| Budget Amount *help |
¥111,020,000 (Direct Cost: ¥85,400,000、Indirect Cost: ¥25,620,000)
Fiscal Year 2021: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
Fiscal Year 2020: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
Fiscal Year 2019: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
Fiscal Year 2018: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
Fiscal Year 2017: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
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| Outline of Final Research Achievements |
Wolbachia species are the most widespread intracellular bacterial endosymbionts in insects. Male killing is one strategy by which Wolbachia manipulate the male-female sex ratio of their host’s progeny. In a previous study, we showed that Wolbachia infection induces male-specific death in the Asian corn borer Ostrinia furnacalis by inducing a failure of dosage compensation through targeting the host factor Masculinizer (Masc), an essential protein for both masculinization and dosage compensation. However, it remains unknown how a male-killing Wolbachia inhibits the functions of Masc. In this study, we identify a Wolbachia protein, designated Oscar, which interacts with Masc. Embryonic expression of Oscar inhibited Masc-induced masculinization and induced male killing in lepidopteran insects. Our results indicated that Oscar is the long-sought Wolbachia’s male-killing factor for lepidopteran insects.
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