| Budget Amount *help |
¥54,990,000 (Direct Cost: ¥42,300,000、Indirect Cost: ¥12,690,000)
Fiscal Year 2021: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2020: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2019: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2018: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2017: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Outline of Final Research Achievements |
We have developed a hybrid catalyst system consisting of a strong base catalyst and a metal or organo catalyst, and applied for catalytic stereoselective reactions using a raw material that is easily available but has poor reactivity. Catalytic asymmetric Mannich reactions using a propionamide, which is a weakly acidic compound, and catalytic asymmetric addition reactions of alkylarenes, such as toluene, and propylene with imines were realized by using chiral strong base hybrid catalyst systems. By constructing a hybrid catalyst system of a base catalyst and an organo photocatalyst, we developed catalytic reactions between styrenes and malonic acid esters, which do not react using the base catalyst alone. We have also developed K/γ-Al2O3 as a strong solid base catalyst and realized catalytic 1,4-addition reactions of a propionamide in a flow reaction system.
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