryosuke、Katoh Kaoru、Morita Eiji
    • Journal Title

      Journal of Virology

      Volume: 93 Issue: 19 Pages: 00612-19

    • DOI

      10.1128/jvi.00612-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bacterial Cell Culture at the Single-Cell Level Inside Giant Vesicles2019

    • Author(s)
      Masamune Morita, Yuri Ota, Kaoru Katoh, Naohiro Noda
    • Journal Title

      Journal of Visualized Experiments

      Volume: 146:e59555 Issue: 146 Pages: 1-7

    • DOI

      10.3791/59555

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] スフィンゴリン脂質2019

    • Author(s)
      花田賢太郎
    • Journal Title

      実験医学別冊「脂質解析ハンドブック」

      Volume: - Pages: 109-118

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 蛍光脂質2019

    • Author(s)
      中村浩之, 花田賢太郎
    • Journal Title

      実験医学別冊「脂質解析ハンドブック」

      Volume: - Pages: 241-249

    • Related Report
      2019 Annual Research Report
  • [Journal Article] A CRISPR screen identifies LAPTM4A and TM9SF proteins as glycolipid-regulating factors2019

    • Author(s)
      Yamaji T, Sekizuka T, Tachida Y, Sakuma C, Morimoto K, Kuroda M, Hanada K
    • Journal Title

      iScience

      Volume: 11 Pages: 409-424

    • DOI

      10.1016/j.isci.2018.12.039

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Natural ligand-nonmimetic inhibitors to the lipid transfer protein CERT2019

    • Author(s)
      Naoki Nakao, Masaharu Ueno, Shota Sakai, Daichi Egawa, Hiroyuki Hanzawa, Shohei Kawasaki, Keigo Kumagai, Makoto Suzuki, Shu Kobayashi and Kentaro Hanada
    • Journal Title

      Communications Chemistry

      Volume: 2 Issue: 1 Pages: 20-20

    • DOI

      10.1038/s42004-019-0118-3

    • NAID

      120006558385

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fascin in lamellipodia contributes to cell elasticity by controlling the orientation of filamentous actin2019

    • Author(s)
      Minami Tanaka, Yuki Fujii, Kazumi Hirano, Takumi Higaki, Akira Nagasaki, Ryoki Ishikawa, Takaharu Okajima, Kaoru Katoh
    • Journal Title

      Genes to Cells

      Volume: 24 Issue: 3 Pages: 202-213

    • DOI

      10.1111/gtc.12671

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif2018

    • Author(s)
      Sugiki Toshihiko、Egawa Daichi、Kumagai Keigo、Kojima Chojiro、Fujiwara Toshimichi、Takeuchi Koh、Shimada Ichio、Hanada Kentaro、Takahashi Hideo
    • Journal Title

      Journal of Biological Chemistry

      Volume: 293 Issue: 28 Pages: 11206-11217

    • DOI

      10.1074/jbc.ra118.002465

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lipid-transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites2018

    • Author(s)
      Kentaro Hanada
    • Journal Title

      Journal of Lipid Research

      Volume: 59 Issue: 8 Pages: 1341-1366

    • DOI

      10.1194/jlr.r085324

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Both the N- and C- terminal regions of the Chlamydial inclusion protein D (IncD) are required for interaction with the pleckstrin homology domain of the ceramide transport protein CERT2018

    • Author(s)
      Kumagai Keigo、Elwell Cherilyn A.、Ando Shuji、Engel Joanne N.、Hanada Kentaro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 505 Issue: 4 Pages: 1070-1076

    • DOI

      10.1016/j.bbrc.2018.09.168

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cdk1-dependent phosphorylation of KIF4A at S1186 triggers lateral chromosome compaction during early mitosis2018

    • Author(s)
      Hideaki Takata, Marliza Madung, Kaoru Katoh, Kiichi Fukui
    • Journal Title

      PLoS ONE

      Volume: 13(12) Issue: 12 Pages: e0209614-e0209614

    • DOI

      10.1371/journal.pone.0209614

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct Observation of Bacterial Growth in Giant Unilamellar Vesicles: A Novel Tool for Bacterial Cultures2018

