| Budget Amount *help |
¥73,450,000 (Direct Cost: ¥56,500,000、Indirect Cost: ¥16,950,000)
Fiscal Year 2021: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2020: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2019: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2018: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2017: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
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| Outline of Final Research Achievements |
The cell biological significance of the organelle zones formed by lipids that are characteristic of the organelle was elucidated. Specifically, we found that phosphatidylserine on recycling endosomes regulates the Hippo-YAP pathway and is involved in cancer cell proliferation. We also found that STING, which is important for innate immune responses, is activated in the lipid raft environment of the Golgi, then ubiquitinated in recycling endosomes and degraded by microautophagy. Furthermore, we found that the membrane environment formed by saturated phosphatidylcholine, cardiolipin, and phosphatidic acid is important for TLR4 response, Cullin3 activation, and IRE1 activation, respectively.
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