| Budget Amount *help |
¥114,660,000 (Direct Cost: ¥88,200,000、Indirect Cost: ¥26,460,000)
Fiscal Year 2021: ¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
Fiscal Year 2020: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2019: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2018: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2017: ¥35,230,000 (Direct Cost: ¥27,100,000、Indirect Cost: ¥8,130,000)
|
|---|
| Outline of Final Research Achievements |
Lipid transport between organelles is thought to occur efficiently in special intracellular subregions (called organelle communication zones) where different organelles contact each other. However, it remains elusive how the zones for lipid transport are formed and functionally regulated. and the visualization of the zone has not been achieved. In this study, we investigated the ceramide transfer protein CERT, which mediates ceramide transport from the endoplasmic reticulum (ER) to the Golgi apparatus in animal cells, and the phosphatidic acid phosphohydrolase, which is involved in phospholipid transport from the ER to the chloroplast in plant cells. Using high-resolution imaging techniques, we elucidated the molecular mechanisms underlying the formation and regulation of the ER communication zones involved in lipid transport.
|