    • Author(s)
      Masamune Morita, Kaoru Katoh, Naohiro Noda
    • Journal Title

      ChemistryOpen

      Volume: 7 Issue: 11 Pages: 845-849

    • DOI

      10.1002/open.201800126

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arabidopsis vegetative actin isoforms, AtACT2 and AtACT7, generate distinct filament arrays in living plant cells2018

    • Author(s)
      Kijima ST, Staiger CJ, Katoh K, Nagasaki A, Ito K, Uyeda TQP
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 4381-4381

    • DOI

      10.1038/s41598-018-22707-w

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 小胞体連携ゾーンを介した脂質輸送機構2018

    • Author(s)
      水池彩、花田賢太郎
    • Journal Title

      生体の科学

      Volume: 69 Pages: 541-545

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 植物の栄養欠乏ストレス耐性における膜脂質転換の役割2018

    • Author(s)
      吉竹悠宇志、下嶋美恵
    • Journal Title

      アグリバイオ

      Volume: 74 Pages: 72-75

    • NAID

      40021803261

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 位相差顕微鏡2018

    • Author(s)
      大瀧達朗、加藤薫
    • Journal Title

      実験医学

      Volume: 36(20) Pages: 24-25

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 偏光観察2018

    • Author(s)
      加藤薫
    • Journal Title

      実験医学

      Volume: 36(20) Pages: 30-31

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 複屈折顕微鏡(Polscope)2018

    • Author(s)
      加藤薫
    • Journal Title

      実験医学

      Volume: 36(20) Pages: 73-75

    • Related Report
      2018 Annual Research Report
  • [Journal Article] アポディゼーション位相差顕微鏡2018

    • Author(s)
      大瀧達朗、加藤薫
    • Journal Title

      実験医学

      Volume: 36(20) Pages: 80-81

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 超解像光学顕微鏡2018

    • Author(s)
      加藤薫
    • Journal Title

      光技術動向調査報告書2017年度

      Volume: - Pages: 234-241

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Uncovering different states of topological defects in schlieren textures of a nematic liquid crystal2017

    • Author(s)
      Ohzono Takuya、Katoh Kaoru、Wang Chenguang、Fukazawa Aiko、Yamaguchi Shigehiro、Fukuda Jun-ichi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 16814-16814

    • DOI

      10.1038/s41598-017-16967-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arabidopsis phosphatidic acid phosphohydrolases are essential for growth under nitrogen-depleted conditions2017

    • Author(s)
      Yoshitake, Y., Sato, R., Madoka, Y., Ikeda, K., Murakawa, M., Suruga, K., Sugiura, D., Noguchi, K., Ohta, H., and Shimojima, M.
    • Journal Title

      Frontiers in Plant Science

      Volume: 8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] How does lipid transport between organelles in the cell occur, and how is it regulated? A lesson from the ceramide transport protein CERT2022

    • Author(s)
      Kentaro Hanada
    • Organizer
      Centenary Institute Tuesday Seminar, the University of Sydney
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] カゼインキナーゼ1γのC末端脂質修飾に依存した細胞内局在変化がスフィンゴミエリン生合成におけるセラミド輸送を制御する2022

    • Author(s)
      後藤麻子、酒井祥太、水池彩、山地俊之、花田賢太郎
    • Organizer
      第64回日本脂質生化学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Casein kinase 1γの分布区画化が小胞体―ゴルジ体間セラミド輸送を制御する2022

    • Author(s)
      後藤麻子、酒井祥太、水池彩、山地俊之、花田賢太郎
    • Organizer
      第15回セラミド研究会学術集会・第16回スフィンゴテラピー研究会合同年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 寄生細菌クラミジアは宿主細胞のセラミドをいかにして利用するのか2021

    • Author(s)
      花田賢太郎
    • Organizer
      日本薬学会生物系薬学部会主催第21回Pharmaco-Hematologyシンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] COOL STRUTTIN’ オルガネラ間脂質輸送2021

    • Author(s)
      花田賢太郎
    • Organizer
      第63回日本脂質生化学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] CERTの多重リン酸化依存的な機能抑制における塩基性アミノ酸クラスターの役割2021

