| Budget Amount *help |
¥76,180,000 (Direct Cost: ¥58,600,000、Indirect Cost: ¥17,580,000)
Fiscal Year 2021: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2020: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2019: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2018: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2017: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
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| Outline of Final Research Achievements |
Sorting zones of GPI-anchored and non-anchored proteins were visualized in yeast. COPII vesicles, carriers of ER-to-Golgi transport, accumulate at ER exit sites (ERES). GPI-anchored and non-anchored proteins were shown to enter distinct ERES, providing evidence for the presence of sorting zones in the ER. The GPI-anchor lipid contains very long chain ceramide in yeast. In a mutant strain that are deficient in synthesizing very long chain ceramides, GPI-anchored and non-anchored proteins both entered the same ERES, indicating that the chain length of ceramides is critical for the sorting of these proteins at ERES.
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