| Budget Amount *help |
¥143,520,000 (Direct Cost: ¥110,400,000、Indirect Cost: ¥33,120,000)
Fiscal Year 2021: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2020: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2019: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
Fiscal Year 2018: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2017: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
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| Outline of Final Research Achievements |
In recent years, there has been a strong demand for molecular design of catalysts and development of organic synthesis that are environmentally friendly. For this reason, incorporation of the advantages of in vivo systems into organic synthesis seems to be a powerful strategy. For example, in biological systems, activation of organic molecules and synthesis of complex natural products are easily carried out by multi-catalytic reactions involving multiple enzymes (biocatalysts), but it is extremely difficult to realize the similar transformations in an artificial manner. In this research, we extract functions such as the recognition and activation of substrates without using macromolecules such as the enzymes. Aiming to construct a "high-performance hybrid catalyst system", a series of new and precise domino-type synthetic transformations have been successfully developed.
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