    • Author(s)
      後藤麻子,江川大地,冨重斉生,熊谷圭悟,花田賢太郎
    • Organizer
      第63回日本脂質生化学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生物の合理性が育んだオルガネラ間脂質輸送システム:近距離で早く正確にものを運ぶ2021

    • Author(s)
      花田賢太郎
    • Organizer
      第73回日本細胞生物学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] カゼインキナーゼ1γのC末端領域依存的な細胞内局在の変化がスフィンゴミエリン生合成におけるセラミド輸送に影響を及ぼす2021

    • Author(s)
      後藤麻子,水池彩,山地俊之,花田賢太郎
    • Organizer
      第73回日本細胞生物学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 抗がん剤OSW-1によるゴルジ体ストレス応答におけるPtdIns transfer protein beta(PITPNB)の機能解析2021

    • Author(s)
      佐々木 桂奈江、森下 史、足立 拓弥、渡部 雄斗、若林 貞夫、櫻井 香里、養王田 正文、山地 俊之、花田 賢太郎、吉田 秀郎
    • Organizer
      第73回日本細胞生物学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アポダイズド位相差顕微鏡による無染色・非侵襲での細胞内微細構造動態の観察2021

    • Author(s)
      島﨑健太朗, 加藤薫, 中村優子, 齊藤恭子, 深澤征義, 花田賢太郎
    • Organizer
      第30回日本バイオイメージング学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 宿主細胞からクラミジア・トラコマティスへのセラミドフローを担う分子機構2021

    • Author(s)
      熊谷圭悟、杉木俊彦、児嶋長次郎、花田賢太郎
    • Organizer
      第94回日本生化学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 小胞体-ゴルジ体間セラミド輸送ゾーンの形成に重要なPI4P関連因子の解析2021

    • Author(s)
      水池彩, 酒井祥太, 加藤薫, 山地俊之, 花田賢太郎
    • Organizer
      第44回日本分子生物学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 抗がん剤OSW-1が引き起こすゴルジ体ストレス依存性細胞死はホスホイノシタイド代謝因子によって制御される2021

    • Author(s)
      佐々木桂奈江、森下史、足立拓弥、渡部雄斗、若林貞夫、櫻井香里、養王田正文、山地俊之、花田賢太郎、吉田秀郎
    • Organizer
      第44回日本分子生物学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 小胞体-ゴルジ体膜接触ゾーンで働くセラミド輸送タンパク質CERTの機能制御とその破綻2021

    • Author(s)
      花田賢太郎
    • Organizer
      第142回日本薬学会年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] シロイヌナズナにおける葉緑体外OPDA生産系の構築2021

    • Author(s)
      金谷貴広, 井原雄太, 若松孝幸、蛯谷裕輝、太田啓之, 下嶋美恵
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] シロイヌナズナにおける葉緑体外OPDA生産系の構築2021

    • Author(s)
      金谷貴広, 井原雄太, 若松孝幸、蛯谷裕輝、太田啓之, 下嶋美恵
    • Organizer
      植物生理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] シロイヌナズナのリン欠乏時の膜脂質転換におけるnon-specific phospholipase C5の機能解析2021

    • Author(s)
      渡邊帆南, 井原雄太, 吉竹悠宇志, 太田啓之, 下嶋美恵
    • Organizer
      植物生理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Introductory remarks for the session of Trafficking and Metabolism2021

    • Author(s)
      Kentaro Hanada
    • Organizer
      11th International Ceramide Conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 小胞体-ゴルジ体連携ゾーンにおけるCERTの機能制御に関する因子の探索2020

    • Author(s)
      水池彩、 酒井祥太、 山地俊之、 花田賢太郎
    • Organizer
      第62回日本脂質生化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 高浸透圧ストレスにより誘導されるセラミド輸送タンパク質 CERT のリン酸化およびその責任キナーゼに関する解析2020

    • Author(s)
      島﨑健太朗、 熊谷圭悟、 花田賢太郎
    • Organizer
      第62回日本脂質生化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 精神発達遅滞との関連が示唆されるセラミド輸送タンパク質遺伝子CERT1上のミスセンス変異の解析2020

