| Budget Amount *help |
¥79,560,000 (Direct Cost: ¥61,200,000、Indirect Cost: ¥18,360,000)
Fiscal Year 2021: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2020: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2019: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2018: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2017: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
|
|---|
| Outline of Final Research Achievements |
We utilized multicomponent coupling reactions to assemble densely functionalized natural products. We developed hybrid catalysis-mediated cross-coupling, two- and three-component radical reactions, radical dimerization, photoredox-catalyzed radical cyclization, and two-component TiO2-mediated radical reactions to streamline the convergent syntheses of highly complex structures. These new strategies and tactics enabled us to minimize the functional group transformations, thereby simplifying the synthetic routes to the target structures. Consequently, we achieved the concise and efficient total syntheses of a diverse collection of densely functionalized natural products, including anticancer agent taxol. Since synthetic organic chemistry is a key science and technology for the development of new pharmaceuticals, the achievements of this project will have a significant impact on chemistry, biology, and pharmaceutical sciences.
|
