| Budget Amount *help |
¥72,670,000 (Direct Cost: ¥55,900,000、Indirect Cost: ¥16,770,000)
Fiscal Year 2021: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2020: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2019: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2018: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2017: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Outline of Final Research Achievements |
To determine whether stem cell genomes are maintained stably in long-lived organisms, they generated a high-quality genome of Shorea laevis and detected somatic mutations that accumulated over 400 years to accurately estimate the mutation rate prior to natural selection and genetic drift in the next generation population. The number of somatic mutations was shown to increase linearly with growth, and the rate of de novo mutations per base per year was accurately estimated. Detailed analysis of the mutation spectrum showed that mutations caused by DNA damage to UV light were the most abundant (53.1%). Comparative genomic analysis suggested that trees have a higher copy number of poly(ADP-ribose) polymerase (PARP) than perennial and annual plants, contributing to their long-term survival and protection from DNA damage and pathogen infection. These results provide important knowledge in understanding the evolution of DNA repair and lifespan in plants.
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