    • Author(s)
      田村律人、 村上博昭、 黒澤健司、 花田賢太郎
    • Organizer
      第62回日本脂質生化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] オルガネラ間脂質輸送の研究:遺伝学と生化学と細胞生物学との幸せなコラボレーションーション2020

    • Author(s)
      花田賢太郎
    • Organizer
      第72回日本細胞生物学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 精神発達遅滞との関連が示唆されるセラミド輸送タンパク質遺伝子CERT1上のドミナント遺伝性変異の解析2020

    • Author(s)
      田村律人、 村上博昭、 黒澤健司、 花田賢太郎
    • Organizer
      第93回日本生化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] セラミド輸送タンパク質CERTのセリンリピートモチーフにおける機能獲得型変異は精神発達遅滞の原因となる2020

    • Author(s)
      村上博昭、 田村律人、 榎本友美、 黒澤健司、 花田賢太郎
    • Organizer
      第65回日本人類遺伝学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] P1糖鎖エピトープを有する糖タンパク質の志賀毒素受容体としての機能解析2020

    • Author(s)
      森本貫太、 鈴木詔子、 谷田以誠、 角田宗一郎、 古田陽子、 内山安男、 花田賢太郎、 鈴木佑典、 山地俊之
    • Organizer
      第39回日本糖質学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 非天然骨格を有するCERT阻害剤のSBDD研究2020

    • Author(s)
      中尾直樹、 上野雅晴、 酒井祥太、 江川大地、 半沢宏之、 川崎祥平、 熊谷圭悟、 鈴木誠 小林修、 花田賢太郎
    • Organizer
      第141回日本薬学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 超解像顕微鏡による各種の生体試料の観察2020

    • Author(s)
      加藤薫
    • Organizer
      新機能イメージングデバイスおよび周辺技術分科会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Localization and motion of ribosomal peptide biosynthetic proteins in fungal hyphae2020

    • Author(s)
      Umemura M. Kuriyama K. Katoh K.
    • Organizer
      Dynamic Cell IV
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] セラミドとの構造類似性のない新規CERT阻害剤の開発2020

    • Author(s)
      花田賢太郎
    • Organizer
      第14回スフィンゴテラピー研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ゼニゴケにおけるホスファチジン酸ホスホヒドロラーゼPAHの役割2020

    • Author(s)
      下城彩、中村将、北浦銀河、佐々木―関本結子、清水信介、堀孝一、岩井雅子、太田啓之、石崎公庸、下嶋美恵
    • Organizer
      第61回日本植物生理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アポダイズド位相差法と画像処理による、小胞体、ミトコンドリア等の運動の無染色での観察2020

    • Author(s)
      加藤薫
    • Organizer
      生体運動合同班会議
    • Related Report
      2019 Annual Research Report
  • [Presentation] Systematic development of natural ligand-nonmimetic inhibitors to the ceramide transport protein CERT2019

    • Author(s)
      Hanada, K
    • Organizer
      FEBS special meeting in “Sphingolipid biology in health and disease”
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hijacking of the ceramide transport protein CERT by Chlamydia trachomatis, an obligatory intracellular bacterium2019

    • Author(s)
      Hanada K
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Natural ligand-nonmimetic inhibitors of the lipid-transfer protein2019

    • Author(s)
      Sakai S, Nakao N, Ueno M, Egawa D, Hanzawa H, Kawasaki S, Kumagai K, Suzuki M, Kobayashi S, Hanada K
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chlamydia trachomatis requires host ceramide-transport protein CERT but not sphingomyelin synthases for the infection and proliferation in HeLa cells2019

    • Author(s)
      Kumagai K, Tachida Y, Sakai S, Yamaji T, Hanada K
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural basis for the specific association between the Chlamydia trachomatis inclusion membrane protein IncD and the PH domain of the ceramide transport protein CERT2019

    • Author(s)
      Sugiki T, Kumagai K, Shinya S, Kobayashi N, Egawa D, Fujiwara T, Hanada K, Kojima C
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] セラミド輸送タンパク質CERTと細胞内寄生細菌クラミジア封入体膜タンパク質IncDとの会合機序2019

    • Author(s)
      花田賢太郎, 熊谷圭悟, 杉木俊彦, 新屋粧子, 小林直宏, 江川大地, 藤原敏道, 児嶋長次郎
    • Organizer
      第61回日本脂質生化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ゲノムワイドスクリーニングによって同定された糖鎖発現制御因子の解析2019

    • Author(s)
      山地俊之, 関塚剛史, 花松久寿, 黒田誠, 古川潤一, 八尋錦之助, 花田賢太郎
    • Organizer
      第38回日本糖質学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] セラミド輸送タンパク質CERTに対する二つのタイプの阻害剤開発2019

    • Author(s)
      花田賢太郎
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] P1糖鎖エピトープを有した糖タンパク質の志賀毒素受容体としての機能解析2019

    • Author(s)
      森本貫太, 鈴木詔子, 花田賢太郎, 鈴木佑典, 山地俊之
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] クラミジアのエフェクタータンパク質IncDと宿主細胞由来のセラミド輸送タンパク質CERTのPHドメインとの結合にはIncDのN末領域とC末領域が必要である2019

    • Author(s)
      熊谷圭悟, 花田賢太郎
    • Organizer
      第3回 オルガネラゾーン 研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Lipid remodeling under acidic conditions and its interplay with low Pi stress in Arabidopsis2019

    • Author(s)
      Shimojima M, Murakawa M, Ohta H
    • Organizer
      9th European Symposium on Plant Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 植物における小胞体―葉緑体間脂質輸送を介した栄養応答2019

    • Author(s)
      下嶋美恵
    • Organizer
      日本植物学会第83回大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ゼニゴケにおけるリン欠乏時の膜脂質転換機構の解析2019

    • Author(s)
      下城彩、中村将、北浦銀河、佐々木―関本結子、清水信介、堀孝一、岩井雅子、太田啓之、石崎公庸、下嶋美恵
    • Organizer
      第5回植物の栄養研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Lipid remodeling under acidic conditions and its interplay with low Pi stress in Arabidopsis2019

    • Author(s)
      Shimojima M, Murakawa M, Ohta H
    • Organizer
      8th Asian-Oceanian Symposium on Plant Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lipid remodeling under phosphate starvation in the liverwort Marchantia polymorpha2019

    • Author(s)
      Shimojo M, Nakamura M, Kitaura G, Sasaki-Sekimoto Y, Shimizu S, Hori KI, Iwai M, Ohta H, Ishizaki K, Shimojima M
    • Organizer
      8th Asian-Oceanian Symposium on Plant Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Observation of fine structures of the cell with optical microscopy2019

    • Author(s)
      Katoh K
    • Organizer
      Nikon Imaging Center Fluorescence Imaging Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fine structures of the cells revealed with conventional and super resolution microscopy2019

    • Author(s)
      Katoh K, Tanaka M, Mitsuyama T
    • Organizer
      The 6th International Symposium on Bioimaging
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] さまざまな顕微鏡でさまざまな細胞を見る。偏光,位相差から,超解像,AIロボットまで2019

    • Author(s)
      加藤薫
    • Organizer
      第14回細胞運動研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 光学顕微鏡で微細な構造をみる ―汎用の光学顕微鏡から超解像顕微鏡まで―2019

    • Author(s)
      加藤薫
    • Organizer
      日本液晶学会 液晶物理・物性研究フォーラム講演会「最新の光学イメージング手法とその液晶への応用」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 様々な光学顕微鏡を駆使し、微細な構造をみる。 ― 偏光、位相差から超解像まで ―2019

    • Author(s)
      加藤薫
    • Organizer
      2019年度イメージングフロンティアシンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Chlamydia trachomatis requires host ceramide-transport protein CERT but not sphingomyelin synthases for the infection and proliferation in HeLa cells2019

    • Author(s)
      Keigo Kumagai, Yuriko Tachida, Shota Sakai, Toshiyuki Yamaji, Kentaro Hanada,
    • Organizer
      9th Chlamydia Basic Research Society(CBRS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differential localization of Arabidopsis phosphatidic acid phosphohydrolases under phosphate starvation2019

    • Author(s)
      Yushi Yoshitake, Kaoru Katoh, Ryoichi Sato, Yuka Madoka, Keiko Ikeda, Masato Murakawa, Ko Suruga, Daisuke Sugiura, Ko Noguchi, Hiroyuki Ohta, Mie Shimojima
    • Organizer
      Gordon Research Conference Plant Lipids: Structure, Metabolism and Function
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 窒素過剰施肥によるオートファジーを介したリン酸欠乏応答の抑制2019

    • Author(s)
      吉竹悠宇志、中村咲耶、泉正範、太田啓之、下嶋美恵
    • Organizer
      第60回日本植物生理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] シロイヌナズナのホスファチジン酸ホスホヒドロラーゼのリン酸欠乏に応答した細胞内局在変化の解析2019

    • Author(s)
      牧村草汰、吉竹悠宇志、太田啓之、下嶋美恵
    • Organizer
      第60回日本植物生理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Observation of fine structures of the cell with super resolution microscopy2019

    • Author(s)
      Kaoru KATOH
    • Organizer
      India_Japan symposium on “Recent advances in Biomedical Research” at Indian Institute of Technology - Guwahati
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Super resolution imaging2019

    • Author(s)
      Kaoru Katoh
    • Organizer
      2nd RCB bioimaging School. Regional Center for Biotechnology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] リン酸化によるセラミド輸送蛋白質CERTのPHドメイン機能抑制機序2018

    • Author(s)
      江川大地, 杉木俊彦, 熊谷圭悟, 児嶋長次郎, 藤原敏道, 竹内 恒, 嶋田一夫, 高橋栄夫, 花田賢太郎
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Chlamydia trachomatisは細胞内寄生に宿主のスフィンゴミエリン生合成を必要としない2018

    • Author(s)
      立田由里子, 熊谷圭悟, 酒井祥太, 山地俊之, 花田賢太郎
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 宿主細胞のスフィンゴミエリン合成酵素はChlamydia trachomatisの細胞内寄生に必須ではない2018

    • Author(s)
      熊谷圭悟, 立田由里子, 酒井祥太, 山地俊之, 花田賢太郎
    • Organizer
      第36回日本クラミジア研究会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 天然リガンドと構造類似性のない脂質輸送タンパク質CERTの新規阻害剤2018

    • Author(s)
      酒井祥太, 中尾直樹, 上野雅晴, 江川大地, 半沢宏之, 川崎祥平, 熊谷圭吾, 鈴木誠, 小林修, 花田賢太郎
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Establishment of natural ligand-mimetic and nonmimetic inhibitors to the ceramide transport protein CERT2018

    • Author(s)
      Kentaro Hanada
    • Organizer
      2nd Japan-Korea Lipid Joint Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nonvesicular comings and goings of lipids in the Golgi2018

    • Author(s)
      Kentaro Hanada
    • Organizer
      FEBS 2018 Advanced Course “The 2018 Golgi meeting: Membrane trafficking in cell organization and homeostasis”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chlamydia trachomatisは細胞内寄生に宿主のスフィンゴミエリン生合成を必要としない2018

    • Author(s)
      立田由里子, 熊谷圭悟, 酒井祥太, 山地俊之, 花田賢太郎
    • Organizer
      第11回セラミド研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 植物における栄養欠乏ストレス時の脂質転換機構2018

    • Author(s)
      下嶋美恵
    • Organizer
      第4回植物の栄養研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 植物のリン酸欠乏時における過剰な窒素施肥の効果2018

    • Author(s)
      吉竹悠宇志、太田啓之、下嶋美恵
    • Organizer
      第4回植物の栄養研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 植物の複合的栄養ストレス応答におけるオートファジーの役割2018

    • Author(s)
      吉竹悠宇志、太田啓之、下嶋美恵
    • Organizer
      日本植物学会第82回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 成長円錐ラメリポディア領域のアクチンの束化タンパク質ファシンの機能解析2018

    • Author(s)
      田中みなみ、藤井裕紀、平野 和己、長崎 晃、石川 良樹、岡嶋孝治、加藤 薫
    • Organizer
      第27回日本バイオイメージング学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 光を用いて、細胞内の数十nmの構造を観察する --偏光、位相差から、超解像顕微鏡まで--2018

    • Author(s)
      加藤 薫
    • Organizer
      日本物理学会第73回大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 超解像光学顕微鏡で細胞の微細構造をみる2018

    • Author(s)
      加藤 薫
    • Organizer
      第13回日本分子イメージング学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 超解像光学顕微鏡による微細構造の機能解析--分子・細胞から、組織・個体へ2018

    • Author(s)
      加藤 薫、田中みなみ、波平昌一、平野和己、上条桂樹、出口友則、足達俊吾、光山統泰
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 超解像光学顕微鏡による繊維状アクチンのイメージング2018

    • Author(s)
      田中みなみ、加藤薫
    • Organizer
      第27回日本バイオイメージング学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 光学顕微鏡で見る世界2018

    • Author(s)
      加藤薫
    • Organizer
      第27回日本バイオイメージング学会 公開講座『顕微鏡イメージングを学ぶ』
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 光学顕微鏡の分解能と超解像顕微鏡2018

    • Author(s)
      加藤薫
    • Organizer
      第27回日本バイオイメージング学会 公開講座『顕微鏡イメージングを学ぶ』
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 超解像顕微鏡による生物試料観察の現状と課題:分子の共局在の検証、厚みのある組織や個体への適用、及び、AIとの連携の試み2018

    • Author(s)
      加藤 薫、田中みなみ、平野和己、出口友則、波平昌一、足達俊吾、光山統泰
    • Organizer
      第13回細胞運動研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Genome-wide CRISPR screening for identifying genes involved in glycolipid metabolism2018

    • Author(s)
      Yamaji T
    • Organizer
      Gordon Research Conference on Glycolipid and Sphingolipid Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 小胞体-ゴルジ体間セラミド輸送を司るCERTの解析とその阻害剤開発2018

    • Author(s)
      花田賢太郎
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 光を用いて、細胞内の数十nmの構造を観察する--偏光、位相差から、超解像顕微鏡まで--2018

    • Author(s)
      加藤 薫
    • Organizer
      日本物理学会第73回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 植物のリン酸欠乏時における過剰な窒素施肥の効果2018

    • Author(s)
      吉竹悠宇志、太田啓之、下嶋美恵
    • Organizer
      第59回日本植物生理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゼニゴケMarchantia polymorphaにおけるリン欠乏時の膜脂質転換機構の解析2018

    • Author(s)
      中村将、北浦銀河、佐々木(関本)結子、堀孝一、岩井雅子、太田啓之、石崎公庸、下嶋美恵
    • Organizer
      第59回日本植物生理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Plant response to the phosphate starvation under various nitrogen-controlled conditions2017

    • Author(s)
      Yoshitake Y, Ohta H, Shimojima M
    • Organizer
      The 7th Asian Symposium on Plant Lipid
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] How does full nitrogen rescue the plants from phosphate deficiency stress?2017

    • Author(s)
      Yoshitake Y, Ohta H, Shimojima M
    • Organizer
      Taiwan-Japan Plant Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CERT研究における今までの総括と今後の展望2017

    • Author(s)
      花田賢太郎
    • Organizer
      第12回スフィンゴテラピー研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リン酸化によるセラミド輸送蛋白質CERTのPHドメイン機能抑制機序2017

    • Author(s)
      江川大地, 杉木俊之, 熊谷圭悟, 児嶋長次郎, 藤原敏道, 竹内恒, 嶋田一夫, 高橋栄夫, 花田賢太郎
    • Organizer
      セラミド研究会10周年記念大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] クラミジアのエフェクタータンパク質IncDと宿主細胞由来のセラミド輸送タンパク質CERTのPHドメインとの結合にはIncDのN末領域とC末領域が必要である2017

    • Author(s)
      熊谷圭悟, Cherilyn A. Elwell, 安藤秀二、Joanne N. Engel, 花田賢太郎
    • Organizer
      2017年度生命科学系学会合同年次大会 第40回日本分子生物学会年会・第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] セラミド輸送蛋白質CERTのリン酸化による機能制御の構造生物学的解析: CERT-Golgi体の結合がCERTのリン酸化によって抑制されるメカニズムの溶液NMR法による解明2017

    • Author(s)
      杉木俊彦, 江川大地, 熊谷圭悟, 児嶋長次郎, 藤原敏道, 竹内 恒, 嶋田一夫, 花田賢太郎, 高橋栄夫
    • Organizer
      2017年度生命科学系学会合同年次大会 第40回日本分子生物学会年会・第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] セラミド輸送タンパク質CERTにおけるリン酸化を介した機能抑制制御に必要な正電荷リピートを持つcoiled-coilモチーフ2017

    • Author(s)
      江川大地, 富重斉生, 山地俊之, 熊谷圭悟, 花田賢太郎
    • Organizer
      2017年度生命科学系学会合同年次大会 第40回日本分子生物学会年会・第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] CRISPRライブラリーを用いた糖脂質生合成に影響を及ぼす因子の探索2017

    • Author(s)
      山地俊之, 関塚剛史,佐久間智理, 立田由里子, 黒田誠, 花田賢太郎
    • Organizer
      2017年度生命科学系学会合同年次大会 第40回日本分子生物学会年会・第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 花田の研究テーマなど

    • URL

      https://www.niid.go.jp/niid/ja/from-biochem/3257-2013-02-25-06-28-53.html

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Remarks] 太田・下嶋研究室

    • URL

      http://www.plantmorphogenesis.bio.titech.ac.jp/~official/

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 国立研究開発法人産業技術総合研究所 バイオメディカル研究部門

    • URL

      https://staff.aist.go.jp/k-katoh/labo/k-katoh.html

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Remarks] Dysregulation of a lipid transfer protein

    • URL

      https://www.asbmb.org/asbmb-today/science/041222/dysregulation-of-a-lipid-transfer-protein-linked-t

    • Related Report
      2021 Annual Research Report
  • [Remarks] CERT依存的なセラミド輸送の場はC10orf76とPI4KBにより形成される

    • URL

      https://www.niid.go.jp/niid/ja/basic-science/biochemistry/12047-biochem-2023-01.html

    • Related Report
      2021 Annual Research Report
  • [Remarks] 細胞内の脂質の物流をコントロール:セラミド輸送タンパク質の新規阻害剤を開発

    • URL

      http://www.s.u-tokyo.ac.jp/ja/press/2019/6269/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 脂質転移タンパク質CERTの天然リガンド非類似性阻害剤

    • URL

      https://www.niid.go.jp/niid/ja/basic-science/466-biochemistory/8660-biochem-2019-2.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 国立感染症研究所 花田の研究テーマなど

    • URL

      https://www.niid.go.jp/niid/ja/from-biochem/3257-2013-02-25-06-28-53.html

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] Ohta & Shimojima Laboratory

    • URL

      http://www.plantmorphogenesis.bio.titech.ac.jp/~official/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 国立研究開発法人産業技術総合研究所 バイオメディカル研究部

    • URL

      https://staff.aist.go.jp/k-katoh/labo/k-katoh.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 「細胞内の脂質の物流をコントロール:セラミド輸送タンパク質の新規阻害剤を開発」

    • URL

      http://www.s.u-tokyo.ac.jp/ja/press/2019/6269/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 「脂質転移タンパク質CERTの天然リガンド非類似性阻害剤」

    • URL

      https://www.niid.go.jp/niid/ja/basic-science/466-biochemistory/8660-biochem-2019-2.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 国立研究開発法人産業技術総合研究所バイオメディカル研究部門

    • URL

      https://staff.aist.go.jp/k-katoh/labo/k-katoh.html

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 東京大学プレスリリース「細胞内の脂質の物流をコントロール:セラミド輸送タンパク質の新規阻害剤を開発」

    • URL

      http://www.s.u-tokyo.ac.jp/ja/press/2019/6269/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 感染研HPでの研究紹介 「タンパク質CERTの天然リガンド非類似性阻害剤」

    • URL

      https://www.niid.go.jp/niid/ja/basic-science/466-biochemistory/8660-biochem-2019-2.html

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-07-04   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi